Effects of levofloxacin: A Synthesis of Findings from 17 Studies

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Original Abstract of the Article

Main Research Findings

Levofloxacin is an effective antibiotic for treating bacterial keratitis, a bacterial infection of the cornea. 14 Both levofloxacin eye drops and levofloxacin eye gel have been shown to be effective in reducing infection symptoms in a rabbit keratitis model. 14 Levofloxacin eye gel, compared to eye drops, has better corneal penetration and is therefore particularly effective in cases of severe infection. 14 Levofloxacin is also an effective antibiotic for treating Pseudomonas aeruginosa infections but there is a risk of developing resistance. 3 Levofloxacin has also been shown to have a potential for suppressing the formation of biofilms caused by Pseudomonas aeruginosa. 5 Levofloxacin may be more effective when used in combination with other antibiotics. 6 Levofloxacin may affect the composition of gut bacteria in humans. 7

Benefits and Risks

Benefits Summary

Levofloxacin is an effective antibiotic for treating bacterial infections. 14 Levofloxacin eye gel is particularly effective for treating bacterial keratitis. 14 Levofloxacin is also effective for treating Pseudomonas aeruginosa infections. 3 Levofloxacin may be more effective when used in combination with other antibiotics. 6 Levofloxacin may improve the composition of gut bacteria. 7

Risks Summary

Levofloxacin, like other antibiotics, can cause side effects. 1 Levofloxacin can cause resistance to develop in bacteria. 3 Levofloxacin may prolong the QT interval. 16

Study Comparisons

Study Similarities

These studies are all looking at the efficacy and side effects of levofloxacin from a variety of perspectives. 14 3 5 1 6 16 7

Study Differences

These studies vary in the diseases they target and their methods. 14 3 5 1 6 16 7

Consistency and Inconsistencies of Results

These studies demonstrate that levofloxacin is an effective antibiotic, but there is a risk of developing resistance and side effects. 14 3 5 1 6 16 7

Considerations for Real-World Applications

Levofloxacin is an effective antibiotic for treating bacterial infections, but it is important to remember the risk of developing resistance and side effects. 14 3 5 1 6 16 7 Always follow your doctor's instructions when taking levofloxacin.

Limitations of Current Research

These studies were all conducted under specific conditions. 14 3 5 1 6 16 7 Therefore, the results of these studies may not be applicable to all patients.

Future Research Directions

Further research is needed into methods to suppress the emergence of resistance to levofloxacin and to reduce side effects. 14 3 5 1 6 16 7

Conclusion

Levofloxacin is an effective antibiotic for treating bacterial infections, but it is important to remember the risk of developing resistance and side effects. 14 3 5 1 6 16 7 Always follow your doctor's instructions when taking levofloxacin.

Literature analysis of 17 papers
Positive Content
13
Neutral Content
1
Negative Content
2
Article Type
2
1
0
0
17
2.

Effects of three fluoroquinolones on QT interval in healthy adults after single doses.

Author: NoelGary J, NatarajanJaya, ChienShuchean, HuntThomas L, GoodmanDaniel B, AbelsRobert

QT interval prolongation

Moxifloxacin caused a greater increase in QT and QTc intervals than levofloxacin or ciprofloxacin in healthy volunteers after a single high dose. The clinical relevance of these differences is not known.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Effects of antibiotics ceftriaxone and levofloxacin on the growth of Lucilia sericata (Diptera: Calliphoridae).

Author: PreußerDaniel, FischerThomas, JuretzekThomas

यो अध्ययनले lucilia sericata larvae मा ceftriaxone र levofloxacin को अन्तराल मा प्रभाव अनुसन्धान गरेको छ।

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Levofloxacin induces differential effects in the transcriptome between the gut, peripheral and axial joints in the Spondyloarthritis DBA/1 mice: Improvement of intestinal dysbiosis and the overall inflammatory process.

Author: González-ChávezSusana Aideé, Salas-LeivaJoan S, Salas-LeivaDayana E, López-LoezaSalma Marcela, Sausameda-GarcíaJasanai, Orrantia-BorundaErasmo, Burgos-VargasRubén, Alvarado-JáquezMaria Fernanda, Torres-QuintanaMayra, Cuevas-MartínezRubén, Chaparro-BarreraEduardo, Marín-TerrazasCarlos, Espino-SolísGerardo Pável, Romero-LópezJosé Pablo, Bernal-AlferesBrian de Jesús, Pacheco-TenaCésar

arthritis treatment
inflammation reduction
levofloxacin-induced microbiota modifications

This study investigated the effect of levofloxacin on intestinal microbiota modifications and inflammation in DBA/1 mice with spontaneous arthritis. Levofloxacin decreased pro-inflammatory bacteria and increased anti-inflammatory bacteria in the gut, leading to reduced inflammation in the intestines, hind paws, and spines. These findings suggest that targeting gut microbiota could be a potential therapeutic strategy for inflammatory arthropathies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Pharmacokinetics of levofloxacin in non-lactating goats and evaluation of drug effects on resistance in coliform rectal flora.

Author: VercelliCristina, Łebkowska-WieruszewskaBeata, BarberoRaffaella, LisowskiAndrzej, ReGiovanni, GiorgiMario

Levofloxacin PK/PD
Bacterial resistance

Levofloxacin was found to have a good bioavailability in non-lactating goats after both intravenous and subcutaneous administration, with mean terminal half-lives of 4.56 and 5.14 h, respectively. However, this study also revealed that levofloxacin can lead to the development of resistance in gastrointestinal bacteria, highlighting the need for careful consideration of its use in goats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled Trial, VeterinaryRandomized controlled trials involving animals. They evaluate the efficacy and safety of treatment methods.

Language : English

15.

Effects of Levofloxacin on Blood Lymphocyte Apoptosis in Patients with Pulmonary Tuberculosis: an In Vitro Study.

Author: SerebryakovaV A, UrazovaO I, NovitskyV V, VengerovskiiA I, KononovaT E, Vasil'evaO A, BeresnevaA E

Apoptotic cell death

This in vitro study investigated the effects of levofloxacin on apoptosis of peripheral blood lymphocytes from patients with infiltrative pulmonary tuberculosis. Levofloxacin stimulated apoptotic cell death in patients with drug-susceptible tuberculosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Effects of the Fluoroquinolones Moxifloxacin and Levofloxacin on the QT Subintervals: Sex Differences in Ventricular Repolarization.

Author: TäubelJӧrg, PrasadKrishna, RosanoGiuseppe, FerberGeorg, WibberleyHelen, ColeSamuel Thomas, Van LangenhovenLeen, FernandesSara, DjumanovDilshat, SugiyamaAtsushi

QT subinterval analysis
QT prolongation
proarrhythmic risks

This study compared the effects of moxifloxacin and levofloxacin, two fluoroquinolones, on cardiac electrophysiology in men and women. Moxifloxacin was a more potent QT-prolonging agent than levofloxacin, with a greater effect on women. The results highlight the importance of considering sex differences in cardiac safety assessments of drugs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities.

Author: WrońskaNatalia, MajoralJean Pierre, AppelhansDietmar, BryszewskaMaria, LisowskaKatarzyna

Antibacterial activity
Drug resistance

This study investigated the antibacterial activity of dendrimers, a type of nanomaterial, in combination with levofloxacin, an antibiotic. The study found that dendrimers enhanced the activity of levofloxacin against certain bacteria.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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