Effects of chlorpheniramine: A Synthesis of Findings from 26 Studies

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Original Abstract of the Article

Major Research Findings

Chlorpheniramine is a first-generation antihistamine that is commonly used to treat allergic symptoms, and several studies have suggested that it might have other effects. For example, 4 shows that chlorpheniramine can reduce catheter-related bladder discomfort after ureteroscopic stone removal surgery. 15 suggests that chlorpheniramine can impair psychomotor function and may affect driving ability. 14 shows that chlorpheniramine may accelerate vestibular function recovery in goldfish. However, 23 indicates that chlorpheniramine can improve maze performance and reduce anxiety in aged rats.

Benefits and Risks

Benefits Summary

Chlorpheniramine may reduce catheter-related bladder discomfort after ureteroscopic stone removal surgery. 4 It may also improve maze performance and reduce anxiety in aged rats. 23 Furthermore, it may accelerate vestibular function recovery in goldfish. 14

Risks Summary

Chlorpheniramine can impair psychomotor function and may affect driving ability. 15 Other possible side effects include drowsiness, dry mouth, and digestive problems.

Comparison between Studies

Commonalities between Studies

Chlorpheniramine, in addition to its antihistamine properties, appears to have other effects that are likely related to its interaction with neurotransmitters and receptors.

Differences between Studies

The extent to which chlorpheniramine exerts its effects varies depending on factors such as the species, the specific condition, and the method of administration. The frequency and severity of side effects also vary between individuals.

Consistency and Contradictions in Findings

There are some inconsistencies and contradictions in the findings related to chlorpheniramine. For example, while some studies indicate that chlorpheniramine can reduce anxiety, others show that it may increase anxiety. These discrepancies are likely due to differences in research design, species, and administration methods. More research is needed to fully understand how chlorpheniramine works and its effects in different situations.

Considerations for Real-World Application

While chlorpheniramine is primarily used to treat allergic symptoms, it may have other effects as well. However, the extent of these effects can vary, and side effects may occur. It’s crucial to follow your doctor’s instructions when taking chlorpheniramine. Also, be cautious when engaging in activities that require alertness, such as driving or operating machinery, as drowsiness is a potential side effect.

Limitations of Current Research

Research on chlorpheniramine is still limited, particularly in human studies. There are many unanswered questions about its long-term safety and efficacy. Furthermore, there is a lack of sufficient research on the impact of chlorpheniramine when used in conjunction with other medications.

Future Research Directions

More research is necessary to fully understand chlorpheniramine. It is essential to conduct more human studies to elucidate its long-term safety and effectiveness. Furthermore, detailed research is needed to explore the effects of chlorpheniramine when used in combination with other medications.

Conclusion

Chlorpheniramine is a commonly used antihistamine for allergic symptoms. While some studies suggest that it may have other effects, the extent of these effects varies. More research is needed to fully understand how chlorpheniramine works. Always follow your doctor’s instructions when taking chlorpheniramine.

Literature analysis of 26 papers
Positive Content
21
Neutral Content
0
Negative Content
5
Article Type
7
0
0
1
26
1.

Comparison of CNS adverse effects between astemizole and chlorpheniramine in children: a randomized, double-blind study.

Author: ShanonA, FeldmanW, LeikinL, PongA H, PetersonR, WilliamsV

No antihistamine CNS effects

Chlorpheniramine and astemizole had no adverse effects on the performance of children in a study of central nervous system side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effects of chlorpheniramine on emergence agitation after general anesthesia for ureteroscopic stone surgery: a retrospective cohort study.

Author: ChoChoon-Kyu, ChangMinhye, LeeSeok-Jin, ChoSung-Ae, SungTae-Yun

EA prevention

This retrospective study investigated the role of chlorpheniramine in emergence agitation (EA) prevention following ureteroscopic stone surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Effects of Chlorpheniramine Maleate on Catheter-Related Bladder Discomfort in Patients Undergoing Ureteroscopic Stone Removal: A Randomized Double-Blind Study.

Author: InChi-Bum, LeeSeok-Jin, SungTae-Yun, ChoChoon-Kyu, JeeYoung Seok

Reduced tramadol administration

CPM administration before the induction of anesthesia had little effect on the incidence and severity of CRBD after surgery, but it reduced the administration of tramadol required to control CRBD postoperatively.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Dorsal hippocampal microinjection of chlorpheniramine reverses the anxiolytic-like effects of l-histidine and impairs emotional memory in mice.

Author: Canto-de-SouzaL, GarçãoD C, RomagueraF, MattioliR

Anxiety relief
Emotional memory improvement
Emotional memory impairment

This study investigated the role of histaminergic neurotransmission in the modulation of anxiety-like behaviors and emotional memory in mice. The study found that histamine and its receptors in the dorsal hippocampus play a role in these processes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

[Protective effects of d-chlorpheniramine maleate pre-treatment against acute side effects of Irinotecan(CPT- 11)].

Author: MisumiNobuhiro, HiraikeMikako, NawataFusako, HashimotoMirai, TanigawaKayoko, TakaseIzumi, NabeshimaAya, HondaShinobu

Cholinomimetic side effect prevention

Pre-administration of d-Chlorpheniramine maleate (d-CM) significantly reduced the number of patients experiencing cholinomimetic side effects after Irinotecan (CPT-11) administration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

9.

Effects of chlorpheniramine and ranitidine on the visceral nociception induced by acetic acid in rats: role of opioid system.

Author: ZanbooriA, TamaddonfardE, MojtahedeinA

Visceral nociception relief

Chlorpheniramine and ranitidine both have antinociceptive effects in visceral pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving.

Author: TashiroManabu, SakuradaYumiko, MochizukiHideki, HorikawaEtsuo, MaruyamaMasahiro, OkamuraNobuyuki, WatanukiShoichi, AraiHiroyuki, ItohMasatoshi, YanaiKazuhiko

Sedative side effects

This study examined regional cerebral blood flow (rCBF) responses during a simulated car-driving task following oral administration of D-chlorpheniramine using positron emission tomography (PET) and [15O]H2O. This research aimed to elucidate the mechanism underlying the sedative side effects of antihistamines, which are potentially dangerous in car driving.

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Comparison of the local anesthetic effects of chlorpheniramine, midazolam, lidocaine, and normal saline after intradermal injection.

Author: OrhanMehmet Emin, YükselUğur, BilginFerruh, DoğrulAhmet

Infiltration pain reduction

This study aimed to assess the infiltration pain and local anesthetic effects of intradermal chlorpheniramine and midazolam.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children.

Author: SowunmiA, AdedejiA A, GbotoshoG O, FateyeB A, HappiT C

Asexual parasitemia
Malaria treatment
Chloroquine resistance
Gametocyte production

Pyrimethamine-sulphadoxine (PS) was less effective than chloroquine plus chlorpheniramine (CQCP) or amodiaquine plus pyrimethamine-sulphadoxine (AQPS) in clearing asexual parasitaemia and symptoms of falciparum malaria. PS significantly increased gametocyte carriage, indicating its potential for contributing to malaria transmission.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

To evaluate and compare the effects of first generation anti-histamine (chlorpheniramine maleate) and second generation anti-histamine (loratadine) on isolated trachea of rabbit.

Author: JalbaniG A, AamirK, ShaikhA M, UnarM A, AshrafR, SoomroF M

Antagonistic effects
Treat allergic disorders

Antihistamines are commonly used to treat allergies. Chlorpheniramine maleate is a sedative antihistamine, while loratadine is a non-sedating antihistamine. Both drugs were effective in blocking histamine-induced contractions in rabbit trachea, with loratadine showing a longer duration of effect.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Effects of Chlorpheniramine and L-histidine on vestibular compensation in goldfish, Carassius auratus.

Author: PiratelloAline Cristina, MattioliRosana

Accelerated functional recovery

This study investigated the effects of post-operative treatment with chlorpheniramine (H1 histamine antagonist) and L-histidine (a histaminergic precursor) after hemilabyrinthectomy in goldfish. The results showed that chlorpheniramine accelerated functional recovery compared to saline, suggesting that inhibiting the histaminergic system facilitates functional recovery.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Comparative study of acute effects of single doses of fexofenadine, olopatadine, d-chlorpheniramine and placebo on psychomotor function in healthy volunteers.

Author: KameiHiroyuki, NodaYukihiro, IshikawaKazuhiro, SenzakiKoji, MuraokaIsao, HasegawaYoshinori, HindmarchIan, NabeshimaToshitaka

Improved cognitive function
Sedative effects

This study compared the acute effects of single doses of second-generation antihistamines, fexofenadine and olopatadine, with placebo and d-chlorpheniramine, a first-generation antihistamine, on cognitive and psychomotor performance. While d-chlorpheniramine and olopatadine impaired tracking ability and reduced behavioral activity, fexofenadine had no significant effects. These results suggest that fexofenadine has a different CNS profile compared to olopatadine and d-chlorpheniramine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

The anti-allergic effects of a cromolyn sodium-chlorpheniramine combination compared to ketotifen in the conjunctival allergen challenge model.

Author: LeonardiA, BuscaF, TavolatoM, SecchiA G

Reduced itching
Reduced redness

Cromolyn sodium (DSCG) 4% with the antihistamine, chlorpheniramine, is more effective than ketotifen 0.05% at preventing itching and redness in the conjunctival allergen challenge (CAC) model.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

The effects of a sedative antihistamine, d-chlorpheniramine, on visuomotor spatial discrimination and regional brain activity as measured by positron emission tomography (PET).

Author: MochizukiHideki, TashiroManabu, TagawaMasaaki, KanoMichiko, ItohMasatoshi, OkamuraNobuyuki, WatanabeTakehiko, YanaiKazuhiko

Spatial Cognition Impairment

d-chlorpheniramine is an antihistamine that can impair spatial cognition. It affects the activity of the brain in areas involved in visual-motor coordination and attention.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

The effects of chloroquine, amodiaquine and chloroquine plus chlorpheniramine on the disposition kinetics of the hepatomegaly associated with acute, uncomplicated, Plasmodium falciparum malaria in children.

Author: SowunmiA, AdedejiA A

Liver enlargement resolution
Malaria treatment

Chloroquine (CQ) plus chlorpheniramine (CQCP) showed a significantly higher rate of complete resolution of liver enlargement associated with acute, uncomplicated Plasmodium falciparum malaria compared to CQ or amodiaquine (AQ). CQCP also showed faster resolution times and a higher fractional reduction of hepatomegaly area, indicating a beneficial effect on both the early and late stages of liver enlargement.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Differential cognitive effects of ebastine and (+)-chlorpheniramine in healthy subjects: correlation between cognitive impairment and plasma drug concentration.

Author: TagawaMasaaki, KanoMichiko, OkamuraNobuyuki, HiguchiMakoto, MatsudaMichiaki, MizukiYasuyuki, AraiHiroyuki, FujiiToshihiko, KomemushiSadao, ItohMasatoshi, SasakiHidetada, WatanabeTakehiko, YanaiKazuhiko

Allergy relief
Sedation

This study evaluates the sedative properties of ebastine, a second-generation antihistamine, by comparing its effect on cognitive performance in healthy subjects to placebo and (+)-chlorpheniramine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Intraventricular infusion of the histamine H(1) receptor antagonist chlorpheniramine improves maze performance and has anxiolytic-like effects in aged hybrid Fischer 344xBrown Norway rats.

Author: HasenöhrlR U, WethK, HustonJ P

Improved maze performance
Improved motor capacity
Reduced anxiety
None mentioned

Continuous intraventricular infusion of the histamine H(1) receptor antagonist chlorpheniramine improved maze performance and reduced fear-related behaviors in old rats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria.

Author: OsifoN G

Reduced itching
Anorexia
Indigestion

Sulphapyridine was the most effective of three antipruritic drugs (chlorpheniramine, cyproheptadine, and sulphapyridine) in palliating pruritus associated with chloroquine chemosuppressive treatment of acute malarial febrile paroxysms in 18 adult patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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