Effects of aluminum hydroxide and magnesium hydroxide: A Synthesis of Findings from 21 Studies

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Original Abstract of the Article

Major Research Findings

Aluminum hydroxide and magnesium hydroxide, often found in antacids, can significantly impact the absorption of various drugs. 19 found that co-administration of hydroxyaluminum gel with HCFU (carmofur), a 5-FU analog, significantly reduced HCFU blood concentration in patients who underwent gastric resection. This suggests that aluminum hydroxide can inhibit the absorption of HCFU, potentially reducing its side effects. The study also observed a similar trend in the area under the time-blood concentration curve, suggesting that hydroxyaluminum gel might delay the absorption of HCFU.

Research 15 showed that aluminum hydroxide/magnesium hydroxide antacids decreased the bioavailability of itraconazole. This underlines the potential of these compounds to interfere with drug absorption. However, not all medications are affected. For instance, 18 showed that olmesartan medoxomil, an antihypertensive drug, was not significantly impacted by co-administration of an aluminum magnesium hydroxide antacid.

Aluminum hydroxide and magnesium hydroxide are widely used for treating heartburn, acid reflux, and ulcers due to their ability to neutralize stomach acid. 21 investigated the effectiveness of low-dose antacids containing aluminum oxide and magnesium oxide in treating erosive gastropathy caused by NSAIDs. The results indicated significant improvement in endoscopic scores and healing rates in patients treated for four weeks. This suggests that these antacids can be beneficial in mitigating the gastrointestinal damage caused by NSAIDs.

Benefits and Risks

Benefit Summary

Aluminum hydroxide and magnesium hydroxide are effective in managing symptoms related to excessive stomach acid. They can provide relief for conditions like heartburn, acid reflux, and ulcers. They are also found to be beneficial in reducing inflammation and ulcers induced by NSAIDs.

Risk Summary

Aluminum hydroxide and magnesium hydroxide can interfere with the absorption of various medications, potentially impacting their effectiveness. This is particularly relevant for drugs like HCFU and itraconazole. They can also affect the body's overall absorption process. Consult a doctor or pharmacist before taking these antacids, especially if you are on other medications.

Comparison Between Studies

Commonalities

Most studies indicate that aluminum hydroxide and magnesium hydroxide can influence drug absorption, either by hindering absorption or adjusting absorption rate and quantity. This suggests a potential for drug interactions when these antacids are taken concurrently with other medications.

Differences

The effects of aluminum hydroxide and magnesium hydroxide vary significantly depending on the drug involved. While some drugs, like olmesartan medoxomil, are not significantly affected, others like itraconazole experience a decrease in absorption. This highlights the importance of individual drug considerations and consulting a medical professional for proper guidance.

Consistency and Discrepancies in Findings

There is a degree of consistency among studies, revealing that aluminum hydroxide and magnesium hydroxide can influence drug absorption. However, the specific impact on different medications varies greatly. The lack of universal effects across all drugs underlines the need for caution when using these antacids alongside other medications.

Precautions for Real-Life Applications

It is crucial to be aware of the potential for drug interactions when using aluminum hydroxide and magnesium hydroxide. Pay particular attention to medications like quinolones, which may be affected by these antacids, and consult your doctor or pharmacist before taking them together. Additionally, consider the potential impact on overall digestion and absorption when taking these antacids.

Limitations of Current Research

Research on the interactions between aluminum hydroxide, magnesium hydroxide, and various medications is still ongoing. More extensive studies are needed to fully understand the complex relationships between these compounds and different drugs.

Directions for Future Research

Future research should focus on further investigating the impact of aluminum hydroxide and magnesium hydroxide on various medications, both in terms of absorption and broader effects on the body's metabolic processes. Understanding these interactions is crucial for developing safe and effective drug therapies.

Conclusion

Aluminum hydroxide and magnesium hydroxide, while effective for heartburn and ulcer management, can interact with various medications. It is crucial to be mindful of potential interactions and to seek professional guidance before combining these antacids with other drugs. Continued research is essential to better understand these interactions and ensure safe and effective medical treatments.

Literature analysis of 21 papers
Positive Content
15
Neutral Content
2
Negative Content
4
Article Type
7
0
0
0
21
4.

Effects of Food and Antacids on Pharmacokinetics and Pharmacodynamics of Lesinurad, a Selective Urate Reabsorption Inhibitor.

Author: ShenZancong, LeeCaroline A, ValdezShakti, YangXiaojuan, WilsonDavid M, FlanaganTalia, GillenMichael

Uric acid reduction
Antacid interaction

Food did not significantly alter the pharmacokinetics and pharmacodynamics of lesinurad, a uric acid reabsorption inhibitor. However, high doses of antacids reduced lesinurad's AUC and uric acid-lowering effect. Low doses of antacids did not affect lesinurad's effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effect of an anti-reflux medical device in the control of deflation cough: A placebo-controlled comparative study with an antacid drug in chronic coughers.

Author: ChelliniElisa, LavoriniFederico, CampiGiacomo, ManniniClaudia, FontanaGiovanni A

Treats chronic cough

This study investigates the effects of an anti-reflux medical device and an antacid drug on deflation cough (DC), a cough triggered by maximal lung emptying. The study compares the two treatments to determine their effectiveness in reducing DC episodes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide.

Author: SaifullahBullo, ArulselvanPalanisamy, El ZowalatyMohamed Ezzat, FakuraziSharida, WebsterThomas J, GeilichBenjamin M, HusseinMohd Zobir

Anti-TB activity
Biocompatibility
Sustained drug release

This study presents a novel nanodelivery system for isoniazid, an anti-TB drug, that achieves sustained release in simulated human conditions and demonstrates high biocompatibility and efficacy against Mycobacterium tuberculosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Comparative study of Mg/Al- and Zn/Al-layered double hydroxide-perindopril erbumine nanocomposites for inhibition of angiotensin-converting enzyme.

Author: Hussein Al AliSamer Hasan, Al-QubaisiMothanna, HusseinMohd Zobir, IsmailMaznah, ZainalZulkarnain, HakimMuhammad Nazrul

Controlled drug release
Enhanced thermal stability
No cytotoxicity

This study describes the creation of a new nanocomposite, PMAE, by intercalating perindopril, a drug used to treat hypertension, into Mg/Al-layered double hydroxide. PMAE demonstrated controlled release of perindopril and enhanced enzyme inhibitory activity compared to the free drug.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Counteractive effect of antacid suspensions on intrinsic dental erosion.

Author: TurssiCecilia P, ViannaLídia M F F, HaraAnderson T, do AmaralFlávia L B, FrançaFabiana M G, BastingRoberta T

Reduced enamel loss
Enamel softening

Antacid suspensions significantly reduced enamel loss caused by hydrochloric acid (HCl), protecting against dental erosion. While effective in reducing enamel loss, they did not reduce enamel softening.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

[Antiulcer effect of calcium pectate on model of chronic gastric ulcer in rats].

Author: KrylovaS G, FominaT I, EfimovaL A, ZuevaE P, KhotimchenkoM Iu, RazinaT G, AmosovaE N, LopatinaK A, KhotimchenkoIu S

Antiulcer activity

Calcium pectate demonstrated antiulcer activity in rats with chronic ulcers, accelerating the repair of experimental damage and decreasing hemodynamic disorders in surrounding mucous and epithelial membranes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

11.

Effect of an aluminum- and magnesium-containing antacid on the bioavailability of garenoxacin in healthy volunteers.

Author: KrishnaGopal, KisickiJames C, OlsenSteven, GraselaDennis M, WangZaiqi

Reduced garenoxacin exposure

Garenoxacin exposure was significantly decreased when coadministered with Al-Mg antacid or within 2 hours after the antacid. The magnitude of the changes in garenoxacin exposure suggests that garenoxacin should be administered at least 2 hours before or 4 hours after administration of Al-Mg antacid or other cation-containing products.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Antacid interaction with new quinolones: dose regimen recommendations based on pharmacokinetic modeling of clinical data for ciprofloxacin, gatifloxacin and norfloxacin and metal cations.

Author: MiyataK, OhtaniH, TsujimotoM, SawadaY

Increase blood concentration
Pharmacological effect

This study aimed to develop a novel pharmacokinetic model to describe interactions between new quinolones (NQs) and metal cations in order to estimate the optimal dosing interval to minimize drug absorption interference.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects.

Author: KubitzaDagmar, BeckaMichael, ZuehlsdorfMichael, MueckWolfgang

Increased absorption with food
Reduced interindividual variability

Food delayed the time to maximum concentration and increased the maximum concentration and area under the curve of BAY 59-7939 (rivaroxaban). Antacids and ranitidine had no significant effects on the pharmacokinetics of BAY 59-7939.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Reduced oral itraconazole bioavailability by antacid suspension.

Author: LohitnavyM, LohitnavyO, ThangkeattiyanonO, SrichaiW

Itraconazole absorption decrease

Taking antacids with itraconazole reduced the rate and extent of itraconazole absorption by 75%. This is likely due to the antacids changing the pH of the stomach. Therefore, it is best to avoid taking antacids with itraconazole.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Mg,Al layered double hydroxides with intercalated indomethacin: synthesis, characterization, and pharmacological study.

Author: Del ArcoM, CebaderaE, GutiérrezS, MartínC, MonteroM J, RivesV, RochaJ, SevillaM A

Reduced ulcer damage

This study investigated the use of magnesium aluminium layered double hydroxides (LDH) as a delivery system for the medication indomethacin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Lack of effect of omeprazole or of an aluminium hydroxide/magnesium hydroxide antacid on the pharmacokinetics of lumiracoxib.

Author: ScottGraham, Vinluan ReynoldsChristine, MilosavljevSlavica, LangholffWayne, ShenoudaMagdy, RordorfChristiane

Coadministration safe

Coadministration of lumiracoxib with omeprazole or an Al/Mg antacid does not significantly affect lumiracoxib pharmacokinetics. Thus, lumiracoxib can be administered concurrently with these agents without dosage adjustments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

The pharmacokinetic and metabolic profile of olmesartan medoxomil limits the risk of clinically relevant drug interaction.

Author: LaeisP, PüchlerK, KirchW

Hypertension treatment

This study investigated the pharmacokinetic properties of olmesartan medoxomil, a prodrug of olmesartan, an angiotensin II receptor antagonist. The results showed that olmesartan medoxomil was rapidly absorbed and converted to olmesartan, which was subsequently excreted without further metabolism.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Bioavailability of the oral selective phosphodiesterase 4 inhibitor cilomilast.

Author: ZussmanB D, DavieC C, KellyJ, MurdochR D, ClarkD J, SchofieldJ P, WallsC, BirrellC, WebberD, QuinlanJ, RitchieS Y, CarrA

High bioavailability
Slower absorption

Oral cilomilast had an absolute bioavailability of 100% and was not adversely affected by food, dosing time, or coadministration with antacid.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

[Treatment of erosive gastropathy caused by nonsteroidal anti-inflammatory agents using low doses of antacids].

Author: RybárI, RovenskýJ, OrlovskáM

Gastric erosion healing

This study evaluated the effectiveness of low-dose antacids containing aluminum oxide and magnesium oxide in treating erosive NSAIDs-induced gastropathy. Healing rate of gastric erosions reached 65% after four weeks, suggesting efficacy of this treatment.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Slovak

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