Effective treatment of lung cancer: A Synthesis of Findings from 117 Studies

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Original Abstract of the Article

Major Research Findings

Lung cancer treatments vary depending on the type of cancer, stage of the disease, and the patient's condition. Different treatments such as surgery, radiation therapy, and chemotherapy are used. These treatments are often used alone or in combination. 10 shows that combination treatment of surgery and radiation is effective in treating small cell lung cancer. 116 shows that immune checkpoint inhibitors are effective in treating early-stage non-small cell lung cancer. Furthermore, 58 shows that Feitai Capsule, a traditional Chinese medicine, can improve the quality of life of patients with advanced non-small cell lung cancer. These studies show that lung cancer treatment is evolving and better treatments are being developed for patients.

Treatment Summary

10 shows that combination treatment of surgery and radiation is effective in treating small cell lung cancer. This treatment is decided based on the size and location of the tumor, whether surgery is performed first or radiation is performed first. Then chemotherapy is performed.

116 shows that immune checkpoint inhibitors are effective in treating non-small cell lung cancer. This treatment is used alone or in combination with chemotherapy. Immune checkpoint inhibitors work by activating immune cells to attack cancer cells, thereby inhibiting the growth of cancer.

Benefits and Risks

Benefit Summary

Lung cancer treatments vary depending on the type of cancer, stage of the disease, and the patient's condition. Different treatments such as surgery, radiation therapy, and chemotherapy are used. These treatments are often used alone or in combination. The goal of lung cancer treatments is to inhibit the growth of cancer and extend the patient's survival. It also has the effect of reducing pain and symptoms caused by cancer, improving the patient's quality of life.

Risk Summary

Lung cancer treatments come with the risk of side effects. Surgery carries the risk of bleeding and infection. Radiation therapy has side effects such as skin inflammation and nausea. Chemotherapy has side effects such as hair loss, nausea, and immunosuppression.

Comparison of Studies

Commonalities of Studies

These studies show that lung cancer treatments vary depending on the type of cancer, stage of the disease, and the patient's condition.

Differences of Studies

These studies differ in the treatments used, the combinations of treatments, and the number of patients studied. Therefore, it is not possible to directly compare the results of these studies.

Consistency and Contradictions in Results

These studies show that the effectiveness of lung cancer treatments varies depending on the type of cancer, stage of the disease, and the patient's condition. Therefore, it is not possible to directly compare the results of these studies. However, these studies show that lung cancer treatment is evolving and better treatments are being developed for patients.

Note on Real-Life Application

Lung cancer treatments vary from patient to patient. It is important to choose the right treatment with the guidance of your doctor.

Limitations of Current Research

There is still not enough research on lung cancer treatments. Further research is needed.

Future Research Directions

Further research is needed to develop lung cancer treatments. In particular, it is necessary to develop more effective treatments with fewer side effects.

Conclusion

Lung cancer treatments vary depending on the type of cancer, stage of the disease, and the patient's condition. Different treatments such as surgery, radiation therapy, and chemotherapy are used. These treatments are often used alone or in combination. Lung cancer treatment is evolving and better treatments are being developed for patients. However, there is still not enough research on lung cancer treatments. Further research is needed.

List of Treatments

  • Surgery
  • Radiation therapy
  • Chemotherapy
  • Immune checkpoint inhibitors
  • Traditional Chinese medicine
Keywords
Benefit Keywords
Improved chemotherapy
1
NSCLC treatment
2
Lung cancer palliation
3
Long-term survival
No survival difference
4
Treatment effect of chemotherapy for stage II and IIIA nonsquamous cancer
5
SCLC treatment
Survival
6
Lung cancer treatment
7
Response to chemotherapy improves prognosis
Survival benefit with chemotherapy
8
Lung cancer treatment
9
Improved survival
Improved tumor control
10
NSCLC response
12
Improved response rates
Prolonged disease-free survival
13
SCLC survival improvement
14
Effective treatment
Improved survival
Prolonged survival
16
Lung cancer treatment
17
Minimized resistance
18
Decreased metastasis
Improved survival
20
Effective treatment
Improved outcome
21
Improved survival
22
Improved lung cancer treatment
23
Improved NSCLC treatment
24
Lung cancer treatment
25
Improved quality of life
Psychosocial interventions
Symptom palliation
26
Improved survival
Increased therapeutic index
27
Improved understanding of lung cancer treatment
28
Improved NSCLC outcome
29
Improved response rate
Increased time to progression
30
NSCLC treatment
33
Lung cancer treatment
34
Improved quality of life
Increased survival
35
Survival improvement
36
NSCLC resection
37
Improved quality of life
38
Improved survival
Symptom relief
39
Lung cancer treatment
40
SCC treatment
41
Improved survival
Quality of life
42
Improve survival
43
Increased survival
44
Improved survival
Quality of life
Symptom relief
45
Survival advantage
Targeted therapies
46
Improved treatment selection
47
Improved survival
48
Improved SCLC treatment
50
NSCLC treatment
51
NSCLC treatment
52
Advanced NSCLC treatment
53
Local control improvement
54
Lung cancer treatment
56
Improved response rate
Improved survival
57
Improved energy levels
Improved quality of life
Improved symptoms
58
Improved quality of life
59
Improved survival
60
NSCLC treatment
61
Improved OS
Improved PFS
62
Stage III NSCLC treatment
63
NSCLC treatment
64
Palliative care for lung cancer
65
Improved survival
Quality of life
66
Improved quality of life
Improved safety
NSCLC treatment
67
Improved NSCLC treatment
68
Lung cancer survival
69
Improved local control
70
Improved survival
71
Lung cancer diagnosis
72
Lung cancer prevention
73
All-cause mortality reduction
Lung cancer reduction
74
Early diagnosis
Optimized therapy
75
Improved quality of life
76
NSCLC treatment
77
SCLC survival
78
NSCLC treatment
79
Improved NSCLC treatment
80
Improve quality of life
81
NSCLC treatment
82
Cabazitaxel potential for enhanced activity
Chemotherapy effective for SCLC
83
NSCLC treatment
84
Improved overall survival
85
NSCLC treatment
86
Effective treatment
Improved survival
87
Early detection
88
ES-NSCLC treatment
89
Improved lung cancer outcomes
90
Targeted agents
91
NSCLC treatment
92
Increased lung cancer diagnosis
93
Improved PFS
94
Early diagnosis
Proper treatment
Quality of life
Tumor healing
95
Improved survival
NSCLC treatment
96
Improved NSCLC treatment
97
Lung cancer treatment
Segmentectomy
98
Improved exercise capacity
Improved pulmonary function
Improved quality of life
Reduced symptoms
99
Improved survival
Less neutropenia
100
Lung cancer survival
Quality of life
101
NSCLC recurrence detection
102
NSCLC treatment
103
Improved NSCLC treatment
104
Improved dyspnea
Increased exercise capacity
105
Improved exercise capacity
106
Improved outcomes
Reduced recurrence
107
Improved survival
108
Improved OS
Improved PFS
Reduced Brain Metastasis
109
Disease-free control
Improved response rate
110
Improved SCLC treatment
111
Lung cancer treatment
112
Overall survival (nivolumab)
Pathological complete response (nivolumab)
Progression-free survival (nivolumab)
113
LS-SCLC treatment
115
NSCLC treatment
Survival improvement
pCR
116
Improved lung cancer treatment
117
Risk Keywords
Chemotherapy toxicity
2
Semicurative radiation
4
Marginal clinical significance
No benefit for stage I disease
No benefit for stage II and IIIA squamous cell carcinoma
Systemic metastasis continues to be a problem
5
Treatment toxicity
7
Lung cancer
Treatment variability
11
Chemotherapy toxicity
Hypoacusis
Polyneuropathy
Sepsis
12
Brain recurrences
13
Sepsis risk
Treatment-related deaths
15
Increased toxicity
22
Complications of prophylactic cranial irradiation
23
Lung cancer
Psychological morbidity
26
Lung cancer
Toxicity
27
Hematotoxicity
Neuropathy
30
Cardiovascular disease
General frailty
Insufficient respiratory reserve
Little evidence for radical radiotherapy
31
Cardiovascular disease
General frailty
Insufficient respiratory reserve
Little evidence for radical radiotherapy
32
None mentioned
35
Neutropenia
Radiotherapy complications
37
Short prolongation in median survival time
38
Local recurrence
Methodological weaknesses
43
Financial cost
44
Cost
Intrusiveness
Toxicity
45
Drug resistance
Toxicity
46
Small cell lung cancer
50
Side effects
56
Increased hematological toxicities
Increased non-hematological toxicities
57
None reported
58
Toxicity
60
Toxicity
62
Esophagitis
Non-small cell lung cancer
Pneumonitis
63
Chemotherapy side effects
65
Poor overall outcome
66
High dose radiation
69
False-positive findings
Incidental findings
Overdiagnosis
Radiation exposure
74
Lung cancer
75
Dyspnea
Fatigue
78
Increased treatment costs
80
Limited efficacy of topotecan
Relapse occurs
83
Oesophagitis
85
Poor cure rate
Relapse
87
Lung cancer
88
Treatment toxicity
89
NSCLC
91
Anemia
Thrombocytopenia
100
None mentioned
105
Grade 3 or 4 Adverse Events
109
PD-L1 negative
116
Literature analysis of 117 papers
Positive Content
107
Neutral Content
3
Negative Content
7
Article Type
46
45
43
52
115
1.

[Advances in lung cancer].

Author: PautierP

Improved chemotherapy

The 28th Annual Meeting of ASCO focused on non-small cell lung cancer (NSCLC). Accurate staging, particularly for stage IIIA, is crucial, as tumor size and lymph node involvement influence treatment outcomes. Neoadjuvant therapy before surgery for stage IIIA and new drugs like Navelbine, taxol, and campthotecine hold promise for improving NSCLC chemotherapy. For small cell lung cancer (SCLC), trials are exploring ways to improve dose intensity using growth factors, therapy fractionation, and autologous bone marrow transplantation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

2.

Chemotherapy for stage IV non-small cell lung cancer.

Author: BitranJ D, VokesE E

NSCLC treatment
Chemotherapy toxicity

While chemotherapy regimens for non-small cell lung cancer (NSCLC) have shown modest improvements in survival, particularly in a large randomized trial, toxicity remains a concern, especially for patients with poor health at diagnosis. Further research is needed to identify more effective chemotherapy regimens for NSCLC. Chemotherapy is recommended for selected stage IV patients with good health in clinical trials or to manage symptoms and potentially improve survival in carefully chosen cases outside of a trial setting.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Palliative radiotherapy.

Author: AwanA M, WeichselbaumR R

Lung cancer palliation

Radiation therapy effectively alleviates symptoms associated with non-small cell lung cancer, including pain, shortness of breath, and neurologic complications. It is a widely applicable treatment that offers prompt relief with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Symptomatic treatment versus combination chemotherapy for patients with extensive non-small cell lung cancer.

Author: KaasaS, LundE, ThorudE, HatlevollR, HøstH

Long-term survival
No survival difference
Semicurative radiation

This study compared combination chemotherapy to symptom management for 87 patients with inoperable, advanced lung cancer. No significant difference in survival was found between the two groups. However, the study notes that the use of radiation therapy, given for symptom relief, may have influenced the results. Despite this, three patients in the symptom management group achieved long-term survival. This study highlights the difficulty in evaluating the effectiveness of chemotherapy for advanced lung cancer when additional treatments like radiation therapy are used concurrently.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Postsurgical adjuvant therapy in stages I, II, and IIIA non-small cell lung cancer.

Author: LadT E

Treatment effect of chemotherapy for stage II and IIIA nonsquamous cancer
Marginal clinical significance
No benefit for stage I disease
No benefit for stage II and IIIA squamous cell carcinoma
Systemic metastasis continues to be a problem

The importance of accurate staging for non-small cell lung cancer was confirmed. A study of lung cancer patients found that adjuvant combination chemotherapy improved survival for stages II and IIIA non-squamous cancer and may have a marginal benefit for squamous cancer. However, there was no benefit for stage I disease or for adjuvant radiation therapy for stage II and IIIA squamous cell carcinoma. Further research is needed to identify patients who benefit from adjuvant chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

The importance of surgery as the first step in multimodality treatment of small cell bronchial carcinoma. The ISC Lung Cancer Study Group.

Author: KarrerK, DenckH, Karnicka-MlodkowskaH, DringsP, SalzerG M, HrabarB, LiaoM L, SunY, ThermannM, ChenD

SCLC treatment
Survival

This study examined the effectiveness of surgery followed by chemotherapy and radiation therapy for early-stage small cell lung cancer. The study found that patients with stage I cancer had a 4-year survival rate of 61%, while those with stage II cancer had a 4-year survival rate of 35%. The study suggests that surgery is an effective treatment option for stages I and II, and may be beneficial for some patients with stage III cancer. Further research is needed to confirm these findings.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Local failure in patients treated with radiotherapy and multidrug chemotherapy for small cell lung cancer.

Author: BrodinO, RiknerG, SteinholtzL, NouE

Lung cancer treatment
Treatment toxicity

This study of 53 patients with small cell lung cancer examined the effectiveness of chemotherapy and radiation therapy. The study found that a high percentage of patients experienced recurrence within the treated area, suggesting that the radiation dose was insufficient to eliminate the tumor. While increasing radiation dose could potentially improve local control, a significant number of patients developed cancer in other parts of the body, suggesting that improving local treatment alone might not be enough to improve long-term survival. The study also found that higher doses of radiation increased the risk of severe side effects. This highlights the challenge of finding a balance between improving cancer control and minimizing side effects in treating this type of cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Chemotherapy in advanced non-small cell lung cancer.

Author: SplinterT A

Response to chemotherapy improves prognosis
Survival benefit with chemotherapy

This review of 142 studies on chemotherapy for advanced non-small cell lung cancer (NSCLC) found that while chemotherapy can improve survival and response rates, there are significant differences in outcomes depending on factors like patient health, tumor size, and treatment center. The study suggests that new drugs should be compared to standard treatments, and that further research is needed to assess the effectiveness of chemotherapy in specific groups of patients with advanced NSCLC. The review also emphasizes the importance of studying the palliative effects of chemotherapy, particularly in alleviating symptoms and improving quality of life for patients with advanced lung cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Radical radiation therapy for lung cancer.

Author: SeagrenS L

Lung cancer treatment

Despite early trials suggesting a wait-and-see approach for non-resectable lung cancer, advancements in staging, treatment planning, and understanding of prognostic factors have led to a 20-30% 2-year survival rate with radical radiotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

[The therapeutic procedure at the 1st stage of the combined therapy of patients with small-cell ling cancer].

Author: BoĭkoA V, TrakhtenbergA Kh, KiselevaE S, FrankG A, ZvekotkinaL S

Improved survival
Improved tumor control

A review of 300 cases of localized small-cell lung cancer found that surgery is preferred over radiation therapy as the first step in treatment, except in cases of lymph node involvement. Combination chemotherapy is used in the second stage of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

11.

Quality, evolution, and clinical implications of randomized, controlled trials on the treatment of lung cancer. A lost opportunity for meta-analysis.

Author: NicolucciA, GrilliR, AlexanianA A, ApoloneG, TorriV, LiberatiA

Lung cancer
Treatment variability

A review of 150 randomized trials on lung cancer treatment identified serious methodological flaws. These included inadequate handling of patient dropouts, insufficient sample size calculations, inadequate blinding of treatment assignments, and incomplete reporting of eligible patients not included in the trials. While the quality of the trials improved over time, the progress was inconsistent. For non-small-cell lung cancer, despite the lack of proven effective treatments, untreated control groups were often not used, and many different treatment regimens were tested, even in higher-quality studies. Research on small-cell lung cancer showed some more reliable, though limited, progress. The study concludes that while clinical research in lung cancer has not defined the best standard care, the wide variety of treatments tested makes it unlikely that a meaningful overall analysis of existing trials is possible.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

High-dose cisplatin and vinblastine infusion with or without radiation therapy in patients with advanced non-small-cell lung cancer.

Author: BlumenreichM S, WoodcockT M, GentileP S, BarnesG R, JoseB, SherrillE J, RichmanS P, EpremianB E, KubotaT T, AllegraJ C

NSCLC response
Chemotherapy toxicity
Hypoacusis
Polyneuropathy
Sepsis

This study evaluated the effectiveness of a chemotherapy regimen using cisplatin and vinblastine in 47 patients with advanced non-small-cell lung cancer (NSCLC). The treatment resulted in a response rate of 28% and a median survival of 22 weeks. Patients who responded to chemotherapy had a longer median survival (63.2 weeks) compared to those who didn't respond (17.9 weeks). The study also evaluated the effect of radiation therapy, finding no significant survival benefit for those who received it. The chemotherapy regimen was associated with significant side effects, including low white blood cell count, low platelet count, infections, nausea, vomiting, hearing loss, and nerve damage. The study concludes that this particular chemotherapy regimen is not recommended for standard treatment of NSCLC due to its significant toxicity and lack of improved survival or response rates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Surgical adjuvant chemotherapy in non-small cell lung cancer.

Author: HolmesE C

Improved response rates
Prolonged disease-free survival
Brain recurrences

Adjuvant chemotherapy has been shown to prolong disease-free survival in lung cancer patients, especially for non-squamous disease and more advanced tumors. Preoperative chemotherapy, either alone or combined with radiation, may improve outcomes and allow surgery in more patients. More effective treatments for brain metastases are needed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Surgery for cure followed by combined modality treatment for small cell bronchial carcinoma. ISC Lung Cancer Study Group.

Author: KarrerK, DenckH, Karnicka-MlodkowskaH, DringsP, ErzenJ, Dell'AmoreD, ThermannM, SalzerG M, SunY, LiaoM L

SCLC survival improvement

This study investigated the treatment outcomes for 121 patients with early-stage small cell lung cancer (SCLC). Patients underwent surgery to remove the primary tumor and lymph nodes, followed by either standard chemotherapy or a sequential chemotherapy regimen. The study found that 3-year survival rates were 65% for stage pT1-3 N0 M0, 56% for stage pT1-3 N1 M0, and 34% for stage pT1-3 N2 M0. While surgery is generally recommended for stages I and II, surgery for stage N2 lesions might be beneficial compared to chemotherapy or radiation alone. The study emphasizes the need for larger, multi-center studies to further investigate the role of surgery and chemotherapy for SCLC.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Treatment-related deaths in small cell lung cancer trials: can patients at risk be identified? Medical Research Council Lung Cancer Working Party.

Author: StephensR J, GirlingD J, MachinD

Sepsis risk
Treatment-related deaths

A high risk group of patients with small cell lung cancer had an excess death rate of more than 15% in the second week after starting chemotherapy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

17.

A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer.

Author: RothJ A, FossellaF, KomakiR, RyanM B, PutnamJ B, LeeJ S, DhingraH, De CaroL, ChasenM, McGavranM

Lung cancer treatment

This report discusses the potential benefits of induction chemotherapy or a combination of chemotherapy and radiation prior to surgery for patients with resectable stage IIIA non-small-cell lung cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Patterns of failure following loco-regional radiotherapy in the treatment of limited stage small cell lung cancer.

Author: CoyP, HodsonD I, MurrayN, PaterJ L, PayneD G, ArnoldA, KostashukE, DixonP, EvansW K, ZeeB

Minimized resistance

This report discusses the theoretical basis for minimizing the development of treatment resistance in tumors, such as small cell lung cancer (SCLC), by using all treatment modalities early in the treatment program.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Cisplatin-cyclophosphamide-mitomycin combination chemotherapy with supportive care versus supportive care alone for treatment of metastatic non-small-cell lung cancer.

Author: CarteiG, CarteiF, CantoneA, CausaranoD, GencoG, TobaldinA, InterlandiG, GiraldiT

This report calls for more consistent and well-designed controlled studies comparing chemotherapy and supportive care for patients with TNM stage IV non-small-cell lung cancer, taking into account disease stage and drug dose intensity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Adjuvant radiotherapy versus combined sequential chemotherapy followed by radiotherapy in the treatment of resected nonsmall cell lung carcinoma. A randomized trial of 267 patients. GETCB (Groupe d'Etude et de Traitement des Cancers Bronchiques).

Author: DautzenbergB, ChastangC, ArriagadaR, Le ChevalierT, BelpommeD, HurdebourcqM, LebeauB, FabreC, CharvolinP, GuérinR A

Decreased metastasis
Improved survival

Adding COPAC chemotherapy to postoperative radiotherapy for resected non-small cell lung cancer (NSCLC) did not improve overall survival but may have decreased the likelihood of metastatic progression, particularly for patients with N2 disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Chemotherapy plus radiotherapy compared with radiotherapy alone in the treatment of locally advanced, unresectable, non-small-cell lung cancer. A meta-analysis.

Author: PritchardR S, AnthonyS P

Improved survival
Increased toxicity

The addition of chemotherapy to radiotherapy improves survival in patients with locally advanced, unresectable, non-small-cell lung cancer. The absolute benefit is relatively small, however, and should be balanced against the increased toxicity associated with the addition of chemotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

23.

Lung cancer.

Author: FrödinJ E

Improved lung cancer treatment
Complications of prophylactic cranial irradiation

This review of 80 studies on radiation therapy for lung cancer found that radiation plays an important role in treating various stages of the disease. Chemotherapy is the primary treatment for small cell lung cancer (SCLC). Adding radiation therapy to the primary tumor and surrounding lymph nodes reduces recurrence and improves long-term survival. For early stage non-small cell lung cancer (NSCLC), surgery is the primary treatment, but radiation can be an alternative for those who can't have surgery. Radiation therapy following surgery for NSCLC has not been proven effective. For more advanced NSCLC, radiation therapy can shrink tumors and extend survival for two and three years, but it's unclear if it improves long-term survival. The benefits of routine radiation therapy for these patients are questionable given the side effects. Radiation is also used to prevent brain metastases in SCLC patients, but this does not improve survival and may lead to complications. In extensive SCLC, radiation therapy is used to relieve symptoms. Radiation therapy can be effective in relieving specific symptoms, such as cough, bleeding, pain, and breathing difficulties.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

24.

[New therapeutic strategies and current research in inoperable locally advanced non small-cell lung cancers (stage IIIB)].

Author: Le CesneA, ArriagadaR, GrunenwaldD, BaldeyrouP, GirardP, BretelJ J, Le ChevalierT

Improved NSCLC treatment

Treating inoperable locally advanced non-small cell lung cancer (NSCLC) remains challenging, with only a small percentage of patients surviving five years. While chemotherapy combined with radiation has shown some benefit compared to radiation alone, the five-year survival rate remains low. New, more intensive chemotherapy regimens and radiation schedules have shown promising results in smaller studies, but these need to be confirmed in larger trials. Innovative therapies, such as radical surgery for initially inoperable tumors, and newer approaches like biotherapies, vaccines, and gene therapy, are being explored to improve outcomes for this challenging disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

25.

[Prognostic factors and therapeutic strategy in non-small-cell bronchial carcinoma].

Author: WolfM

Lung cancer treatment

This study reviewed the treatment options for non-small cell lung cancer, emphasizing the importance of accurate staging and the potential for new prognostic factors to guide treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

26.

Quality of life in patients with lung cancer: a review of literature from 1970 to 1995.

Author: MontazeriA, GillisC R, McEwenJ

Improved quality of life
Psychosocial interventions
Symptom palliation
Lung cancer
Psychological morbidity

This study reviewed the literature on quality of life in lung cancer patients, highlighting the importance of regularly measuring quality of life and the need for further research to understand the impact of socioeconomic factors on patients' quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

27.

Clinical studies in non-small cell lung cancer: the CALGB experience.

Author: VokesE E, GreenM R

Improved survival
Increased therapeutic index
Lung cancer
Toxicity

This study discusses the Cancer and Leukemia Group B's (CALGB) clinical research in stage IV non-small cell lung cancer (NSCLC), emphasizing the focus on identifying non-cisplatin-based combinations and exploring multimodality therapies for stage III disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

28.

Postoperative adjuvant therapy for stage II non-small-cell lung cancer.

Author: ParkJ H, ShimY M, BaekH J, KimM S, ChoeD H, ChoK J, LeeC T, ZoJ I

Improved understanding of lung cancer treatment

Stage II non-small-cell lung cancer is an early form of lung cancer. While surgery, including removal of lymph nodes in the chest, is the standard treatment, survival rates are not good. The most common causes of death are the cancer returning in the same area or spreading to other parts of the body. There is no clear consensus on the best additional treatments to improve survival after surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

A palliative accelerated irradiation regimen for advanced non-small-cell lung cancer vs. conventionally fractionated 60 GY: results of a randomized equivalence study.

Author: NestleU, NiederC, WalterK, AbelU, UkenaD, SybrechtG W, SchnabelK

Improved NSCLC outcome

This study compared palliative treatment to more intensive treatment in patients with advanced non-small-cell lung cancer (NSCLC) who are not candidates for radical treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

Phase III comparative study of high-dose cisplatin versus a combination of paclitaxel and cisplatin in patients with advanced non-small-cell lung cancer.

Author: GatzemeierU, von PawelJ, GottfriedM, ten VeldeG P, MattsonK, de MarinisF, HarperP, SalvatiF, RobinetG, LucentiA, BogaertsJ, GallantG

Improved response rate
Increased time to progression
Hematotoxicity
Neuropathy

The combination of paclitaxel and cisplatin showed a better clinical response, with a 9% improvement in overall response rate and a longer time to progression compared to high-dose cisplatin alone in patients with advanced NSCLC. However, the combination did not show a significant improvement in survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

A systematic overview of chemotherapy effects in non-small cell lung cancer.

Author: SörensonS, GlimeliusB, NygrenP,

NSCLC treatment

This review of chemotherapy trials in several tumor types found that platinum-based chemotherapy confers a modest survival benefit in patients with stage IIIB-IV non-small cell lung cancer (NSCLC). There is also evidence that it can improve quality of life. Chemotherapy can be recommended for selected patients with advanced NSCLC, but patients should be encouraged to participate in controlled clinical trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Preoperative treatment strategies in stage III non-small cell lung cancer.

Author: EberhardtW, BildatS, KorfeeS, StamatisG

Lung cancer treatment

This abstract discusses the benefits of preoperative chemotherapy in patients with stage III non-small cell lung cancer, suggesting it may improve patient compliance, achieve higher drug dosages, and facilitate downstaging. However, it acknowledges that more research is needed, especially regarding the role of early radiotherapy before surgery and the development of individualized treatment plans based on prognostic factors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

35.

Clinical and cost effectiveness of paclitaxel, docetaxel, gemcitabine, and vinorelbine in non-small cell lung cancer: a systematic review.

Author: CleggA, ScottD A, HewitsonP, SidhuM, WaughN

Improved quality of life
Increased survival
None mentioned

Gemcitabine, paclitaxel, and vinorelbine as first line treatment and docetaxel as second line treatment appear to be more beneficial for non-small cell lung cancer than best supportive care and older chemotherapy agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

[The role of chemotherapy in the treatment of non-metastatic, non-small cell bronchial cancers].

Author: SculierJ P, BerghmansT, PaesmansM, BranleF, LemaitreF, MascauxC, MeertA P, SteelsE, VallotF, LafitteJ J

Survival improvement

A review of 35 randomized trials showed that chemotherapy improved survival in patients with non-small cell lung cancer, regardless of whether it was used as adjuvant, neoadjuvant, concomitant, or induction therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : French

37.

Randomized study of adjuvant chemotherapy for completely resected stage I, II, or IIIA non-small-cell Lung cancer.

Author: ScagliottiGiorgio V, FossatiRoldano, TorriValter, CrinòLucio, GiacconeGiuseppe, SilvanoGiovanni, MartelliMassimo, ClericiMaurizia, CognettiFrancesco, TonatoMaurizio,

NSCLC resection
Neutropenia
Radiotherapy complications

This study investigated the role of adjuvant chemotherapy in patients with completely resected stage I, II, or IIIA non-small-cell lung cancer (NSCLC). The study found no statistically significant difference in overall survival or progression-free survival between patients who received adjuvant chemotherapy (MVP) and those who did not. Only 69% of patients in the MVP group received the planned three cycles of chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

38.

Chemotherapy versus best supportive care for extensive small cell lung cancer.

Author: AgraY, PelayoM, SacristanM, SacristánA, SerraC, BonfillX

Improved quality of life
Short prolongation in median survival time

Combination chemotherapy has been the main treatment for extensive small cell lung cancer (SCLC) for decades, but it only provides a small increase in survival time. For these patients with limited survival, the focus should be on managing symptoms and improving their quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

A systematic overview of radiation therapy effects in non-small cell lung cancer.

Author: SirzénFlorin, KjellénElisabeth, SörensonSverre, Cavallin-StåhlEva

Improved survival
Symptom relief

The study concludes that radiotherapy for medically inoperable or surgically refused non-small cell lung cancer (NSCLC) stage I/II prolongs survival, with 15-20% achieving long-term survival. However, no randomized trials have addressed this directly. There is strong evidence supporting combined modality treatment with platinum-based chemotherapy and radiotherapy for locally advanced unresectable NSCLC, offering superior survival compared to radiotherapy alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Non-invasive interventions for improving well-being and quality of life in patients with lung cancer.

Author: SolàI, ThompsonE, SubiranaM, LópezC, PascualA

Lung cancer treatment

Lung cancer is a major cause of death worldwide, and despite treatment advances, many patients face a poor prognosis and significant emotional and psychological distress. While chemotherapy is effective for advanced lung cancer, its side effects and the symptoms of the disease itself highlight the importance of high-quality palliative and supportive care to minimize suffering and improve quality of life for patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

[Modalities of radiotherapy in small cell lung cancer: thoracic radiotherapy and prophylactic cerebral irradiation].

Author: Le PéchouxC, DhermainF, BretelJ-J, LaplancheA, DunantA, TarayreM, RuffiéP, Le ChevalierT

SCC treatment

This study discusses the challenges of treating small cell lung cancer (SCC), which accounts for 20% of all lung cancers. While combined chemotherapy and radiation have improved survival rates, long-term survival remains low (10-15%, rarely exceeding 25%). Despite initial success, relapse is common, with a high risk of cancer spreading to the brain (50% within 2 years). Prophylactic cranial irradiation (PCI) is now standard practice for patients in complete remission to reduce this risk. The study highlights the need for further research to improve treatment strategies and potentially find new therapies to improve long-term survival for patients with SCC.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

42.

Meta-analyses of clinical trials in patients with non-small cell lung cancer. Minireview.

Author: KovacV, SmrdelU

Improved survival
Quality of life

This review of meta-analyses on non-small cell lung cancer (NSCLC) treatment found that postoperative radiotherapy may be detrimental in radically operated patients using standard fields, chemotherapy with cisplatin-based regimens provides a survival benefit, and chemoradiation is superior to radiotherapy alone for locally advanced NSCLC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

43.

Surgery for early stage non-small cell lung cancer.

Author: ManserR, WrightG, HartD, ByrnesG, CampbellD A

Improve survival
Local recurrence
Methodological weaknesses

There is limited evidence to support the efficacy of surgery for early-stage non-small cell lung cancer (NSCLC). Current evidence suggests that lung cancer resection combined with complete mediastinal lymph node dissection may be associated with a small improvement in survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Role of adjuvant chemotherapy in the treatment of non-small-cell lung cancer.

Author: WilhelmLindsey, KolesarJill M

Increased survival
Financial cost

Adjuvant chemotherapy in patients with non-small-cell lung cancer can modestly increase survival, with platinum-based regimens being the most studied. Further studies are needed to determine the optimal regimen and patient population for this treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

45.

Duration of therapy in advanced, metastatic non-small-cell lung cancer.

Author: SocinskiMark A, BaggstromMaria Q, HensingThomas A

Improved survival
Quality of life
Symptom relief
Cost
Intrusiveness
Toxicity

This review of three recent randomized trials suggests that brief durations of first-line chemotherapy (3 to 4 cycles) may be optimal for advanced, metastatic non-small-cell lung cancer (NSCLC), as prolonged therapy did not improve survival and carried a higher risk of toxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

46.

Second-line treatment for advanced non-small cell lung cancer: a systematic review.

Author: BarlésiFabrice, JacotWilliam, AstoulPhilippe, PujolJean-Louis

Survival advantage
Targeted therapies
Drug resistance
Toxicity

Second-line chemotherapy offers a small but significant survival improvement for patients with advanced non-small cell lung cancer (NSCLC) who have resisted or relapsed after first-line chemotherapy. Docetaxel 75 mg/m(2) every 3 weeks is the current standard, and pemetrexed has emerged as a less toxic alternative.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

A gene expression signature predicts survival of patients with stage I non-small cell lung cancer.

Author: LuYan, LemonWilliam, LiuPeng-Yuan, YiYijun, MorrisonCarl, YangPing, SunZhifu, SzokeJanos, GeraldWilliam L, WatsonMark, GovindanRamaswamy, YouMing

Improved treatment selection

This study underscores the need for reliable predictors of recurrent disease in patients with stages I and II non-small cell lung cancer (NSCLC) to tailor treatment strategies and improve outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

48.

[Randomised phase II study evaluating oral combination chemotherapy (CCNU, cyclophosphamide, etoposide) and intravenous chemotherapy as second-line treatment for relapsed small cell bronchial carcinoma (Trial GFPC0501)].

Author: GervaisR, Le GuenY, Le CaerH, PaillotinD, ChouaidC,

Improved survival

This phase II randomised trial will compare oral multi drug chemotherapy (CCNU, cyclophosphamide, etoposide) and classical intravenous chemotherapy with cyclophosphamide, doxorubicin and vincristine (CAV) in patients with progressive SCLC after first-line platinum based chemotherapy.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

49.

Management of small cell lung cancer.

Author: SeidenfeldJerome, SamsonDavid J, BonnellClaudia J, ZieglerKathleen M, AronsonNaomi

The systematic review addressed key questions in managing small cell lung cancer (SCLC), including the sequence, timing, and dosing characteristics of primary thoracic radiotherapy (TRTx) for limited-stage disease, primary TRTx for extensive-stage disease, the effect of prophylactic cranial irradiation (PCI), positron emission tomography (PET) for staging, treatment of mixed histology tumors, surgery, and second- and subsequent-line treatment for relapsed/progressive disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Evidence for management of small cell lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition).

Author: SamsonDavid J, SeidenfeldJerome, SimonGeorge R, TurrisiAndrew T, BonnellClaudia, ZieglerKathleen M, AronsonNaomi,

Improved SCLC treatment
Small cell lung cancer

This review addressed key questions about treating small cell lung cancer (SCLC), including: * The order, timing, and dosage of radiation therapy for early-stage SCLC * Radiation therapy for advanced SCLC * The use of radiation to prevent spread to the brain * The use of PET scans for staging * Treatment for tumors with mixed cell types * Surgery * Second-line and subsequent treatments for recurrent or worsening disease

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

[Influence of chemiotherapeutic protocol and neuroendocrine differentiation on metastatic non-small cell lung cancer treatment results].

Author: TomićIlija, PetrovićMarina, PlavecGoran, IlićSrbislav

NSCLC treatment

The influence of two different chemiotherapeutic protocols and neuroendocrine differentiation on treatment response and survival in patients with metastatic NSCLC was determined.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Serbian

52.

A prospective and randomized study of radiotherapy, sequential chemotherapy radiotherapy and concomitant chemotherapy-radiotherapy in unresectable non small cell carcinoma of the lung.

Author: DasguptaAnirban, DasguptaChandan, BasuSiddhartha, MajumdarAnup

NSCLC treatment

A prospectively randomized trial compared combined treatment modalities versus radiotherapy alone in treating unresectable NSCLC.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

Second-line treatment of advanced non-small cell lung cancer.

Author: GridelliCesare, ArdizzoniAndrea, CiardielloFortunato, HannaNasser, HeymachJohn V, PerroneFrancesco, RosellRafael, ShepherdFrances A, ThatcherNick, VansteenkisteJohan, De PetrisLuigi, Di MaioMassimo, De MarinisFilippo

Advanced NSCLC treatment

This article provides recommendations for second- and third-line treatment options for patients with advanced non-small cell lung cancer (NSCLC) after failure of first-line chemotherapy.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

54.

Palliative endobronchial brachytherapy for non-small cell lung cancer.

Author: CardonaA F, ReveizL, OspinaE G, OspinaV, YepesA

Local control improvement

Endobronchial brachytherapy (EBB) is being used to improve local control of non-small cell lung cancers (NSCLC).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

Turning gray: the natural history of lung cancer over time.

Author: DetterbeckFrank C, GibsonChristopher J

This study emphasizes the importance of understanding how lung cancer grows naturally, especially as new treatments are being developed. While untreated lung cancer is almost always fatal, even in early stages, the study found that tumors discovered through routine screening grow much slower on average compared to those found through traditional methods. However, while this difference in growth rate is significant, it's not yet possible to predict how long someone will live without treatment based on how fast the tumor is growing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

56.

Induction therapy of loco-regional non-small-cell lung cancer with reliable response and low toxicity (low dose radiotherapy sensitizes tumor to subsequent chemotherapy?).

Author: TakitaHiroshi, ShinKyu H, SohAndrew Y, YiWon S, WildingGreg

Lung cancer treatment
Side effects

The regimen of 20Gy radiation followed by two courses of chemotherapy consisting of paclitaxel, cisplatin, and ifosfamide is a suitable regimen for induction therapy for early-stage resectable non-small-cell lung cancers.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

57.

Randomised multicenter phase II study of two schedules of docetaxel and gemcitabine or cisplatin/gemcitabine followed by docetaxel as first line treatment for advanced non-small cell lung cancer.

Author: NovelloSilvia, FalconeAlfredo, CrinòLucio, RinaldiMassimo, NardiMario, De MarinisFilippo, TonatoMaurizio, TibaldiCarmelo, TinazziAngelo, RussoFrancesca, GrassivaroNicoletta, ScagliottiGiorgio Vittorio

Improved response rate
Improved survival
Increased hematological toxicities
Increased non-hematological toxicities

The results of this phase II randomised clinical trial do not indicate a clear superior efficacy of one of the tested combinations according to the planned statistical design and none of these regimens is sufficiently active or less toxic to warrant further investigation in a phase III study.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

58.

[Effects of Feitai Capsule on quality of life in patients with advanced non-small-cell lung cancer: a randomized controlled trial].

Author: LiuZhi-zhen, YuZong-yang, OuyangXue-nong, DaiXi-hu, ChenXi, ZhaoZhong-quan, WangWen-wu, LiJie, TuHua, YeLei, YanYan

Improved energy levels
Improved quality of life
Improved symptoms
None reported

Feitai Capsule, a compound traditional Chinese herbal medicine, improved symptom response and physical energy level in patients with mid-to-late stage non-small-cell lung cancer (NSCLC). This resulted in a significantly improved quality of life.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

59.

Chemotherapy versus best supportive care for extensive small cell lung cancer.

Author: Pelayo AlvarezMarta, Gallego RubioOscar, Bonfill CospXavier, Agra VarelaYolanda

Improved quality of life

Combination chemotherapy has been the mainstay of treatment for extensive stage small celI lung cancer (SCLC) over the last 30 years.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

First-line systemic chemotherapy in the treatment of advanced non-small cell lung cancer: a systematic review.

Author: GoffinJohn, LacchettiChristina, EllisPeter M, UngYee C, EvansWilliam K,

Improved survival
Toxicity

Platinum-based doublets are the standard of care for first-line systemic therapy for non-small cell lung cancer (NSCLC). No single agent is superior to others when combined with platinum. While the addition of bevacizumab to carboplatin and paclitaxel showed improved survival, its applicability is limited. In patients aged 70 or older or with ECOG performance status 2, a single agent is an alternative.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

62.

Maintenance therapy with continuous or switch strategy in advanced non-small cell lung cancer: a systematic review and meta-analysis.

Author: ZhangXinji, ZangJiajie, XuJinfang, BaiChong, QinYingyi, LiuKe, WuCheng, WuMeijing, HeQian, ZhangShanshan, WeiLixin, HeJia

Improved OS
Improved PFS
Toxicity

Maintenance therapy for non-small cell lung cancer (NSCLC) significantly increases overall survival (OS) and progression-free survival (PFS) compared with placebo or observation. However, the benefits must be balanced against toxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

63.

The optimal chemotherapy for stage III non-small cell lung cancer patients.

Author: GadgeelShirish M

Stage III NSCLC treatment
Esophagitis
Non-small cell lung cancer
Pneumonitis

Concurrent chemoradiation is the standard of care for patients with unresectable stage III non-small cell lung cancer (NSCLC), but ongoing trials are evaluating newer agents for this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

64.

A systematic review and Canadian consensus recommendations on the use of biomarkers in the treatment of non-small cell lung cancer.

Author: EllisPeter M, BlaisNormand, SoulieresDennis, IonescuDiana N, KashyapMeenakshi, LiuGeoff, MeloskyBarb, ReimanTony, RomeoPhillippe, ShepherdFrances A, TsaoMing-Sound, LeighlNatasha B

NSCLC treatment

Personalized treatment for non-small cell lung cancer (NSCLC) based on molecular abnormalities is gaining traction. However, the abundance of data and conflicting results create confusion for clinicians.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Non-invasive interventions for improving well-being and quality of life in patients with lung cancer.

Author: RuedaJosé-Ramón, SolàIvan, PascualAntonio, Subirana CasacubertaMireia

Palliative care for lung cancer
Chemotherapy side effects

Lung cancer is a major cause of death worldwide, and despite advances in treatment, most patients have a poor outlook, facing emotional and psychological distress. While chemotherapy is effective for advanced lung cancer, the significant side effects and symptoms of the disease emphasize the need for quality palliative and supportive care to manage symptoms and improve quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

66.

Strategies for maintenance therapy in advanced non-small cell lung cancer: current status, unanswered questions and future directions.

Author: CustodioAna, de CastroJavier

Improved survival
Quality of life
Poor overall outcome

This review examines maintenance therapy options for patients with advanced non-small cell lung cancer (NSCLC) who have achieved at least stable disease after first-line treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

67.

Noninferiority trials in second-line treatments of nonsmall cell lung cancer: a systematic review of literature with meta-analysis of phase III randomized clinical trials.

Author: TassinariDavide, ScarpiEmanuela, SartoriSergio, DrudiFabrizio, CastellaniCinzia, CarloniFederica, TombesiPaola, Lazzari-AgliLuigi

Improved quality of life
Improved safety
NSCLC treatment

Novel second-line treatments for nonsmall cell lung cancer (NSCLC), including pemetrexed, oral topotecan, and gefitinib, were noninferior to every-3-weeks docetaxel in terms of one-year survival rate. However, these treatments showed a significant advantage in quality of life and safety, highlighting their palliative value in NSCLC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

Targeted agents in non-small cell lung cancer (NSCLC): clinical developments and rationale for the combination with thoracic radiotherapy.

Author: KohPek Keng, Faivre-FinnCorinne, BlackhallFiona H, De RuysscherDirk

Improved NSCLC treatment

This study explores the combination of targeted agents and radiotherapy in treating non-small cell lung cancer (NSCLC), highlighting the growing understanding of molecular subtypes and the need for further research on optimal treatment approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

69.

Novel approaches of chemoradiotherapy in unresectable stage IIIA and stage IIIB non-small cell lung cancer.

Author: StinchcombeThomas E, BogartJeffrey A

Lung cancer survival
High dose radiation

For patients with stage IIIA or stage IIIB non-small cell lung cancer, concurrent chemoradiotherapy has demonstrated superior overall survival compared to sequential chemotherapy and thoracic radiation therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

70.

Palliative endobronchial brachytherapy for non-small cell lung cancer.

Author: ReveizLudovic, RuedaJosé-Ramón, CardonaAndrés Felipe

Improved local control

This review examines the role of endobronchial brachytherapy (EBB) in treating non-small cell lung cancer (NSCLC). While surgery is the only curative treatment, EBB can be used to improve local control, either alone or in combination with other treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

Clinical effectiveness of first-line chemoradiation for adult patients with locally advanced non-small cell lung cancer: a systematic review.

Author: BrownT, PilkingtonG, BolandA, OyeeJ, Tudur SmithC, DundarY, RichardsE, YangR, DicksonR

Improved survival

This study reviews the current guidelines for treating non-small cell lung cancer (NSCLC), specifically focusing on patients with advanced, but potentially curable, disease (stage IIIA). The study notes that the standard treatment for these patients involves chemotherapy and radiation (CTX-RT), but highlights the need to separate this group from patients with more advanced disease who are treated primarily for symptom relief (palliative care). The study aims to provide an in-depth review of the effectiveness of CTX and CTX-RT specifically for patients with potentially curable NSCLC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

72.

Dual time point 18FDG-PET/CT versus single time point 18FDG-PET/CT for the differential diagnosis of pulmonary nodules: a meta-analysis.

Author: ZhangLi, WangYinzhong, LeiJunqiang, TianJinhui, ZhaiYanan

Lung cancer diagnosis

Dual-time point 18FDG-PET/CT and single-time point 18FDG-PET/CT have similar accuracy in the diagnosis of pulmonary nodules, with sensitivities of 79% and 77%, respectively. Dual-time point 18FDG-PET/CT has a higher specificity of 73% compared to single-time point 18FDG-PET/CT at 59%.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

73.

Screening for lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.

Author: DetterbeckFrank C, MazzonePeter J, NaidichDavid P, BachPeter B

Lung cancer prevention

Lung cancer is the leading cause of cancer deaths, often diagnosed at an advanced stage when a cure is unlikely. This article examines the evidence on whether screening for lung cancer can reduce the number of deaths from this disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

74.

Screening for lung cancer with low-dose computed tomography: a systematic review to update the US Preventive services task force recommendation.

Author: HumphreyLinda L, DeffebachMark, PappasMiranda, BaumannChristina, ArtisKathryn, MitchellJennifer Priest, ZakherBernadette, FuRongwei, SlatoreChristopher G

All-cause mortality reduction
Lung cancer reduction
False-positive findings
Incidental findings
Overdiagnosis
Radiation exposure

Low-dose computed tomography (LDCT) screening for lung cancer can reduce lung cancer and all-cause mortality, but must be balanced against harms like radiation exposure and overdiagnosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

Diagnostic efficacy of PET and PET/CT for recurrent lung cancer: a meta-analysis.

Author: HeYan-Qi, GongHan-Lin, DengYi-Fu, LiWei-Min

Early diagnosis
Optimized therapy
Lung cancer

Lung cancer is a leading cause of cancer-related death. Although there is no conclusive evidence supporting the survival benefits of early detection or early treatment for recurrence, an early and accurate diagnosis of recurrence is crucial for optimizing therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

76.

Chemotherapy versus best supportive care for extensive small cell lung cancer.

Author: Pelayo AlvarezMarta, WesteelVirginie, Cortés-JofréMarcela, Bonfill CospXavier

Improved quality of life

Combination chemotherapy, despite only modestly extending median survival time, remains the mainstay treatment for extensive stage small cell lung cancer (SCLC) over the past 30 years. Palliative care is crucial for improving quality of life in these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

77.

Systematic review of efficacy and safety of pemetrexed in non-small-cell-lung cancer.

Author: Pérez-MorenoMaria Antonia, Galván-BanqueriMercedes, Flores-MorenoSandra, Villalba-MorenoAngela, Cotrina-LuqueJesús, Bautista-PalomaFrancisco Javier

NSCLC treatment

Lung cancer is a leading cause of cancer deaths in Spain, with non-small cell lung cancer (NSCLC) being the most common type. Pemetrexed, a newer medication, has become a popular treatment option for NSCLC in the past few years.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

78.

Use of thoracic radiotherapy for extensive stage small-cell lung cancer: a phase 3 randomised controlled trial.

Author: SlotmanBen J, van TinterenHarm, PraagJohn O, KnegjensJoost L, El SharouniSherif Y, HattonMatthew, KeijserAstrid, Faivre-FinnCorinne, SenanSuresh

SCLC survival
Dyspnea
Fatigue

A phase 3 randomized controlled trial of 498 patients with extensive stage small-cell lung cancer (ES-SCLC) found that thoracic radiotherapy in addition to prophylactic cranial irradiation should be considered for all patients who respond to chemotherapy. The thoracic radiotherapy group showed a lower rate of disease progression and a significant improvement in 2-year overall survival compared to the control group.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

79.

Third- and further-line therapy in advanced non-small-cell lung cancer patients: an overview.

Author: GenestretiGiovenzio, GrossiFrancesco, GenovaCarlo, BurgioMarco A, BongiovanniAlberto, GavelliGiampaolo, BartolottiMarco, Di BattistaMonica, CavalloGiovanna, BrandesAlba A

NSCLC treatment

Treatment for non-small-cell lung cancer (NSCLC) has improved, with personalized approaches based on the specific type of cancer. Newer medications like pemetrexed and bevacizumab have extended survival for people with nonsquamous NSCLC. Pemetrexed and erlotinib have also been shown to be helpful in later stages of the disease. While the benefit of treatment over supportive care is clear, the role of treatment in later stages is still under debate. This review summarizes current treatment approaches for NSCLC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

80.

A systematic review of the cost-effectiveness of targeted therapies for metastatic non-small cell lung cancer (NSCLC).

Author: LangeAnsgar, PrenzlerAnne, FrankMartin, GolponHeiko, WelteTobias, von der SchulenburgJ-Matthias

Improved NSCLC treatment
Increased treatment costs

This article reviews the economic evidence for targeted therapies in metastatic non-small cell lung cancer (NSCLC). The increasing use of these agents raises significant concerns about treatment costs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

81.

Cisplatin/Pemetrexed Followed by Maintenance Pemetrexed Versus Carboplatin/Paclitaxel/Bevacizumab Followed by Maintenance Bevacizumab in Advanced Nonsquamous Lung Cancer: The GOIM (Gruppo Oncologico Italia Meridionale) ERACLE Phase III Randomized Trial.

Author: GalettaDomenico, CinieriSaverio, PiscontiSalvatore, GebbiaVittorio, MorabitoAlessandro, BorsellinoNicola, MaielloEvaristo, FebbraroAntonio, CatinoAnnamaria, RizzoPietro, MontroneMichele, MisinoAndrea, LogroscinoAntonio, RizziDaniele, Di MaioMassimo, ColucciGiuseppe

Improve quality of life

Cisplatin with pemetrexed (CP) and carboplatin with paclitaxel and bevacizumab (CbTB) are standard first-line treatments for advanced nonsquamous (NS) non-small-cell lung cancer (NSCLC). This study investigates the impact of these treatments on quality of life (QoL) in patients with advanced NSCLC.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

82.

Erlotinib and gefitinib for treating non-small cell lung cancer that has progressed following prior chemotherapy (review of NICE technology appraisals 162 and 175): a systematic review and economic evaluation.

Author: GreenhalghJanette, BagustAdrian, BolandAngela, DwanKerry, BealeSophie, HockenhullJuliet, ProudloveChristine, DundarYenal, RichardsonMarty, DicksonRumona, MullardAnna, MarshallErnie

NSCLC treatment

Lung cancer is a leading cause of cancer in the UK, with non-small cell lung cancer (NSCLC) being the most common type. While some treatments can improve survival, disease control, and quality of life for people with advanced lung cancer, about a third of these patients need further treatment after the disease progresses. This review examines treatments for these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

83.

Cabazitaxel Versus Topotecan in Patients with Small-Cell Lung Cancer with Progressive Disease During or After First-Line Platinum-Based Chemotherapy.

Author: EvansTracey L, ChoByoung Chul, UdudKatalin, FischerJuergen R, ShepherdFrances A, MartinezPablo, RamlauRodryg, SyrigosKonstantinos N, ShenLiji, ChadjaaMustapha, WolfMartin

Cabazitaxel potential for enhanced activity
Chemotherapy effective for SCLC
Limited efficacy of topotecan
Relapse occurs

Small-cell lung cancer (SCLC) typically responds well to initial chemotherapy, but relapse is common. Topotecan is the only approved second-line treatment, but its effectiveness is limited. This study explores the potential of cabazitaxel, a second-generation taxane, as a more effective treatment option for chemorefractory SCLC.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

84.

The Use of Systemic Treatment in the Maintenance of Patients with Non-Small Cell Lung Cancer: A Systematic Review.

Author: KulkarniSwati, VellaEmily T, CoakleyNadia, ChengSusanna, GreggRichard, UngYee C, EllisPeter M

NSCLC treatment

This systematic review examines the use of systemic treatment for maintenance therapy in patients with non-small cell lung cancer (NSCLC).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

Impact of thoracic radiotherapy timing in limited-stage small-cell lung cancer: usefulness of the individual patient data meta-analysis.

Author: De RuysscherD, LuezaB, Le PéchouxC, JohnsonD H, O'BrienM, MurrayN, SpiroS, WangX, TakadaM, LebeauB, BlackstockW, SkarlosD, BaasP, ChoyH, PriceA, SeymourL, ArriagadaR, PignonJ-P,

Improved overall survival
Oesophagitis

This meta-analysis of individual patient data from 12 trials found that earlier or shorter delivery of thoracic radiotherapy with planned chemotherapy significantly improved 5-year overall survival in patients with limited-stage small-cell lung cancer. However, earlier or shorter radiotherapy was associated with a higher incidence of severe acute oesophagitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

86.

Chemotherapy for advanced non-small cell lung cancer with a focus on squamous cell carcinoma.

Author: KuribayashiKozo, FunaguchiNorihiko, NakanoTakashi

NSCLC treatment

Lung cancer is divided into small-cell and non-small-cell (NSCLC) types, each with different treatments. While NSCLC subtypes have been treated similarly, recent discoveries about genetic mutations in NSCLC, like EGFR mutations and ALK translocations, have led to targeted therapies. However, effective treatments for squamous cell carcinoma and a large percentage of adenocarcinomas are still lacking. This paper reviews treatment options for advanced NSCLC, particularly focusing on squamous cell carcinoma, where new drugs are urgently needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

87.

Surgery for limited-stage small-cell lung cancer.

Author: BarnesHayley, SeeKatharine, BarnettStephen, ManserRenée

Effective treatment
Improved survival
Poor cure rate
Relapse

This study discusses the current treatment guidelines for limited-stage small-cell lung cancer (SCLC), highlighting the need for further research on the role of surgery in stage 1 SCLC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

88.

Lung cancer in symptomatic patients presenting in primary care: a systematic review of risk prediction tools.

Author: Schmidt-HansenMia, BerendseSabine, HamiltonWillie, BaldwinDavid R

Early detection
Lung cancer

Lung cancer is the leading cause of cancer deaths. Approximately 70% of patients diagnosed with lung cancer have advanced disease, at which point current treatments have little effect on survival. This abstract discusses the need for primary care to identify patients with lung cancer earlier, requiring an assessment of lung cancer risk.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

Treatment-Related Toxicity in Patients With Early-Stage Non-Small Cell Lung Cancer and Coexisting Interstitial Lung Disease: A Systematic Review.

Author: ChenHanbo, SenanSuresh, NossentEsther J, BoldtR Gabriel, WarnerAndrew, PalmaDavid A, LouieAlexander V

ES-NSCLC treatment
Treatment toxicity

This systematic review examines the treatment-related mortality and ILD-specific toxicity in patients with early-stage non-small cell lung cancer (ES-NSCLC) and coexisting interstitial lung disease (ILD). The review highlights the increased risk of severe treatment-related toxicity in this population and aims to identify trends for further research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

90.

Predictive and prognostic value of tumor volume and its changes during radical radiotherapy of stage III non-small cell lung cancer : A systematic review.

Author: KäsmannLukas, NiyaziMaximilian, BlanckOliver, BauesChristian, BaumannRené, DobiaschSophie, EzeChukwuka, FleischmannDaniel, GauerTobias, GiordanoFrank A, GoyYvonne, HausmannJan, HenkenberensChristoph, KaulDavid, KlookLisa, KrugDavid, MäurerMatthias, PanjeCédric M, RosenbrockJohannes, SautterLisa, SchmittDaniela, SüßChristoph, ThiemeAlexander H, Trommer-NestlerMaike, ZieglerSonia, EbertNadja, MedenwaldDaniel, OstheimerChristian,

Improved lung cancer outcomes

This study discusses the treatment of stage III non-small cell lung cancer (NSCLC) using an interdisciplinary approach, including radiotherapy. The research highlights the potential benefits of adaptive replanning during radiotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

91.

A systematic review of targeted agents for non-small cell lung cancer.

Author: VestergaardHannah H, ChristensenMarcus R, LassenUlrik N

Targeted agents
NSCLC

This systematic review provides an overview of available literature on the use of targeted agents (TAs) for treating advanced-stage non-small cell lung cancer (NSCLC), evaluating the resulting survival outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

92.

PORTAF - postoperative radiotherapy of non-small cell lung cancer: accelerated versus conventional fractionation - study protocol for a randomized controlled trial.

Author: BütofR, SimonM, LöckS, TroostE G C, AppoldS, KrauseM, BaumannM

NSCLC treatment

This study examines the effect of overall treatment time (OTT) on postoperative radiotherapy in patients with early-stage non-small cell lung cancer (NSCLC) who have undergone surgery and possibly chemotherapy.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

93.

Low-dose computed tomography (LDCT) versus other cancer screenings in early diagnosis of lung cancer: A meta-analysis.

Author: WangXiaojing, LiuHongli, ShenYuanbing, LiWei, ChenYuqing, WangHongtao

Increased lung cancer diagnosis

Low-dose computed tomography (LDCT) screening for lung cancer was associated with a higher incidence of diagnosed lung cancer compared to other screening methods. However, there was no significant difference in lung cancer mortality between LDCT and other methods.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

94.

A cost-effectiveness analysis of consolidative local therapy in oligometastatic non-squamous non-small cell lung cancer (NSCLC).

Author: PanjeCedric M, DedesKonstantin J, Matter-WalstraKlazien, SchwenkglenksMatthias, GautschiOliver, SianoMarco, AebersoldDaniel M, PlasswilmLudwig, LupatschJudith E,

Improved PFS

An analysis of the cost-effectiveness of local therapies in oligometastatic NSCLC found that local therapies may be cost-effective compared to maintenance chemotherapy (MC) alone.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

95.

Biomarkers in Non-Small Cell Lung Cancer: Perspectives of Individualized Targeted Therapy.

Author: AokiMateus N, AmaranteMarla K, de OliveiraCarlos E C, WatanabeMaria A E

Early diagnosis
Proper treatment
Quality of life
Tumor healing

A systematic literature search of the PubMed and Web of Science databases found that biomarkers and genes can be used to improve the diagnosis and treatment of non-small cell lung cancer (NSCLC).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

96.

Treatment of metastatic non-small cell lung cancer: 2018 guidelines of the Italian Association of Medical Oncology (AIOM).

Author: FacchinettiFrancesco, PilottoSara, MetroGiulio, BaldiniEditta, BertolacciniLuca, CappuzzoFederico, DelmonteAngelo, GaspariniStefano, InnoAlessandro, MarchettiAntonio, PassigliaFrancesco, PumaFrancesco, RicardiUmberto, RossiAntonio, CrinòLucio, NovelloSilvia

Improved survival
NSCLC treatment

These guidelines provide a practical tool for oncologists, physicians, and other healthcare professionals to easily embrace the updated key points of NSCLC treatment strategies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

97.

Stereotactic Body Radiotherapy Versus Surgery for Early-Stage Non-Small-Cell Lung Cancer.

Author: LiHui, ShenYefeng, WuYuanzhou, CaiShaoru, ZhuYaru, ChenSiping, ChenXin, ChenQunqing

Improved NSCLC treatment

Surgery is the standard treatment for early-stage non-small-cell lung cancer (NSCLC), but stereotactic body radiotherapy (SBRT) may offer an alternative for patients who are medically inoperable or refuse surgery.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

98.

Segmentectomy Versus Wedge Resection for Stage I Non-Small Cell Lung Cancer: A Meta-analysis.

Author: ZhangHaihua, LiuChen, TanZhijun, ZhangTao

Lung cancer treatment
Segmentectomy

The survival benefit of segmentectomy compared to wedge resection for stage I non-small cell lung cancer (NSCLC) is still undecided.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

99.

Impact of an Animation Education Program on Promoting Compliance With Active Respiratory Rehabilitation in Postsurgical Lung Cancer Patients: A Randomized Clinical Trial.

Author: LiJina, DaviesMarianne, YeMan, LiYingxia, HuangLingzhi, LiLezhi

Improved exercise capacity
Improved pulmonary function
Improved quality of life
Reduced symptoms

Lung resection is a proven treatment for early-stage non-small cell lung cancer. This study emphasizes the importance of pulmonary rehabilitation after lung resection. Pulmonary rehabilitation improves exercise capacity, lung function, reduces cancer-related symptoms, and enhances quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

100.

Comparison of Carboplatin Plus Pemetrexed Followed by Maintenance Pemetrexed With Docetaxel Monotherapy in Elderly Patients With Advanced Nonsquamous Non-Small Cell Lung Cancer: A Phase 3 Randomized Clinical Trial.

Author: OkamotoIsamu, NokiharaHiroshi, NomuraShogo, NihoSeiji, SugawaraShunichi, HorinouchiHidehito, AzumaKoichi, YoneshimaYasuto, MurakamiHaruyasu, HosomiYukio, AtagiShinji, OzakiTomohiro, HoriikeAtsushi, FujitaYuka, OkamotoHiroaki, AndoMasahiko, YamamotoNobuyuki, OheYuichiro, NakagawaKazuhiko

Improved survival
Less neutropenia
Anemia
Thrombocytopenia

Carboplatin-pemetrexed treatment followed by pemetrexed maintenance is a valid option for first-line treatment of elderly patients with advanced nonsquamous NSCLC.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

102.

Effect of Follow-Up Surveillance After Curative-Intent Treatment of NSCLC on Detection of New and Recurrent Disease, Retreatment, and Survival: A Systematic Review and Meta-Analysis.

Author: StirlingRob G, ChauCerys, SharehAli, ZalcbergJohn, FischerBarbara M

NSCLC recurrence detection

This review examines the available evidence for a systematic follow-up strategy for the detection of disease recurrence or second primary lung cancer (SPLC) after curative-intent treatment of non-small cell lung cancer (NSCLC).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

103.

Computational Analysis of Drug Resistance Network in Lung Adenocarcinoma.

Author: KaraAltan, ÖzgürAykut, TekinŞaban, TutarYusuf

NSCLC treatment

Lung cancer is a major cause of death worldwide, with non-small cell lung cancer (NSCLC) being the most common type. Chemotherapy is a primary treatment, but many people develop resistance to the drugs, limiting its effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

104.

Safety and Efficacy of Neoadjuvant Immune Checkpoint Inhibitor Therapy in Patients with Resectable Non-small-Cell Lung Cancer: A Systematic Review.

Author: ZhaoZiran, GaoYibo, XueQi, GaoShugeng, HeJie

Improved NSCLC treatment

A clinical trial has shown that neoadjuvant immunotherapy is effective in treating resectable non-small-cell lung cancer (NSCLC) with high morbidity and mortality rates.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

105.

Multimodal Exercise Program: A Pilot Randomized Trial for Patients With Lung Cancer Receiving Surgical Treatment.

Author: MaRui-Chen, ZhaoYong, LiuXin, CaoHui-Ping, WangYa-Qing, YinYing-Ying, XieJiao

Improved dyspnea
Increased exercise capacity
None mentioned

Both intervention groups, combined intervention and breathing exercise, achieved significant improvements in dyspnea, exercise capacity, and inspiratory capacity, with the combined intervention group showing greater improvements.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

106.

Rehabilitation for lung cancer patients undergoing surgery: results of the PUREAIR randomized trial.

Author: TenconiSara, MaininiCarlotta, RapicettaCristian, BragliaLuca, GaleoneCarla, CavutoSilvio, MerloDomenico F, CostiStefania, PaciMassimiliano, PiroRoberto, FugazzaroStefania

Improved exercise capacity

Intensive pulmonary rehabilitation, administered pre and postoperatively, significantly improved exercise capacity at 6 months in patients undergoing lung resection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

107.

Immunotherapy (excluding checkpoint inhibitors) for stage I to III non-small cell lung cancer treated with surgery or radiotherapy with curative intent.

Author: ZhuJianwei, YuanYun, WanXiaoyu, YinDan, LiRui, ChenWenwen, SuoChen, SongHuan

Improved outcomes
Reduced recurrence

This Cochrane Review examines the use of immunotherapy in non-small cell lung cancer (NSCLC), updating a previous review and including new randomized controlled trials (RCTs) to assess its potential benefits in reducing postoperative recurrence rates and improving clinical outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

108.

Quitting Smoking At or Around Diagnosis Improves the Overall Survival of Lung Cancer Patients: A Systematic Review and Meta-Analysis.

Author: CainiSaverio, Del RiccioMarco, VettoriVirginia, ScottiVieri, MartinoliChiara, RaimondiSara, CammarataGiulio, PalliDomenico, BaniniMarco, MasalaGiovanna, GandiniSara

Improved survival

Quitting smoking at or around the time of lung cancer diagnosis is associated with improved overall survival. This finding is consistent across studies of non-small cell lung cancer, small cell lung cancer, and lung cancer of both or unspecified histological types. Studies have shown that quitting smoking at diagnosis can increase survival by 29% (95% CI 0.64-0.80).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

109.

Durvalumab with chemoradiotherapy for limited-stage small-cell lung cancer.

Author: ParkSehhoon, NohJae Myoung, ChoiYoon-La, ChiSang Ah, KimKyunga, JungHyun Ae, LeeSe-Hoon, AhnJin Seok, AhnMyung-Ju, SunJong-Mu

Improved OS
Improved PFS
Reduced Brain Metastasis
Grade 3 or 4 Adverse Events

This study investigated the efficacy and safety of durvalumab combined with chemotherapy and concurrent chemoradiotherapy (CCRT) for treating limited-stage small-cell lung cancer (LS-SCLC). The combination showed promising clinical efficacy, with a median progression-free survival (PFS) of 14.4 months and a 24-month overall survival rate of 67.8%. Prophylactic cranial irradiation (PCI) was associated with a significantly lower rate of brain metastasis. The treatment was well-tolerated, with manageable adverse events.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

111.

First-line immune-checkpoint inhibitor treatment in extensive-disease small-cell lung cancer: A classical and network meta-analysis.

Author: MutluHasan, BozcukHakan, ArtaçMehmet, Eserİrfan

Improved SCLC treatment

Small-cell lung cancer (SCLC) has a poor prognosis. For the last 30 years, first-line systemic treatment has remained unchanged. A new first-line gold standard, atezolizumab in combination with carboplatin plus etoposide, was approved in 2019 for extensive-disease SCLC (ED-SCLC) after the integration of immunotherapy.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

112.

Lung Cancer Screening With Low-Dose Computed Tomography.

Author: ReckMartin, DettmerSabine, KauczorHans-Ulrich, KaaksRudolf, ReinmuthNiels, Vogel-ClaussenJens

Lung cancer treatment

In Germany, about 21,900 women and 35,300 men were diagnosed with lung cancer in 2018, with a high number of deaths from the disease. Most patients are diagnosed at advanced stages when treatment is less effective. Early detection through screening with low-dose CT scans is crucial for improving survival rates.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

113.

Perioperative Nivolumab and Chemotherapy in Stage III Non-Small-Cell Lung Cancer.

Author: ProvencioMariano, NadalErnest, González-LarribaJosé L, Martínez-MartíAlex, BernabéReyes, Bosch-BarreraJoaquim, Casal-RubioJoaquín, CalvoVirginia, InsaAmelia, PonceSantiago, ReguartNoemí, de CastroJavier, MosqueraJoaquín, CoboManuel, AguilarAndrés, López VivancoGuillermo, CampsCarlos, López-CastroRafael, MoránTeresa, BarnetoIsidoro, Rodríguez-AbreuDelvys, Serna-BlascoRoberto, BenítezRaquel, Aguado de la RosaCarlos, PalmeroRamón, Hernando-TranchoFlorentino, Martín-LópezJavier, Cruz-BermúdezAlberto, MassutiBartomeu, RomeroAtocha

Overall survival (nivolumab)
Pathological complete response (nivolumab)
Progression-free survival (nivolumab)

A phase 2 trial of 86 patients with resectable stage IIIA or IIIB non-small-cell lung cancer (NSCLC) found that neoadjuvant nivolumab plus platinum-based chemotherapy resulted in a higher percentage of patients with a pathological complete response and longer survival than chemotherapy alone.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

114.

Best first-line therapy for people with advanced non-small cell lung cancer, performance status 2 without a targetable mutation or with an unknown mutation status.

Author: GijtenbeekRolof Gp, de JongKim, VenmansBen Jw, van VollenhovenFemke Hm, Ten BrinkeAnneke, Van der WekkenAnthonie J, van GeffenWouter H

Patients with non-small cell lung cancer (NSCLC) and performance status (PS) 2 remain a significant population with unclear treatment options. They are often excluded from clinical trials, leading to a knowledge gap.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

115.

Design and Rationale for a Phase II/III, Randomized, Double-Blind, Placebo-Controlled Study of Sugemalimab as Consolidation Therapy in Patients With Limited-Stage Small-Cell Lung Cancer Who Have Not Progressed Following Concurrent or Sequential Chemoradiotherapy: The SURPASS Study.

Author: ZhaoShen, ChenKehui, ShiXinyi, SunJing, FangWenfeng, HuangYan, ZhangLi

LS-SCLC treatment

This study highlights the need for new treatment options for patients with limited-stage small cell lung cancer (LS-SCLC). The standard therapy for LS-SCLC is platinum-based chemotherapy combined with thoracic radiotherapy, but most patients eventually experience disease progression.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

116.

Systematic review and meta-analysis of immune checkpoint inhibitors as single agent or in combination with chemotherapy in early-stage non-small cell lung cancer: Impact of clinicopathological factors and indirect comparison between treatment strategies.

Author: NuccioAntonio, ViscardiGiuseppe, SalomoneFabio, ServettoAlberto, VenanziFrancesco Maria, RivaSilvia Teresa, OrestiSara, OgliariFrancesca Rita, ViganòMariagrazia, BulottaAlessandra, CameronRobert, EspositoAlessandra, HinesJacobi, BiancoRoberto, ReniMichele, CasconeTina, GarassinoMarina Chiara, TorriValter, VeronesiGiulia, CinquiniMichela, FerraraRoberto

NSCLC treatment
Survival improvement
pCR
PD-L1 negative

This meta-analysis of randomized controlled trials found that immune checkpoint inhibitors (ICIs) significantly improved pathological complete response, event-free survival, overall survival, and major pathological response in patients with early-stage NSCLC, especially when combined with platinum-based chemotherapy.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

117.

Efficacy and safety of veliparib combined with traditional chemotherapy for treating patients with lung cancer: a comprehensive review and meta-analysis.

Author: ZhaoGuanhua, FengEnzhi, LiuYalu

Improved lung cancer treatment

This study evaluated the efficacy and safety of Veliparib combined with chemotherapy versus pharmacotherapy alone for lung cancer treatment.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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