Treatment of adult T-cell leukaemia/lymphoma: current strategy and future perspectives.

Author: BazarbachiA, HermineO

Paper Details 
Original Abstract of the Article :
Human T-cell leukaemia virus type I (HTLV-I) associated adult T-cell leukaemia/lymphoma (ATL) carries a very poor prognosis due to an intrinsic resistance of leukaemic cells to conventional or even high doses of chemotherapy and to an associated severe immunosuppression. Therefore, the potential rol...See full text at original site
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引用元:
https://doi.org/10.1016/s0168-1702(01)00286-6

データ提供:米国国立医学図書館(NLM)

Unveiling New Paths in Adult T-Cell Leukemia/Lymphoma Treatment: A Journey Through the Desert of Resistance

The fight against adult T-cell leukemia/lymphoma (ATL) resembles a journey across a vast desert, where the leukaemic cells are a formidable enemy, resistant to conventional therapies. This study delves into the challenges of ATL treatment and explores potential strategies for overcoming the resistance of these cells. The authors discuss the limitations of conventional chemotherapy and the encouraging results achieved with the combination of zidovudine (AZT) and interferon-alpha (IFN). They also explore promising future directions, including the use of retinoid acid, immunotherapy, and the combination of arsenic trioxide (As) and IFN, which has shown potential for targeting the viral transactivator Tax.

Beyond the Conventional: Seeking New Oasis of Solutions

This study emphasizes the need for innovative approaches to combat ATL. The desert of resistance to conventional therapies necessitates a search for new oases of solutions. The research explores multiple promising avenues, highlighting the importance of a multi-pronged strategy in tackling this challenging disease.

Hope on the Horizon: A Collaborative Journey

The exploration of new treatment options for ATL represents a collaborative journey. Researchers, clinicians, and patients must work together to navigate the desert of resistance and find the oasis of effective therapies. This research provides valuable insights into the potential of emerging treatments and the need for continued research and development.

Dr.Camel's Conclusion

The research on ATL treatment is a reminder that we must keep searching for solutions, even in the most challenging of deserts. I have faith that through continued exploration and collaboration, we will find the oases of effective therapies for those facing this formidable disease.

Date :
  1. Date Completed 2001-12-04
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

11520582

DOI: Digital Object Identifier

10.1016/s0168-1702(01)00286-6

Related Literature

SNS
PICO Info
in preparation
Languages

English

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