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Differential cognitive effects of ebastine and (+)-chlorpheniramine in healthy subjects: correlation between cognitive impairment and plasma drug concentration.

Author: AraiHiroyuki, FujiiToshihiko, HiguchiMakoto, ItohMasatoshi, KanoMichiko, KomemushiSadao, MatsudaMichiaki, MizukiYasuyuki, OkamuraNobuyuki, SasakiHidetada, TagawaMasaaki, WatanabeTakehiko, YanaiKazuhiko

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluates the sedative properties of ebastine, a second-generation antihistamine, by comparing its effect on cognitive performance in healthy subjects to placebo and (+)-chlorpheniramine.
Paper Details　
Original Abstract of the Article :
It has been widely recognized that classical antihistamines induce sedation as an adverse effect, while second-generation antihistamines have few if any sedative effects. In order to evaluate the sedative properties of ebastine, a second-generation antihistamine, its effect on cognitive performance ...See full text at original site
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引用元：
https://doi.org/10.1046/j.0306-5251.2001.01183.x

データ提供：米国国立医学図書館（NLM）

Differential cognitive effects of ebastine and (+)-chlorpheniramine in healthy subjects: correlation between cognitive impairment and plasma drug concentration

The world of antihistamines is like a vibrant garden, with different species offering unique properties and potential side effects. This study, like a meticulous gardener tending to their diverse plants, investigates the cognitive effects of two antihistamines, ebastine and (+)-chlorpheniramine, on healthy volunteers. It examines the potential for sedation and cognitive impairment, shedding light on the varying effects of these medications.

Ebastine: a promising species in the antihistamine garden

The study reveals that ebastine, a second-generation antihistamine, has fewer sedative effects than (+)-chlorpheniramine, a first-generation antihistamine. This finding suggests that ebastine may be a more suitable option for individuals seeking relief from allergies while minimizing cognitive impairment.

Navigating the antihistamine garden

This study emphasizes the importance of understanding the potential side effects of medications, particularly those affecting cognitive function. It highlights the need for careful consideration when choosing antihistamines, especially for individuals who rely on optimal cognitive performance.

Dr. Camel's Conclusion

This study, like a skilled gardener meticulously tending to their diverse plants, provides valuable insights into the cognitive effects of different antihistamines. It emphasizes the importance of choosing the right medication to minimize side effects and optimize individual well-being, ensuring a healthy and fulfilling life for everyone.
Date :
  1. Date Completed 2002-11-26
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

11874393

DOI: Digital Object Identifier

10.1046/j.0306-5251.2001.01183.x

Related Literature

Article Analysis
・Effects of chlorpheniramine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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