Paper Details

  1. Home
  2. Paper Details

Effects of ticlopidine on von Willebrand factor-mediated shear-induced platelet activation and aggregation.

Author: GotoS, HandaS, IkedaY, SakakibaraM, TamuraN

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the mechanism of the in vivo antithrombotic effects of ticlopidine, a P2Y(12) ADP receptor blocker. Continuous ticlopidine intake significantly inhibited shear-induced von Willebrand factor (vWF) binding to platelets and caused dissociation of aggregated platelets under high shear rates. The study suggests that these effects on platelet thrombus formation contribute to ticlopidine's antithrombotic effects.
Paper Details　
Original Abstract of the Article :
Ticlopidine, recently classified as a P2Y(12) ADP receptor blockade, is known to be an effective antiplatelet agent preventing arterial thrombosis, e.g., myocardial infarction or cerebral infarction, but the mechanism of the in vivo antithrombotic effects of ticlopidine is not fully understood. Bloo...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1080/09537100120078377

データ提供：米国国立医学図書館（NLM）

Ticlopidine's Impact on Platelet Activation: A Journey Through the Desert of Antiplatelet Therapy

The world of [antiplatelet therapy] is complex, with various medications targeting different mechanisms of platelet activation. This study examines the effects of [ticlopidine] on [von Willebrand factor (vWF)]-mediated [shear-induced platelet activation] and [aggregation]. The authors found that [ticlopidine] significantly inhibited [vWF] binding to platelets and promoted the dissociation of aggregated platelets, suggesting a unique mechanism of action that contributes to its [antithrombotic] effects.

A New Understanding of Ticlopidine's Mechanism

This study, like a guide through the desert of [antiplatelet therapy], sheds light on the specific mechanism by which [ticlopidine] exerts its effects. The findings highlight [ticlopidine]'s unique ability to interfere with [vWF]-mediated platelet activation, a crucial step in the process of [thrombus formation].

Navigating the Desert of Thrombosis Prevention

The desert of [thrombosis prevention] is vast and complex, and [ticlopidine] offers a unique approach. This study provides a deeper understanding of its mechanism of action, highlighting its ability to inhibit [vWF]-mediated platelet activation and promote the dissociation of aggregated platelets. This knowledge can contribute to the development of more effective antithrombotic therapies.

Dr.Camel's Conclusion

The journey through the desert of antiplatelet therapy is filled with discoveries, and this study reveals a new facet of ticlopidine's mechanism of action. Its ability to inhibit vWF-mediated platelet activation and promote the dissociation of aggregated platelets underscores its potential as a valuable tool in the fight against thrombosis.

Date :
  1. Date Completed 2002-03-08
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11674857

DOI: Digital Object Identifier

10.1080/09537100120078377

Related Literature

Article Analysis
・Effects of ticlopidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.