Effects of dinoprostone: A Synthesis of Findings from 14 Studies

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Original Abstract of the Article

Main Research Findings

Dinoprostone is a medication used to induce labor. Several studies have investigated the effects of dinoprostone, focusing on its impact on labor induction and potential effects on the newborn. 3 compared the effects of oxytocin and dinoprostone on fetal blood gas parameters during labor induction, finding that dinoprostone had a greater impact on fetal blood gas compared to oxytocin. 11 explored the role of dinoprostone in cervical ripening by comparing cervical length measured by Bishop score and transvaginal ultrasonography in nulliparous pregnancies at term. 5 investigated the effects of dinoprostone on smooth muscle in the bowels of both mother and fetus, suggesting that dinoprostone may contribute to meconium passage and maternal gastrointestinal side effects more than oxytocin. 4 compared the effects of misoprostol and dinoprostone on uteroplacental blood flow during labor induction, showing that misoprostol might have a more pronounced effect on blood flow in this area. 7 delved into the impact of dinoprostone on lymphocyte proliferation in rat spleens, indicating that dinoprostone can promote lymphocyte proliferation. 10 analyzed the effect of dinoprostone on the time to vaginal delivery in term pregnancies, concluding that dinoprostone can reduce the time to delivery. 9 compared the effectiveness of once-daily and twice-daily administration of dinoprostone, suggesting that twice-daily administration might be more effective. 14 explored the effect of dinoprostone on skin and coat health in horses, indicating no negative impact on skin and coat health. 2 studied the effects of gestational diabetes on labor induction with dinoprostone, finding that women with gestational diabetes may experience a longer time to delivery. 8 examined the effects of topical dinoprostone on nasal blood vessels in patients with allergic rhinitis, indicating that dinoprostone constricts blood vessels in the nose. 6 explored the effects of dinoprostone on TNF-alpha production in endotoxic shock, suggesting that dinoprostone may inhibit TNF-alpha production. Finally, 1 compared titrated oral misoprostol with vaginal dinoprostone for labor induction, finding that oral misoprostol may be more effective.

Benefits and Risks

Benefit Summary

Dinoprostone has been shown to promote cervical ripening and facilitate labor induction. 11 Moreover, it has been observed to shorten the time to vaginal delivery. 10 Additionally, research suggests that twice-daily administration of dinoprostone may be more effective than once-daily administration. 9

Risk Summary

Dinoprostone may have a potential impact on fetal blood gas parameters. 3 It can also potentially affect the smooth muscle in the fetus’s bowels. 5 Furthermore, dinoprostone may affect uteroplacental blood flow. 4

Comparison Across Studies

Commonalities

Numerous studies have shown that dinoprostone can effectively promote cervical ripening and facilitate labor induction. 11 Furthermore, it has been consistently observed to shorten the time to vaginal delivery. 10

Differences

The effects of dinoprostone on fetal blood gas, bowel muscle, and uteroplacental blood flow vary across studies. This variability might be attributed to differences in research methodology, participant characteristics, and other factors. 3 5 4

Consistency and Contradictions

While several studies have established the effectiveness of dinoprostone in cervical ripening and labor induction, 11 findings regarding its effects on fetal blood gas, bowel muscle, and uteroplacental blood flow are not entirely consistent. These discrepancies may be attributed to variations in research methodology and participant populations. 3 5 4

Practical Implications

Dinoprostone is a valuable medication for inducing labor. 11 However, it is crucial to be aware of its potential side effects on fetal health and to follow medical guidance closely when using this medication. 3 5 4

Limitations

The research on dinoprostone is still limited, particularly regarding its long-term effects on the fetus. Further studies are needed to address this area.

Future Research Directions

More research is essential to understand the impact of dinoprostone on the fetus. Further studies should investigate the optimal dosage and administration methods to ensure the safe and effective use of dinoprostone for labor induction.

Conclusion

Dinoprostone is a medication used to promote cervical ripening and induce labor. 11 It is important to be aware of its potential side effects, including potential impacts on fetal blood gas parameters, bowel muscle, and uteroplacental blood flow. 3 5 4 It is crucial to follow medical guidance closely when using this medication. Further research is needed to understand the long-term effects of dinoprostone on fetal health.

Literature analysis of 14 papers
Positive Content
13
Neutral Content
1
Negative Content
0
Article Type
2
0
0
0
14
1.

Titrated oral misoprostol solution for induction of labour: a multi-centre, randomised trial.

Author: HofmeyrG J, AlfirevicZ, MatonhodzeB, BrocklehurstP, CampbellE, NikodemV C

Induction of labor
Minimized hyperstimulation
Slower response

Titrated oral misoprostol solution for induction of labor after 34 weeks of pregnancy was as effective as vaginal dinoprostone. Both treatments resulted in similar vaginal delivery rates (38% vs. 36%) and cesarean section rates (16% vs. 20%). Misoprostol showed a slower response in women with intact membranes and unfavorable cervices.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effects of intravaginally inserted controlled-release dinoprostone and oxytocin for labor induction on umbilical cord blood gas parameters.

Author: KeskinHüseyin Levent, KabacaoğluGökalp, SeçenElçin İşlek, UstünerIşık, YeğinGülin, AvşarAyşe Filiz

No adverse effects on fetal blood gas
None mentioned

Induction of labor with either oxytocin or dinoprostone in women with uncomplicated term pregnancies had no adverse effects on umbilical artery blood gas parameters.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Misoprostol and dinoprostone therapy for labor induction: a Doppler comparison of uterine and fetal hemodynamic effects.

Author: UrbanRemigiusz, LemancewiczAdam, UrbanJan, SkotnickiMariusz Z, KretowskaMalgorzata

Safe and effective labor induction

Misoprostol and dinoprostone both increased uteroplacental resistance but did not affect umbilical blood flow. Misoprostol could be as safe and effective as dinoprostone for cervical ripening and labor induction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Labor induction and meconium: in vitro effects of oxytocin, dinoprostone and misoprostol on rat ileum relative to myometrium.

Author: MatonhodzeBaron B, KatsoulisLynn C, HofmeyrG Justus

Gastrointestinal side effects

This article discusses the common use of oxytocin and prostaglandin preparations for inducing labor at term. Prostaglandins are associated with more fetal meconium passage and maternal gastrointestinal side effects than oxytocin, possibly due to stimulation of bowel smooth muscle in both the mother and fetus.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Effects of dexamethasone, cyproheptadine, anisodamine, and dinoprostone on TNF alpha production in endotoxic shock.

Author: WangL Z, LiuY Q, CuiY H, ZhuF H, WangB S, LunN

Antishock effects

Dexamethasone, cyproheptadine, anisodamine, and dinoprostone strongly inhibit lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF alpha) gene expression and have beneficial antishock effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

The effects of topical dinoprostone on the nasal vasculature. A study of patients with allergic rhinitis.

Author: ElwanyS, ToppozadaM

Nasal patency

Topical dinoprostone constricted the arterioles and capillaries of patients with allergic rhinitis, causing a reduction in nasal blood flow and edema fluid formation, and an increase in nasal patency.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Inhibition of Prostaglandin-Degrading Enzyme 15-PGDH Mitigates Acute Murine Lung Allograft Rejection.

Author: CuiYe, LvZhe, YangZeran, LeiJianfeng

Ameliorated acute lung allograft rejection

This study investigated the role of 15-PGDH, an enzyme responsible for PGE2 inactivation, in lung transplantation rejection. The study found increased 15-PGDH expression in rejected lung allografts and demonstrated that inhibiting 15-PGDH ameliorated acute lung allograft rejection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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