Paper Details

  1. Home
  2. Paper Details

Effects of two preparations of 75-mg extended-release aspirin on platelet aggregation, prostanoids and nitric oxide production in humans.

Author: González-CorreaJ A, GuerreroA, MárquezE, NacleI, Sánchez de la CuestaF, de la CruzJ P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the effects of two extended-release aspirin formulations on prostanoid and nitric oxide synthesis. The study found that both formulations were effective in preventing thrombotic accidents, but they had different effects on prostanoid and nitric oxide synthesis.
Paper Details　
Original Abstract of the Article :
The lowest dose of aspirin shown to be effective in the secondary prevention of thrombotic accidents is 75 mg/day. Presystemic acetylation of cyclooxygenase and the formation of salicylic acid in the liver are fundamental to ensure optimum antithrombotic effects of aspirin. This study was designed t...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s00228-001-0391-8

データ提供：米国国立医学図書館（NLM）

Aspirin: Investigating the Impact of Extended-Release Preparations on Platelet Aggregation and Nitric Oxide Production

Aspirin, a widely used antiplatelet agent, plays a crucial role in the prevention of thrombotic events. This research explores the effects of two different formulations of extended-release aspirin on platelet aggregation, prostanoid synthesis, and nitric oxide production. The authors aimed to compare the impact of these formulations on these key parameters, providing insights into the potential for variations in aspirin's antithrombotic effects based on its formulation. This study contributes to a deeper understanding of aspirin's mechanisms of action and its implications for cardiovascular health.

Extended-Release Aspirin: Exploring the Impact on Platelet Aggregation and Nitric Oxide Production

This study investigates the impact of two extended-release aspirin formulations on platelet aggregation, prostanoid synthesis, and nitric oxide production. The findings highlight the potential for variations in aspirin's effects based on its formulation. This underscores the importance of considering the specific formulation when prescribing aspirin for cardiovascular prevention.

Navigating the Desert of Cardiovascular Health: Choosing the Right Aspirin

Imagine the cardiovascular system as a vast desert landscape, where blood vessels must maintain smooth flow to prevent blockages. Aspirin, like a skillful navigator, helps prevent the formation of blood clots. This research delves into the intricacies of different aspirin formulations, highlighting the importance of selecting the right formulation to optimize cardiovascular health.

Dr. Camel's Conclusion

This study highlights the importance of understanding the nuances of drug formulations and their impact on therapeutic efficacy. By exploring the effects of different aspirin formulations, we can gain valuable insights into optimizing aspirin's effectiveness in preventing cardiovascular events. The journey towards better cardiovascular health involves a continuous exploration of drug mechanisms and treatment strategies, and this research contributes valuable insights to this ongoing effort.

Date :
  1. Date Completed 2002-06-26
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

11871383

DOI: Digital Object Identifier

10.1007/s00228-001-0391-8

Related Literature

Article Analysis
・Effects of aspirin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.