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Preliminary observations on differing psychological effects of conjugated and esterified estrogen treatments.

Author: FriebelyJ S, RegesteinQ R, SchiffI, ShifrenJ L

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study found that esterified estrogen treatment improved scores on the Zung Self-Rated Depression Scale and Switching Attention Test performance compared to conjugated equine estrogen treatment.
Paper Details　
Original Abstract of the Article :
During a double-blind comparison of menopausal replacement therapy with estrogen alone compared with estrogen plus methyltestosterone (meT), subjects who had been on conjugated equine estrogen (CEE) said they felt better when placed on esterified estrogen (EE). We, therefore, tested whether these es...See full text at original site
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引用元：
https://doi.org/10.1089/152460901300039548

データ提供：米国国立医学図書館（NLM）

Estrogen's Many Faces: Exploring the Neuropsychological Landscape

The realm of [menopausal hormone therapy] continues to be a topic of much discussion, with researchers exploring the nuances of different estrogen treatments. This study investigates the potential [neuropsychological effects] of [conjugated equine estrogen (CEE)] and [esterified estrogen (EE)], two commonly used forms of estrogen replacement. Employing [a randomized controlled trial], the researchers evaluated the cognitive and mood changes associated with each treatment in [34] menopausal women.

A Journey Through the Desert of Menopause

The study's findings suggest that EE treatment, compared to CEE, may be associated with [improved cognitive performance] and [reduced depressive symptoms]. This highlights the potential for [individualized hormone therapy] based on a patient's specific needs and responses to different estrogen formulations.

Navigating the Oasis of Menopause

This research underscores the need for [tailoring hormone therapy] to each individual's unique needs and preferences. As a wise desert traveler, I emphasize the importance of open communication with your healthcare provider to discuss the potential benefits and risks of different estrogen treatments.

Dr. Camel's Conclusion

This study suggests that esterified estrogen might have a more favorable neuropsychological profile compared to conjugated equine estrogen. Further research is needed to fully understand the complex interplay between estrogen type and neuropsychological effects.

Date :
  1. Date Completed 2001-08-09
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

11268301

DOI: Digital Object Identifier

10.1089/152460901300039548

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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