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Testosterone-mediated modulation of HERG blockade by proarrhythmic agents.

Author: DegtiarV E, NaidenovV G, OsipenkoV N, ShubaY M, WoosleyR L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Testosterone may reduce the cardiotoxic effects of neuroleptic agents, potentially protecting against drug-induced torsades de pointes, a life-threatening cardiac arrhythmia. This suggests a potential role for androgen therapy in mitigating drug-induced cardiac toxicity.
Paper Details　
Original Abstract of the Article :
Diverse drugs from many therapeutic classes exert cardiotoxic side effects by inducing torsades de pointes (TdP), a life threatening cardiac arrhythmia, which often results from drug interaction with HERG (human ether-a-go-go related gene) encoded K(+) channels, that generate an I(Kr) component of t...See full text at original site
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引用元：
https://doi.org/10.1016/s0006-2952(01)00611-6

データ提供：米国国立医学図書館（NLM）

Testosterone and its Influence on HERG Blockade

This study delves into the complex interplay between [pharmacology] and [cardiology] by investigating the potential role of testosterone in modulating the sensitivity of HERG (human ether-a-go-go related gene) encoded potassium channels to proarrhythmic drugs. The study uses a [Xenopus oocyte] system to express HERG channels and examines the effects of testosterone on the blockade of HERG currents by various neuroleptic agents. The researchers found that testosterone significantly reduced the HERG-blocking potency of these neuroleptics, suggesting that testosterone could potentially protect against drug-induced cardiac arrhythmias.

Testosterone: A Potential Protector Against Cardiac Arrhythmias

The findings highlight the potential cardioprotective effects of testosterone, particularly in the context of drug-induced cardiac arrhythmias. This research underscores the importance of considering sex differences in drug responses and suggests that testosterone could potentially be a factor in the lower risk of drug-induced torsades de pointes in men.

Understanding Sex Differences in Drug Responses

This study emphasizes the need to consider sex differences in drug responses. It highlights the potential role of testosterone in influencing the sensitivity of cardiac potassium channels to proarrhythmic drugs. As a wise old camel, I've always said that appreciating the nuances of our physiology is key to understanding health and disease.

Dr.Camel's Conclusion

This study explores the potential role of testosterone in modulating the sensitivity of HERG channels to proarrhythmic drugs. It highlights the importance of considering sex differences in drug responses and underscores the need for further research in this area.

Date :
  1. Date Completed 2001-06-14
  2. Date Revised 2019-06-23
Further Info :

Pubmed ID

11377395

DOI: Digital Object Identifier

10.1016/s0006-2952(01)00611-6

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