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The effects of different repeated doses of entacapone on the pharmacokinetics of L-Dopa and on the clinical response to L-Dopa in Parkinson's disease.

Author: GordinA, HeikkinenH, KollerW C, LeWittP A, NuttJ G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Entacapone, a COMT inhibitor, effectively reduced the levels of 3-OMD, increasing the bioavailability of L-Dopa and potentially improving clinical outcomes in Parkinson's disease patients with levodopa-related fluctuations.
Paper Details　
Original Abstract of the Article :
We performed a double-blind, placebo-controlled, randomized, crossover, multiple-dose study on entacapone in 25 patients with Parkinson's disease with levodopa (L-Dopa) treatment-related fluctuations. A run-in period was followed by four 2-week treatment periods during which the patients took 4 to 6...See full text at original site
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引用元：
https://doi.org/10.1097/00002826-200105000-00006

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2001-10-04
  2. Date Revised 2019-09-15
Further Info :

Pubmed ID

11391126

DOI: Digital Object Identifier

10.1097/00002826-200105000-00006

Related Literature

Article Analysis
・Effects of entacapone
SNS
PICO Info
in preparation
Languages

English

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