Paper Details

  1. Home
  2. Paper Details

Effects of l-thyroxine administration, TSH-receptor antibodies and smoking on the risk of recurrence in Graves' hyperthyroidism treated with antithyroid drugs: a double-blind prospective randomized study.

Author: , BexM, GlinoerD, de NayerP

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Graves' disease is a condition that causes hyperthyroidism, often treated with antithyroid drugs (ATDs). However, the condition often returns after stopping these medications (30-50% of patients). There is debate about whether combining ATDs with thyroxine (T4) and continuing T4 after stopping ATDs is helpful. Additionally, doctors are looking for ways to predict who is more likely to experience a return of hyperthyroidism after treatment.
Paper Details　
Original Abstract of the Article :
In Graves' hyperthyroidism treated with antithyroid drugs (ATD), the overall relapse rate reaches 30-50% following ATD discontinuation. Conflicting results have previously been reported with regard to the usefulness of combining ATD with thyroxine (l-T4), and thereafter maintaining l-T4 treatment af...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1530/eje.0.1440475

データ提供：米国国立医学図書館（NLM）

Predicting Recurrence in Graves' Hyperthyroidism: A Double-Blind Prospective Randomized Study

Greetings from Dr. Camel, your guide through the sometimes-complex landscape of endocrinology! This study delves into the complexities of Graves' hyperthyroidism, a condition characterized by an overactive thyroid gland. This research aims to identify factors that can predict the risk of recurrence after treatment with antithyroid drugs. It's like searching for a hidden oasis in the vast desert of thyroid health, seeking to understand the factors that influence disease progression.

Unveiling the Factors Behind Recurrence

The study explores the impact of various factors on the recurrence of Graves' hyperthyroidism, including l-thyroxine administration, TSH-receptor antibodies, and smoking. The researchers sought to identify potential predictors for recurrence, offering valuable insights into the management of this condition. It's like finding a map through the desert, guiding clinicians towards a more effective approach for managing this disease.

Informed Management Strategies

The study provides valuable insights into the factors that may contribute to the recurrence of Graves' hyperthyroidism, offering a foundation for more effective treatment strategies. The results emphasize the importance of individualized care, considering patient-specific factors and risk profiles. It's like finding a well-stocked oasis in the desert of thyroid health, offering a source of knowledge and tools for managing this challenging condition.

Dr.Camel's Conclusion

This study explores the complex interplay of factors that contribute to the recurrence of Graves' hyperthyroidism. The findings highlight the importance of individualized care and offer valuable insights into the management of this condition. It's like finding a reliable source of water in the vast desert of thyroid health, a source of knowledge that can help guide us towards a more effective treatment approach.

Date :
  1. Date Completed 2001-06-28
  2. Date Revised 2019-09-06
Further Info :

Pubmed ID

11331213

DOI: Digital Object Identifier

10.1530/eje.0.1440475

Related Literature

Article Analysis
・Effective treatment of hyperthyroidism
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.