The use of valrubicin for the chemoresection of superficial bladder cancer -- a marker lesion study.

Author: HetheringtonJ, KisbenedekL, NewlingD W, RobinsonM R, SundaramS K

Paper Details 
Original Abstract of the Article :
OBJECTIVES: To assess the effect and tolerance of a 6-week course of intravesical valrubicin on a tumour intentionally left in the bladder (marker lesion) following incomplete transurethral resection of the bladder (TURBT). PATIENTS AND METHODS: In a prospective phase II study, 40 patients with ref...See full text at original site
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引用元:
https://doi.org/10.1159/000052521

データ提供:米国国立医学図書館(NLM)

A Clever Approach to Bladder Cancer: Targeting Marker Lesions

Superficial bladder cancer is a complex condition that often requires ongoing treatment. This research explored a new strategy for managing this condition by focusing on a 'marker lesion' - a small tumor intentionally left in the bladder after initial surgery. The researchers utilized a phase II clinical trial to evaluate the effectiveness of intravesical valrubicin, a chemotherapy drug, in eliminating this marker lesion. Forty patients with refractory superficial bladder cancer underwent transurethral resection of the bladder tumor, leaving a small portion behind. These patients then received six weekly instillations of valrubicin. The researchers found that valrubicin was effective in eliminating the marker lesion in a significant number of patients and delaying further tumor recurrence.

Valrubicin: A Potential Weapon Against Bladder Cancer

The results suggest that intravesical valrubicin holds promise as a treatment for superficial bladder cancer. This approach may be particularly valuable for patients with refractory disease, offering a potential alternative to more invasive treatments. The study also highlights the importance of carefully monitoring patients for tumor recurrence after treatment.

Early Detection and Ongoing Monitoring: Keys to Bladder Cancer Management

Understanding and managing bladder cancer requires a multifaceted approach. Early detection is crucial, and ongoing monitoring after treatment is equally important. This study offers a glimpse into a potential new tool for managing bladder cancer, but further research is needed to refine this approach and determine its long-term efficacy.

Dr.Camel's Conclusion

This study highlights a new approach to fighting bladder cancer, like a camel finding a way through a sandstorm. By targeting marker lesions, this research provides a potential avenue for preventing recurrence and improving the quality of life for patients. This study is a reminder that innovation and creative solutions are essential in the battle against cancer.

Date :
  1. Date Completed 2001-09-27
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

11464052

DOI: Digital Object Identifier

10.1159/000052521

Related Literature

SNS
PICO Info
in preparation
Languages

English

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