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The pharmacokinetic and metabolic profile of olmesartan medoxomil limits the risk of clinically relevant drug interaction.

Author: KirchW, LaeisP, PüchlerK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the pharmacokinetic properties of olmesartan medoxomil, a prodrug of olmesartan, an angiotensin II receptor antagonist. The results showed that olmesartan medoxomil was rapidly absorbed and converted to olmesartan, which was subsequently excreted without further metabolism.
Paper Details　
Original Abstract of the Article :
Orally administered olmesartan medoxomil was rapidly absorbed from the gastrointestinal tract and converted during absorption to olmesartan, the pharmacologically active metabolite that was subsequently excreted without further metabolism. The medoxomil moiety was released as diacetyl that was rapid...See full text at original site
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引用元：
https://doi.org/10.1097/00004872-200106001-00004

データ提供：米国国立医学図書館（NLM）

Olmesartan Medoxomil: A Safe and Effective Journey Through the Desert of Hypertension

This research explores the world of [olmesartan medoxomil], an antihypertensive medication that is used to manage high blood pressure. It's like having a reliable camel that can help you navigate the desert of hypertension, ensuring a smooth and safe journey. The study focuses on the pharmacokinetic and metabolic profile of olmesartan medoxomil, highlighting its safety and effectiveness.

A Smooth Ride: Olmesartan's Pharmacokinetic Profile

The study found that olmesartan medoxomil is rapidly absorbed and converted to its active metabolite, [olmesartan], which is then excreted without further metabolism. This efficient process ensures that the medication reaches its target quickly and effectively, providing a reliable and consistent therapeutic effect. This is like having a camel that can carry its load efficiently and reliably, reaching its destination without delays or setbacks.

A Safe Oasis: Minimizing Drug Interactions

The study also found that olmesartan medoxomil has a low potential for drug interactions, making it a safe option for patients who are taking other medications. This is like having a camel that can navigate a complex desert landscape without getting tangled up with other caravans or encountering unexpected obstacles.

Health Implications and Everyday Life

High blood pressure is a major risk factor for heart disease and stroke. If you have high blood pressure, it's crucial to consult with your healthcare provider to discuss treatment options. This research highlights the importance of understanding the pharmacokinetic and metabolic profiles of medications to ensure their safety and effectiveness.

Dr.Camel's Conclusion

This research provides a comprehensive overview of the pharmacokinetic and metabolic profile of olmesartan medoxomil, highlighting its safety and efficacy as an antihypertensive medication. It's a reminder that even in the complex landscape of cardiovascular health, there are medications available to help people manage their conditions and live longer, healthier lives.
Date :
  1. Date Completed 2001-12-05
  2. Date Revised 2019-11-05
Further Info :

Pubmed ID

11451211

DOI: Digital Object Identifier

10.1097/00004872-200106001-00004

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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