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Safety of ofloxacin otic and other ototopical treatments in animal models and in humans.

Author: GatesG A

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study reviewed animal and human studies on the safety of topical ofloxacin in the middle ear. In animal studies, ofloxacin caused no hair cell loss or auditory threshold shifts, unlike aminoglycoside-containing preparations. In humans, topical ofloxacin 0.3% was not associated with any change in hearing. These findings suggest that topical ofloxacin is safe for use in the middle ear.
Paper Details　
Original Abstract of the Article :
To assess the safety of topical agents in the middle ear, animal studies were reviewed. Compared with aminoglycoside-containing preparations, which caused significant loss of hair cells in the basal turn of the cochlea, ofloxacin caused no loss of hair cells, even at concentrations higher than used ...See full text at original site
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引用元：
https://doi.org/10.1097/00006454-200101000-00038

データ提供：米国国立医学図書館（NLM）

Otic Ofloxacin: A Safe and Effective Treatment for Ear Infections

Otolaryngology is a specialized field focused on the health of the ear, nose, and throat. Ear infections are a common problem, and finding safe and effective treatments is crucial. This review explores the safety of topical ofloxacin, a common antibiotic used to treat ear infections, assessing its potential impact on hearing and overall ear health.

A Safe Haven in the Desert of Ear Infections

The review provides reassuring evidence of the safety of topical ofloxacin for ear infections. Animal studies revealed no adverse effects on hearing or cochlear function, even at higher concentrations than those used clinically. Human studies further supported the safety of topical ofloxacin, demonstrating no significant changes in hearing after treatment. It's like finding a safe oasis in the vast desert of ear infections, offering a reliable and safe treatment option for patients.

Navigating the Complex World of Ear Infections

This review underscores the importance of safe and effective treatment options for ear infections. It's a reminder that the desert of medical practice requires careful consideration of both efficacy and safety. It encourages us to continue evaluating and refining our treatment approaches, ensuring the best possible outcomes for our patients. After all, in the vast desert of medical knowledge, we must tread carefully, seeking out treatments that offer both healing and safety.

Dr.Camel's Conclusion

This review offers a reassuring glimpse into the safety and effectiveness of topical ofloxacin for ear infections. It's a testament to the power of medical research to identify safe and effective treatments, offering a beacon of hope in the desert of ear infections. It encourages us to continue exploring and refining our treatment options, striving to create a world where ear infections are effectively treated and patients experience a swift and safe recovery.

Date :
  1. Date Completed 2001-12-04
  2. Date Revised 2019-08-18
Further Info :

Pubmed ID

11176587

DOI: Digital Object Identifier

10.1097/00006454-200101000-00038

Related Literature

Article Analysis
・Effects of ofloxacin otic
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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