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Photodynamic therapy using Verteporfin (benzoporphyrin derivative monoacid ring A, BPD-MA) and 630 nm laser light in canine esophagus.

Author: BowerRobert, DeNovoRobert C, KellyBarbara, OverholtBergein F, PanjehpourMasoud, PetersenMark G, RubinchikValery

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Verteporfin and 630 nm light doses of 60, 80, 145, and 200 J/cm delivered at 15, 30, 60, and 120 minutes after the drug injection, respectively, achieved effective mucosal ablation in canine esophagus.
Paper Details　
Original Abstract of the Article :
BACKGROUND AND OBJECTIVE: Verteporfin is a new photosensitizer with short-term skin photosensitivity. The objective of this preclinical study was to find the light dose that effectively ablates canine esophageal mucosa when delivered 30 minutes after Verteporfin injection. STUDY DESIGN/MATERIALS AN...See full text at original site
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引用元：
https://doi.org/10.1002/lsm.10014

データ提供：米国国立医学図書館（NLM）

Photodynamic Therapy: A Light-Based Approach to Esophageal Treatment

The field of medicine is constantly seeking new and innovative treatments, like a desert explorer searching for a hidden spring. This preclinical study investigated the potential of photodynamic therapy (PDT) using verteporfin, a photosensitizer drug, and laser light for treating canine esophageal lesions. The study found that PDT was effective in ablating canine esophageal mucosa, suggesting its potential as a therapeutic option for treating esophageal lesions.

Exploring New Treatment Frontiers

This study suggests that PDT could be a promising therapeutic approach for treating esophageal lesions in dogs, and potentially humans. Further research is needed to evaluate the safety and efficacy of PDT in clinical settings.

Harnessing Light for Healing

This research explores the potential of light-based therapies for treating disease, offering a new avenue for exploring and developing novel treatments. The study highlights the importance of continued research into PDT, as it may hold the key to developing less invasive and more effective treatment options.

Dr. Camel's Conclusion

Just as the sun's rays can provide warmth and energy, PDT harnesses the power of light for therapeutic purposes. This study shines a light on the potential of this approach, offering hope for new ways to treat esophageal lesions and potentially improve the lives of patients.

Date :
  1. Date Completed 2002-03-14
  2. Date Revised 2019-09-16
Further Info :

Pubmed ID

11857600

DOI: Digital Object Identifier

10.1002/lsm.10014

Related Literature

Article Analysis
・Effects of verteporfin injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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