Effects of levonorgestrel intrauterine system: A Synthesis of Findings from 25 Studies

  1. Home
  2. Effects of levonorgestrel intrauterine system
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of levonorgestrel intrauterine system: A Synthesis of Findings from 25 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of levonorgestrel intrauterine system: A Synthesis of Findings from 25 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Key Research Findings

The levonorgestrel intrauterine system (LNG-IUS) has been shown to be an effective treatment for heavy menstrual bleeding in women with various conditions, including uterine adenomyosis, 8 , perimenopausal abnormal uterine bleeding (AUB), 19 , and postmenstrual spotting related to a niche in the uterine cesarean scar. 12 , 21 . It has also been found to be effective in preventing endometrial hyperplasia, a precursor to endometrial cancer. 15 . The LNG-IUS is a long-acting contraceptive option that has been approved for use for up to 7 years. 16 It is also considered a safe and effective contraceptive for nulligravidas and adolescent girls. 24 . Additionally, studies have shown that the LNG-IUS can provide endometrial protection against tamoxifen-stimulated changes in women with breast cancer. 1 , 25 .

Benefits and Risks

Benefits Summary

The LNG-IUS offers several benefits, including its effectiveness in treating heavy menstrual bleeding, preventing endometrial hyperplasia, and acting as a long-acting contraceptive method. It is also considered safe for nulligravidas and adolescent girls. In addition, it can provide endometrial protection against tamoxifen-stimulated changes in women with breast cancer.

Risks Summary

While the LNG-IUS is generally considered safe, there are some potential risks and side effects associated with its use. These may include irregular bleeding, headaches, weight gain, mood swings, and potential thinning of the uterine lining, which could increase the risk of endometrial cancer. 15 , 1 , 25 , 7 , 14 , 11 , 、 23 、 13 、 12 、 9 、 24 、 21 、 10 It's important to discuss these potential risks with a healthcare provider before using the LNG-IUS.

Comparison of Studies

Commonalities Among Studies

Several studies consistently demonstrate the effectiveness of the LNG-IUS in treating heavy menstrual bleeding and its role as a contraceptive method. There is also agreement on its general safety profile, with most studies highlighting a good safety record. Furthermore, many studies emphasize the protective effects of the LNG-IUS on the endometrium, particularly in situations where the endometrium might be susceptible to complications.

Differences Among Studies

While the studies generally agree on the effectiveness and safety of the LNG-IUS, some differences exist in their specific objectives and designs. For example, 8 compares the efficacy of LNG-IUS with dienogest for treating adenomyosis, whereas other studies do not include such a comparison. The target populations and the specific conditions being studied also vary across the research.

Consistency and Contradictions in Findings

While the research generally supports the effectiveness of the LNG-IUS in treating heavy menstrual bleeding and its role as a contraceptive, there are some inconsistencies in findings regarding potential side effects and risks. For instance, suggests a possible association between LNG-IUS use and subsequent psychotropic drug use, while other studies do not report this correlation. This highlights the need for further research to fully evaluate potential risks associated with LNG-IUS use.

Considerations for Real-World Application

Based on the research, the LNG-IUS appears to be a valuable option for women experiencing heavy menstrual bleeding or seeking long-acting contraception. However, it's crucial to be aware of the potential side effects and risks, including irregular bleeding, headaches, weight gain, mood swings, and potential thinning of the uterine lining, which could increase the risk of endometrial cancer. 15 , 1 , 25 , 7 , 14 , 11 , 、 23 、 13 、 12 、 9 、 24 、 21 、 10 Thorough discussions with a healthcare provider are essential to weigh the benefits and risks and determine if the LNG-IUS is the right option for individual needs.

Limitations of Current Research

While substantial research exists on the LNG-IUS, some limitations exist. Not all studies utilize the same research design, making it challenging to compare findings directly and reach conclusive conclusions about its overall effectiveness and safety. The target populations in different studies also vary in age, ethnicity, and health status, highlighting the need for caution in generalizing findings to all individuals.

Future Research Directions

Future research on the LNG-IUS should focus on addressing these limitations. Studies involving diverse populations with varying age ranges, ethnicities, and health conditions are crucial to broaden the understanding of its effectiveness and safety. Longitudinal studies investigating the long-term effects of LNG-IUS use are also needed, as are studies specifically designed to evaluate the risk of endometrial cancer associated with its use. 15 , 1 , 25 , 7 , 14 , 11 , 、 8 、 23 、 13 、 12 、 9 、 24 、 21 、 10 、 5 、 4 Moreover, comparative research examining the LNG-IUS alongside other contraceptive methods and studies investigating optimal usage practices are also necessary to refine clinical guidance.

Conclusion

The LNG-IUS appears to be a valuable option for women seeking treatment for heavy menstrual bleeding or a long-acting contraceptive method. However, it's important to weigh the potential benefits and risks through thorough discussions with a healthcare provider. Further research is needed to enhance the understanding of LNG-IUS effects and to guide clinical practice effectively.

Literature analysis of 25 papers
Positive Content
22
Neutral Content
2
Negative Content
0
Article Type
9
4
4
3
24
1.

Endometrial protection from tamoxifen-stimulated changes by a levonorgestrel-releasing intrauterine system: a randomised controlled trial.

Author: GardnerF J, KonjeJ C, AbramsK R, BrownL J, KhannaS, Al-AzzawiF, BellS C, TaylorD J

Modulates uterine responses
Uterine bleeding

This study aimed to assess the effects of a levonorgestrel intrauterine system on uterine responses to tamoxifen, a breast cancer treatment. The study also evaluated women's tolerance of the insertion, removal, and potential side effects of the device.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Levonorgestrel-releasing intrauterine system and endometrial ablation in heavy menstrual bleeding: a systematic review and meta-analysis.

Author: KaunitzAndrew M, MeredithSusanna, InkiPirjo, KubbaAli, Sanchez-RamosLuis

Bleeding reduction
Quality of life
No major complications

The levonorgestrel intrauterine system and endometrial ablation were equally effective in reducing heavy menstrual bleeding, with similar therapeutic effects up to 2 years after treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Comparison of levonorgestrel intrauterine system versus hysterectomy on efficacy and quality of life in patients with adenomyosis.

Author: OzdegirmenciOzlem, KayikciogluFulya, AkgulMehmet Akif, KaplanMetin, KarcaaltincabaMusturay, HaberalAli, AkyolMesut

Improved quality of life
Reduced menorrhagia

LNG-IUS can improve hemoglobin levels and quality of life in patients with adenomyosis, similar to hysterectomy. Though both treatments improve quality of life, LNG-IUS has a superior impact on psychological and social well-being. It may be a better alternative to hysterectomy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Pharmacokinetics of two low-dose levonorgestrel-releasing intrauterine systems and effects on ovulation rate and cervical function: pooled analyses of phase II and III studies.

Author: ApterDan, Gemzell-DanielssonKristina, HauckBrian, RosenKimberly, ZurthChristian

Lower LNG exposure
Lower anovulation incidence

Pooled pharmacokinetic and pharmacodynamic analyses of phase II and III studies comparing levonorgestrel intrauterine system (LNG-IUS) 13.5 mg and LNG-IUS 19.5 mg to LNG-IUS 20 μg/24 h found that LNG-IUS 13.5 mg and LNG-IUS 19.5 mg resulted in lower systemic exposure to LNG, lower incidence of anovulation, and similar progestin impact on the endometrium and cervical function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Effects of a levonorgestrel intrauterine system versus a copper intrauterine device on menstrual changes and uterine artery Doppler.

Author: RezkMohamed, ElshamyElsayed, ShaheenAbd-Elhamid, ShawkyMohamed, MarawanHala

Menstrual changes
Uterine artery blood flow
Abnormal bleeding

LNG-IUS-related abnormal bleeding was associated with changes in uterine artery blood flow that were not evident among Cu-IUD users.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Language : English

7.

Weight-Loss Interventions and Levonorgestrel Intrauterine System Implantation for Early-Stage Endometrial Cancer and Atypical Endometrial Hyperplasia to Reduce Perioperative Risk of Severely Obese Patients.

Author: Isono-TaniguchiRoze, TsubamotoHiroshi, InoueKayo, UedaTomoko, SaekiShinichiro, TakimotoYumi, WakimotoYu, ShibaharaHiroaki

Laparoscopic hysterectomy
Reduced morbidity
Weight loss

The study described preoperative management of weight-loss interventions (WLIs) using levonorgestrel intrauterine system (LNG-IUS) in seven highly obese women with atypical endometrial hyperplasia (AEH) and endometrial cancer (EC). LNG-IUS was used to minimize tumor progression until planned surgery.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

8.

Compare the Efficacy of Dienogest and the Levonorgestrel Intrauterine System in Women with Adenomyosis.

Author: GuoWeina, LinYuchen, HuSijian, ShenYi

Pain relief
Uterine volume control

Dienogest (DNG) and levonorgestrel intrauterine system (LNG-IUS) are both effective in improving pain associated with adenomyosis. DNG demonstrates continuous pain relief and effectively controls uterine volume growth, making it a more favorable option compared to LNG-IUS.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

A randomized trial comparing the 52-mg levonorgestrel system with combination oral contraceptives for treatment of heavy menstrual bleeding.

Author: MattesonKristen A, ValcinJosie, RakerChristina A, ClarkMelissa A

Effective treatment
Improved quality of life

This randomized trial compared the effectiveness of the 52-mg levonorgestrel intrauterine system (LNG-IUS) with combined oral contraceptives (COCs) for improving quality of life in individuals with self-reported heavy menstrual bleeding. Both LNG-IUS and COCs significantly improved bleeding-related quality of life, with no significant difference between the two groups at 6 or 12 months. The study concludes that both LNG-IUS and COCs are effective options for improving bleeding-related quality of life, and patients should be counseled accordingly.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

11.

Comparison of the effect of levonorgestrel-intrauterine system with or without oral megestrol acetate on fertility-preserving treatment in patients with atypical endometrial hyperplasia: A prospective, open-label, randomized controlled phase II study.

Author: XuZhiying, YangBingyi, ShanWeiwei, LiaoJiongbo, ShaoWenyu, WuPengfei, ZhouShuang, NingChengcheng, LuoXuezhen, ZhuQin, ZhangHongwei, MaFenghua, GuanJun, ChenXiaojun

Less side effects with LNG-IUS
Underpowered study

This randomized controlled trial compared the efficacy of levonorgestrel-intrauterine system (LNG-IUS) with or without oral megestrol acetate (MA) versus MA alone for atypical endometrial hyperplasia (AEH). There was no significant difference in complete response rate or other secondary endpoints between the groups. Further studies are needed with a larger sample size to confirm these findings.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Comparing levonorgestrel intrauterine system with hysteroscopic niche resection in women with postmenstrual spotting related to a niche in the uterine cesarean scar: a randomized, open-label, controlled trial.

Author: ZhangJian, ZhuChenfeng, YanLi, WangYang, ZhuQian, HeChuqing, HeXiaoqing, JiSifan, TianYuan, XieLi, LiangYan, XiaWei, MolBen W, HuirneJudith A F

Reduced pain
Reduced spotting

This randomized controlled trial compared the effectiveness of a 52-mg levonorgestrel intrauterine system with hysteroscopic niche resection in reducing niche-related postmenstrual spotting after cesarean delivery. While the levonorgestrel intrauterine system was not more effective than hysteroscopic niche resection at 6 months, it showed superior reduction in spotting from 9 months onward and reduced the absolute number of spotting days and pelvic pain from 6 months onward.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Practice variation in the stepped care approach to idiopathic heavy menstrual bleeding: A population-based study.

Author: VinkMaarten D H, PortraitFrance R M, van WezepTim C, KoolmanXander, MolBen W, BongersMarlies Y, van der HijdenEric J E

HMB management
Increased healthcare costs
Suboptimal health outcomes

Dutch guidelines recommend a stepped care approach for managing idiopathic heavy menstrual bleeding (HMB), but practice variation between hospitals can lead to suboptimal health outcomes and increased healthcare costs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Comparison of the effect of oral megestrol acetate with or without levonorgestrel-intrauterine system on fertility-preserving treatment in patients with early-stage endometrial cancer: a prospective, open-label, randomized controlled phase II trial (ClinicalTrials.gov NCT03241914).

Author: XuZhiying, YangBingyi, GuanJun, ShanWeiwei, LiaoJiongbo, ShaoWenyu, ChenXiaojun

EEC treatment
Fertility preservation
Vaginal hemorrhage

The addition of levonorgestrel-releasing intrauterine system (LNG-IUS) to oral megestrol acetate (MA) may not improve the early complete response (CR) rate for early-stage endometrial cancer (EEC) and may produce more adverse events. This randomized controlled trial of 63 patients showed no significant difference in the 16-week CR rate between the MA and MA + LNG-IUS groups. However, more women in the MA + LNG-IUS group experienced vaginal hemorrhage.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Contraceptive efficacy and safety of the 52-mg levonorgestrel intrauterine system for up to 8 years: findings from the Mirena Extension Trial.

Author: JensenJeffrey T, Lukkari-LaxEeva, SchulzeAndrea, WahdanYesmean, SerraniMarco, KrollRobin

Favorable safety profile
High contraceptive efficacy
User satisfaction
Ectopic pregnancy

This study evaluated the efficacy and safety of the 52-mg levonorgestrel-releasing intrauterine system during extended use for up to 8 years. The study found that the system maintained high contraceptive efficacy, user satisfaction, and a favorable safety profile for up to 8 years. The study also found that bleeding patterns remained favorable for women who continued using the system for 8 years.

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
CommentA short article/note that provides an opinion/perspective/interpretation on a published paper/topic.

Language : English

17.

Efficacy of high-intensity focused ultrasound combined with LNG-IUS for adenomyosis: a systematic review and meta-analysis.

Author: ZhaoTing-Ting, PangLi-Li, YangLei-Lei, LiRuo-Nan, FanLing-Xiu, WenYi

Lower recurrence rate
Reduced uterine volume
Symptom relief

High-intensity focused ultrasound (HIFU) combined with the levonorgestrel intrauterine system (LNG-IUS) was more effective in reducing uterine volume and dysmenorrhea than HIFU alone in patients with adenomyosis. The HIFU/LNG-IUS group had a lower recurrence rate than the HIFU control group. However, this conclusion should be referenced with caution due to the small number of included studies and the fact that some were not randomized controlled trials.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Reasons for satisfaction with the use of the 52-mg levonorgestrel intrauterine system.

Author: LaporteMontas, CharlesCharles M, MetelusSherly, SouzaRafael B, PeloggiaAlessandra, BahamondesLuis

Reduced bleeding
Reduced dysmenorrhea

A study of 517 women using the levonorgestrel 52-mg intrauterine system (LNG-IUS) found a high satisfaction rate (91%) mainly due to the reduction of menstrual bleeding (81%) and dysmenorrhea (56.1%).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Levonorgestrel intrauterine system for the treatment of intermenstrual spotting in patients with previous cesarean delivery scar defect.

Author: OuYu-Che, ChenYing-Yi, LanKuo-Chung, TsaiChing-Chang, ChuLi-Ching, ChengLing-Yun

Intermenstrual bleeding

Levonorgestrel 52 mg intrauterine system was safe and effective in managing intermenstrual spotting in patients with previous cesarean delivery scar defects (PCDSs).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Comparing levonorgestrel intrauterine system versus hysteroscopic resection in patients with postmenstrual spotting related to a niche in the caesarean scar (MIHYS NICHE trial): protocol of a randomised controlled trial.

Author: HeChuqing, HeXiaoqing, LiangYan, SunTaotao, YanLi, ZhuChenfeng, ZhaoXiaoya, XieLi, MolBen W, ZhangJian, HuirneJ A F

Postmenstrual spotting
Caesarean section complications

This study will compare the effectiveness of LNG-IUS 52 mg and hysteroscopic niche resection in improving postmenstrual spotting related to a niche in women.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Comparison of two levonorgestrel-releasing intrauterine systems for the treatment of heavy menstrual bleeding: a randomised, controlled, phase 3 trial.

Author: IlyinAlexey B, KhasanovAlbir A, SuturinaLarisa V, BorisovaNatalia I, ReshetovZakhar S, FoidartJean-Michel, DériJudit Alexandra, TóthVera

Reduced menstrual bleeding

The levonorgestrel-releasing intrauterine system Donasert was found to be non-inferior to the levonorgestrel-releasing intrauterine system Mirena in treating heavy menstrual bleeding (HMB) in non-menopausal women. In a randomized, active-controlled study, Donasert showed similar effectiveness in reducing HMB and improving quality of life compared to Mirena.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

The combined use of endometrial ablation or resection and levonorgestrel-releasing intrauterine system in women with heavy menstrual bleeding: A systematic review.

Author: OderkerkTamara J, van de KarMajorie M A, van der ZandenCarlijn H M, GeominiPeggy M A J, HermanMalou C, BongersMarlies Y

Menstrual bleeding treatment
LNG-IUS side effects
Re-intervention rate

This systematic review assesses the impact of combining endometrial ablation/resection with a levonorgestrel-intrauterine system (LNG-IUS) on re-intervention rates in women with heavy menstrual bleeding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Intrauterine device use is safe among nulligravidas and adolescent girls.

Author: BahamondesM Valeria, BahamondesLuis

Contraception
Unplanned pregnancy prevention
Bleeding
Expulsion rate
Pain

This review discusses the safety and efficacy of intrauterine devices (IUDs) as contraceptives in nulligravidas and adolescent girls, highlighting their effectiveness and potential side effects. The review emphasizes the importance of IUDs in reducing unplanned pregnancies among these populations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

25.

Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen.

Author: RomeroSally Ad, YoungKatie, HickeyMartha, SuH Irene

This systematic review explored the evidence for the levonorgestrel-releasing intrauterine system (LNG-IUS) in preventing endometrial pathology in women taking tamoxifen for breast cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.