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Fluorodeoxyuridine improves imaging of human glioblastoma xenografts with radiolabeled iododeoxyuridine.

Author: BucheggerF, De TriboletN, DupertuisY M, MachJ P, PichardC, SlosmanD O, VazquezM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated whether blocking thymidine (dThd) synthesis with 5-fluoro-2'-deoxyuridine (FdUrd) could improve scintigraphy with radio-dThd analogues, such as 5-iodo-2'-deoxyuridine (IdUrd). Pre-administration of FdUrd significantly increased the uptake of [125I]IdUrd in human glioblastoma cell lines in vitro and in vivo, leading to improved tumor detection in nude mice. FdUrd pre-administration also increased uptake in normal proliferating tissues, but to a lesser extent than in tumors.
Paper Details　
Original Abstract of the Article :
Use of radiolabeled nucleotides for tumor imaging is hampered by rapid in vivo degradation and low DNA-incorporation rates. We evaluated whether blocking of thymidine (dThd) synthesis by 5-fluoro-2'-deoxyuridine (FdUrd) could improve scintigraphy with radio-dThd analogues, such as 5-iodo-2'-deoxyuri...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11691821

データ提供：米国国立医学図書館（NLM）

Improving Glioblastoma Imaging with Fluorodeoxyuridine

Glioblastoma is an aggressive form of brain cancer, making it difficult to treat. It's like a hidden fortress in the desert, difficult to locate and even harder to conquer. This study explores the use of a drug called fluorodeoxyuridine (FdUrd) to improve imaging of glioblastoma tumors, allowing doctors to pinpoint their location and potentially target them more effectively.

A Sharper View of the Enemy

The study found that FdUrd helps to increase the uptake of a radioactive tracer in glioblastoma tumors. This is like using a powerful beacon in the desert to illuminate a hidden oasis. This improved visibility allows doctors to create more accurate images of the tumors, making it easier to track their growth and guide treatment.

A More Precise Approach to Treatment

This research demonstrates that FdUrd can be a valuable tool in the fight against glioblastoma. It's like finding a new weapon in the desert, allowing doctors to strike at the heart of the enemy with greater precision. With improved imaging, doctors can tailor treatments to individual patients, potentially leading to more successful outcomes.

Dr. Camel's Conclusion

This research is a testament to the power of innovation in the field of medicine. It's a reminder that even in the face of challenging diseases, there is always hope for finding new solutions. It's like a glimmer of light in the vast desert, guiding us towards a future where we can conquer even the most formidable foes.

Date :
  1. Date Completed 2001-12-04
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

11691821

DOI: Digital Object Identifier

11691821

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English

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