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Titrated oral misoprostol solution for induction of labour: a multi-centre, randomised trial.

Author: AlfirevicZ, BrocklehurstP, CampbellE, HofmeyrG J, MatonhodzeB, NikodemV C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Titrated oral misoprostol solution for induction of labor after 34 weeks of pregnancy was as effective as vaginal dinoprostone. Both treatments resulted in similar vaginal delivery rates (38% vs. 36%) and cesarean section rates (16% vs. 20%). Misoprostol showed a slower response in women with intact membranes and unfavorable cervices.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To determine the effects of titrated oral misoprostol solution, compared with vaginal dinoprostone. STUDY DESIGN: Open, randomised clinical trial. SETTING: Academic hospitals in South Africa and Liverpool, UK. METHODS: Women undergoing induction of labour after 34 weeks of pregnancy w...See full text at original site
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引用元：
https://doi.org/10.1111/j.1471-0528.2001.00231.x

データ提供：米国国立医学図書館（NLM）

Induction of Labor: A Gentle Breeze in the Desert

Induction of labor is a common procedure for women who are past their due date or have medical conditions that necessitate delivery. This research explores the use of titrated oral misoprostol solution as a method for inducing labor, comparing it to vaginal dinoprostone, a traditional approach. The study included 695 women who were randomly assigned to receive either titrated oral misoprostol or vaginal dinoprostone.

The study found that both methods were effective in inducing labor, with no significant differences in the primary outcome of vaginal delivery within 24 hours. The researchers also observed that oral misoprostol was associated with a lower risk of uterine hyperstimulation compared to vaginal dinoprostone. However, the study noted that oral misoprostol might have a slightly slower response rate in women with unfavorable cervices and intact membranes.

Finding the Right Path in the Desert

This research provides valuable insights into the use of titrated oral misoprostol for inducing labor, offering a potentially safer and more controlled approach compared to vaginal dinoprostone. The study suggests that oral misoprostol could be a valuable tool for managing labor induction, but it's important to consider factors like cervical status and membrane integrity when determining the most appropriate approach.

A Gentle Breeze

The research on titrated oral misoprostol for inducing labor offers a gentle breeze in the desert of this complex medical process. It provides a potentially safer and more controlled approach compared to vaginal dinoprostone, potentially leading to more comfortable and manageable labor experiences.

Dr. Camel's Conclusion

This research provides valuable insights into the use of titrated oral misoprostol for inducing labor, offering a potentially safer and more controlled approach compared to vaginal dinoprostone. While further research is needed to optimize the use of this method, it holds promise for a more comfortable and manageable labor experience for women.

Date :
  1. Date Completed 2002-01-08
  2. Date Revised 2019-10-25
Further Info :

Pubmed ID

11563466

DOI: Digital Object Identifier

10.1111/j.1471-0528.2001.00231.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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