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Peripheral neuropathy during stavudine-didanosine antiretroviral therapy.

Author: ChennebaultJ M, LafeuilladeA, MussiniJ M, RaffiF, ReliquetV

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that the d4T-ddI combination did not seem to increase the incidence of peripheral neuropathy in HIV infected patients, but the low number of patients with PN prevented the identification of risk factors.
Paper Details　
Original Abstract of the Article :
Peripheral neuropathy (PN) is among the most frequent side effects described with nucleoside reverse transcriptase inhibitors (NRTIs). We investigated the incidence, evolution and predictive factors of PN during stavudine (d4T)-didanosine (ddI) combination therapy in 65 HIV infected patients, previo...See full text at original site
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引用元：
https://doi.org/10.1046/j.1468-1293.2001.00066.x

データ提供：米国国立医学図書館（NLM）

Peripheral Neuropathy: A Potential Side Effect of Antiretroviral Therapy

[Peripheral neuropathy (PN)] is a [common side effect] associated with [nucleoside reverse transcriptase inhibitors (NRTIs)], a class of medications used to treat [HIV infection]. This study investigates the [incidence and predictors] of PN in patients receiving [stavudine (d4T)-didanosine (ddI)] combination therapy. The study found that [the combination did not significantly increase the incidence of PN], and [no specific risk factors were identified].

Managing Antiretroviral Therapy Side Effects

[This study underscores the importance of monitoring] for [potential side effects] of antiretroviral therapy. [Early detection and appropriate management] are crucial for [minimizing the impact] of PN and [improving the quality of life] for patients with HIV infection.

Personalized Care for HIV Patients

This research highlights the [need for individualized care] for patients with HIV infection. [Treatment strategies] should be [tailored to the patient's individual needs and risk factors]. [Ongoing research and advancements in antiretroviral therapy] are crucial for [improving the safety and efficacy] of treatment options.

Dr. Camel's Conclusion

Like a camel who navigates the desert with a keen sense of touch, we must be [aware of our bodies' signals]. This research reminds us that [even beneficial medications] can sometimes have [unintended side effects]. It's essential to [stay informed and communicate openly] with healthcare professionals to [manage any potential side effects] and [optimize our overall health].

Date :
  1. Date Completed 2002-04-15
  2. Date Revised 2019-11-05
Further Info :

Pubmed ID

11737385

DOI: Digital Object Identifier

10.1046/j.1468-1293.2001.00066.x

Related Literature

Article Analysis
・Side Effects of d4t
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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