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The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide.

Author: KivistöK T, NeuvonenP J, NiemiM

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Clarithromycin was found to increase the plasma concentrations and effects of repaglinide. Clarithromycin increased the area under the concentration-time curve of repaglinide by 40% and the peak plasma concentration by 67%. Concomitant use of clarithromycin or other potent inhibitors of CYP3A4 with repaglinide may enhance its blood glucose-lowering effect and increase the risk of hypoglycemia.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Our objective was to study the effects of the macrolide antibiotic clarithromycin on the pharmacokinetics and pharmacodynamics of repaglinide, a novel short-acting antidiabetic drug. METHODS: In a randomized, double-blind, 2-phase crossover study, 9 healthy volunteers were treated for 4 ...See full text at original site
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引用元：
https://doi.org/10.1067/mcp.2001.116511

データ提供：米国国立医学図書館（NLM）

Clarithromycin and Repaglinide: A Cautionary Tale

The study explores the interaction between clarithromycin, a macrolide antibiotic, and repaglinide, a short-acting antidiabetic drug. The researchers wanted to determine how clarithromycin affects the pharmacokinetics and pharmacodynamics of repaglinide. They conducted a randomized, double-blind, crossover study to assess the impact of clarithromycin on repaglinide's blood levels and its effects on blood sugar.

The CYP3A4 Connection

This research shows that clarithromycin, a strong inhibitor of the cytochrome P450 3A4 (CYP3A4) enzyme, significantly increases the blood levels and effects of repaglinide. This means that when clarithromycin and repaglinide are taken together, the risk of dangerously low blood sugar (hypoglycemia) is increased. This is like adding a little bit of extra fuel to a campfire – a small change can have a big impact.

Navigating Drug Interactions

This research emphasizes the importance of being aware of potential drug interactions, especially when taking medications like clarithromycin and repaglinide. Always consult with your doctor or pharmacist to ensure that your medications are safe and effective. This research serves as a reminder that even seemingly small interactions can have significant consequences – it's like navigating a desert with a compass that points in the wrong direction.

Dr.Camel's Conclusion

This research is like a camel caravan crossing a desert, carefully navigating a path that can be unpredictable and full of potential dangers. It underlines the importance of being aware of potential drug interactions, especially when taking medications that can impact your health. It's a lesson in the importance of being mindful of the details, making the journey through the desert of medications a little smoother and safer.

Date :
  1. Date Completed 2001-08-09
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

11452245

DOI: Digital Object Identifier

10.1067/mcp.2001.116511

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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