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A systematic overview of chemotherapy effects in non-small cell lung cancer.

Author: , GlimeliusB, NygrenP, SörensonS

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This review of chemotherapy trials in several tumor types found that platinum-based chemotherapy confers a modest survival benefit in patients with stage IIIB-IV non-small cell lung cancer (NSCLC). There is also evidence that it can improve quality of life. Chemotherapy can be recommended for selected patients with advanced NSCLC, but patients should be encouraged to participate in controlled clinical trials.
Paper Details　
Original Abstract of the Article :
A systematic review of chemotherapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for the evaluation of the scientific literature are described separately (Acta Oncol 2001; 40: 155-65). This overview of the literatur...See full text at original site
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引用元：
https://doi.org/10.1080/02841860151116402

データ提供：米国国立医学図書館（NLM）

Chemotherapy in Non-Small Cell Lung Cancer: A Systematic Overview

Lung cancer, like a vast, unforgiving desert, presents a formidable challenge to healthcare professionals. This systematic review, published in 2001, provides a comprehensive overview of chemotherapy's role in treating non-small cell lung cancer (NSCLC), a common type of lung cancer. The review synthesizes findings from multiple studies, providing insights into the effectiveness, safety, and limitations of chemotherapy in different stages of NSCLC.

Chemotherapy: A Modest but Vital Tool

The review found that platinum-based chemotherapy can modestly extend survival in advanced NSCLC (stages IIIB-IV), although the benefits are relatively small, typically a median of 1.5 to 3 months. It also highlighted the potential for chemotherapy to improve quality of life by reducing symptoms and improving physical functioning. However, the review emphasized that chemotherapy is not recommended for patients in poor general condition or for elderly patients, and further research is needed to clarify its role in these specific populations.

Navigating Treatment Decisions: A Careful Approach

The review suggests that platinum-based chemotherapy may be considered for selected patients with advanced NSCLC, but it emphasizes the need for ongoing research and encourages patients to participate in clinical trials to further evaluate the role of chemotherapy in this setting. The review also highlights the emergence of newer agents like gemcitabine, paclitaxel, irinotecan, and vinorelbine, which may offer additional survival benefits compared to earlier chemotherapy regimens.

Dr.Camel's Conclusion

This comprehensive review provides valuable insights into the complexities of chemotherapy's role in NSCLC treatment. It highlights the importance of considering the specific stage of the disease, the patient's overall health, and the potential benefits and risks of treatment when making decisions about chemotherapy. The review emphasizes the need for ongoing research to further refine our understanding of chemotherapy's effectiveness and to explore novel treatment options that can help us conquer the vast and challenging desert of lung cancer.

Date :
  1. Date Completed 2001-07-19
  2. Date Revised 2022-11-09
Further Info :

Pubmed ID

11441939

DOI: Digital Object Identifier

10.1080/02841860151116402

Related Literature

Article Analysis
・Effective treatment of lung cancer
SNS
PICO Info
in preparation
Languages

English

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