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Improved safety with equivalent asthma control in adults with chronic severe asthma on high-dose fluticasone propionate.

Author: , BerendN, KellettB, KentN, SlyP D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the efficacy and safety of fluticasone propionate (FP) with beclomethasone dipropionate (BDP) and budesonide (BUD) in adult asthmatics requiring high doses of inhaled corticosteroids. FP was found to be as effective as BDP and BUD at high doses, with a similar safety profile.
Paper Details　
Original Abstract of the Article :
High-dose inhaled corticosteroids (ICS) have been associated with the same side-effects as oral corticosteroids. Beclomethasone dipropionate (BDP) and budesonide (BUD) in doses greater than 2000 microg/day are used regularly in severe asthma, despite the fact that safety and efficacy data at such hi...See full text at original site
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引用元：
https://doi.org/10.1046/j.1440-1843.2001.00329.x

データ提供：米国国立医学図書館（NLM）

Comparing the Safety and Effectiveness of Inhaled Corticosteroids for Severe Asthma

The world of asthma treatment is a vast desert, and finding the right medication for each individual can be like searching for a cool oasis. This study focuses on the effectiveness and safety of high-dose inhaled corticosteroids, a type of medication commonly used for severe asthma. Researchers wanted to compare the efficacy and safety of three different inhaled corticosteroids: fluticasone propionate (FP), beclomethasone dipropionate (BDP), and budesonide (BUD). They conducted a study on 133 adults with severe asthma who required high doses of BDP or BUD. Their goal was to see if FP, which is often marketed as twice as potent as BDP or BUD, could provide similar asthma control with fewer side effects.

Exploring the Potential of Fluticasone Propionate for Asthma Management

The researchers discovered that FP was as effective as BDP and BUD in controlling asthma symptoms. This suggests that FP could be a valuable alternative for patients who need high-dose inhaled corticosteroids. The study also found that FP had a similar safety profile to BDP and BUD, indicating that it may be a safer option for some patients.

The Importance of Finding the Right Treatment for Asthma

This research provides valuable insight into the use of inhaled corticosteroids for severe asthma. Finding the right treatment for asthma can be a challenging journey, but this study highlights the importance of considering the individual needs of each patient. Finding the right medication can make a big difference in the quality of life for people with asthma.

Dr.Camel's Conclusion

Finding the right treatment for severe asthma is like finding a cool, refreshing oasis in a vast, dry desert. This research helps us understand the potential of fluticasone propionate as a safe and effective treatment option for severe asthma. It's crucial to remember that every person's asthma is unique, and finding the right treatment requires careful consideration of individual needs.

Date :
  1. Date Completed 2001-12-04
  2. Date Revised 2019-11-05
Further Info :

Pubmed ID

11555383

DOI: Digital Object Identifier

10.1046/j.1440-1843.2001.00329.x

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・Side Effects of beclomethasone oral inhalation
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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