Effects of ticlopidine: A Synthesis of Findings from 23 Studies

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Original Abstract of the Article

Main Research Findings

Ticlopidine is an antiplatelet drug that inhibits platelet aggregation. It is sometimes used to prevent blood clots from forming in the arteries. Several studies have shown that ticlopidine can be effective in preventing blood clots from forming after coronary stent placement. It is also a potential treatment for peripheral artery disease and stroke. 16 , 20 , 21

High glucose concentrations can decrease the effectiveness of aspirin and increase platelet aggregation. 16

The effects of ticlopidine and clopidogrel are not significantly modified by high glucose concentrations. 16

In rats with neuropathic intermittent claudication, a PGE1 analogue called OP-1206 alpha-CD was effective in improving walking dysfunction and spinal cord blood flow, while ticlopidine, cilostazol, and nifedipine showed no significant effects. 18

Benefits and Risks

Benefits Summary

Ticlopidine can prevent blood clots from forming in the arteries. It is used to prevent blood clots from forming after coronary stent placement and may also be used to prevent peripheral artery disease and stroke. 16 , 20 , 21

Risks Summary

Ticlopidine can cause side effects such as liver damage and bone marrow suppression. 16 , 20 , 21

Comparison Between Studies

Commonalities

Most studies indicate that ticlopidine is effective in preventing blood clots from forming. 16 , 20 , 21

Differences

Some studies show different results regarding the effectiveness and side effects of ticlopidine. This is likely due to differences in the study participants and the methods used in each study. 16 , 20 , 21

Consistency and Contradictions in the Results

The majority of studies have shown that ticlopidine is effective in inhibiting platelet aggregation and preventing blood clots. However, there are some studies that show different results. This may be due to differences in the study participants, the methods used in each study, or other factors. 16 , 20 , 21

Considerations for Practical Application

Ticlopidine can be used to prevent blood clots from forming. However, it is important to remember that it can cause side effects. Therefore, ticlopidine should be used only under the supervision of a doctor. 16 , 20 , 21

Limitations of Current Research

More research is needed to fully understand the long-term effects and side effects of ticlopidine. We also need more research to determine how ticlopidine interacts with other drugs. 16 , 20 , 21

Future Research Directions

More research is needed to understand the long-term effects and side effects of ticlopidine. We also need to learn more about how ticlopidine interacts with other drugs. 16 , 20 , 21

Conclusion

Ticlopidine is an effective antiplatelet drug that can prevent blood clots from forming. It is used to prevent blood clots from forming after coronary stent placement and may also be used to prevent peripheral artery disease and stroke. 16 , 20 , 21

Ticlopidine can cause side effects such as liver damage and bone marrow suppression. 16 , 20 , 21

Literature analysis of 23 papers
Positive Content
20
Neutral Content
1
Negative Content
2
Article Type
6
0
0
0
23
1.

Comparison of the effects of omeprazole and rabeprazole on ticlopidine metabolism in vitro.

Author: KinoshitaYuichi, MatsumotoNaoki, WatanabeMinoru, TakebaYuko, YoshidaYutoku, OhbaKeiichiro, SuzukiSatoshi, ItohFumio, KumaiToshio, KobayashiShinichi

Gastrointestinal bleeding prevention
Hemorrhagic complications

This study investigated the effects of omeprazole and rabeprazole, proton pump inhibitors, on ticlopidine metabolism in human liver microsomes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Influence of Ginkgo biloba extract on the pharmacodynamic effects and pharmacokinetic properties of ticlopidine: an open-label, randomized, two-period, two-treatment, two-sequence, single-dose crossover study in healthy Korean male volunteers.

Author: KimBo-Hyung, KimKyu-Pyo, LimKyoung Soo, KimJung-Ryul, YoonSeo Hyun, ChoJoo-Youn, LeeYong-Oh, LeeKyung-Hee, JangIn-Jin, ShinSang-Goo, YuKyung-Sang

Vascular disorder treatment
Drug interactions

Ginkgo biloba extract is a herbal medicine that may interact with antiplatelet agents such as ticlopidine. This study evaluated the pharmacodynamic and pharmacokinetic interactions between these entities.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Inhibitory effects of ticlopidine and clopidogrel on the intimal hyperplastic response after arterial injury.

Author: GöncüTuğrul, TiryakioğluOsman, OzcanAyhan, AriHasan, SezenMustafa, VuralHakan, BayerAhmet, YalçinkayaSerhat, YavuzSenol, OzyazicioğluAhmet

Clopidogrel prevents hyperplasia
Ticlopidine prevents hyperplasia

Ticlopidine and clopidogrel can similarly prevent the development of intimal hyperplasia after experimental arterial injury.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Incidence of side-effects of ticlopidine after sirolimus-eluting stent implantation.

Author: FukushimaKenichi, KobayashiYoshio, OkunoTomonobu, NakamuraYoshitake, SakakibaraMasayoshi, NakayamaTakashi, KurodaNakabumi, MiyazakiAkira, ShimizuYouichi, KomuroIssei

Liver dysfunction
Neutropenia
Rash

Ticlopidine has a high rate of side effects, including liver dysfunction, rash, and neutropenia. Clopidogrel should be approved for prevention of stent thrombosis as soon as possible.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

7.

Inhibitory effects of ticlopidine on platelet function as assessed by three different methods.

Author: Cuyun-LiraO, KanekoM, TakafutaT, SatohK, OhnishiM, YatomiY, OzakiY

Platelet function evaluation

This study compared three different methods for evaluating the effect of ticlopidine on platelet function. All three methods were useful, but the collagen-bead column method was found to be the most convenient and cost-effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

The effects of ergoloid mesylates and ginkgo biloba on the pharmacokinetics of ticlopidine.

Author: LuWen-Jen, HuangJin-Ding, LaiMing-Liang

Drug interactions

This study examined the effect of ergoloid mesylates and ginkgo biloba on ticlopidine pharmacokinetics. Ergoloid mesylates, but not ginkgo biloba, significantly decreased the AUC and C(max) of ticlopidine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Increase in tumor oxygenation and potentiation of radiation effects using pentoxifylline, vinpocetine and ticlopidine hydrochloride.

Author: AmanoMorikazu, MonzenHajime, SuzukiMinoru, TeraiKaoru, AndohSatoshi, TsumurayaAkio, HasegawaTakeo

Radiopotentiation

Pentoxifylline, Vinpocetine, and Ticlopidine Hydrochloride increased the oxygen levels in SCCVII tumors in mice. They also delayed tumor growth after radiation therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Comparative inhibitory effects of cilostazol and ticlopidine on subacute stent thrombosis and platelet function in acute myocardial infarction patients with percutaneous coronary intervention.

Author: KawataMasahito, KuramotoEmi, KataokaToshio, SaitoAtsushi, AdachiKazumasa, MatsuuraAkira, SakamotoSusumu

Subacute stent thrombosis prevention

Ticlopidine was more effective than cilostazol in preventing subacute stent thrombosis after stenting in patients with acute myocardial infarction. The difference may be related to cilostazol's weaker inhibition of ADP-induced platelet aggregation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Preventive effects of Ticlopidine on the incidence of late A-V fistula thrombosis complications in haemodialyses patients.

Author: JanickiKrzysztof, Bojarska-SzmyginAnna, PieturaRadosław, JanickaLucyna

Reduced fistula thrombosis
Side effects

This study investigated the effects of ticlopidine on the prevention of late thrombosis complications in freshly created arteriovenous fistulas in patients receiving hemodialysis. The results showed that ticlopidine significantly reduced the extent of late thrombosis complications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Effects of policosanol and ticlopidine in patients with intermittent claudication: a double-blinded pilot comparative study.

Author: CastañoGladys, MásRosa, GámezRafael, FernándezLilia, IllnaitJosé

Improved walking distance
Reduced cholesterol

This study compared the effectiveness of two drugs for treating intermittent claudication, a condition causing leg pain during walking. Policosanol and ticlopidine both improved walking distance, but policosanol had the added benefit of lowering cholesterol levels. The study suggests that policosanol might be a better option for patients with claudication as it addresses both the leg pain and overall cardiovascular health.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Effects of antiplatelet agents on subacute thrombosis and restenosis after successful coronary stenting: a randomized comparison of ticlopidine and cilostazol.

Author: SekiguchiMakoto, HoshizakiHiroshi, AdachiHitoshi, OhshimaShigeru, TaniguchiKoichi, KurabayashiMasahiko

Inhibition of neointimal proliferation
Reduced SAT risk

This study compared the preventive effects of ticlopidine plus aspirin therapy versus cilostazol plus aspirin therapy on subacute thrombosis (SAT) and restenosis after coronary stenting. The study found that ticlopidine was more effective in preventing SAT, but that cilostazol was more effective in inhibiting neointimal proliferation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Evaluation of antiplatelet effects of ticlopidine in cats.

Author: HoganDaniel F, AndrewsDina A, TalbottKristen K, GreenHenry W, WardMichael P, CallowayBetsy M

Antiplatelet effect
Anorexia
Vomiting

Ticlopidine had a consistent antiplatelet effect in cats at the 250-mg dosage, but dose-dependent anorexia and vomiting precluded its clinical usefulness.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Influence of glucose concentration on the effects of aspirin, ticlopidine and clopidogrel on platelet function and platelet-subendothelium interaction.

Author: De La CruzJosé Pedro, ArrebolaMaría Monsalud, VillalobosMaría Auxiliadora, PinachoAraceli, GuerreroAna, González-CorreaJosé Antonio, Sánchez de la CuestaFelipe

Cerebrovascular accident prevention

This study examined the effect of high concentrations of glucose on the antiplatelet effects of aspirin, ticlopidine, and clopidogrel.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Effects of high ticlopidine doses on platelet function in acute coronary syndrome patients.

Author: BélangerPatrick, PalisaitisDonald A, DiodatiJean G, PharandChantal

Faster inhibition of platelet activation
Faster inhibition of platelet aggregation

This study investigated whether a higher dose of ticlopidine would lead to a faster inhibition of platelet activation and aggregation in patients with acute coronary syndromes. The study found that 500 mg twice daily of ticlopidine resulted in significantly greater reduction in platelet activation and aggregation compared to 250 mg twice daily, especially after 2 days of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Effects of OP-1206 alpha-CD on walking dysfunction in the rat neuropathic intermittent claudication model: comparison with nifedipine, ticlopidine and cilostazol.

Author: NakaiKatsuhiko, TakenobuYoshifumi, TakimizuHideyuki, AkimaruShinji, MaegawaHitoshi, ItoHidenori, MarsalaMartin, KatsubeNobuo

Improved blood flow
Improved walking function

OP-1206 alpha-CD, a prostaglandin E1 analogue, improves walking dysfunction and spinal cord blood flow in rats with neuropathic intermittent claudication. This abstract suggests its potential as a treatment for spinal stenosis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Effects of clopidogrel and ticlopidine on experimental diabetic ischemic retinopathy in rats.

Author: De La CruzP, ArrebolaM, González-CorreaA, Martinez-CerdánE, MorenoA, de la CuestaF Sánchez

Diabetic retinopathy

This study evaluates the effect of clopidogrel on ischemic retinopathy in diabetic rats and its influence on prostanoids and nitric oxide (NO) production. Early administration of thienopyridines in diabetic rats partially prevented the appearance of diabetic retinal ischemia.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Comparison of effects of clopidogrel versus ticlopidine on platelet function in patients undergoing coronary stent placement.

Author: GawazM, SeyfarthM, MüllerI, RüdigerS, Pogatsa-MurrayG, WolfB, SchömigA

Accelerated antiplatelet effect

This study demonstrates that clopidogrel combined with aspirin as a loading dose significantly accelerates the antiplatelet effect in patients undergoing coronary stent placement.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Ticlopidine, Alka-Seltzer, or a combination of citric acid with aspirin: effects on platelet aggregation in individuals with an insufficient response to aspirin alone.

Author: KaplanS, KaplanA, MarcoeK, SauvageL R

Platelet aggregation inhibition

This study investigated the effect of ticlopidine, Alka-Seltzer, and aspirin plus citric acid (ASA + CTA) on platelet aggregation in subjects resistant to aspirin's antiaggregation effect. Ticlopidine was the most potent inhibitor, followed by ASA + CTA, which was more effective than Alka-Seltzer.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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