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Endometrial protection from tamoxifen-stimulated changes by a levonorgestrel-releasing intrauterine system: a randomised controlled trial.

Author: AbramsK R, Al-AzzawiF, BellS C, BrownL J, GardnerF J, KhannaS, KonjeJ C, TaylorD J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aimed to assess the effects of a levonorgestrel intrauterine system on uterine responses to tamoxifen, a breast cancer treatment. The study also evaluated women's tolerance of the insertion, removal, and potential side effects of the device.
Paper Details　
Original Abstract of the Article :
Tamoxifen is currently the most commonly used adjuvant treatment for breast cancer, however, it frequently causes episodes of unscheduled uterine bleeding, which could be associated with proliferative changes of the endometrium, or even endometrial cancer. We aimed to assess whether a levonorgestrel...See full text at original site
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引用元：
https://doi.org/10.1016/s0140-6736(00)03204-9

データ提供：米国国立医学図書館（NLM）

Endometrial Protection with Levonorgestrel Intrauterine System

Tamoxifen is a commonly used treatment for breast cancer, but it can have significant side effects on the endometrium. This randomized controlled trial investigates the potential of a levonorgestrel-releasing intrauterine system (LNG-IUS) to protect the endometrium from the changes induced by tamoxifen. The researchers sought to determine if the LNG-IUS could mitigate the risk of unscheduled uterine bleeding and other endometrial complications associated with tamoxifen therapy.

Protecting the Endometrium During Tamoxifen Therapy

The results of this study suggest that a levonorgestrel-releasing intrauterine system may be effective in protecting the endometrium from the negative effects of tamoxifen. Think of it like building a protective barrier in a desert oasis, shielding valuable resources from the harsh and unpredictable environment. The LNG-IUS creates a protective barrier around the endometrium, mitigating the potential harm caused by tamoxifen.

Implications for Patient Care

This study has important implications for the management of breast cancer patients undergoing tamoxifen therapy. By understanding the potential benefits of using a LNG-IUS, healthcare professionals can provide more personalized and effective treatment plans for their patients. This approach allows for a safer and more comfortable experience for patients undergoing this essential therapy. The study also emphasizes the importance of assessing patient tolerance for the insertion, removal, and potential side effects of the device. Just as a traveler must assess the terrain and potential hazards before embarking on a desert journey, healthcare providers must assess the individual needs and risks associated with each treatment option.

Dr.Camel's Conclusion

The study suggests that the LNG-IUS could be a valuable tool for mitigating the adverse effects of tamoxifen on the endometrium. This research highlights the importance of developing targeted therapies that address the specific needs of individual patients. The study also emphasizes the crucial role of patient-centered care, ensuring that treatment plans are tailored to individual needs and preferences.

Date :
  1. Date Completed 2000-12-14
  2. Date Revised 2022-02-01
Further Info :

Pubmed ID

11095258

DOI: Digital Object Identifier

10.1016/s0140-6736(00)03204-9

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Article Analysis
・Effects of levonorgestrel intrauterine system
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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