Sulfinpyrazone reduces cyclosporine levels: a new drug interaction in heart transplant recipients.

Author: AngeliniA, CaforioA L, CasarottoD, Dalla VoltaS, FeltrinG, GambinoA, MarchiniF, PompeiE, TestolinL, TonaF

Paper Details 
Original Abstract of the Article :
BACKGROUND: Management of cyclosporine (CsA)-associated hyperuricemia in heart transplantation (HT) is difficult. Because of the myelotoxicity of combined allopurinol and azathioprine, we tested sulfinpyrazone. METHODS: We studied 120 HT recipients (109 men; mean age at HT, 52+/-10 years). All had ...See full text at original site
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引用元:
https://doi.org/10.1016/s1053-2498(00)00216-3

データ提供:米国国立医学図書館(NLM)

Sulfinpyrazone: A Double-Edged Sword in Heart Transplant Recipients

Imagine you're a camel, carrying a precious cargo across the vast desert. You need to be strong and healthy to complete your journey, but sometimes, even the most reliable tools can have unexpected side effects. In the world of organ transplantation, medications are like the camel's strength, helping to prevent rejection and ensure the success of the transplant.

This study explores the use of sulfinpyrazone, a medication used to manage high uric acid levels, in heart transplant recipients. It's like checking the camel's health regularly to ensure it's strong enough to carry its cargo. The researchers wanted to see if sulfinpyrazone could effectively manage uric acid levels without impacting the effectiveness of cyclosporine, a crucial medication for preventing organ rejection.

Sulfinpyrazone: A Potential Challenge in Heart Transplant Management

The study found that sulfinpyrazone was effective in reducing uric acid levels, but it also led to a decrease in cyclosporine levels. It's like the camel's strength being temporarily compromised while using a particular tool to manage its health. This is a crucial finding, as it highlights the potential risks of using sulfinpyrazone in heart transplant recipients and emphasizes the need for careful monitoring.

Heart Transplants: Navigating the Complex Landscape of Medications

This study underscores the importance of carefully managing medications in heart transplant recipients. It's like navigating the desert with a keen eye, understanding the potential benefits and risks of different tools. By working closely with healthcare professionals, individuals can find the right balance of medications to ensure a successful transplant and a healthy future.

Dr. Camel's Conclusion

Heart transplantation is a remarkable medical achievement, but it requires careful management to ensure a successful outcome. This study reminds us that even well-intentioned medications can have unintended consequences. By understanding the complexities of these medications and their potential interactions, we can provide our patients with the best possible care and help them navigate the challenging landscape of post-transplant recovery.

Date :
  1. Date Completed 2001-02-01
  2. Date Revised 2019-09-21
Further Info :

Pubmed ID

11124491

DOI: Digital Object Identifier

10.1016/s1053-2498(00)00216-3

Related Literature

SNS
PICO Info
in preparation
Languages

English

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