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Polysomnographic effects of adjuvant ginkgo biloba therapy in patients with major depression medicated with trimipramine.

Author: AnnenB, BischofR, BrüderlinU, HatzingerM, HemmeterU, Holsboer-TrachslerE, RoseU

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ginkgo biloba extract (EGb) has been shown to improve cognitive abilities in elderly subjects and in patients with disorders of the dementia spectrum. An open non-randomized pilot study has been conducted to investigate the effects of ginkgo biloba extract (EGb Li 1370) on cognitive performance and sleep regulation in depressed inpatients. EGb significantly improved sleep pattern by an increase of sleep efficiency and a reduction of awakenings. The compensation of the deficient Non-REM component in depression by the EGb application may provide a new additional treatment strategy, especially in the treatment of the depressive syndrome with sleep disturbance.
Paper Details　
Original Abstract of the Article :
Sleep disturbance and cognitive impairment are frequent complaints of depressed patients under standard antidepressant medication. Therefore, additional therapies are required which specifically focus on the improvement of these deficits without exerting major side effects. Ginkgo biloba extract (EG...See full text at original site
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引用元：
https://doi.org/10.1055/s-2001-15182

データ提供：米国国立医学図書館（NLM）

Ginkgo Biloba: A Potential Sleep Aid for Depression

This research investigates the impact of ginkgo biloba extract (EGb) on sleep quality in patients with major depression already taking trimipramine, a common antidepressant. The study is a pilot study, meaning it's a small-scale investigation to see if there is a potential benefit, and the results are promising! The researchers used polysomnography (sleep studies) to measure the effects of EGb on sleep patterns.

Ginkgo Biloba Improves Sleep Quality

The study revealed that adding EGb to trimipramine improved sleep efficiency and reduced awakenings during the night. Furthermore, the researchers found that EGb led to a decrease in sleep stage 1 and REM sleep density, while stage 2 sleep increased. Non-REM sleep, especially slow-wave sleep in the first sleep cycle, was significantly enhanced compared to trimipramine alone.

Ginkgo Biloba for Sleep Disturbances: A Promising Approach

The findings suggest that EGb might be a valuable addition to treatment strategies for major depression, particularly for patients experiencing sleep disturbances. The results, while promising, require further investigation through larger and controlled studies.

Dr.Camel's Conclusion

This study offers hope for those struggling with both depression and sleep problems. Ginkgo biloba, with its potential to improve sleep quality, might be a valuable tool in the desert of depression. Further research is needed to confirm these findings, but the results are promising.

Date :
  1. Date Completed 2001-08-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11302564

DOI: Digital Object Identifier

10.1055/s-2001-15182

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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