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Route-dependent endocrine and metabolic effects of estrogen replacement therapy.

Author: HoK K, O'SullivanA J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Oral estrogen replacement therapy can reduce IGF-I and increase GH levels in postmenopausal women, leading to a reduction in lean body mass and an increase in fat mass. However, transdermal estrogen therapy does not have these effects. Oral estrogen also reduces postprandial lipid oxidation compared to transdermal estrogen. Both routes of estrogen therapy have no impact on carbohydrate metabolism or the estrogen-induced increase in bone mineral density.
Paper Details　
Original Abstract of the Article :
The route of estrogen replacement therapy has a major impact on the growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis. Estrogen administration by the oral, but not the transdermal, route reduces IGF-I and increases GH levels in postmenopausal women. This perturbation of the GH-IGF-I axis...See full text at original site
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引用元：
https://doi.org/10.1515/jpem-2000-s620

データ提供：米国国立医学図書館（NLM）

Estrogen Replacement Therapy: A Route-Dependent Journey

This study explores the route-dependent effects of estrogen replacement therapy (ERT) on the growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis. It's like traversing a desert landscape, where the path you choose can significantly impact your journey. The study reveals that the route of ERT, whether oral or transdermal, can have distinct effects on the GH-IGF-I axis, highlighting the importance of considering this factor in treatment decisions.

ERT: A Route-Dependent Impact on Hormone Levels

The study reveals that oral ERT, unlike transdermal ERT, can lead to reduced IGF-I levels and increased GH levels. It's like choosing different trails in the desert, each leading to unique destinations. These findings suggest that the route of ERT can significantly influence hormone levels, potentially impacting overall health and well-being.

Navigating the Desert of ERT: A Personalized Approach

This research underscores the importance of personalized care and individualized treatment plans for women undergoing ERT. It's like choosing the right camel for your journey across the desert, ensuring a safe and effective experience. The study's findings emphasize the need to carefully consider individual needs, health goals, and potential risks and benefits when deciding on the optimal route of ERT.

Dr. Camel's Conclusion

This study takes us on a fascinating journey through the world of ERT, revealing the importance of considering the route of administration. It's like choosing the right path in the desert, ensuring a safe and effective journey. The findings highlight the need for personalized care and individualized treatment plans for women undergoing ERT, ensuring the optimal approach for each individual's needs.

Date :
  1. Date Completed 2001-03-29
  2. Date Revised 2019-09-06
Further Info :

Pubmed ID

11202222

DOI: Digital Object Identifier

10.1515/jpem-2000-s620

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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