Effects of aspirin: A Synthesis of Findings from 29 Studies

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Original Abstract of the Article

Major Findings

Aspirin is a widely used medication that has been shown to have a variety of effects on the body. One of the most well-known effects of aspirin is its ability to inhibit platelet aggregation, which is the process by which platelets clump together to form blood clots. 8 This effect of aspirin is thought to be responsible for its ability to reduce the risk of cardiovascular disease. 22 However, aspirin can also have other effects on the body, including its ability to reduce inflammation, 23 protect against certain types of cancer, 6 and even affect cognitive function in diabetic patients. 28

The effectiveness of aspirin can vary depending on factors such as the dose, formulation, timing of administration, and individual patient characteristics. 17 It is important to note that aspirin can interact with other medications, which can alter its effects. 18 Moreover, aspirin can also have side effects, such as gastrointestinal bleeding, 22 and it is essential to weigh the potential benefits against the risks before taking aspirin.

Benefits and Risks

Benefits Summary

Aspirin has been shown to have potential benefits, including reducing the risk of cardiovascular disease, protecting against certain types of cancer, reducing inflammation, and possibly improving cognitive function in diabetic patients. 8 、 22 、 6 、 23 、 28 Aspirin's anti-platelet properties make it an effective medication for cardiovascular disease prevention. 12 、 1 、 25

Risks Summary

Aspirin can also have potential risks, including gastrointestinal bleeding, 22 gastrointestinal ulcers, 3 and other side effects. 17 It is essential to be aware of these potential risks and to discuss them with your doctor before taking aspirin.

Comparison Across Studies

Commonalities

Several studies have suggested that aspirin can reduce the risk of cardiovascular disease and certain types of cancer. 8 、 22 、 6 These studies have also highlighted the potential for drug interactions with aspirin, emphasizing the importance of careful consideration when prescribing or taking aspirin. 18 Many research efforts have emphasized the significance of weighing the benefits and risks of aspirin use and choosing appropriate administration strategies. 15 、 1

Differences

Research findings have indicated that the effectiveness of aspirin can vary significantly depending on the dose, formulation, timing of administration, and individual patient characteristics. 17 Some studies have suggested that aspirin might offer gastric protection. 13 Aspirin's potential influence on cognitive function in diabetic patients has also been explored in certain studies. 28 Consequently, it is crucial to select appropriate administration strategies to maximize aspirin's benefits and minimize potential side effects. 12 、 1 、 25

Consistency and Discrepancies in Results

Research findings on the effects of aspirin have demonstrated both consistency and discrepancies. 17 、 13 、 28 While some studies suggest that aspirin can reduce the risk of cardiovascular disease and certain types of cancer, 8 、 22 、 6 others highlight the potential for aspirin to increase the risk of side effects such as gastrointestinal bleeding. 22 、 3 The effectiveness of aspirin can vary significantly based on factors such as dose, formulation, timing of administration, and individual patient characteristics. 17 Therefore, it is crucial to consider the benefits and risks of aspirin use and select appropriate administration strategies in consultation with a healthcare professional. 15

Considerations for Real-World Application

Aspirin is a medication with potential benefits and risks. 8 、 22 、 6 It is important to weigh these factors carefully and discuss them with your doctor before taking aspirin. 15

Limitations of Current Research

Research on the effects of aspirin is ongoing and there are still areas where more research is needed. 17 、 13 、 28

Future Research Directions

Further research is necessary to better understand the effects of aspirin. 26 Research is needed to understand the individual variability in response to aspirin. 17 Long-term studies are also needed to assess the long-term effects and safety of aspirin. 28

Conclusion

Aspirin is a commonly used medication with a range of potential benefits and risks. 8 、 22 、 6 、 22 It's crucial to carefully consider both the benefits and risks before taking aspirin, and to consult with your doctor to determine the appropriate dosage, formulation, and administration strategy. 15

Literature analysis of 29 papers
Positive Content
26
Neutral Content
2
Negative Content
1
Article Type
20
8
3
6
29
1.

Aspirin: dose and indications in modern stroke prevention.

Author: van GijnJ

Myocardial infarction prevention
Reduced side effects
Stroke prevention

Low-dose aspirin has been shown to be effective in reducing the incidence of vascular death, stroke, or myocardial infarction. While previous studies relied on higher doses, recent trials have demonstrated similar effects with lower doses, accompanied by fewer side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

2.

Dose-dependent aspirin hydrolysis and platelet aggregation in patients with atherosclerosis.

Author: AkopovS S, GrigorianG S, GabrielianE S

Aspirin for atherosclerosis

The effectiveness of aspirin in low dosage on platelet aggregation in patients with atherosclerosis may be ineffective without control of aspirin hydrolysis velocity in blood.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Non-steroid anti-inflammatory drug associated ulcer: epidemiology, causation and treatment.

Author: LangmanM J, BrooksP, HawkeyC J, SilversteinF, YeomansN

Therapeutic effects
Bleeding
Gastric ulceration
Ulcer death

Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with an increased risk of gastric ulcers and bleeding. The mechanisms underlying this effect are complex and not entirely understood. Anti-secretory drugs and prostaglandins can protect against some NSAID-related complications, but further research is needed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Aspirin at very ultra low dosage in healthy volunteers: effects on bleeding time, platelet aggregation and coagulation.

Author: DoutremepuichC, de SèzeO, Le RoyD, LalanneM C, AnneM C

Bleeding time reduction

Ultra low-dose aspirin reduced bleeding time in volunteers who had previously ingested aspirin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Effects of 1 gram oral or intravenous aspirin on urinary excretion of thromboxane B2 and 6-keto-PGF1 alpha in healthy subjects.

Author: BucchiF, BodzentaA, de GaetanoG, CerlettiC

Platelet Cyclo-oxygenase Activity Suppression

Aspirin was administered orally and intravenously to 6 healthy subjects to compare its effects on platelet and renal prostanoids. Both routes suppressed platelet cyclooxygenase activity, but only intravenous aspirin significantly reduced urinary excretion of TxB2 and 6-keto-PGF1 alpha.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Aspirin and the prevention of colorectal cancer: a review of the evidence.

Author: Paganini-HillA

Reduced risk of colorectal cancer
Confounding
Recall bias
Selection bias

Regular aspirin use may reduce the risk of colorectal cancer and polyps by about half, but further research is needed to determine optimal dose, duration, and individual risk factors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

7.

Anti-platelet effects of 100 mg alternate day oral aspirin: a randomized, double-blind, placebo-controlled trial of regular and enteric coated formulations in men and women.

Author: RidkerP M, HennekensC H, ToflerG H, LipinskaI, BuringJ E

Cardiovascular benefit
Reduced gastrointestinal symptoms

Further research is needed to determine the optimal dose of aspirin to produce a cardiovascular benefit while minimizing side effects, particularly in women.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Platelet responses to several agonists and combinations of agonists in whole blood: a placebo controlled comparison of the effects of a once daily dose of plain aspirin 300 mg, plain aspirin 75 mg and enteric coated aspirin 300 mg, in man.

Author: MayJ A, HeptinstallS, ColeA T, HawkeyC J

Reduced platelet aggregation
Reduced platelet release reaction

This study investigated the effects of different aspirin preparations on platelet responses to various agonists. All aspirin preparations reduced platelet aggregation and release reaction, with plain aspirin 300 mg achieving maximal effect after a single dose.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Comparison of the effects of ketoprofen on platelet function in the presence and absence of aspirin.

Author: Van SolingenR M, RosensteinE D, MihailescuG, DrejkaM L, KaliaA, CohenA J, KramerN

Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) exert inhibitory effects on platelets in vitro and in vivo, but there are insufficient data to substantiate the use of NSAIDs alone as antiplatelet drugs in patients already taking aspirin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Effects of two preparations of 75-mg extended-release aspirin on platelet aggregation, prostanoids and nitric oxide production in humans.

Author: de la CruzJ P, GuerreroA, González-CorreaJ A, MárquezE, NacleI, Sánchez de la CuestaF

Thrombosis prevention

This study compared the effects of two extended-release aspirin formulations on prostanoid and nitric oxide synthesis. The study found that both formulations were effective in preventing thrombotic accidents, but they had different effects on prostanoid and nitric oxide synthesis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Effects of enteric-coated, low-dose aspirin on parameters of platelet function.

Author: Van HeckenA, JulianoM L, DepréM, De LepeleireI, ArnoutJ, DynderA, WildongerL, PettyK J, GottesdienerK, De HoonJ N

Reduced platelet aggregation
Reduced thromboxane B2

Enteric-coated, low-dose aspirin is effective in inhibiting serum generated thromboxane B2 and platelet aggregation in healthy subjects. The mean percentage inhibition of serum thromboxane B2 was 97.4% after 7 daily doses of enteric-coated aspirin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Effect of different aspirin doses on platelet aggregation in patients with stable coronary artery disease.

Author: MalhotraS, SharmaY P, GroverA, MajumdarS, HanifS M, BhargavaV K, BhatnagarA, PandhiP

Antiplatelet agent
Gastrointestinal side effects

This study aims to investigate whether very low doses of aspirin are as effective as higher doses in inhibiting platelet aggregation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans.

Author: FiorucciStefano, MencarelliAndrea, MeneguzziAlessandra, LechiAlessandro, RengaBarbara, del SoldatoPiero, MorelliAntonio, MinuzPietro

Inhibited platelet aggregation
Reduced gastric damage
Reduced monocyte activation

NCX-4016, an aspirin derivative, was found to be equally effective as aspirin in inhibiting platelet aggregation and cyclooxygenase activity. However, NCX-4016 caused less gastric damage and prevented monocyte activation, suggesting broader anti-inflammatory and antithrombotic effects. Larger multicenter trials are needed to establish clinical efficacy and safety.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Impact of nonsteroidal antiinflammatory drugs on the cardioprotective effects of aspirin.

Author: CormanShelby L, FedutesBethany A, AnsaniNicole T

Pharmacodynamic data indicating an interaction between aspirin and NSAIDs have not translated to a consistent clinical effect in observational studies. In the absence of a randomized, controlled, clinical outcomes study, there is insufficient evidence to dictate a change in therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

[Primary prevention of coronary heart disease with aspirin].

Author: KüblerW, DariusH

Coronary heart disease prevention
Gastrointestinal bleeding
Hemorrhagic stroke

Aspirin is effective in primary prevention of coronary heart disease. These beneficial effects, however, are at least partially out-weight by unwanted effects-such as intense gastrointestinal bleeding and hemorrhagic stroke.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : German

16.

Enhanced antiplatelet effect of clopidogrel in patients whose platelets are least inhibited by aspirin: a randomized crossover trial.

Author: EikelboomJ W, HankeyG J, ThomJ, ClaxtonA, YiQ, GilmoreG, StatonJ, BardenA, NormanP E

Platelet inhibition
Aspirin resistance

The greatest platelet inhibitory effect of clopidogrel occurs in patients with the least inhibition of arachidonic acid-induced platelet aggregation by aspirin. This raises the possibility that the clinical benefits of adding clopidogrel to aspirin may be greatest in patients whose platelets are least inhibited by aspirin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Effect of aspirin dose, preparation, and withdrawal on platelet response in normal volunteers.

Author: ColemanJacqueline L, AlbertsMark J

Antiplatelet effects

Aspirin dose and preparation can affect antiplatelet effects. Higher doses of aspirin lead to a faster antiplatelet response, while enteric-coated aspirin delays the response time.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

The antiplatelet effect of six non-steroidal anti-inflammatory drugs and their pharmacodynamic interaction with aspirin in healthy volunteers.

Author: GladdingPatrick A, WebsterMark W I, FarrellHelen B, ZengIrene S L, ParkRobert, RuijneNicola

Antiplatelet effect
Reduced vascular events
Antagonizes aspirin

This study compared the antiplatelet effects of six NSAIDs and their interaction with aspirin. Ibuprofen, indomethacin, naproxen, and tiaprofenic acid blocked aspirin's antiplatelet effect. Sulindac and celecoxib did not affect aspirin's action.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Effect of maximum OTC doses of naproxen sodium or acetaminophen on low-dose aspirin inhibition of serum thromboxane B2.

Author: OldenhofJohn, HochbergMarc, SchiffMichael, BruneKay

Platelet inhibition
Drug interaction

This study evaluated the platelet inhibitory effects of low-dose enteric-coated aspirin (EC-ASA) when used concomitantly with maximum over-the-counter (OTC) doses of naproxen sodium (NAPSO) or acetaminophen. The results suggest that NAPSO and acetaminophen do not interfere with the anti-platelet effect of aspirin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Antihypertensive effects of aspirin: what is the evidence?

Author: BautistaLeonelo E, VeraLina M

Cardiovascular event prevention
Gastric bleeding
Hemorrhagic stroke
Hypertension risk

This review summarizes published data on the effects of aspirin on blood pressure. While some uncontrolled trials suggest that aspirin may lower blood pressure, this conflicts with cohort studies showing an increased risk of hypertension among aspirin users. The review highlights the potential risks and benefits of aspirin use, emphasizing the need for careful consideration of its effects on blood pressure and other health outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

21.

Gastrointestinal adverse effects of short-term aspirin use: a meta-analysis of published randomized controlled trials.

Author: BaronJohn A, SennStephen, VoelkerMichael, LanasAngel, LauroraIrene, ThielemannWolfgang, BrücknerAndreas, McCarthyDenis

Fever relief
Pain relief
GI adverse effects

This meta-analysis summarizes the available data on the gastrointestinal adverse effects of short-term aspirin use for pain, fever, or colds. It compares aspirin with placebo and other commonly used medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Aspirin for prophylactic use in the primary prevention of cardiovascular disease and cancer: a systematic review and overview of reviews.

Author: SutcliffeP, ConnockM, GurungT, FreemanK, JohnsonS, KandalaN-B, GroveA, GurungB, MorrowS, ClarkeA

CVD prevention
Cancer prevention
Aspirin side effects
Bleeding
Gastrointestinal symptoms

Prophylactic aspirin has been used to reduce the risk of heart disease and cancer. This report aimed to summarise current scientific evidence regarding the potential harms of prophylactic aspirin in primary prevention of cardiovascular disease and cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Aspirin in type 2 diabetes, a randomised controlled study: effect of different doses on inflammation, oxidative stress, insulin resistance and endothelial function.

Author: RaghavanR P, LaightD W, CummingsM H

Cardiovascular protection

This study examined the effects of different doses of aspirin on cardiovascular risk markers, including oxidative stress, vascular inflammation, endothelial dysfunction, and dysglycaemia, in patients with type 2 diabetes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Aspirin desensitization in patients with aspirin-induced and aspirin-tolerant asthma: a double-blind study.

Author: Świerczyńska-KrępaMonika, SanakMarek, BochenekGrażyna, StrękPaweł, ĆmielAdam, GieliczAnna, PluteckaHanna, SzczeklikAndrzej, Niżankowska-MogilnickaEwa

Reduces nasal symptoms

Aspirin desensitization (AD) improved nasal and bronchial symptoms in patients with aspirin-induced asthma (AIA) but not in those with aspirin-tolerant asthma (ATA).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

The Effects of Different Aspirin Dosing Frequencies and the Timing of Aspirin Intake in Primary and Secondary Prevention of Cardiovascular Disease: A Systematic Review.

Author: BemD, LordkipanidzéM, HodgkinsonJ, StevensS, BaylissS, MooreD, FitzmauriceD, DretzkeJ

Cardiovascular disease prevention

This systematic review evaluated the evidence on the effects of different aspirin regimens in terms of timing (chronotherapy) or frequency of dosing in the prevention of cardiovascular disease. Only two out of the 28 included studies reported long-term cardiovascular outcomes, highlighting an evidence gap that future research should address.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Effects of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs on the incidence of recurrent colorectal adenomas: a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials.

Author: VeettilSajesh K, LimKean Ghee, ChingSiew Mooi, SaokaewSurasak, PhisalprapaPochamana, ChaiyakunaprukNathorn

Adenoma prevention

This review summarizes the existing evidence on the effects of aspirin and non-aspirin NSAIDs on recurrent colorectal adenomas.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Aspirin effects on platelet gene expression are associated with a paradoxical, increase in platelet function.

Author: MyersRachel A, OrtelThomas L, WaldropAlexander, DaveSandeep, GinsburgGeoffrey S, VooraDeepak

Platelet function

Aspirin has a dose-independent effect on the platelet transcriptome, potentially acting as an inhibitor of protein synthesis. This effect was associated with higher levels of platelet function, counteracting aspirin's known antiplatelet effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

28.

Effects of aspirin on dementia and cognitive function in diabetic patients: the ASCEND trial.

Author: ParishSarah, MafhamMarion, OfferAlison, BartonJill, WallendszusKarl, StevensWilliam, BuckGeorgina, HaynesRichard, CollinsRory, BowmanLouise, ArmitageJane

Cardiovascular prevention
Bleeding risk

The ASCEND trial, which involved 15,480 people with diabetes, found no large proportional effect of aspirin on the risk of dementia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Effect of low-dose aspirin on urinary 11-dehydro-thromboxane B2 in the ASCEND (A Study of Cardiovascular Events iN Diabetes) randomized controlled trial.

Author: ParishSarah, BuckGeorgina, AungTheingi, MafhamMarion, ClarkSarah, HillMichael R, CollinsRory, BowmanLouise, ArmitageJane,

Aspirin suppression

Daily aspirin significantly reduced thromboxane A2 production in participants with diabetes, even 12-24 hours after ingestion. These findings suggest that aspirin remains effective for cardioprotection in those with diabetes.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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