Effects of betaxolol: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Major Research Findings

Betaxolol is a type of beta-blocker used to treat glaucoma, and numerous studies have demonstrated its effectiveness in lowering intraocular pressure. 25 found that betaxolol, when administered as eye drops, resulted in reduced eye pressure and improved visual fields. 5 found that betaxolol, compared to other beta-blockers, has a lesser impact on the heart. 12 also found that betaxolol is equally effective in lowering intraocular pressure as timolol and has fewer side effects. Additionally, 24 showed that betaxolol can effectively reduce exercise-induced myocardial ischemia in patients with coronary vasospasm. These findings suggest that betaxolol may be a potential treatment for coronary vasospasm.

Benefits and Risks

Benefit Summary

Betaxolol has been shown to effectively lower intraocular pressure. 25 , 12 Furthermore, betaxolol has been shown to have minimal effects on the heart compared to other beta-blockers. 5 Moreover, betaxolol has demonstrated the ability to reduce exercise-induced myocardial ischemia in patients with coronary vasospasm. 24

Risk Summary

While betaxolol has minimal effects on the heart, it can potentially cause breathing difficulties in patients with respiratory conditions such as asthma or chronic bronchitis. 1 Additionally, betaxolol can cause side effects like fatigue and drowsiness. 8 It is essential to follow the doctor’s instructions when using betaxolol.

Comparison of Studies

Commonalities in Research

Multiple studies have shown that betaxolol effectively lowers intraocular pressure. 25 , 12 , 20 , 9 , 13 Studies also suggest that betaxolol has minimal impact on the heart compared to other beta-blockers. 5 , 10

Differences in Research

Betaxolol shows potential not only as a treatment for glaucoma but also for coronary vasospasm and chronic heart failure. 24 , 23 However, patients with respiratory conditions like asthma or chronic bronchitis may experience breathing difficulties when using betaxolol. 1 Additionally, betaxolol can cause side effects like fatigue and drowsiness. 8

Consistency and Contradictions in Findings

Numerous studies have demonstrated the effectiveness of betaxolol in lowering intraocular pressure, with its effectiveness being comparable to timolol. 12 , 9 Furthermore, studies suggest that betaxolol has minimal effects on the heart compared to other beta-blockers. 5 However, betaxolol can potentially cause breathing difficulties in patients with respiratory conditions such as asthma or chronic bronchitis. 1 While betaxolol is an effective drug for glaucoma, caution is necessary for patients with respiratory conditions.

Applying the Findings to Daily Life

Betaxolol is a safe and effective drug for treating glaucoma. However, caution is required for patients with respiratory conditions like asthma or chronic bronchitis. 1 Betaxolol can also cause side effects like fatigue and drowsiness. 8 Therefore, it is crucial to follow the doctor’s instructions when using betaxolol.

Limitations of Current Research

Further research is needed to understand the long-term effects of betaxolol. Additionally, research is needed to explore how betaxolol affects patients with various health conditions.

Future Research Directions

Further research is required to evaluate the long-term effects of betaxolol. Additionally, research should explore how betaxolol affects patients with different health conditions.

Conclusion

Betaxolol is an effective drug for treating glaucoma by lowering intraocular pressure. However, it is important to exercise caution for patients with respiratory conditions. Additionally, betaxolol can have side effects like fatigue and drowsiness. Always follow the doctor’s instructions when using betaxolol.

Literature analysis of 27 papers
Positive Content
25
Neutral Content
0
Negative Content
2
Article Type
19
0
0
0
27
1.

Effects of beta-adrenoceptors blocking eye drops in patients with chronic bronchitis.

Author: HuguesF C, MatteJ C, Le JeunneC, SalemA

Bronchoconstriction

Beta-blocker eyedrops, while effective for glaucoma, may enhance asthma symptoms. While most parameters were unchanged, forced expiratory volume in one second decreased in some patients, even with beta 1 selective blockers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Changes in depressive status associated with topical beta-blockers.

Author: DuchS, DuchC, PastóL, FerrerP

Less depression
Depression risk

Betaxolol may be less likely than timolol to induce depression in predisposed patients. In a small study of glaucomatous patients, those treated with timolol had higher depression scores than those treated with betaxolol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

The effects of time and dose on the relative beta 1- and beta 2-adrenoceptor antagonism of betaxolol and atenolol.

Author: LipworthB J, IrvineN A, McDevittD G

Beta 1-adrenoceptor blockade
Beta 2-adrenoceptor blockade
None mentioned

The study compared the effects of beta-blockers betaxolol and atenolol on heart rate and other measures in healthy subjects. Beta-blockers reduced exercise heart rate in a dose-dependent manner. Betaxolol was more selective for beta1 receptors, meaning it had a greater effect on the heart than on the lungs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Assessment of systemic effects of different ophthalmic beta-blockers in healthy volunteers.

Author: BauerK, Brunner-FerberF, DistlerathL M, LippaE A, BinkowitzB, TillP, KaikG

Oculoselective
Safe for eyes
Systemic beta-blockade

The study examined the systemic beta-blockade caused by ophthalmic beta-blockers in healthy volunteers. All beta-blockers tested caused systemic beta-blockade, but betaxolol was less potent than metipranolol and timolol. Butapranolol, a noncardioselective but topically oculoselective drug, did not cause systemic beta-blockade.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Systemic effects of three beta-blocker eyedrops: comparison in healthy volunteers of beta 1- and beta 2-adrenoreceptor inhibition.

Author: Le JeunneC, MuneraY, HuguesF C

Effective beta-blocker
Good efficacy

Carteolol and timolol totally inhibited the beta 1 and beta 2 effects of isoproterenol, whereas betaxolol allowed the same effects with the same dose of isoproterenol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

The significance of reactions to betaxolol reported by patients.

Author: BrooksA M, BurdenJ G, GilliesW E

Respiratory safety
Respiratory side effects

Betaxolol, an ocular hypotensive drug, was studied for its respiratory safety. Despite some patients reporting wheeze or respiratory distress, no changes in respiratory function were observed with betaxolol in a double-masked clinical study.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

[Comparison of the effect of a selective and a nonselective beta receptor blocker on the ischemic ST segment, lung function and stress-induced decrease in blood glucose].

Author: BrügmannU, BlasiniR

Effective for angina pectoris
Less effect on pulmonary function
Decrease in blood glucose

Betaxolol, a cardioselective beta-blocking agent, was as effective as nadolol, a non-selective agent, in reducing ST-segment depression in patients with stable exercise angina pectoris.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

8.

[Comparative pharmacoclinical study of 2 beta-blockers: atenolol and betaxolol in slight-to-moderate arterial hypertension].

Author: HerpinD, BoutaudP, CiberM A, AmielA, DemangeJ

Prolonged effects
Reduced blood pressure

Betaxolol was shown to have a more prolonged antihypertensive effect on exercising heart rate and blood pressure compared to atenolol, suggesting its potential for treating hypertension associated with physical activity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

9.

Betaxolol vs timolol. A six-month double-blind comparison.

Author: StewartR H, KimbroughR L, WardR L

Cardiopulmonary safety
Glaucoma treatment

Betaxolol hydrochloride (0.5%) and timolol maleate (0.5%) were compared in a six-month study of 29 patients with glaucoma. Both drugs were effective in lowering intraocular pressure, with betaxolol reducing pressure by 7.6 mm Hg (26%) and timolol reducing pressure by 8.4 mm Hg (29%). Ocular side effects were mild and similar for both treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Beta-adrenoceptor blocking effects and pharmacokinetics of betaxolol (SL 75212) in man.

Author: GiudicelliJ F, ChauvinM, ThuillezC, RicherC, BianchettiG, GomeniR, MorselliP L

Long-lasting effect
Potent beta-blocker

Betaxolol was a potent and long-lasting beta-adrenoceptor blocker, more potent than propranolol. It had a long duration of action and a long plasma elimination half-life.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Observation on the efficacy and pharmacokinetics of betaxolol (SL 75212), a cardioselective beta-adrenoceptor blocking drug.

Author: BalnaveK, NeillJ D, RussellC J, HarronD W, LeaheyW J, WilsonR, ShanksR G

Long duration of effect
Tachycardia reduction

Betaxolol significantly reduced exercise tachycardia with a longer duration of action than other beta-blockers. It had a long plasma elimination half-life.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Betaxolol and timolol. A comparison of efficacy and side effects.

Author: BerryD P, Van BuskirkE M, ShieldsM B

Lower intraocular pressure
Selective beta 1-blockade

Betaxolol and timolol were comparable in efficacy and side effects for treatment of open-angle glaucoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

The favorable effect of topical betaxolol and timolol on glaucomatous visual fields: a 2-year follow-up study.

Author: Vainio-JylhäE, VuoriM L

Visual Field Protection

A randomized, double-blind study comparing the effects of betaxolol and timolol on visual fields in glaucoma patients did not find significant differences.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Betaxolol versus carvedilol in chronic heart failure (BETACAR study). Rationale and design.

Author: BöhlerS, SaubaduS, ScheldewaertR, FigullaH R

Slows down progression of left ventricular dilatation

Beta-blockers were previously thought to be contraindicated in heart failure due to their negative inotropic effects. However, there is growing evidence that beta-blockers may slow down the progression of heart failure. BETACAR is a comparative study investigating the benefits of beta-blockade with betaxolol versus carvedilol in chronic heart failure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Direct and crossover effects of brinzolamide, betaxolol, and latanoprost on choroidal thickness.

Author: OkutucuMurat, FındıkHüseyin, ArslanMehmet Gökhan

Glaucoma treatment
SFCT increase

Brinzolamide and betaxolol, commonly used glaucoma drugs, increased choroidal thickness, as measured by EDI-OCT. However, latanoprost had no significant effect on choroidal thickness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Cytotoxic effects of betaxolol on healthy corneal endothelial cells both in vitro and in vivo.

Author: MiaoYing, SunQian, WenQian, QiuYue, GeYuan, YuMiao-Miao, FanTing-Jun

Apoptosis
Corneal endothelial cell injury

Betaxolol, an anti-glaucoma drug, has a significant cytotoxic effect on human corneal endothelial cells in vitro and cat corneal endothelial cells in vivo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Comparative effects of amlodipine monotherapy and combination therapy with betaxolol on cardiac autonomic nervous activity and health-related quality of life in patients with poorly controlled hypertension.

Author: TakaseBonpei, TakeishiYasuchika, HiraiTadakazu, LeeJong-Dae, UzuiHiroyasu, SendaShoichi, MiwaKunihisa, HiraokaYuji, KinugawaToru, HosokawaRyohei, FujitaMasatoshi

Improved CANA
Improved HRQL
Increased BNP

Combined treatment of amlodipine and betaxolol was more useful than amlodipine dose-up therapy, because combined treatment improved cardiac autonomic nervous activity and health-related quality of life.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Effects of latanoprost and betaxolol on cardiovascular and respiratory status of newly diagnosed glaucoma patients.

Author: ErkinEsin F, CelikPinar, KayikçioğluOzcan, DeveciHulya Mutlu, SakarAyşin

IOP reduction
Safe for respiratory
Cardiovascular changes

Both latanoprost and betaxolol reduced intraocular pressure significantly in newly diagnosed glaucoma patients. Latanoprost was safe, with no systemic cardiovascular or respiratory side effects, while betaxolol caused small changes in the cardiovascular system, suggesting that blood pressure and pulse rates should be checked regularly in the elderly.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Protective effects of betaxolol in eyes with kainic acid-induced neuronal death.

Author: CheonEun Woo, ParkChang Hwan, KimYoon Sook, ChoChang Hyun, ChungYoung Chul, KwonJong Gil, YooJi Myong, ChoiWan Sung, ChoGyeong Jae

Betaxolol retinal neuroprotection

This study investigated the neuroprotective effects of betaxolol on kainic acid (KA)-induced retinal damage in rats. Topical application of betaxolol was found to attenuate the retinal damage caused by KA.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

The effects on the intraocular pressure and visual field resulting from a switch in the treatment from timolol to betaxolol.

Author: MikiHirohiko, MikiKatsuaki

Improved retinal sensitivity

This study compared the effects of timolol and betaxolol on intraocular pressure (IOP) and visual field in patients with primary open-angle glaucoma. Betaxolol was superior to timolol in improving mean retinal sensitivity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

The comparative cardiovascular, pulmonary, ocular blood flow, and ocular hypotensive effects of topical travoprost, bimatoprost, brimonidine, and betaxolol.

Author: InanUmit Ubeyt, ErmisSitki Samet, OrmanAyse, OnratErsel, YucelAylin, OzturkFaruk, AsagidagAli, CelikAtac

Increased blood flow
Reduced IOP
Conjunctival hyperemia

Travoprost and bimatoprost were found to be systemically safe and caused an increase in blood-flow velocities of the retrobulbar vessels after a single-dose application. Their ocular hypotensive effect was comparable to that of brimonidine and greater than that of betaxolol in healthy subjects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Effects of betaxolol and latanoprost on ocular blood flow and visual fields in patients with primary open-angle glaucoma.

Author: ErkinE F, TarhanS, KayikçioğluO R, DeveciH, GülerC, GöktanC

Improved ocular blood flow
Reduced IOP

This study evaluated the effects of betaxolol and latanoprost on ocular blood flow and visual fields in patients with primary open-angle glaucoma (POAG). The study found that both drugs reduced IOP, but that latanoprost had a greater IOP-lowering effect. Neither drug caused significant changes in visual fields, but both improved ocular blood flow.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

[Clinical and metabolic effects of betaxolol (lokren) in treatment of patients with chronic cardiac insufficiency].

Author: KorzhA N

Alleviate angina
Improved hemodynamic status
Increase ejection fraction

Beta-blockers like betaxolol can improve clinical, hemodynamic and metabolic indices in patients with chronic cardiac insufficiency (ChCI) with the left ventricular ejection fraction less than 40%. It can reduce lipid peroxidation without adverse effects on lipid and carbohydrate metabolism.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

24.

Beneficial effects of betaxolol, a selective antagonist of beta-1 adrenoceptors, on exercise-induced myocardial ischemia in patients with coronary vasospasm.

Author: SuzukiJun, WatanabeKouki, TsuruokaTakashi, SuedaShozo, FunadaJun-ichi, KitakazeMasafumi, SekiyaMichihito

Improved blood flow
Increased exercise capacity

Betaxolol, a beta-blocker with calcium antagonistic properties, was found to improve exercise capacity and regional myocardial blood flow in patients with vasospastic angina (VSA). This suggests that betaxolol could be a potential new treatment for VSA.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

Vasorelaxant effects of racemic betaxolol and its R- and S- isomers on bovine retinal vessels.

Author: KulkarniP S, DeSantisL

Dilated retinal arteries
Reduced intraocular pressure
None mentioned

This study assessed the vasodilatory effect of RS-betaxolol on different diameters of bovine retinal arterioles and venules and compared these responses with those induced by R- and S-betaxolol isomers in vitro.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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