Effective treatment of endocrine diseases: A Synthesis of Findings from 106 Studies

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Original Abstract of the Article

Major research findings

Crohn's disease is a chronic inflammatory bowel disease that can affect any part of the gastrointestinal tract, from the mouth to the anus. It is characterized by periods of flare-ups, when symptoms are worse, followed by periods of remission, when symptoms are less severe or absent ( 62 ). While there are effective treatments available, outcomes can be suboptimal due to factors such as nonadherence, medication intolerance, inconsistent monitoring, poor patient knowledge and limited access to care ( 62 ).

Perianal fistulas, which affect up to one-third of Crohn's patients, are a common and debilitating complication. These fistulas can lead to pain, drainage, and infection, and they are difficult to treat ( 69 ). Recent research suggests that early use of biologics, a type of medication that targets the immune system, can improve clinical outcomes in Crohn's disease ( 91 ).

Early surgery for Crohn's disease may reduce the risk of recurrence, especially for those who experience a longer time between diagnosis and surgery ( 1 ). For patients with Crohn's disease, particularly children, nutritional therapy, such as exclusive enteral nutrition, can be an effective treatment option that can induce remission, control inflammation, promote mucosal healing, and improve overall nutritional status ( 31 ).

Treatment summary

Crohn's disease treatment should be tailored to the individual patient, taking into account the severity of inflammation, location of disease, disease behavior, comorbidities, extra-intestinal manifestations, age, and previous therapies ( 90 ).

Treatments for Crohn's disease include anti-inflammatory drugs, immunosuppressants, biologics, antibiotics, corticosteroids, and nutritional therapy ( 94 , 19 , 17 , 31 , 27 ). Biologic therapies, such as certolizumab pegol, infliximab, and adalimumab, have shown significant benefits in inducing and maintaining remission in Crohn's disease ( 87 , 39 , 52 , 94 , 103 ).

While antibiotics have been used in Crohn's disease, their efficacy is not consistently demonstrated ( 17 ).

Benefits and risks

Benefits summary

The main benefit of treatment for Crohn's disease is to induce and maintain remission. Effective treatment can reduce the frequency and severity of flare-ups, improve quality of life, and reduce the need for surgery ( 94 , 62 , 52 , 48 ).

Risk summary

Treatments for Crohn's disease, especially biologics, can have side effects, such as infections, allergic reactions, and gastrointestinal issues. The risk of side effects should be weighed against the potential benefits of treatment ( 103 , 39 , 13 , 17 ).

Comparison of studies

Commonalities between studies

Many studies highlight the importance of individualized treatment plans for Crohn's disease, taking into account patient factors and disease characteristics ( 66 , 90 , 30 ).

The use of biologics as a treatment option for Crohn's disease is consistently explored in numerous studies ( 87 , 39 , 52 , 94 , 103 ).

Differences between studies

Research on Crohn's disease focuses on a variety of aspects, including the effectiveness and safety of different treatments, the impact of early treatment, the development of new treatment strategies, the role of nutrition, and the management of specific complications. These studies may use different methodologies and target diverse patient populations, making direct comparisons challenging ( 59 , 95 , 98 , 47 , 66 , 70 , 10 , 85 , 81 ).

Consistency and contradictions in the results

While there is a degree of consistency in research findings regarding the use of anti-inflammatory drugs, immunosuppressants, and biologics for Crohn's disease, contradictions can arise due to factors such as study design, participant characteristics, and specific treatment protocols ( 17 , 90 ).

Application to real life and cautionary notes

It is important to consult with a healthcare professional to discuss the best treatment options based on individual needs and disease characteristics ( 90 ). While medication is a crucial part of Crohn's disease management, lifestyle modifications such as dietary adjustments and regular exercise can also contribute to overall well-being ( 31 ).

Current limitations of the research

There is a need for more extensive and long-term research on the effectiveness and safety of various treatments for Crohn's disease, especially regarding potential long-term side effects of biologics and the development of new treatment strategies ( 91 , 103 ).

Future research directions

Future research should focus on refining treatment strategies, optimizing medication combinations, developing personalized medicine approaches, and investigating the potential of new therapies to address the specific needs of Crohn's disease patients ( 98 , 81 ).

Conclusion

Crohn's disease is a complex and challenging condition. Despite significant advances in treatment, ongoing research is vital to improve patient outcomes and develop more effective and safe therapies.

Treatment list

Anti-inflammatory drugs, immunosuppressants, biologics, antibiotics, corticosteroids, nutritional therapy, surgery, endoscopic dilation, exclusive enteral nutrition, budesonide, sulfasalazine, infliximab, adalimumab, certolizumab pegol, mesalazine, azathioprine, methotrexate, rifaximin, ciprofloxacin, ustekinumab, mycophenolate mofetil.

Keywords
Benefit Keywords
Crohn's disease treatment
1
Crohn's disease remission
3
Improved symptoms
Weight gain
4
Improved immune function
Reduced inflammatory factors
5
Improved Crohn's disease treatment
6
Effective maintenance
Safe maintenance
7
Crohn's remission
Safe treatment
8
Improved Crohn's disease treatment
10
Antimycobacterial therapy
Crohn's disease remission
11
Maintained remission
Reduced prednisone use
Reduced relapse risk
12
Improved understanding of Crohn's disease treatment
13
Induction of remission of Crohn's disease
15
Fistula improvement
16
Induction of remission of Crohn's disease
17
Ciprofloxacin efficacy
Metronidazole efficacy
19
Crohn's disease treatment
20
Effective treatment of Crohn's disease
21
Induction of remission in Crohn's disease
22
Improved perianal Crohn's disease
23
Induction of remission of Crohn's disease
24
Crohn's disease treatment
25
Well tolerated
26
Crohn's disease remission
27
Improved Crohn's disease treatment
28
Crohn's remission
29
Crohn's disease treatment
30
Improved Crohn's disease treatment
31
Corticosteroid-sparing effects
Maintenance of fistula healing
Maintenance of remission
32
Remission
Response
33
Minimal side effects
34
Improved quality of life
35
Reduced hospitalization
Reduced surgery
36
Crohn's disease treatment
37
Crohn's disease treatment
38
Cost-effective for severe active CD
39
Effective treatment
40
Fistula closure
41
Improved social interaction
Laparoscopy benefits
Reduced hospital stay
42
CD treatment
43
Induced remission
Prevented relapse
44
IBD relapse prevention
IBD remission
45
Crohn's disease treatment
46
Improved Crohn's disease management
47
Improved Crohn's disease management
48
Improved Crohn's disease treatment
49
CD treatment
50
Reduced Crohn's disease recurrence
51
Maintains remission
Safe long-term
52
Crohn's treatment
53
Anti-TNF
Immunomodulator use
54
Rifaximin
55
Methotrexate
56
Effective induction
57
Methotrexate
58
Effective remission
59
Improved CD symptoms
60
Improved biological remission
Improved clinical remission
Improved mucosal healing
61
IBD treatment
62
Enteral nutrition
63
ECI for Crohn's disease
66
Crohn's disease treatment
68
Crohn's disease treatment
69
Minimized complications
Preserved intestinal length
70
Improved endoscopic outcomes
71
Crohn's disease treatment
75
Better tolerance
POR-CD prophylaxis
77
CD treatment
78
Improved quality of life
79
CD treatment
Early intervention
Therapeutic de-escalation
80
Improved CD treatment
81
Reduced TGF-beta activation
Tissue repair
82
Reduce inflammation
83
Improved IBD treatment
84
Crohn's disease treatment
85
Crohn's disease and ulcerative colitis treatment
Treat-to-target management
86
Induced remission
Reduced inflammation
87
Remission induction
89
CD treatment
90
Crohn's disease treatment
91
Stricturing CD treatment
92
Crohn's disease treatment
93
CD treatment
94
Improved strictures
Reduced surgery
95
Fistula healing
Ustekinumab effective
96
ECI for CD
97
Crohn's disease treatment
98
Treatment for perianal disease in IBD
99
Remission induction
100
Improved stricture response
101
Probiotic treatment for IBD
102
Fistulizing CD remission
Fistulizing CD response
103
Lower recurrence rates
Surgery effective for limited disease
104
IBD treatment
105
Crohn's disease treatment
106
Risk Keywords
Side effects
8
Bone turnover impairment
9
Antimycobacterial treatment
Corticosteroid therapy
11
Nausea
12
Adverse effects of corticosteroids
Relapse when steroids are withdrawn
Steroid dependence
15
Adverse events
16
Publication bias
17
Efficacy not clearly demonstrated
Unclear if chronic corticosteroid therapy is beneficial
18
Steroid dependence
Steroid-related adverse effects
22
Adverse effects of corticosteroids
Relapse when steroids are withdrawn
Steroid dependence
24
Ineffective for steroid-dependent Crohn's
26
Crohn's disease
28
Limited evidence
Need for further research
29
High cost
High-risk patient identification
Long-term safety
30
Crohn's disease
31
Serious adverse events
32
Crohn's disease
33
High cost
35
Early recurrence
Laparoscopy risks
Missed disease segments
42
Infectious complications
46
Crohn's disease
Surgery
54
Crohn's disease
Intestinal microbiota
55
Crohn's disease
56
Adverse events
Long treatment course risks
57
Crohn's disease
58
Lack of direct trials
59
Adverse events
Discontinuation
60
None reported
61
Crohn's disease
63
Treatment failure
64
High cost
65
Low evidence quality
No surgical cure
70
Increased withdrawals
71
Crohn's disease recurrence
74
Dose intensification
Loss of response
76
Bowel damage
Disease relapse
Drug desensitization
Need for surgery
80
Diarrhea
Surgery risk
Weakness
83
Infections
Malignancy
87
Stricturing disease
88
Disease recurrence
89
Repeat endoscopic dilation
Surgical resection
93
None reported
95
Limited economic evidence
98
Literature analysis of 106 papers
Positive Content
94
Neutral Content
5
Negative Content
7
Article Type
41
32
54
39
106
1.

Postoperative treatment with corticosteroids and salazosulphapyridine (Salazopyrin) after radical resection for Crohn's disease.

Author: BergmanL, KrauseU

Crohn's disease treatment

A study of 84 patients with Crohn's disease who underwent radical bowel resection showed no significant difference in recurrence rates between those treated with corticosteroids and Salazopyrin and those without medical treatment. Patients with recurrences had a significantly longer time between diagnosis and surgery, suggesting early surgery may reduce recurrence risk.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Sulphasalazine in asymptomatic Crohn's disease. A multicentre trial.

Author: Lennard-JonesJ E

A double-blind controlled trial of sulphasalazine in 43 patients with Crohn's disease showed no benefit in reducing relapse rates after resection or in asymptomatic patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

European Cooperative Crohn's Disease Study (ECCDS): clinical features and natural history.

Author: SteinhardtH J, LoeschkeK, KasperH, HoltermüllerK H, SchäferH

Crohn's disease remission

This study investigated the natural course of Crohn's disease in 110 patients who received placebo. The study found that patients with ileocolonic Crohn's disease were younger than those with only colonic or small intestinal involvement. The most common location of Crohn's disease was the small and large intestines (49%). Patients with small intestinal involvement experienced milder symptoms compared to those with other locations. 60% of patients with active disease achieved a temporary remission within 5 months, and 23% of those with active disease and 68% of those with inactive disease remained in remission after 2 years. Factors associated with a better outcome in the placebo group included longer disease duration, normal albumin levels, and combined small and large intestinal involvement. However, extensive small bowel disease, previous steroid treatment, and previous surgery were associated with poorer outcomes. The study suggests that while some patients experience remission without treatment, Crohn's disease is a complex condition with varying factors influencing its course.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

[Basic diet in Crohn's disease].

Author: StoberB, NützenadelW, UllrichF

Improved symptoms
Weight gain

A study of 26 children with Crohn's disease compared three treatment approaches: steroids and sulfasalazine, elementary diet and sulfasalazine, and elementary diet plus steroids and sulfasalazine. All treatments improved symptoms and reduced inflammation. However, patients receiving an elementary diet had the greatest weight gain and showed signs of less inflammation. These findings suggest that an elementary diet may be beneficial in treating Crohn's disease, potentially leading to better weight gain and reduced inflammation compared to steroid treatment alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

5.

Nutrition support in inflammatory bowel disease.

Author: LewisJ D, FisherR L

Improved immune function
Reduced inflammatory factors

Nutritional therapy may play a role in the treatment of inflammatory bowel disease, but more research is needed to determine the optimal diet for different patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Low-dose cyclosporine for the treatment of Crohn's disease. The Canadian Crohn's Relapse Prevention Trial Investigators.

Author: FeaganB G, McDonaldJ W, RochonJ, LaupacisA, FedorakR N, KinnearD, SaibilF, GrollA, ArchambaultA, GilliesR

Improved Crohn's disease treatment

Long-term corticosteroid treatment for Crohn's disease can cause serious side effects, like osteoporosis. While cyclosporine has shown short-term benefits for active Crohn's disease, its long-term safety and effectiveness have not been determined.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

[Maintenance treatment of Crohn's disease using orally administered mesalazine (Pentasa). A controlled multicenter study. The Study Groups on the Treatment of Inflammatory Digestive Disorders].

Author: GendreJ P, MaryJ Y, FlorentC, ModiglianiR, ColombelJ F, SouléJ C, GalmicheJ P, LereboursE, DescosL, ViteauJ M

Effective maintenance
Safe maintenance

Slow-release mesalamine (Pentasa) was found to be a safe and effective maintenance treatment for Crohn's disease when given within 3 months of achieving remission. The study involved 161 patients with inactive Crohn's disease who were randomized to receive either Pentasa (2 g/day) or placebo. The study showed a significant benefit from Pentasa in the high relapse risk stratum.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : French

8.

Oral mesalamine (Pentasa) as maintenance treatment in Crohn's disease: a multicenter placebo-controlled study. The Groupe d'Etudes Thérapeutiques des Affections Inflammatoires Digestives (GETAID)

Author: GendreJ P, MaryJ Y, FlorentC, ModiglianiR, ColombelJ F, SouléJ C, GalmicheJ P, LereboursE, DescosL, ViteauJ M

Crohn's remission
Safe treatment
Side effects

Slow-release mesalamine was effective in maintaining remission in Crohn's disease, particularly in patients with a high relapse risk. The 2-year ongoing remission rate was 45% in the mesalamine group compared to 29% in the placebo group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Bone turnover during short-term therapy with methylprednisolone or budesonide in Crohn's disease.

Author: D'HaensG, VerstraeteA, CheynsK, AerdenI, BouillonR, RutgeertsP

Bone turnover impairment

Short-term methylprednisolone therapy impairs osteoblast activity in patients with Crohn's disease, while budesonide does not. Budesonide may be a safer alternative for long-term treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn's disease.

Author: NeurathM F, WanitschkeR, PetersM, KrummenauerF, Meyer zum BüschenfeldeK H, SchlaakJ F

Improved Crohn's disease treatment

Azathioprine is an effective treatment for Crohn's disease, a chronic inflammatory bowel condition, and can lead to long-term remission of symptoms. However, a small number of patients experience limited benefit or side effects from this treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

A meta-analysis of antimycobacterial therapy for Crohn's disease.

Author: BorgaonkarM R, MacIntoshD G, FardyJ M

Antimycobacterial therapy
Crohn's disease remission
Antimycobacterial treatment
Corticosteroid therapy

Antimycobacterial therapy is effective in maintaining remission in patients with Crohn's disease after a course of corticosteroids. However, it does not seem to be effective without a course of corticosteroids to induce remission.

CommentA short article/note that provides an opinion/perspective/interpretation on a published paper/topic.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

12.

A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators.

Author: FeaganB G, FedorakR N, IrvineE J, WildG, SutherlandL, SteinhartA H, GreenbergG R, KovalJ, WongC J, HopkinsM, HanauerS B, McDonaldJ W

Maintained remission
Reduced prednisone use
Reduced relapse risk
Nausea

In patients with Crohn's disease who enter remission after treatment with methotrexate, a low dose of methotrexate (15 mg intramuscularly once weekly) can help maintain remission. A significant reduction in the risk of relapse was observed in the methotrexate group compared to the placebo group (26.1%; 95% CI, 4.4% to 47.8%).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Enteral nutrition and corticosteroids in the treatment of acute Crohn's disease in children.

Author: HeuschkelR B, MenacheC C, MegerianJ T, BairdA E

Improved understanding of Crohn's disease treatment

The best way to treat acute Crohn’s disease in children is still being debated. While steroid therapy is preferred for adults, enteral nutrition (feeding through a tube) is often effective for children. Steroid use in children can cause side effects, particularly growth and puberty delays.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Randomized controlled trial of clarithromycin and ethambutol in the treatment of Crohn's disease.

Author: GoodgameR W, KimballK, AkramS, IkeE, OuC N, SuttonF, GrahamD

Three months of treatment with clarithromycin and ethambutol does not benefit Crohn's disease patients who are receiving standard medical therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Methotrexate for induction of remission in refractory Crohn's disease.

Author: AlfadhliA A, McDonaldJ W, FeaganB G

Induction of remission of Crohn's disease
Adverse effects of corticosteroids
Relapse when steroids are withdrawn
Steroid dependence

While corticosteroids are effective in treating Crohn’s disease initially, about 20% of patients experience a relapse when they stop taking steroids and become dependent on them. Since corticosteroids also have significant side effects, new treatments are needed. Methotrexate, a medication used for rheumatoid arthritis, has been investigated as a treatment for Crohn’s disease that doesn’t respond to other treatments. While it has become an alternative to other medications, its effectiveness needs further review.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial.

Author: SandbornWilliam J, PresentDaniel H, IsaacsKim L, WolfDouglas C, GreenbergEugene, HanauerStephen B, FeaganBrian G, MayerLloyd, JohnsonTherese, GalankoJoseph, MartinChristopher, SandlerRobert S

Fistula improvement
Adverse events

Oral tacrolimus is effective for fistula improvement, but not fistula remission, in patients with perianal Crohn's disease. Adverse events can be managed by dose reduction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

17.

Review article: mild to moderate Crohn's disease--defining the basis for a new treatment algorithm.

Author: SandbornW J, FeaganB G

Induction of remission of Crohn's disease
Publication bias

This review evaluated the effectiveness and safety of common treatments for mild to moderate Crohn's disease. Sulfasalazine showed modest benefits when the disease was limited to the colon. Mesalamine did not offer a clear advantage over placebo for active Crohn's disease. Conventional corticosteroids effectively induced remission but had significant side effects. Budesonide was as effective as conventional steroids but with fewer side effects. Antibiotics did not consistently show effectiveness. Based on these findings, the review suggests using budesonide for patients with ileal or right-sided colon involvement, sulfasalazine for those with colon-only disease, and conventional steroids for high activity, budesonide failure, or left-sided disease with sulfasalazine intolerance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Corticosteroids for maintenance of remission in Crohn's disease.

Author: SteinhartA H, EweK, GriffithsA M, ModiglianiR, ThomsenO O

Efficacy not clearly demonstrated
Unclear if chronic corticosteroid therapy is beneficial

While corticosteroids are effective for initially treating Crohn’s disease, their long-term use to prevent relapses has not been proven. This study examines available research to determine if long-term corticosteroids are beneficial for people with Crohn’s disease who are in remission or if there is a specific group of patients who may benefit from this treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Antibiotic treatment of small bowel bacterial overgrowth in patients with Crohn's disease.

Author: CastiglioneF, RispoA, Di GirolamoE, CozzolinoA, MangusoF, GrassiaR, MazzaccaG

Ciprofloxacin efficacy
Metronidazole efficacy

Small bowel bacterial overgrowth is common in Crohn's disease and can be treated effectively with metronidazole or ciprofloxacin. Both antibiotics resulted in improvement of intestinal symptoms, including bloating, stool softness, and abdominal pain.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Remission in patients with Crohn's disease is associated with improvement in employment and quality of life and a decrease in hospitalizations and surgeries.

Author: LichtensteinGary R, YanSongkai, BalaMohan, HanauerStephen

Crohn's disease treatment

This study looked at the impact of achieving remission, as defined by the Crohn's disease activity index (CDAI), on various aspects of life for patients with Crohn's disease, including employment, quality of life, hospitalizations, and surgeries. The study aimed to validate clinical remission as the primary goal of treatment for Crohn's disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Tumor necrosis factor-alpha antibody for induction of remission in Crohn's disease.

Author: AkobengA K, ZachosM

Induction of remission in Crohn's disease
Steroid dependence
Steroid-related adverse effects

Crohn’s disease can be difficult to treat, and some patients don’t respond to standard treatments like corticosteroids, enteral nutrition, and immunosuppressants. Some people also become dependent on steroids, which can lead to side effects. Recent studies suggest that medications that block tumor necrosis factor (TNF)-alpha may be effective in inducing remission in Crohn’s disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Clinical and endosonographic effect of ciprofloxacin on the treatment of perianal fistulae in Crohn's disease with infliximab: a double-blind placebo-controlled study.

Author: WestR L, van der WoudeC J, HansenB E, Felt-BersmaR J F, van TilburgA J P, DrapersJ A G, KuipersE J

Improved perianal Crohn's disease

A combination of ciprofloxacin and infliximab was more effective than infliximab alone in treating perianal Crohn's disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Methotrexate for induction of remission in refractory Crohn's disease.

Author: AlfadhliA A F, McDonaldJ W D, FeaganB G

Induction of remission of Crohn's disease
Adverse effects of corticosteroids
Relapse when steroids are withdrawn
Steroid dependence

Corticosteroids are effective for Crohn's disease but cause side effects and about 20% of patients relapse when they stop taking them. Methotrexate, a drug successful for rheumatoid arthritis, has become a main alternative to other medications for Crohn's disease, but its effectiveness hasn't been thoroughly reviewed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Oral 5-aminosalicylic acid for maintenance of medically-induced remission in Crohn's Disease.

Author: AkobengA K, GardenerE

Crohn's disease treatment

The study discussed the challenges of preventing relapses in Crohn's disease, noting the limited effectiveness of corticosteroids for maintenance of remission and the conflicting results of trials comparing 5-ASA agents with placebo or other drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

CDP571, a humanized monoclonal antibody to tumour necrosis factor-alpha, for steroid-dependent Crohn's disease: a randomized, double-blind, placebo-controlled trial.

Author: FeaganB G, SandbornW J, LichtensteinG, Radford-SmithG, PatelJ, InnesA

Well tolerated
Ineffective for steroid-dependent Crohn's

CDP571 was ineffective for sparing steroids in patients with steroid-dependent Crohn's disease.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Antibiotic treatment of Crohn's disease: results of a multicentre, double blind, randomized, placebo-controlled trial with rifaximin.

Author: PranteraC, LochsH, CampieriM, ScribanoM L, SturnioloG C, CastiglioneF, CottoneM

Crohn's disease remission

Rifaximin 800 mg b.d. was superior to placebo in inducing clinical remission of active Crohn's disease. The number of the failures in the placebo group was significantly higher than those who received rifaximin 800 mg b.d.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Crohn's disease: systematic review of assessment of disease severity and its relevance to surgery.

Author: RaoP K Dhruva, DaviesM, PriceP E, TorkingtonJ

Improved Crohn's disease treatment
Crohn's disease

The goals of treating Crohn's disease are to control symptoms through medication or surgery and to improve quality of life. While there are many systems for classifying Crohn's disease and measuring its severity and impact on quality of life, few are used routinely in surgical practice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Meta-analysis: enteral nutrition in active Crohn's disease in children.

Author: DziechciarzP, HorvathA, ShamirR, SzajewskaH

Crohn's remission
Limited evidence
Need for further research

Enteral nutrition (EN) showed similar efficacy to corticosteroids in inducing remission in active Crohn's disease in children. However, the evidence is limited and further research is needed to determine the optimal treatment approach, considering factors like growth and quality of life.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

30.

Medical therapy for Crohn's disease: top-down or step-up?

Author: BaertFilip, CaprilliRenzo, AngelucciErika

Crohn's disease treatment
High cost
High-risk patient identification
Long-term safety

Early introduction of intensive therapies, including biological agents and immunosuppressive drugs, is under debate as a strategy for Crohn's disease (CD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

Systematic review: nutritional therapy in paediatric Crohn's disease.

Author: DayA S, WhittenK E, SidlerM, LembergD A

Improved Crohn's disease treatment
Crohn's disease

Around 25% of children are diagnosed with Crohn's disease (CD). Most children with CD have nutritional problems, such as weight loss or stunted growth. Nutritional therapy, specifically providing only liquid nutrition through the digestive tract, has been proven effective in treating CD in children. This approach helps to reduce inflammation, improve gut health, promote growth, improve overall nutrition, and avoid other medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

Tumor necrosis factor-alpha antibody for maintenance of remission in Crohn's disease.

Author: BehmB W, BickstonS J

Corticosteroid-sparing effects
Maintenance of fistula healing
Maintenance of remission
Serious adverse events

Infliximab, adalimumab, and certolizumab pegol were effective in maintaining remission in Crohn's disease patients who responded to induction therapy. Infliximab also showed effectiveness in maintaining fistula healing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Meta-analysis: remission and response from control arms of randomized trials of biological therapies for active luminal Crohn's disease.

Author: TinèF, RossiF, SferrazzaA, OrlandoA, MocciaroF, ScimecaD, OlivoM, CottoneM

Remission
Response
Crohn's disease

Control rates of remission and response in Crohn's disease trials were 17% and 33%, respectively.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

34.

Probiotics for induction of remission in Crohn's disease.

Author: ButterworthAndrew D, ThomasAdrian G, AkobengAnthony Kwaku

Minimal side effects

Crohn's disease is a chronic condition with no known cure and significant morbidity. While current treatments have side effects, probiotics are being investigated as a potential alternative with minimal side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Laparoscopic ileocolic resection versus infliximab treatment of distal ileitis in Crohn's disease: a randomized multicenter trial (LIR!C-trial).

Author: EshuisEmma J, BemelmanWillem A, van BodegravenAd A, SprangersMirjam A G, BossuytPatrick M M, van Milligen de WitA W Marc, CrollaRogier M P H, CahenDjuna L, OostenbrugLiekele E, SosefMeindert N, VoorburgAnnet M C J, DavidsPaul H P, van der WoudeC Janneke, LangeJohan, MallantRosalie C, BoomMaarten J, LieverseRob J, van der ZaagEdwin S, HoubenMartin H M G, VechtJuda, PierikRobert E G J M, van DitzhuijsenTheo J M, PrinsHubert A, MarsmanWillem A, StockmannHenricus B, BrinkMenno A, ConstenEsther C J, van der WerfSjoerd D J, MarinelliAndreas W K S, JansenJeroen M, GerhardsMichael F, BolwerkClemens J M, StassenLaurents P S, SpanierB W Marcel, BilgenErnst Jan Spillenaar, van BerkelAnne-Marie, CenseHuib A, van HeukelemHenk A, van de LaarArnold, SlotWarner Bruins, EijsboutsQuirijn A, van OoteghemNancy A M, van WagensveldBart, van den BrandeJan M H, van GelovenAnna A W, BruinKarien F, MaringJohn K, OldenburgBas, van HillegersbergRichard, de JongDirk J, BleichrodtRobert, van der PeetDonald L, DekkersPascal E P, GoeiT Hauwy, StokkersPieter C F

Improved quality of life
High cost

This study compares two treatments for recurrent Crohn's disease in the lower part of the small intestine: 1) infliximab (a medication that targets inflammation) and 2) laparoscopic ileocolic resection (surgical removal of the affected portion of the intestine). The study aims to assess the impact of both approaches on quality of life and treatment costs, considering that infliximab is expensive and its long-term use is uncertain.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Effects of adalimumab therapy on incidence of hospitalization and surgery in Crohn's disease: results from the CHARM study.

Author: FeaganBrian G, PanaccioneRemo, SandbornWilliam J, D'HaensGeert R, SchreiberStefan, RutgeertsPaul J, LoftusEdward V, LomaxKathleen G, YuAndrew P, WuEric Q, ChaoJingdong, MulaniParvez

Reduced hospitalization
Reduced surgery

Adalimumab maintenance treatment in patients with moderate-to-severe Crohn's disease (CD) significantly reduced the risks of hospitalization and surgery compared to placebo.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

Mild to moderate Crohn's disease: still room for step-up therapies?

Author: Bar-MeirSimon

Crohn's disease treatment

Treatment for Crohn's disease typically involves starting with less intensive medications and gradually increasing treatment as the disease worsens (step-up therapy). A newer approach, using biologics and thiopurines as initial treatment (top-down therapy), has been debated, but current recommendations favor the step-up approach. Budesonide is recommended for mild to moderate Crohn's disease, while mesalazine is only slightly better than placebo for small bowel disease. Antibiotics are only recommended for suspected infections. For mild symptoms, no treatment may be an option. Budesonide is preferred to prednisone for mild Crohn's disease as it has fewer side effects. Sulfasalazine and, if needed, steroids can be used for mild colon involvement. Topical treatment may be helpful for disease in the lower part of the colon. Corticosteroids effectively induce remission in Crohn's disease, with success rates of 60-83%. Azathioprine and 6-mercaptopurine are effective for maintaining remission. Methotrexate is another effective option. Once remission is achieved with steroids, long-term treatment with azathioprine is recommended. Mesalazine may reduce the risk of colon cancer, but this is not proven for Crohn's disease. Overall, most people with Crohn's disease have a relatively mild course, making step-up therapy a good approach. While most medications are as effective as infliximab but with fewer side effects, infliximab should be reserved for patients who haven't responded to other treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Methotrexate for maintenance of remission in Crohn's disease.

Author: PatelVishal, MacdonaldJohn K, McDonaldJohn Wd, ChandeNilesh

Crohn's disease treatment

Long-term treatments for Crohn's disease that reduce the need for corticosteroids and are safe and effective are needed. While medications that slow down the immune system (purine antimetabolites) are somewhat effective, many people experience a return of symptoms. Methotrexate may be a safer and more affordable alternative to expensive medications that block tumor necrosis factor (TNF).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Cost-effectiveness of scheduled maintenance treatment with infliximab for pediatric Crohn's disease.

Author: PunekarYogesh Suresh, SunderlandThomas, HawkinsNeil, LindsayJames

Cost-effective for severe active CD

Scheduled maintenance treatment with infliximab was likely cost-effective for children with severe active Crohn's disease (CD), providing a significant improvement in quality-adjusted life-years (QALY) compared to standard care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

Long-term antibiotic treatment for Crohn's disease: systematic review and meta-analysis of placebo-controlled trials.

Author: FellerMartin, HuwilerKarin, SchoepferAlain, ShangAijing, FurrerHansjakob, EggerMatthias

Effective treatment

Long-term treatment with nitroimidazoles or clofazimine appears to be effective in patients with Crohn's disease. The study found that both drug classes were associated with significant improvements in remission rates and reduced relapse rates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Randomised clinical trial: certolizumab pegol for fistulas in Crohn's disease - subgroup results from a placebo-controlled study.

Author: SchreiberS, LawranceI C, ThomsenO Ø, HanauerS B, BloomfieldR, SandbornW J

Fistula closure

Certolizumab pegol improves the likelihood of sustained perianal fistula closure in patients with fistulizing Crohn's disease compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

42.

Laparoscopic versus Open surgery for small bowel Crohn's disease.

Author: DasariBobby Vm, McKayDamian, GardinerKeith

Improved social interaction
Laparoscopy benefits
Reduced hospital stay
Early recurrence
Laparoscopy risks
Missed disease segments

Laparoscopic surgery for Crohn's disease offers potential benefits such as faster recovery, reduced hospital stay, and better cosmesis compared to open surgery, but concerns remain about missing occult disease and potential increased recurrence. Further research is needed to evaluate the benefits and risks of each approach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

A systematic review and economic evaluation of the use of tumour necrosis factor-alpha (TNF-α) inhibitors, adalimumab and infliximab, for Crohn's disease.

Author: DretzkeJ, EdlinR, RoundJ, ConnockM, HulmeC, CzeczotJ, Fry-SmithA, McCabeC, MeadsC

CD treatment

Crohn's disease (CD) is a serious, lifelong condition that causes inflammation in the digestive system. While traditional treatments are complex and often ineffective, a new class of drugs called TNF inhibitors, specifically infliximab, has proven successful for patients with severe, active CD who haven't responded to other treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Efficacy of biological therapies in inflammatory bowel disease: systematic review and meta-analysis.

Author: FordAlexander C, SandbornWilliam J, KhanKhurram J, HanauerStephen B, TalleyNicholas J, MoayyediPaul

Induced remission
Prevented relapse

Biological therapies, including anti-tumor necrosis factor-α (TNFα) antibodies and natalizumab, were superior to placebo in inducing remission of active Crohn’s disease (CD) and ulcerative colitis (UC). Anti-TNFα antibodies were also superior to placebo in preventing relapse of quiescent CD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Efficacy of immunosuppressive therapy for inflammatory bowel disease: a systematic review and meta-analysis.

Author: KhanKhurram J, DubinskyMarla C, FordAlexander C, UllmanThomas A, TalleyNicholas J, MoayyediPaul

IBD relapse prevention
IBD remission

The efficacy of immunosuppressive therapies (thiopurine analogs, methotrexate, and cyclosporine) in inducing remission and preventing relapse in inflammatory bowel disease (IBD) is being investigated through a systematic review of the literature.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Postoperative infliximab is not associated with an increase in adverse events in Crohn's disease.

Author: RegueiroMiguel, El-HachemSandra, KipKevin E, SchrautWolfgang, BaidooLeonard, WatsonAndrew, SwogerJason, SchwartzMarc, BarrieArthur, PesciMarilyn, BinionDavid

Crohn's disease treatment
Infectious complications

Infliximab is effective for Crohn's disease but can cause serious infections. It may prevent postoperative Crohn's disease recurrence, but further research is needed on potential complications from post-operative administration.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

Postoperative recurrent luminal Crohn's disease: a systematic review.

Author: De CruzPeter, KammMichael A, PrideauxLani, AllenPatrick B, DesmondPaul V

Improved Crohn's disease management

This study discusses the challenges of treating Crohn's disease, a condition that causes inflammation in the digestive tract. While surgery is often needed, it is not a cure, and the disease frequently returns. The study highlights the importance of early detection and treatment of the disease's return, before symptoms appear, to prevent further complications. The study also notes that research has identified risk factors for early recurrence and suggests the need for using this knowledge to develop more effective treatment strategies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

Mucosal healing in Crohn's disease: a systematic review.

Author: De CruzPeter, KammMichael A, PrideauxLani, AllenPatrick B, MooreGreg

Improved Crohn's disease management

This study discusses the evolving goals of Crohn's disease therapy, highlighting the importance of achieving and maintaining mucosal healing to potentially alter the disease's natural history. It acknowledges the challenges of achieving high rates of mucosal healing in clinical practice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Methotrexate for induction of remission in refractory Crohn's disease.

Author: McDonaldJohn W D, TsoulisDavid J, MacdonaldJohn K, FeaganBrian G

Improved Crohn's disease treatment

This study examines the use of methotrexate as a treatment for Crohn's disease that does not respond to steroids. While steroids are effective initially, many patients experience a return of symptoms or become reliant on steroids, which have significant side effects. The study provides an update on research about methotrexate, which has become a common alternative treatment for Crohn's disease that does not respond to other medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Early administration of azathioprine vs conventional management of Crohn's Disease: a randomized controlled trial.

Author: CosnesJacques, BourrierAnne, LaharieDavid, NahonStéphane, BouhnikYoram, CarbonnelFranck, AllezMatthieu, DupasJean-Louis, ReimundJean-Marie, SavoyeGuillaume, JouetPauline, MoreauJacques, MaryJean-Yves, ColombelJean-Frédéric,

CD treatment

This study compares the effectiveness of early treatment with azathioprine (an immune-suppressing medication) versus standard care for people with Crohn's disease (CD) who are at high risk for severe disease. The study focuses on starting treatment within 6 months of diagnosis to see if it can slow disease progression.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

51.

Prevention of postoperative recurrence with azathioprine or infliximab in patients with Crohn's disease: an open-label pilot study.

Author: ArmuzziAlessandro, FeliceCarla, PapaAlfredo, MarzoManuela, PuglieseDaniela, AndrisaniGianluca, FedericoFrancesco, De VitisItalo, RapacciniGian Lodovico, GuidiLuisa

Reduced Crohn's disease recurrence

Crohn's disease (CD) is a chronic inflammatory bowel disease that often requires surgery. This study will compare the effectiveness of azathioprine and infliximab in preventing the recurrence of CD after surgery.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

52.

Adalimumab maintains remission of Crohn's disease after up to 4 years of treatment: data from CHARM and ADHERE.

Author: PanaccioneR, ColombelJ-F, SandbornW J, D'HaensG, ZhouQ, PollackP F, ThakkarR B, RobinsonA M

Maintains remission
Safe long-term

Prolonged adalimumab therapy maintained clinical remission and response in patients with moderately to severely active Crohn's disease for up to 4 years.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

53.

Systematic review: The use of thiopurines or anti-TNF in post-operative Crohn's disease maintenance--progress and prospects.

Author: JonesG R, KennedyN A, LeesC W, ArnottI D, SatsangiJ

Crohn's treatment

Crohn's disease can recur after surgery, with recurrence rates as high as 77% within two years. Treatment with thiopurines or infliximab can reduce recurrence rates, but variations exist in effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

Have we changed the natural history of pediatric Crohn's disease with biologics?

Author: DubinskyMarla

Anti-TNF
Immunomodulator use
Crohn's disease
Surgery

This research examines the impact of treatments for Crohn's disease (CD) on the need for surgery. While recent studies indicate a decrease in surgical rates, the role of biologics, thiopurine use, and early intervention remains unclear. The study emphasizes the need for further research to determine the long-term effects of current treatment strategies on the natural history of CD, particularly in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

Is rifaximin effective in maintaining remission in Crohn's disease?

Author: JigaranuAnca Olivia, NedelciucOtilia, BlajAndreea, BadeaMircea, MihaiCatalina, DiculescuMircea, Cijevschi-PrelipceanCristina

Rifaximin
Crohn's disease
Intestinal microbiota

This research explores the potential benefits of antibiotics, specifically rifaximin, for the treatment of Crohn's disease (CD). The study suggests that abnormal intestinal microbiota may contribute to persistent inflammation in CD, and antibiotics could potentially play a role in managing the condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

56.

Methotrexate for induction of remission in refractory Crohn's disease.

Author: McDonaldJohn W D, WangYongjun, TsoulisDavid J, MacDonaldJohn K, FeaganBrian G

Methotrexate
Crohn's disease

This systematic review updates previous research on the use of methotrexate for treating refractory Crohn's disease. Methotrexate has been explored as an alternative to azathioprine or 6-mercaptopurine for inducing remission in Crohn's disease, and this review examines the current evidence for its efficacy and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Budesonide for maintenance of remission in Crohn's disease.

Author: KuenzigM Ellen, RezaieAli, SeowCynthia H, OtleyAnthony R, SteinhartA Hillary, GriffithsAnne Marie, KaplanGilaad G, BenchimolEric I

Effective induction
Adverse events
Long treatment course risks

While corticosteroids are effective for inducing remission in Crohn's disease, they are not suitable for long-term maintenance due to the risk of adverse events. This review discusses the use of budesonide, a glucocorticoid with limited systemic bioavailability, for inducing remission in Crohn's disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

58.

Methotrexate for maintenance of remission in Crohn's disease.

Author: PatelVishal, WangYongjun, MacDonaldJohn K, McDonaldJohn W D, ChandeNilesh

Methotrexate
Crohn's disease

This updated review examines the use of methotrexate as a long-term treatment for Crohn's disease. Methotrexate may offer a safe and effective alternative to TNF-α antagonists for maintaining remission in Crohn's disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

Comparative effectiveness of immunosuppressants and biologics for inducing and maintaining remission in Crohn's disease: a network meta-analysis.

Author: HazlewoodGlen S, RezaieAli, BormanMeredith, PanaccioneRemo, GhoshSubrata, SeowCynthia H, KuenzigEllen, TomlinsonGeorge, SiegelCorey A, MelmedGil Y, KaplanGilaad G

Effective remission
Lack of direct trials

Adalimumab and infliximab + azathioprine were the most effective therapies for induction and maintenance of remission of Crohn's disease based on a network meta-analysis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

60.

Systematic review with meta-analysis: the efficacy of a second anti-TNF in patients with inflammatory bowel disease whose previous anti-TNF treatment has failed.

Author: GisbertJ P, MarínA C, McNichollA G, ChaparroM

Improved CD symptoms
Adverse events
Discontinuation

The efficacy of a second anti-TNF in CD patients largely depends on the cause for switching. The remission rate is higher when the reason to withdraw the first anti-TNF is intolerance (61%), compared with secondary (45%) or primary failure (30%).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

61.

Randomised clinical trial: deep remission in biologic and immunomodulator naïve patients with Crohn's disease - a SONIC post hoc analysis.

Author: ColombelJ-F, ReinischW, MantzarisG J, KornbluthA, RutgeertsP, TangK L, OortwijnA, BevelanderG S, CornillieF J, SandbornW J

Improved biological remission
Improved clinical remission
Improved mucosal healing
None reported

Combination therapy with infliximab and azathioprine was more effective in achieving various composite remission measures vs. azathioprine or infliximab monotherapy in patients with Crohn's disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

62.

TELEmedicine for Patients with Inflammatory Bowel Disease (TELE-IBD): Design and implementation of randomized clinical trial.

Author: CrossRaymond K, JambaulikarGuruprasad, LangenbergPatricia, TracyJ Kathleen, CollinsJoseph F, KatzJonathan, RegueiroMiguel, SchwartzDavid A, QuinnCharlene C

IBD treatment

Inflammatory bowel diseases (IBD), like ulcerative colitis and Crohn's disease, are chronic conditions with alternating periods of worsening symptoms and symptom-free periods. These symptoms severely impact quality of life and lead to increased healthcare use. Although effective treatments exist, outcomes are often poor due to factors like non-adherence to treatment, medication intolerance, inconsistent monitoring, insufficient patient understanding, and limited access to care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

63.

Clinical effectiveness and cost-effectiveness of elemental nutrition for the maintenance of remission in Crohn's disease: a systematic review and meta-analysis.

Author: TsertsvadzeAlexander, GurungTara, CourtRachel, ClarkeAileen, SutcliffePaul

Enteral nutrition
Crohn's disease

Enteral nutrition may be a viable alternative to standard treatments like steroids for maintaining remission in patients with Crohn's disease (CD), potentially reducing the risk of adverse events associated with drug use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

64.

Characterizing unmet medical need and the potential role of new biologic treatment options in patients with ulcerative colitis and Crohn's disease: a systematic review and clinician surveys.

Author: GordonJason P, McEwanPhil C, MaguireAndy, SugrueDaniel M, PuellesJorge

Treatment failure

High treatment failure rates with existing biologics for ulcerative colitis (UC) and Crohn's disease (CD) indicate a need for new treatment options. These new treatments should be investigated in head-to-head randomized trials to compare their effectiveness and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Multimodal treatment of perianal fistulas in Crohn's disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial.

Author: de GroofE Joline, BuskensChristianne J, PonsioenCyriel Y, DijkgraafMarcel G W, D'HaensGeert R A M, SrivastavaNidhi, van AckerGijs J D, JansenJeroen M, GerhardsMichael F, DijkstraGerard, LangeJohan F M, WittemanBen J M, KruytPhilip M, PronkApollo, van TuylSebastiaan A C, BodelierAlexander, CrollaRogier M P H, WestRachel L, VrijlandWietske W, ConstenEsther C J, BrinkMenno A, TuynmanJurriaan B, de BoerNanne K H, BreukinkStephanie O, PierikMarieke J, OldenburgBas, van der MeulenAndrea E, BonsingBert A, SpinelliAntonino, DaneseSilvio, SacchiMatteo, WarusavitarneJanindra, HartAilsa, YassinNuha A, KennellyRory P, CullenGarret J, WinterDesmond C, HawthorneA Barney, TorkingtonJared, BemelmanWillem A

High cost

There are no clear guidelines for the treatment of Crohn's disease with high perianal fistulas. This study aims to develop treatment consensus and reduce costs associated with managing this complex condition.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

66.

Early combined immunosuppression for the management of Crohn's disease (REACT): a cluster randomised controlled trial.

Author: KhannaReena, BresslerBrian, LevesqueBarrett G, ZouGuangyong, StittLarry W, GreenbergGordon R, PanaccioneRemo, BittonAlain, ParéPierre, VermeireSéverine, D'HaensGeert, MacIntoshDonald, SandbornWilliam J, DonnerAllan, VandervoortMargaret K, MorrisJoan C, FeaganBrian G,

ECI for Crohn's disease

Early combined immunosuppression (ECI) with a TNF antagonist and antimetabolite was compared to conventional management for Crohn's disease treatment. ECI showed potentially greater effectiveness than conventional management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

67.

Randomised clinical trial: vercirnon, an oral CCR9 antagonist, vs. placebo as induction therapy in active Crohn's disease.

Author: FeaganB G, SandbornW J, D'HaensG, LeeS D, AllezM, FedorakR N, SeidlerU, VermeireS, LawranceI C, MaroneyA C, JurgensenC H, HeathA, ChangD J

Vercirnon did not demonstrate efficacy as an induction therapy in patients with moderately-to-severely active Crohn's disease.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

68.

The Swedish Crohn Trial: A Prematurely Terminated Randomized Controlled Trial of Thiopurines or Open Surgery for Primary Treatment of Ileocaecal Crohn's Disease.

Author: GerdinLinda, ErikssonAnders S, OlaisonGunnar, SjödahlRune, StrömMagnus, SöderholmJohan D, MyrelidPär

Crohn's disease treatment

Crohn's disease is a chronic condition that requires effective and safe treatment. While both medication and surgery can help manage Crohn's disease that primarily affects the lower part of the small intestine, this study compares the effectiveness of these two approaches.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

69.

Results of the Fifth Scientific Workshop of the ECCO [II]: Clinical Aspects of Perianal Fistulising Crohn's Disease-the Unmet Needs.

Author: GecseKrisztina B, SebastianShaji, HertoghGert de, YassinNuha A, KotzePaulo G, ReinischWalter, SpinelliAntonino, KoutroubakisIoannis E, KatsanosKonstantinos H, HartAilsa, van den BrinkGijs R, RoglerGerhard, BemelmanWillem A

Crohn's disease treatment

This study focuses on the issue of perianal fistulas, which affect up to one-third of people with Crohn's disease, causing significant problems. Despite the severity, current treatment options are not ideal. This workshop discusses the causes and impact of these fistulas in Crohn's disease patients.

Consensus Development ConferenceA conference organized by the National Institutes of Health (NIH) to develop consensus and recommendations on medical issues.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

70.

Current challenges in the surgical management of Crohn's disease: a systematic review.

Author: SchlusselAndrew T, SteeleScott R, AlaviKarim

Minimized complications
Preserved intestinal length
Low evidence quality
No surgical cure

This review summarizes current recommendations for the surgical management of Crohn's disease. Surgical goals are to minimize postoperative complications, preserve intestinal length, and slow the progression of clinical recurrence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

Adalimumab Monotherapy and a Combination with Azathioprine for Crohn's Disease: A Prospective, Randomized Trial.

Author: MatsumotoTakayuki, MotoyaSatoshi, WatanabeKenji, HisamatsuTadakazu, NakaseHiroshi, YoshimuraNaoki, IshidaTetsuya, KatoShingo, NakagawaTomoo, EsakiMotohiro, NagahoriMasakazu, MatsuiToshiyuki, NaitoYuji, KanaiTakanori, SuzukiYasuo, NojimaMasanori, WatanabeMamoru, HibiToshifumi,

Improved endoscopic outcomes
Increased withdrawals

This open-labelled prospective study found that the clinical efficacy of a combination of adalimumab and azathioprine at week 26 did not differ from that of adalimumab monotherapy in patients with Crohn's disease naïve to both medications. However, the rate of endoscopic improvement at week 26 was significantly higher in the combination group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

72.

Recent advances in clinical practice: a systematic review of isolated colonic Crohn's disease: the third IBD?

Author: SubramanianSreedhar, EkbomAnders, RhodesJonathan M

This systematic review examines isolated colonic Crohn's disease, suggesting it should be considered a distinct condition due to its unique characteristics and potential for different responses to treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

73.

Prognostic biomarkers to identify patients destined to develop severe Crohn's disease who may benefit from early biological therapy: protocol for a systematic review, meta-analysis and external validation.

Author: HalliganSteve, BooneDarren, BhatnagarGauraang, AhmadTariq, BloomStuart, Rodriguez-JustoManuel, TaylorStuart A, MallettSusan

This systematic review and meta-analysis examines the use of biological therapy for Crohn's disease. The study aims to identify biomarkers that can predict the development of severe disease, enabling earlier intervention with biological therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

74.

Systematic review with meta-analysis: recurrence of Crohn's disease after total colectomy with permanent ileostomy.

Author: FumeryM, DulaiP S, MeirickP, FarrellA M, RamamoorthyS, SandbornW J, SinghS

Crohn's disease recurrence

This systematic review and meta-analysis evaluated the rate, risk factors, and outcomes of Crohn's disease (CD) recurrence after total colectomy with permanent ileostomy (TC-PI). The pooled clinical recurrence rate after TC-PI was 28%, with a 5-year median cumulative rate of 23.5% and a 10-year median cumulative rate of 40%. The surgical recurrence rate was 16%. History of ileal disease was associated with a 3.2 times higher risk of recurrence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

Comparative Effectiveness of Mesalamine, Sulfasalazine, Corticosteroids, and Budesonide for the Induction of Remission in Crohn's Disease: A Bayesian Network Meta-analysis.

Author: CowardStephanie, KuenzigM Ellen, HazlewoodGlen, ClementFiona, McBrienKerry, HolmesRebecca, PanaccioneRemo, GhoshSubrata, SeowCynthia H, RezaieAli, KaplanGilaad G

Crohn's disease treatment

Corticosteroids and high-dose budesonide were found to be effective treatments for inducing remission in patients with mild-to-moderate Crohn's disease. High-dose mesalamine is an alternative option for patients who prefer to avoid steroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

76.

Systematic review with meta-analysis: loss of response and requirement of anti-TNFα dose intensification in Crohn's disease.

Author: QiuYun, ChenBai-Li, MaoRen, ZhangSheng-Hong, HeYao, ZengZhi-Rong, Ben-HorinShomron, ChenMin-Hu

Dose intensification
Loss of response

This review found that around one-third of Crohn's disease patients experience a loss of response to anti-TNF-α and required dose intensification in primary anti-TNF-α responders.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

77.

Adalimumab vs Azathioprine in the Prevention of Postoperative Crohn's Disease Recurrence. A GETECCU Randomised Trial.

Author: López-SanrománAntonio, Vera-MendozaIsabel, DomènechEugeni, TaxoneraCarlos, Vega RuizVicente, Marín-JiménezIgnacio, GuardiolaJordi, CastroLuisa, EsteveMaría, IglesiasEva, CeballosDaniel, Martínez-MontielPilar, GisbertJavier P, MínguezMiguel, EcharriAna, CalvetXavier, BarrioJesús, HinojosaJoaquín, Martín-ArranzMaría Dolores, Márquez-MosqueraLucía, BermejoFernando, RimolaJordi, PonsVicente, NosPilar,

Better tolerance
POR-CD prophylaxis

This phase 3 randomized controlled trial compared the efficacy of adalimumab (ADA) and azathioprine (AZA) in preventing postoperative recurrence of Crohn's disease (POR-CD) after ileocolonic resection. The study found that ADA did not demonstrate better efficacy than AZA in preventing POR-CD, although ADA was significantly better tolerated. This suggests that both ADA and AZA may be effective in preventing POR-CD, but that ADA may be a more suitable option for patients who experience adverse effects with AZA.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

78.

The current therapeutic options for Crohn's disease: from medical therapy to intestinal transplantation.

Author: LauroAugusto, D'AmicoFrancesco, GondolesiGabriel

CD treatment

Crohn's disease (CD) is a chronic condition affecting the intestines. While medications and nutritional support are the main treatments, over half of patients need surgery to remove part of the intestine. This often needs to be repeated over time, and some people develop short bowel syndrome, requiring intravenous feeding. Intestinal transplantation (ITx) can be an option for people with severe intestinal problems, with a survival rate of 79% at one year, 53% at three years, and 43% at five years. This review examines the medical, endoscopic, surgical, and transplant options for managing CD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

79.

Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: a randomised controlled, open-label, multicentre trial.

Author: PonsioenCyriel Y, de GroofE Joline, EshuisEmma J, GardenbroekTjibbe J, BossuytPatrick M M, HartAilsa, WarusavitarneJanindra, BuskensChristianne J, van BodegravenAd A, BrinkMenno A, ConstenEsther C J, van WagensveldBart A, RijkMarno C M, CrollaRogier M P H, NoomenCasper G, HoudijkAlexander P J, MallantRosalie C, BoomMaarten, MarsmanWillem A, StockmannHein B, MolBregje, de GroofA Jeroen, StokkersPieter C, D'HaensGeert R, BemelmanWillem A,

Improved quality of life

Laparoscopic ileocaecal resection and infliximab both offer benefits for patients with ileocaecal Crohn's disease unresponsive to conventional therapy. Laparoscopic ileocaecal resection appears to have a greater positive impact on health-related quality of life.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

80.

Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease.

Author: BoyapatiRay K, TorresJoana, PalmelaCarolina, ParkerClaire E, SilverbergOrli M, UpadhyayaSonam D, NguyenTran M, ColombelJean-Frédéric

CD treatment
Early intervention
Therapeutic de-escalation
Bowel damage
Disease relapse
Drug desensitization
Need for surgery

Crohn's disease (CD) is a chronic digestive condition that can cause significant health problems. While strong medications are recommended for people with severe CD, it's not clear if these medications can be safely stopped once symptoms improve. Stopping medications could reduce side effects and costs, but may lead to the disease returning, requiring additional treatments or surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

81.

An expert consensus to standardise definitions, diagnosis and treatment targets for anti-fibrotic stricture therapies in Crohn's disease.

Author: RiederF, BettenworthD, MaC, ParkerC E, WilliamsonL A, NelsonS A, van AsscheG, Di SabatinoA, BouhnikY, StidhamR W, DignassA, RoglerG, TaylorS A, StokerJ, RimolaJ, BakerM E, FletcherJ G, PanesJ, SandbornW J, FeaganB G, JairathV

Improved CD treatment

Fibrotic stricture is a common complication of Crohn's disease (CD), with no specific anti-fibrotic therapies currently available. Standardized definitions, diagnostic modalities, and clinical trial criteria are needed for drug development in stricturing CD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

82.

Treatments for Crohn's Disease-Associated Bowel Damage: A Systematic Review.

Author: ParienteBenjamin, HuShurong, BettenworthDominik, SpecaSilvia, DesreumauxPierre, MeuwisMarie-Alice, DaneseSilvio, RiederFlorian, LouisEdouard

Reduced TGF-beta activation
Tissue repair

Treatment approaches that reduce transforming growth factor beta (TGFB) activation and local injections of mesenchymal stem cells show promise for treating tissue damage lesions in Crohn's disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

83.

Cannabis for the treatment of Crohn's disease.

Author: KafilTahir S, NguyenTran M, MacDonaldJohn K, ChandeNilesh

Reduce inflammation
Diarrhea
Surgery risk
Weakness

Cannabis and cannabinoids have shown potential benefit in reducing inflammation in Crohn's disease (CD) in animal models. However, there is evidence to suggest that cannabis use in people with CD is associated with transient adverse events, such as weakness, dizziness, and diarrhea, and may increase the risk of surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

84.

A randomised, double-blind, placebo-controlled trial of a multi-strain probiotic in patients with asymptomatic ulcerative colitis and Crohn's disease.

Author: BjarnasonIngvar, SissionGuy, HayeeBu'Hussaine

Improved IBD treatment

The role of gut microflora in inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn's disease (CD), is being investigated. Probiotics may offer a potential adjuvant treatment, but their efficacy requires further research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

85.

Canadian Association of Gastroenterology Clinical Practice Guideline for the Medical Management of Pediatric Luminal Crohn's Disease.

Author: MackDavid R, BenchimolEric I, CritchJeff, deBruynJennifer, TseFrances, MoayyediPaul, ChurchPeter, DeslandresColette, El-MataryWael, HuynhHien, JantchouPrévost, LawrenceSally, OtleyAnthony, SherlockMary, WaltersThomas, KappelmanMichael D, SadowskiDan, MarshallJohn K, GriffithsAnne

Crohn's disease treatment

Evidence-based medical treatment of Crohn's disease in children is recommended, with ongoing assessments to determine treatment success. Corticosteroids, exclusive enteral nutrition, and biologic tumor necrosis factor antagonists are suggested treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

86.

Outcomes and Strategies to Support a Treat-to-target Approach in Inflammatory Bowel Disease: A Systematic Review.

Author: ColombelJean-Frédéric, D'haensGeert, LeeWan-Ju, PeterssonJoel, PanaccioneRemo

Crohn's disease and ulcerative colitis treatment
Treat-to-target management

Crohn's disease and ulcerative colitis are typically treated based on symptoms, but a new approach focuses on addressing underlying inflammation. This "treat-to-target" approach aims to manage inflammation early in the disease, prevent it from worsening, and improve long-term outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

87.

Certolizumab pegol for induction of remission in Crohn's disease.

Author: YamazakiHajime, SoRyuhei, MatsuokaKatsuyoshi, KobayashiTaku, ShinzakiShinichiro, MatsuuraMinoru, OkabayashiShinji, KataokaYuki, TsujimotoYasushi, FurukawaToshi A, WatanabeNorio

Induced remission
Reduced inflammation
Infections
Malignancy

Certolizumab pegol (CZP) was effective in inducing clinical remission and clinical response in patients with active Crohn's disease (CD). The risk of serious adverse events was uncertain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

88.

Small bowel capsule endoscopy and treat-to-target in Crohn's disease: A systematic review.

Author: Le BerreCatherine, Trang-PoissonCaroline, BourreilleArnaud

Stricturing disease

This study discusses the importance of assessing proximal small bowel (SB) lesions in patients with Crohn's disease (CD) due to their association with stricturing disease and multiple abdominal surgeries. The study highlights the potential role of small bowel capsule endoscopy (SBCE) in monitoring and managing CD patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

Interventions for maintenance of surgically induced remission in Crohn's disease: a network meta-analysis.

Author: Iheozor-EjioforZipporah, GordonMorris, CleggAndrew, FreemanSuzanne C, Gjuladin-HellonTeuta, MacDonaldJohn K, AkobengAnthony K

Remission induction
Disease recurrence

Crohn's disease (CD) is a chronic digestive condition. About 75% of people with CD have surgery at least once to relieve symptoms, but the disease can return even after surgery. There are various treatments used to maintain remission after surgery, but it's unclear which approach is best.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

90.

Treatment Algorithms for Crohn's Disease.

Author: SulzMichael Christian, BurriEmanuel, MichettiPierre, RoglerGerhard, Peyrin-BirouletLaurent, SeiboldFrank,

CD treatment

Crohn's disease is a complex condition to treat, and the best approach depends on many factors, including where the inflammation is, how severe it is, the type of inflammation, other health problems, and the patient's age and past treatments. This means that each patient needs a personalized treatment plan.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

91.

Systematic review and meta-analysis: efficacy and safety of early biologic treatment in adult and paediatric patients with Crohn's disease.

Author: UngaroRyan C, AggarwalSaurabh, TopalogluOzlem, LeeWan-Ju, ClarkRyan, ColombelJean-Frederic

Crohn's disease treatment

A systematic review and meta-analysis of 47 studies found that early biologic treatment in Crohn's disease was associated with higher rates of clinical remission, lower relapse rates, and higher mucosal healing rates compared to late/conventional management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

92.

Efficacy of anti-TNFα drugs in patients with stricturing Crohn's disease.

Author: D'AmicoFerdinando, PuglieseNicola, Peyrin-BirouletLaurent, DaneseSilvio

Stricturing CD treatment

This review examines the potential benefits of anti-TNFα medications for treating narrowing of the intestines (stenosis) in people with Crohn's disease. Surgery has been the main treatment option for this problem, but these medications, which target a specific protein involved in inflammation, may offer a less invasive approach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

93.

Systematic review: medical therapy for fibrostenosing Crohn's disease.

Author: LuCathy, BaratyBrandon, Lee RobertsonHelen, FilykAlexis, ShenHua, FungTak, NovakKerri, MaChristopher, PanaccioneRemo, AchkarJean-Paul, El OualiSara, BruiningDavid, JairathVipul, FeaganBrian, RiederFlorian,

Crohn's disease treatment
Repeat endoscopic dilation
Surgical resection

A systematic review of ten studies describing systemic medical therapy and eight studies of intralesional injection for small bowel fibrostenotic Crohn's disease (CD) found that no favoured therapies exist. Data are lacking for ustekinumab and vedolizumab. No endoscopic intralesional medications provided a clear benefit for prevention of repeat endoscopic balloon dilation or surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

94.

Adalimumab for maintenance of remission in Crohn's disease.

Author: TownsendCassandra M, NguyenTran M, CepekJeremy, AbbassMohamad, ParkerClaire E, MacDonaldJohn K, KhannaReena, JairathVipul, FeaganBrian G

CD treatment

Common treatments for Crohn's disease (CD) include anti-inflammatory drugs, medications that suppress the immune system, and steroids. If these don't work or stop working, biologic therapies like adalimumab (which blocks a substance called TNF-α) are used. Keeping CD under control is important because relapses can greatly affect quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

95.

Efficacy of drug and endoscopic treatment of Crohn's disease strictures: A systematic review.

Author: SchulbergJulien D, WrightEmily K, HoltBronte A, WildingHelen E, HamiltonAmy L, RossAlyson L, KammMichael A

Improved strictures
Reduced surgery
None reported

Anti-tumor necrosis factor (TNF) therapy and endoscopic balloon dilation are effective strategies for avoiding surgery in patients with stricturing Crohn's disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

96.

Efficacy of ustekinumab for active perianal fistulizing Crohn's disease: a systematic review and meta-analysis of the current literature.

Author: AttauabiMohamed, BurischJohan, SeidelinJakob Benedict

Fistula healing
Ustekinumab effective

This systemic review and meta-analysis investigated the clinical effectiveness of ustekinumab for perianal Crohn's disease (pCD). The study found a signal of efficacy of ustekinumab on fistulizing pCD, emphasizing that these patients might benefit from this therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

97.

Early Combined Immunosuppression Reduces Complications in Long-standing Crohn's Disease: A Post Hoc Analysis of REACT.

Author: HanzelJurij, MaChristopher, ZouGuangyong, SinghSiddharth, DulaiParambir S, FeaganBrian G, D'HaensGeert R, SandbornWilliam J, JairathVipul

ECI for CD

This post hoc analysis of the REACT trial examines the impact of baseline disease duration on surgical outcomes in patients with Crohn's disease (CD) treated with early combined immunosuppression (ECI) versus conventional management (CM).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

98.

Cost-Effectiveness Analysis of Parenteral Methotrexate for the Treatment of Crohn's Disease.

Author: MlcochTomas, DeckerBarbora, DolezalTomas

Crohn's disease treatment
Limited economic evidence

This study addressed the need for more health economic evidence regarding the use of parenteral methotrexate (pMTX) in Crohn's disease (CD) despite its widespread use, especially for mild-to-moderate disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

99.

[Symptoms, diagnostic and therapy of perianal disease in patients with inflammatory bowel diseases].

Author: MisselwitzBenjamin, RickenbacherAndreas, BrandStephan

Treatment for perianal disease in IBD

This article reviews the symptoms, diagnosis, and treatment of perianal disease in patients with inflammatory bowel diseases (IBD). Perianal disease is a common complication of IBD and can significantly impact patients’ quality of life. This review covers various aspects of perianal disease management, including diagnosis, treatment options, and the importance of preserving anal sphincter function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

100.

Efficacy of Biologic Drugs in Short-Duration Versus Long-Duration Inflammatory Bowel Disease: A Systematic Review and an Individual-Patient Data Meta-Analysis of Randomized Controlled Trials.

Author: Ben-HorinShomron, NovackLena, MaoRen, GuoJing, ZhaoYue, SergienkoRuslan, ZhangJian, KobayashiTaku, HibiToshifumi, ChowersYehuda, Peyrin-BirouletLaurent, ColombelJean Frederic, KaplanGilaad G, ChenMin-Hu

Remission induction

Biologic treatment for Crohn's disease (CD) was equally effective for patients with short-duration (≤18 months) and long-duration disease (>18 months). In ulcerative colitis (UC), there was no difference in effectiveness based on disease duration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

101.

Intensive drug therapy versus standard drug therapy for symptomatic intestinal Crohn's disease strictures (STRIDENT): an open-label, single-centre, randomised controlled trial.

Author: SchulbergJulien D, WrightEmily K, HoltBronte A, HamiltonAmy L, SutherlandTom R, RossAlyson L, VogrinSara, MillerAshley M, ConnellWilliam C, LustMark, DingNik S, MooreGregory T, BellSally J, SheltonEdward, ChristensenBritt, De CruzPeter, RongYuwei J, KammMichael A

Improved stricture response

This study investigates the effectiveness of drug therapy for strictures in Crohn's disease, a common complication. The researchers explore whether strictures respond to drug treatment and whether intensive therapy is more effective than standard treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

102.

Probiotics in the Treatment of Inflammatory Bowel Disease in Adulthood: A Systematic Review.

Author: LorentzAxel, MüllerLeonie

Probiotic treatment for IBD

This review examined the potential benefits of probiotics for patients with Crohn's disease (CD) and ulcerative colitis (UC), considering the challenges of current IBD treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

103.

Comparative Efficacy of Biologic Therapies for Inducing Response and Remission in Fistulizing Crohn's Disease: Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Author: ShehabMohammad, AlrashedFatema, HeronValérie, RestelliniSophie, BessissowTalat

Fistulizing CD remission
Fistulizing CD response

Fistulizing Crohn's disease (CD) remains a clinical challenge. This study compares the efficacy of different biologic therapies in inducing response and remission in fistulizing CD.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

104.

Disease recurrence in patients with Crohn's disease after biologic therapy or surgery: a meta-analysis.

Author: KneißlSarah, StallhoferJohannes, SchlattmannPeter, StallmachAndreas

Lower recurrence rates
Surgery effective for limited disease

This meta-analysis of patients with Crohn's disease (CD) found that surgical resection was associated with a lower risk of recurrence compared to medical therapy, including biologics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

105.

Prevalence of aphthous stomatitis in patients with inflammatory bowel disease after the treatment with monoclonal antibodies: a systematic review and meta-analysis.

Author: Salgado-PeralvoA-O, Montero-AlonsoM, KewalramaniN, Pérez-SayánsM, Mateos-MorenoM-V, Garcillán-IzquierdoM-R

IBD treatment

This study aims to determine which type of medication, anti-TNFs or vedolizumab (VDZ), is better at reducing mouth sores (aphthous stomatitis or AS) in people with inflammatory bowel disease (IBD). AS is a common complication of IBD, and the study seeks to compare the effectiveness of these medications in managing this symptom.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

106.

Use of biologics for the management of Crohn's disease: IG-IBD technical review based on the GRADE methodology.

Author: BonovasStefanos, PiovaniDaniele, PansieriClaudia, MacalusoFabio Salvatore, OrlandoAmbrogio, FestaStefano, PapiClaudio, PuglieseDaniela, ArmuzziAlessandro

Crohn's disease treatment

This technical review systematically searched and identified the current evidence, synthesized it using meta-analytic methodology, appraised its quality, and concisely presented it, thus forming the basis for developing clinical practice recommendations on the use of biologic treatments in adult patients with CD.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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