Randomized controlled trial of clarithromycin and ethambutol in the treatment of Crohn's disease.

Author: AkramS, GoodgameR W, GrahamD, IkeE, KimballK, OuC N, SuttonF

Paper Details 
Original Abstract of the Article :
BACKGROUND: A mycobacterial infection may be the cause of Crohn's disease in some patients. Measurement of intestinal permeability may identify Crohn's disease patients with a high likelihood of relapse and may quantify the severity of intestinal injury. AIM: To assess the effect of 3 months of cla...See full text at original site
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引用元:
https://doi.org/10.1046/j.1365-2036.2001.01099.x

データ提供:米国国立医学図書館(NLM)

Clarithromycin and Ethambutol: A Dusty Trail in Crohn's Disease

The world of Crohn's disease is a challenging one, marked by chronic inflammation of the digestive tract. Researchers are constantly seeking new pathways to manage this condition, akin to navigating a vast desert in search of relief. This study focused on the potential role of clarithromycin and ethambutol, commonly used to combat mycobacterial infections, in treating Crohn's disease. The study, a randomized controlled trial, aimed to determine if these drugs could improve disease activity and intestinal permeability in patients at high risk of relapse. After a 3-month trial, the researchers concluded that clarithromycin and ethambutol, despite being a common duo in the fight against mycobacterial infections, provided no significant benefit for patients with Crohn's disease.

A Dead End in the Desert?

This study's findings are a bit like a dead end in a desert journey, suggesting that clarithromycin and ethambutol may not be the answer for Crohn's disease patients. While the researchers found no significant difference in disease activity or intestinal permeability between the treatment and placebo groups, it's important to remember that every patient is unique, like a different oasis in the desert. Further research is needed to explore other potential treatments for Crohn's disease.

Health Implications: Understanding Crohn's

Living with Crohn's disease can be challenging. It's essential to consult with a healthcare professional to discuss treatment options and manage symptoms. Remember, there are many oases in the desert of healthcare, and finding the right one for you is crucial.

Dr.Camel's Conclusion

The search for effective treatments for Crohn's disease continues. This study, like a lost caravan in the desert, adds to our understanding of the disease and the limitations of certain medications. The journey toward finding a cure may be long and arduous, but researchers continue to explore new paths, hoping to discover a true oasis of relief for those affected by Crohn's disease.

Date :
  1. Date Completed 2002-04-15
  2. Date Revised 2019-09-01
Further Info :

Pubmed ID

11736715

DOI: Digital Object Identifier

10.1046/j.1365-2036.2001.01099.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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