Influence of beta-adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5-HT1B/1D agonist: differential effects of propranolol, nadolol and metoprolol.

Author: De SmetM, GoldbergM R, HalpinR, JamesI, KariP H, LeeY, LowryR, OlahT V, SciberrasD, TomaskoL, VyasK P, ZhaoJ

Paper Details 
Original Abstract of the Article :
Patients with migraine may receive the 5-HT1B/1D agonist, rizatriptan (5 or 10 mg), to control acute attacks. Patients with frequent attacks may also receive propranolol or other beta-adrenoceptor antagonists for migraine prophylaxis. The present studies investigated the potential for pharmacokineti...See full text at original site
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引用元:
https://doi.org/10.1046/j.0306-5251.2001.01417.x

データ提供:米国国立医学図書館(NLM)

Beta-Blockers and Rizatriptan: Navigating a Sandstorm of Interactions

Imagine a camel caravan traversing a vast desert, each camel carrying a precious cargo of medication. This study explores the potential interactions between beta-blockers, medications commonly used for migraine prophylaxis, and rizatriptan, a drug used to treat migraine attacks. The study investigated how beta-blockers might affect the pharmacokinetics and pharmacodynamics of rizatriptan.

The researchers found that different beta-blockers, like different types of camels, had varying effects on rizatriptan. Some beta-blockers, like propranolol, could potentially alter the way rizatriptan is processed by the body.

Understanding Drug Interactions: A Crucial Oasis in the Desert

This research highlights the importance of understanding drug interactions, especially when multiple medications are involved. Think of the camel caravan navigating a desert with unpredictable sandstorms. Knowing how each camel's load might affect the others is crucial for ensuring a smooth journey.

Communicating with Your Healthcare Provider

If you're taking medications for migraine, it's important to inform your healthcare provider about all the medications you're using, including over-the-counter products. This information is like sharing a map of the desert with your camel caravan, ensuring that everyone is prepared for the journey ahead.

Dr.Camel's Conclusion

This study emphasizes the importance of understanding drug interactions to ensure optimal treatment outcomes. It's like navigating a vast desert with multiple camel caravans. Knowing how each caravan's supplies and routes might affect the others is crucial for a safe and successful journey. Open communication with your healthcare provider is essential for managing your medications effectively.

Date :
  1. Date Completed 2001-09-20
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

11453892

DOI: Digital Object Identifier

10.1046/j.0306-5251.2001.01417.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

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