Vasorelaxant effects of racemic betaxolol and its R- and S- isomers on bovine retinal vessels.

Author: DeSantisL, KulkarniP S

Paper Details 
Original Abstract of the Article :
RS-Betaxolol (equimolar R- and S- isomers) lowers intraocular pressure and dilates precontracted retinal and posterior ciliary arteries in vitro. Betaxolol's vasorelaxant effect is thought to involve the inhibition of calcium influx into vascular smooth muscle and is unrelated to its stereoselective...See full text at original site
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引用元:
https://doi.org/10.1097/00061198-200110000-00011

データ提供:米国国立医学図書館(NLM)

Betaxolol: A Cool Oasis in the Desert of Ocular Hypertension

Ocular hypertension, like a relentless desert wind, can gradually erode vision, leading to serious consequences. This study, like a camel seeking respite from the heat, explores the vasodilatory effects of betaxolol, a beta-blocker commonly used to treat glaucoma, on bovine retinal vessels. The researchers meticulously investigated the effects of betaxolol and its R- and S- isomers on different diameters of bovine retinal arterioles and venules, revealing a complex interplay of these compounds on vascular function. Their findings contribute to the understanding of betaxolol's mechanism of action in reducing intraocular pressure.

Betaxolol: A Cool Oasis in the Desert of Ocular Hypertension

This study, like a scientist analyzing a complex equation, reveals the intricate effects of betaxolol on bovine retinal vessels. The researchers found that betaxolol's vasorelaxant effect, which contributes to its ability to lower intraocular pressure, is unrelated to its beta-adrenergic blocking action. This study provides a deeper understanding of betaxolol's mechanism of action, paving the way for more targeted and effective treatments for ocular hypertension.

Navigating the Desert of Ocular Health: A Closer Look

This research, like a magnifying glass revealing hidden details, provides a closer look at betaxolol's effects on retinal vessels. By understanding the complex interplay of betaxolol and its isomers on vascular function, researchers can develop more effective treatment strategies for ocular hypertension. This knowledge could lead to improved management of this condition, preserving vision and enhancing quality of life for affected individuals.

Dr.Camel's Conclusion

This research, like a cool oasis in the desert of ocular hypertension, provides valuable insights into the vasodilatory effects of betaxolol. By understanding the mechanisms underlying betaxolol's actions, researchers can develop more targeted and effective treatments for ocular hypertension, preserving vision and enhancing quality of life for affected individuals. This study offers a beacon of hope for those battling this challenging condition, paving the way for a brighter future in ocular health.

Date :
  1. Date Completed 2001-12-17
  2. Date Revised 2019-11-05
Further Info :

Pubmed ID

11711842

DOI: Digital Object Identifier

10.1097/00061198-200110000-00011

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