Paper Details

  1. Home
  2. Paper Details

Healing and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine, and placebo: evidence from randomized clinical trials.

Author: CaroJ J, SalasM, WardA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Newer proton pump inhibitors (PPIs) lansoprazole, rabeprazole, and pantoprazole were similar in efficacy to omeprazole in terms of heartburn control, healing rates, and relapse rates in acute and maintenance treatment of GERD. All PPIs were superior to ranitidine and placebo in healing erosive esophagitis and decreasing relapse rates.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The older proton pump inhibitor (PPI) omeprazole and the newer PPIs lansoprazole, rabeprazole, and pantoprazole are approved for the acute and maintenance treatment of gastroesophageal reflux disease (GERD). OBJECTIVE: On the basis of the results of randomized clinical trials, this stud...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/s0149-2918(01)80087-4

データ提供：米国国立医学図書館（NLM）

Proton Pump Inhibitors: A Comparative Review of Efficacy in Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is a common condition affecting millions of people worldwide. This study, published in the journal American Journal of Gastroenterology, provides a comprehensive analysis of the efficacy of various proton pump inhibitors (PPIs) in treating GERD, comparing their effectiveness to omeprazole, ranitidine, and placebo. The authors meticulously reviewed a large number of randomized clinical trials to determine the healing and relapse rates associated with different PPI therapies.

The New Generation of PPIs

The study found that the newer PPIs, including lansoprazole, rabeprazole, and pantoprazole, were generally comparable in efficacy to omeprazole in terms of heartburn control, healing rates, and relapse rates. All of the PPIs demonstrated significant superiority to ranitidine and placebo in healing erosive esophagitis and reducing relapse rates. This highlights the effectiveness of PPIs in managing GERD symptoms and underscores their importance in the treatment of this common condition.

Choosing the Right PPI for You

The study provides valuable information for patients and healthcare providers regarding the effectiveness of various PPI therapies. It suggests that the newer PPIs are comparable to omeprazole in efficacy, offering a broader range of treatment options. However, it is essential to discuss your specific symptoms and medical history with your healthcare provider to determine the best PPI for your individual needs.

Dr.Camel's Conclusion

The field of GERD treatment is constantly evolving, and this review offers a comprehensive snapshot of the current state of PPI therapies. It underscores the importance of evidence-based medicine in guiding treatment decisions and highlights the need for ongoing research to refine our understanding of the mechanisms and optimal use of these medications.

Date :
  1. Date Completed 2002-01-09
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

11519776

DOI: Digital Object Identifier

10.1016/s0149-2918(01)80087-4

Related Literature

Article Analysis
・Effective treatment of gerd
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.