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Effect of prior steroid treatment on temporal artery biopsy findings in giant cell arteritis.

Author: CartlidgeN, DayanM R, KinéD Ah, ParumsD V, Ray-ChaudhuriN, StrongN P, TijaniS O

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Temporal artery biopsy can be useful even after 4 weeks of corticosteroid treatment for giant cell arteritis.
Paper Details　
Original Abstract of the Article :
AIM: To examine the effect of up to 6 weeks of corticosteroid treatment on the positive temporal artery biopsy rate in giant cell arteritis (GCA). METHODS: Prospective comparative clinical study of 11 patients meeting the American College of Rheumatology criteria for diagnosis of GCA. Patients unde...See full text at original site
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引用元：
https://doi.org/10.1136/bjo.86.5.530

データ提供：米国国立医学図書館（NLM）

Steroid Treatment and Temporal Artery Biopsy in Giant Cell Arteritis

This study investigates the impact of steroid treatment on the accuracy of temporal artery biopsies in patients diagnosed with giant cell arteritis (GCA), a condition that can cause inflammation of blood vessels in the head. The authors studied 11 patients who met the criteria for GCA diagnosis and performed temporal artery biopsies at different time points before and after steroid treatment. Their findings suggest that temporal artery biopsies are still helpful even after a few weeks of steroid treatment, despite the initial expectation that steroids might interfere with the results.

The Persistence of Biopsy Findings

Even after 4 or more weeks of steroid treatment, 86% of temporal artery biopsies were positive. This suggests that the inflammation associated with GCA can still be detected, even though the patient's symptoms might have improved. This discovery is important because it offers reassurance to clinicians who may be concerned about the accuracy of biopsies in patients receiving steroid therapy.

Implications for Diagnosis and Treatment

The results indicate that temporal artery biopsies can continue to play a vital role in the diagnosis and management of GCA, even in patients who have already received steroid treatment. This knowledge is crucial for accurate diagnosis and effective treatment planning. While steroids can be effective in controlling the inflammation, the biopsy results can help determine the extent of the disease and guide long-term treatment strategies.

Dr. Camel's Conclusion

This study sheds light on the enduring value of temporal artery biopsies in patients with GCA, even in the face of steroid treatment. The findings suggest that despite potential changes in the inflammatory response, biopsies can still accurately reveal the presence of the disease. This research adds valuable information to the diagnostic toolkit for GCA, helping clinicians make informed decisions about treatment and patient care.

Date :
  1. Date Completed 2002-06-12
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

11973248

DOI: Digital Object Identifier

10.1136/bjo.86.5.530

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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