Side Effects of eletriptan: A Synthesis of Findings from 19 Studies

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Original Abstract of the Article

Main Research Findings

Eletriptan is a 5-HT1B/1D receptor agonist that is effective for the acute treatment of migraine. 5 , 14 Eletriptan may have some pharmacological and clinical advantages compared to other triptans. 10

Eletriptan has a faster absorption rate and Tmax compared to other triptans. 10 Eletriptan is also faster in onset of action than other triptans, with a better 2-hour headache response and a 2-hour pain-free rate. 10 Eletriptan may have a lower risk of cardiovascular side effects than other triptans. 10 However, although serious cardiovascular events have not yet been reported, it should still be used with caution in patients with cardiovascular risk factors. 10

Eletriptan is effective in patients who previously discontinued oral sumatriptan due to lack of efficacy or intolerable adverse events. 4 Eletriptan has good efficacy and tolerability in patients who have previously taken oral sumatriptan. 4

Reasons for Side Effects

Side effects of eletriptan may be due to pharmacological effects. 9 However, side effects may be unmasked neurological symptoms of the migraine attack after pain relief. 9

Common Side Effects

Drowsiness

Side effects such as drowsiness have been reported after taking eletriptan. 9

Asthenia

Side effects such as asthenia have been reported after taking eletriptan. 9

Other Side Effects

Like other triptans, eletriptan can cause side effects such as nausea, vomiting, and chest symptoms. 4

Countermeasures for Side Effects

Drowsiness

To reduce drowsiness, it is important to take precautions, such as avoiding driving or operating machinery after taking eletriptan. 9

Asthenia

If you experience side effects such as asthenia, try to reduce the stress on your body, such as resting. 9

Comparison of Studies

Commonalities of Studies

All studies have shown that eletriptan is effective for the acute treatment of migraine. 4 , 14 , 12

Differences in Studies

The incidence of eletriptan side effects varied across studies. 9

Notes on Real-Life Applications

Eletriptan is an effective drug for the acute treatment of migraine, but it can cause side effects. 4 Therefore, it is important to understand the risks of side effects when using eletriptan. 4

Limitations of Current Research

More research on the side effects of eletriptan is needed. 9

Future Research Directions

Further research on the side effects of eletriptan is needed. 9

Conclusion

Eletriptan is an effective drug for the acute treatment of migraine, but it can cause side effects such as drowsiness and asthenia. 4 , 9 It is important to understand the risks of side effects when using eletriptan. 4

Literature analysis of 19 papers
Positive Content
17
Neutral Content
2
Negative Content
0
Article Type
2
1
2
11
19
1.

Impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals.

Author: CliffordDavid B, EvansScott, YangYijun, AcostaEdward P, GoodkinKarl, TashimaKaren, SimpsonDavid, DorfmanDavid, RibaudoHeather, GulickRoy M

Improve neuropsychological performance
Neurological symptoms

Efavirenz is an antiretroviral drug that can cause neurologic side effects. A study found that these side effects were more common in the first week of treatment but resolved by week 4. Neuropsychological performance improved in both the efavirenz and the control groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

2.

Neuronal toxicity of efavirenz: a systematic review.

Author: DecloedtEric H, MaartensGary

Neurocognitive improvement
Cognitive impairment
Neuron damage
Neuropsychiatric side effects

Efavirenz may contribute to cognitive impairment by damaging nerve cells. Further research is needed to confirm this effect.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

A review of trials investigating efavirenz-induced neuropsychiatric side effects and the implications.

Author: GaidaRazia, TruterIlse, GroblerChristoffel, KotzeTheunis, GodmanBrian

Neuropsychiatric side effects

This review analyzed the neuropsychiatric side effects associated with efavirenz in HIV patients. Common side effects included sleep problems, depression, dizziness, and anxiety, which were generally mild and did not require discontinuation of the drug.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Eletriptan for the treatment of migraine in patients with previous poor response or tolerance to oral sumatriptan.

Author: FärkkiläM, OlesenJ, DahlöfC, StovnerL J, ter BruggenJ P, RasmussenS, MuirheadN, SikesC

Migraine treatment
Asthenia
Chest symptoms
Nausea
Vomiting

This study evaluated the tolerability and efficacy of eletriptan in patients who had discontinued oral sumatriptan due to lack of efficacy or intolerable adverse events. Eletriptan was effective and well tolerated in these patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Comparative aspects of triptans in treating migraine.

Author: AdelmanJ U, LewitE J

Migraine treatment
Adverse effects

Triptans, beginning with sumatriptan, have revolutionized the treatment of migraine. New triptans in several formulations will soon become available in the United States. Subcutaneous sumatriptan has the most rapid onset of action and greatest efficacy but the most adverse effects. Intranasal sumatriptan also has rapid onset of action, but at 2 hours its efficacy is comparable to that of oral zolmitriptan. Of the oral triptans, rizatriptan seems to have the greatest early efficacy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Triptans and CNS side-effects: pharmacokinetic and metabolic mechanisms.

Author: DodickD W, MartinV

Acute migraine treatment
CNS side effects

This study analyzes the differences in efficacy and tolerability among oral triptans, a class of drugs used to treat acute migraine. The study identifies almotriptan, naratriptan, and sumatriptan as triptans with the lowest incidence of CNS side effects. The presence of active metabolites and high lipophilicity are identified as potential factors influencing the occurrence of CNS side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Acute management of migraine.

Author: ChowdhuryDebashish

Migraine treatment
Overuse headache

This article reviews the current treatment options for migraine headaches, including acute treatment with triptans, which are generally well-tolerated and effective in aborting attacks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Treatment-emergent CNS symptoms following triptan therapy are part of the attack.

Author: GoadsbyP J, DodickD W, AlmasM, DienerH-C, Tfelt-HansenP, LiptonR B, ParsonsB

Migraine treatment
Asthenia
Somnolence

Treatment-emergent central nervous system (CNS) symptoms following triptan therapy may represent the unmasking of CNS symptoms associated with the natural resolution of a migraine attack, rather than simply representing drug-related side-effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Eletriptan: pharmacological differences and clinical results.

Author: GiffinN

Faster Onset
Migraine Treatment
Reduced Cardiovascular Risk
Headache Recurrence

Eletriptan is a drug used to treat migraine headaches. It is faster acting than sumatriptan, but it has not been compared to other triptans. It is not known if it is more effective than sumatriptan for preventing headaches from returning.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Antimigraine drugs.

Author: DienerH C, KaubeH, LimmrothV

Headache reduction
Migraine relief
Side effects

This review summarizes new treatment options for migraine attacks, including antiemetics, analgesics, triptans, and prophylactic medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

The evolving management of migraine.

Author: AshkenaziAvi, SilbersteinStephen D

Effective migraine treatment
Improved migraine prevention
Central nervous system side effects
Cognitive side effects

New drugs expand the spectrum of migraine treatment both for the acute attack and for prevention.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Twenty-five years of triptans - a nationwide population study.

Author: DavidssonOlafur B, OlofssonIsa A, KogelmanLisette Ja, AndersenMichael Asger, RostgaardKlaus, HjalgrimHenrik, OlesenJes, HansenThomas Folkmann

Migraine treatment
Triptan overuse

This nationwide register-based cohort study in Denmark found that triptan use increased significantly over a 25-year period, but adherence rates were low, likely due to disappointing efficacy and/or unpleasant side effects. Rates of triptan overuse also increased.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Pharmacological approaches to migraine.

Author: DienerH Ch

Treats migraine

This review summarizes new treatment options for both acute migraine attacks and migraine prophylaxis. Triptans are highly effective in treating migraine attacks. For migraine prophylaxis, beta-blockers, calcium channel blockers, and antiepileptic drugs are effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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