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Antioxidant action of bixin against cisplatin-induced chromosome aberrations and lipid peroxidation in rats.

Author: AntunesL M, BianchiM L, SilvaC R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the protective effect of the carotenoid bixin on cisplatin-induced oxidative stress in rats. Bixin reduced cisplatin-induced chromosome aberrations, lipid peroxidation, and renal glutathione depletion.
Paper Details　
Original Abstract of the Article :
Cisplatin is one of the most active cytotoxic agents in the treatment of cancer, but has serious side effects, inducing nephrotoxicity and chromosome aberrations. In this study we evaluated the role of the carotenoid bixin on cisplatin-induced oxidative stress in Wistar rats through three markers of...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11419966

データ提供：米国国立医学図書館（NLM）

Bixin: A Potential Antioxidant Against Cisplatin-Induced Toxicity

Cisplatin, a powerful chemotherapeutic agent used to treat various cancers, can cause severe side effects, including nephrotoxicity and chromosome aberrations. This study investigates the potential protective effects of bixin, a carotenoid found in annatto seeds, against cisplatin-induced oxidative stress in rats. The researchers found that bixin significantly reduced chromosome aberrations and lipid peroxidation induced by cisplatin, suggesting its potential as a protective agent against the toxic effects of this widely used chemotherapy drug.

Bixin: A Protective Shield Against Cisplatin-Induced Oxidative Damage

The researchers' findings highlight the potential of bixin as a natural antioxidant that can help mitigate the damaging effects of cisplatin. This discovery opens up new avenues for developing strategies to protect patients from the toxic side effects of chemotherapy, improving their overall well-being during cancer treatment.

Natural Solutions for Cancer Treatment: Exploring the Potential of Phytochemicals

This study exemplifies the growing interest in exploring natural compounds for their therapeutic potential in cancer treatment. The researchers' findings suggest that bixin, a readily available natural compound, could play a significant role in reducing the toxic side effects of chemotherapy, enhancing the overall effectiveness of cancer treatments. This approach could pave the way for safer and more effective therapies for cancer patients.

Dr.Camel's Conclusion

Imagine a desert landscape, where the scorching sun represents the harsh effects of cisplatin on the body. Bixin, like a refreshing oasis, emerges as a natural shield, protecting against the damaging effects of this powerful chemotherapy drug. This study provides a beacon of hope in the search for natural solutions to mitigate the harmful side effects of cancer treatment.
Date :
  1. Date Completed 2001-09-27
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

11419966

DOI: Digital Object Identifier

S1043661801908229

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Article Analysis
・Side Effects of cisplatin injection
SNS
PICO Info
in preparation
Languages

English

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