Effects of clarithromycin: A Synthesis of Findings from 6 Studies

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Original Abstract of the Article

Key research findings

Clarithromycin is an antibiotic that is widely used to treat Helicobacter pylori infection. Several studies have shown that the dosage of clarithromycin and the drugs it is combined with can affect its effectiveness and side effects. 3 compared low and high doses of clarithromycin in combination with amoxicillin and pantoprazole in elderly patients with Helicobacter pylori infection. This study showed that high doses of clarithromycin were more effective than low doses in eradicating Helicobacter pylori. 6 compared the efficacy and adverse effects of a standard triple clarithromycin-containing regimen with high-dose amoxicillin and bismuth therapy in Helicobacter pylori eradication. This study showed that the clarithromycin-based triple therapy was more effective than high-dose amoxicillin and bismuth therapy in eradicating Helicobacter pylori. However, the clarithromycin-based triple therapy also showed a higher incidence of adverse effects compared to high-dose amoxicillin and bismuth therapy. Clarithromycin is also shown to be effective for treating upper respiratory tract infections compared to other antibiotics. 5 . In addition, clarithromycin has shown fewer side effects compared to amoxicillin-clavulanate. 5 . Clarithromycin has also been shown to be effective in treating community-acquired pneumonia. 1 . Clarithromycin can affect gastrointestinal motility and may affect patients with functional dyspepsia and Helicobacter pylori gastritis. 2 . Clarithromycin can increase the plasma concentrations and effects of drugs such as repaglinide. 4 .

Benefits and Risks

Benefit Summary

Clarithromycin is an effective antibiotic for treating Helicobacter pylori infection, upper respiratory tract infections, and community-acquired pneumonia. It may also have fewer side effects compared to other antibiotics.

Risk Summary

Clarithromycin can cause side effects. The most common side effects are gastrointestinal symptoms, skin rash, and headache. Serious side effects include liver dysfunction, myocarditis, and kidney failure. Clarithromycin can also interact with other drugs. It is important to note the interaction with drugs such as repaglinide.

Study Comparison

Commonalities among Studies

These studies demonstrate the efficacy of clarithromycin as an antibacterial agent. In addition, these studies show that clarithromycin may have fewer side effects compared to other antibiotics.

Differences among Studies

These studies used different methods to evaluate the efficacy and side effects of clarithromycin. These studies also targeted different populations. Therefore, it is difficult to directly compare the results of these studies.

Consistency and Contradictions in Results

These studies show that clarithromycin is an effective antibiotic, but its efficacy and side effects may vary depending on the dosage, concomitant medications, and population. Therefore, it is important to consider the patient's condition and select the appropriate dosage and concomitant medications when administering clarithromycin.

Implications for Real-World Application

Clarithromycin is an effective antibiotic for treating Helicobacter pylori infection, upper respiratory tract infections, and community-acquired pneumonia. However, clarithromycin can cause side effects. Therefore, it is important to consider the patient's condition and select the appropriate dosage and concomitant medications when administering clarithromycin.

Limitations of Current Research

These studies were conducted on specific populations, and it is not clear whether the results are applicable to all populations. These studies also did not evaluate the long-term effects and side effects of clarithromycin.

Future Research Directions

Further research is needed to more thoroughly evaluate the efficacy and side effects of clarithromycin. Research is particularly needed on the long-term effects and side effects of clarithromycin, its efficacy in different populations, and its interactions with other drugs.

Conclusion

Clarithromycin is an effective antibiotic for treating Helicobacter pylori infection, upper respiratory tract infections, and community-acquired pneumonia. However, clarithromycin can cause side effects. Therefore, it is important to consider the patient's condition and select the appropriate dosage and concomitant medications when administering clarithromycin. Further research is needed to more thoroughly evaluate the efficacy and side effects of clarithromycin.

Literature analysis of 6 papers
Positive Content
4
Neutral Content
0
Negative Content
2
Article Type
5
1
1
0
6
1.

Clarithromycin versus amoxicillin-clavulanic acid in the treatment of community-acquired pneumonia.

Author: GennéD, SiegristH H, HumairL, Janin-JaquatB, de TorrentéA

Effective pneumonia treatment
Drug interaction
Phlebitis

Clarithromycin and amoxicillin-clavulanic acid had similar efficacy in treating community-acquired pneumonia, but clarithromycin had a slightly higher rate of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Effects of oral clarithromycin and amoxycillin on interdigestive gastrointestinal motility of patients with functional dyspepsia and Helicobacter pylori gastritis.

Author: BortolottiM, BrunelliF, SartiP, MariC, MiglioliM

Gastrointestinal symptoms

Clarithromycin, but not amoxycillin, stimulated cyclic gastroduodenal motility, which may be responsible for gastrointestinal symptoms during Helicobacter pylori eradication treatment. In a study of 14 patients with functional dyspepsia and H. pylori gastritis, clarithromycin administration was followed by a typical gastroduodenal activity front in a significantly higher number of patients than for amoxycillin administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Cure of Helicobacter pylori infection in elderly patients: comparison of low versus high doses of clarithromycin in combination with amoxicillin and pantoprazole.

Author: PilottoA, FranceschiM, LeandroG, BozzolaL, RassuM, SoffiatiG, Di MarioF, ValerioG

H. pylori cure
Reduced gastritis
Adverse events

Clarithromycin at the lower dose of 250 mg b.d. achieved excellent cure rates and minimized adverse events and costs in elderly patients with H. pylori-associated ulcer disease or chronic gastritis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide.

Author: NiemiM, NeuvonenP J, KivistöK T

Lower blood glucose
Hypoglycemia

Clarithromycin was found to increase the plasma concentrations and effects of repaglinide. Clarithromycin increased the area under the concentration-time curve of repaglinide by 40% and the peak plasma concentration by 67%. Concomitant use of clarithromycin or other potent inhibitors of CYP3A4 with repaglinide may enhance its blood glucose-lowering effect and increase the risk of hypoglycemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

[Meta-analysis of clarithromycin compared with other antimicrobial drugs in the treatment of upper respiratory tract infections].

Author: Abad-SantosF, Gálvez-MúgicaM A, Espinosa de los MonterosM J, Gallego-SandínS, NovalbosJ

Improved Compliance
Upper Respiratory Infection Treatment
Adverse Events

Clarithromycin is an effective and safe treatment for upper respiratory infections. It may be more effective than other antibiotics for sinusitis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Spanish

6.

Randomised clinical trial: comparison of efficacy and adverse effects of a standard triple clarithromycin-containing regimen with high-dose amoxicillin and bismuth therapy in Helicobacter pylori eradication.

Author: SjominaOlga, LielauseAlise, RūduleAiga, VangravsReinis, ParšutinsSergejs, PoļakaInese, DauguleIlva, StonānsIlmārs, ParkJin Young, LejaMārcis

Adverse effects
Clarithromycin resistance

This study highlights the need for alternative therapies to the clarithromycin-based triple therapy for Helicobacter pylori eradication due to its adverse effects and increasing clarithromycin resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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