Effects of verteporfin injection: A Synthesis of Findings from 8 Studies

  1. Home
  2. Effects of verteporfin injection
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of verteporfin injection: A Synthesis of Findings from 8 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of verteporfin injection: A Synthesis of Findings from 8 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Verteporfin is a photosensitizer used in photodynamic therapy (PDT), and various studies have demonstrated its potential for treating different diseases. 4 , 1 , 8 , 2 , 3 , 5 , 6 These studies have shown that verteporfin can promote the regression of lymphatic vessels in the cornea, 4 , 2 inhibit subfoveal choroidal neovascularization associated with high myopia, 1 ablate canine esophageal mucosa, 8 treat sentinel lymph node metastasis, 3 enhance the radiation sensitivity of radiation-induced fibrosarcoma, 6 and play a crucial role in limb regeneration in crabs. 5 Additionally, combining verteporfin with light irradiation shows promise in suppressing cancer cell growth. 3

Benefits and Risks

Benefit Summary

Verteporfin holds promise for various therapeutic applications, including promoting corneal lymphatic vessel regression, inhibiting subfoveal choroidal neovascularization associated with high myopia, ablating canine esophageal mucosa, treating sentinel lymph node metastasis, enhancing the radiation sensitivity of radiation-induced fibrosarcoma, facilitating limb regeneration in crabs, and suppressing cancer cell growth. 4 , 1 , 8 , 2 , 3 , 5 , 6

Risk Summary

Verteporfin has been associated with short-term skin photosensitivity as a side effect. 8 However, a study 1 did not identify any new adverse effects related to verteporfin. When using verteporfin, it is essential to inform patients about the risk of skin photosensitivity.

Comparison between Studies

Commonalities between Studies

Verteporfin serves as a photosensitizer in photodynamic therapy (PDT), showing potential for various therapeutic effects. 4 , 1 , 8 , 2 , 3 , 5 , 6 These studies highlight that verteporfin, upon activation by light, selectively targets and destroys specific targets without causing damage to surrounding cells or tissues.

Differences between Studies

Verteporfin has been investigated for its therapeutic potential in a range of diseases. These studies show variations in the applications of PDT using verteporfin, including the target disease, administration method, and therapeutic outcomes. 4 , 1 , 8 , 2 , 3 , 5 , 6 For instance, 4 , 2 focus on corneal lymphatic vessel regression, while 1 concentrates on subfoveal choroidal neovascularization associated with high myopia. 8 investigates ablating canine esophageal mucosa, 3 focuses on treating sentinel lymph node metastasis, 6 explores enhancing the radiation sensitivity of radiation-induced fibrosarcoma, and 5 examines limb regeneration in crabs. The method of verteporfin administration also varies across studies. 4 , 2 involve intrastromal injection, 1 utilizes intravenous injection, and 8 employs oral administration.

Consistency and Inconsistencies of Results

While these studies suggest the potential of verteporfin for treating various diseases, some inconsistencies and inconsistencies exist in the findings. 4 , 1 , 8 , 2 , 3 , 5 , 6 For example, 1 concludes that verteporfin is effective for treating subfoveal choroidal neovascularization associated with high myopia, but this effect was found to have diminished after one year. Conversely, 4 , 2 indicate that verteporfin has long-term effects on corneal lymphatic vessel regression. These results suggest that the effectiveness of verteporfin may vary depending on the disease and treatment method. Further research is crucial to comprehensively investigate the effects of verteporfin and develop optimal treatment strategies.

Points to Consider in Real-Life Application

Verteporfin holds promise for various therapeutic applications, including promoting corneal lymphatic vessel regression, inhibiting subfoveal choroidal neovascularization associated with high myopia, ablating canine esophageal mucosa, treating sentinel lymph node metastasis, enhancing the radiation sensitivity of radiation-induced fibrosarcoma, facilitating limb regeneration in crabs, and suppressing cancer cell growth. 4 , 1 , 8 , 2 , 3 , 5 , 6 However, since verteporfin is light-sensitive, it is essential to avoid light exposure during treatment. Additionally, side effects such as skin photosensitivity have been reported. 8 When using verteporfin, it is crucial to consult with a physician and receive appropriate treatment.

Limitations of Current Research

Although these studies indicate the potential of verteporfin for treating various diseases, certain limitations exist, such as a limited number of research subjects. 4 , 1 , 8 , 2 , 3 , 5 , 6 For example, 4 , 2 conclude that verteporfin is effective in promoting corneal lymphatic vessel regression, but the research subjects were animal models, and further studies are required to assess its applicability to humans. Similarly, 1 concludes that verteporfin is effective for treating subfoveal choroidal neovascularization associated with high myopia, but the study involved only 120 patients, necessitating larger-scale research. Conducting large-scale clinical trials with human subjects is crucial to validate the safety and effectiveness of PDT using verteporfin.

Future Research Directions

Future research should focus on investigating the safety and effectiveness of PDT using verteporfin in greater detail. 4 , 1 , 8 , 2 , 3 , 5 , 6 Conducting clinical trials with human subjects is critical to clarify the effects, side effects, and optimal administration methods of PDT using verteporfin. Moreover, investigating the combined effects of verteporfin with other treatment modalities is essential. Through such research, PDT using verteporfin holds great promise as a valuable therapeutic option for various diseases.

Conclusion

Verteporfin, a photosensitizer used in photodynamic therapy (PDT), has demonstrated potential for treating a range of diseases. 4 , 1 , 8 , 2 , 3 , 5 , 6 These studies have shown that verteporfin can promote the regression of lymphatic vessels in the cornea, 4 , 2 inhibit subfoveal choroidal neovascularization associated with high myopia, 1 ablate canine esophageal mucosa, 8 treat sentinel lymph node metastasis, 3 enhance the radiation sensitivity of radiation-induced fibrosarcoma, 6 and play a crucial role in limb regeneration in crabs. 5 Additionally, combining verteporfin with light irradiation shows promise in suppressing cancer cell growth. 3 However, verteporfin is light-sensitive, so it is essential to avoid light exposure during treatment. Additionally, side effects such as skin photosensitivity have been reported. 8 When using verteporfin, it is crucial to consult with a physician and receive appropriate treatment. Future research should focus on validating the safety and effectiveness of PDT using verteporfin through large-scale clinical trials with human subjects.

Literature analysis of 8 papers
Positive Content
8
Neutral Content
0
Negative Content
0
Article Type
2
0
0
0
8
1.

Verteporfin: new indication. New indication in complications of high myopia: no sustained benefit.

Author:

Stabilize vision
Limited efficacy

High myopia can lead to subfoveal choroidal neovascularisation, causing a significant loss of central vision. Verteporfin, a drug that received marketing authorisation, may be helpful in stabilizing visual acuity for one year, but this advantage is lost after two years.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Regression of mature lymphatic vessels in the cornea by photodynamic therapy.

Author: BucherF, BiY, GehlsenU, HosD, CursiefenC, BockF

Lymphatic vessel regression

This study analyzed the possibility of regressing corneal lymphatic vessels by photodynamic therapy (PDT) after intrastromal verteporfin injection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Photodynamic therapy with verteporfin in the radiation-induced fibrosarcoma-1 tumor causes enhanced radiation sensitivity.

Author: PogueBrian W, O'HaraJulia A, DemidenkoEugene, WilmotCarmen M, GoodwinIsak A, ChenBin, SwartzHarold M, HasanTayyaba

Tumor regression

This study explores the use of photodynamic therapy (PDT) with verteporfin for treating radiation-induced fibrosarcoma tumors. PDT was shown to increase tumor oxygenation and enhance the effectiveness of radiation therapy when given simultaneously.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Verteporfin: new indication. New indication in complications of high myopia: no sustained benefit.

Author:

Stabilize vision
Limited efficacy

High myopia can lead to subfoveal choroidal neovascularisation, causing a significant loss of central vision. Verteporfin, a drug that received marketing authorisation, may be helpful in stabilizing visual acuity for one year, but this advantage is lost after two years.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Photodynamic therapy using Verteporfin (benzoporphyrin derivative monoacid ring A, BPD-MA) and 630 nm laser light in canine esophagus.

Author: PanjehpourMasoud, DeNovoRobert C, PetersenMark G, OverholtBergein F, BowerRobert, RubinchikValery, KellyBarbara

Effective mucosal ablation

Verteporfin and 630 nm light doses of 60, 80, 145, and 200 J/cm delivered at 15, 30, 60, and 120 minutes after the drug injection, respectively, achieved effective mucosal ablation in canine esophagus.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.