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The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma.

Author: BeiserJulia A, BrandtJames D, GordonMae O, HeuerDale K, HigginbothamEve J, JohnsonChris A, KassMichael A, KeltnerJohn L, MillerJ Philip, ParrishRichard K, WilsonM Roy

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS. Central corneal thickness was found to be a powerful predictor for the development of POAG.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The Ocular Hypertension Treatment Study (OHTS) has shown that topical ocular hypotensive medication is effective in delaying or preventing the onset of primary open-angle glaucoma (POAG) in individuals with elevated intraocular pressure (ocular hypertension) and no evidence of glaucomato...See full text at original site
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引用元：
https://doi.org/10.1001/archopht.120.6.714

データ提供：米国国立医学図書館（NLM）

Predicting Glaucoma: A Sandstorm of Risk Factors

The Ocular Hypertension Treatment Study (OHTS) is a colossal effort to understand the development of primary open-angle glaucoma (POAG). This research, akin to a meticulous explorer charting a vast and unknown desert, aims to identify the factors that predict who will develop POAG. The study utilizes a [prospective, longitudinal study design] with a cohort of individuals with elevated intraocular pressure, but no signs of glaucoma.

The Landscape of Glaucoma Risk

The study found that [older age, larger vertical and horizontal cup-disc ratio, higher intraocular pressure, greater pattern standard deviation, and thinner central corneal measurement] were significant predictors of POAG development. The findings are like discovering a hidden pattern in the dunes of a desert, revealing the intricate factors that contribute to the development of glaucoma.

Keeping an Eye on Glaucoma

The OHTS study provides valuable information for early detection and management of glaucoma, which can [help preserve vision and prevent blindness]. It emphasizes the importance of regular eye exams, particularly for individuals at higher risk, and highlights the role of factors like central corneal thickness in predicting glaucoma development.

Dr. Camel's Conclusion

This research, like a wise desert nomad with keen eyesight, has identified key factors that can help predict the onset of glaucoma, allowing us to navigate the sandstorm of risks and potentially protect our precious vision.

Date :
  1. Date Completed 2002-06-17
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

12049575

DOI: Digital Object Identifier

10.1001/archopht.120.6.714

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・Effective treatment of glaucoma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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