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[Levofloxacin adverse effects, data from clinical trials and pharmacovigilance].

Author: CarbonC

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

With more than 130 million prescriptions of levofloxacin worldwide, the tolerability profile of this anti-infective is now well defined. During clinical trials, 12 per cent of patients treated with levofloxacin experienced an adverse event considered to be related to the study drug compared with 13 per cent of the patients with a comparator. Nausea and diarrhoea were the most frequent adverse effects. The notification rate of significant severe liver injuries (hepatitis, necrosis, hepatic failure) has been less than 1 for 5 million prescriptions.
Paper Details　
Original Abstract of the Article :
With 5388 patients in the marketing application dossiers and post-marketing experience of more than 130 million prescriptions of levofloxacin worldwide, the tolerability profile of this anti-infective is now well defined. During clinical trials, 12 per cent of patients treated with levofloxacin expe...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11322015

データ提供：米国国立医学図書館（NLM）

Levofloxacin: A Comprehensive Look at its Adverse Effects

This review provides a comprehensive overview of the adverse effects associated with levofloxacin, a widely used antibiotic in the fluoroquinolone class. The authors analyze data from clinical trials and post-marketing surveillance reports to assess the drug’s safety profile. The analysis reveals that while levofloxacin is generally well tolerated, it can cause a range of side effects, including nausea, diarrhea, tendinitis, psychotic episodes, and seizures. The review also highlights the importance of monitoring for serious liver injuries and evaluating the drug’s phototoxic potential, which is relatively low compared to other fluoroquinolones.

The Balancing Act of Antibiotics: Effectiveness vs. Side Effects

This review underscores the importance of considering the potential risks and benefits of antibiotics, even those that are generally well tolerated. It reminds us that the use of antibiotics, much like a camel traversing the desert, requires careful navigation to ensure that the benefits outweigh the risks.

Navigating the Desert of Antibiotics: A Balanced Approach

When taking antibiotics, it is crucial to follow your doctor’s instructions carefully. Be aware of potential side effects and report any unusual symptoms immediately. Remember, the wise camel always prepares for the journey, and that includes understanding the risks and benefits of the path ahead.

Dr. Camel's Conclusion

This review offers valuable insights into the safety profile of levofloxacin, reminding us that even seemingly harmless medications can have unexpected side effects. Just as a camel must be vigilant for dangers in the desert, we must be mindful of the potential risks associated with any medication.
Date :
  1. Date Completed 2001-05-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11322015

DOI: Digital Object Identifier

11322015

SNS
PICO Info
in preparation
Languages

French

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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