Effective treatment of glaucoma: A Synthesis of Findings from 126 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of glaucoma: A Synthesis of Findings from 126 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Glaucoma, a leading cause of irreversible blindness worldwide, has various treatment options including medication, laser therapy, and surgery. 10 found that surgery resulted in the lowest mean intraocular pressure (IOP), which is the pressure inside the eye. This study also noted that surgery was most effective in controlling the diurnal swing of IOP, meaning the fluctuation of IOP throughout the day. Laser trabeculoplasty showed less pressure reduction compared to surgery, but it was associated with more frequent high pressure spikes. Medical therapy, unfortunately, was the least effective in lowering IOP. 63 highlights the effectiveness of laser iridotomy and laser iridoplasty in treating angle-closure glaucoma, a type of glaucoma where the angle between the iris and the cornea is narrowed, hindering fluid drainage from the eye. 88 underscores the importance of neuroprotective therapies for glaucoma, as these treatments aim to prevent damage to the optic nerve, the nerve connecting the eye to the brain, which is crucial for vision.

Treatment Summary

Treatment for glaucoma primarily aims to reduce IOP to prevent further optic nerve damage and vision loss. 10 suggests that surgery is the most effective treatment for lowering IOP and controlling its fluctuation. While laser therapy shows some effectiveness, it can lead to more pressure spikes, requiring further attention. Medical therapy, although a common starting point for glaucoma management, appears to be the least effective in lowering IOP. 63 advocates for laser iridotomy and iridoplasty as effective treatments for angle-closure glaucoma, often used when other options are ineffective. 88 emphasizes the potential benefit of neuroprotective therapies, which aim to protect the optic nerve from further damage.

Benefits and Risks

Benefits Summary

Glaucoma treatments, particularly those aimed at lowering IOP, can slow down the progression of vision loss and reduce the risk of blindness. By decreasing IOP, these treatments can help protect the optic nerve from further damage. Neuroprotective therapies also hold promise in preventing optic nerve damage and preserving vision.

Risks Summary

Like most medical interventions, glaucoma treatment carries some risks. Medications can cause side effects such as red eyes, eye irritation, and headaches. Laser therapy may lead to temporary pressure spikes, changes in iris color, or vision loss. Surgical procedures can result in complications like bleeding, infection, low IOP, or vision loss.

Comparison between Studies

Commonalities

Multiple studies concur that lowering IOP is essential in treating glaucoma. Surgery is frequently recognized as an effective method for IOP reduction.

Differences

Studies often differ in their focus, including the types of glaucoma studied, the treatment methods employed, and the specific outcomes evaluated. While 10 emphasizes the effectiveness of surgery, 63 highlights the benefit of laser treatment. These discrepancies may arise from the study design, the type of glaucoma being investigated, or other factors.

Consistency and Inconsistencies

Although there is consistency in the importance of lowering IOP, some discrepancies exist within the research. For instance, while many studies suggest that surgery effectively lowers IOP, 10 suggests that laser therapy might be safer compared to surgery. These inconsistencies may result from differences in study design, patient populations, or other factors, highlighting the need for further research.

Implications for Daily Life

If you are diagnosed with glaucoma, it's crucial to consult with a qualified eye doctor to determine the best treatment plan for your specific condition. The treatment approach will depend on several factors, including your age, symptoms, IOP, and visual acuity. Regular eye examinations are vital for early detection and management of glaucoma.

Limitations of Current Research

The effectiveness and safety of neuroprotective therapies for glaucoma remain uncertain and require further investigation. Additionally, research on personalized treatment options tailored to individual patient needs is needed.

Future Research Directions

Further research is needed to thoroughly assess the effectiveness and safety of neuroprotective therapies for glaucoma. Research focusing on the development of new treatment methods for glaucoma and personalized treatment approaches is crucial.

Conclusion

Glaucoma, while a serious eye condition, can be managed with effective treatment options. Lowering IOP is vital in preventing further damage and vision loss. It is essential to consult with a qualified eye doctor to determine the most appropriate treatment plan for your individual situation. Early detection and regular eye exams are crucial in managing glaucoma effectively.

List of Treatments

Medications, Laser Therapy (Trabeculoplasty, Iridotomy, Iridoplasty), Surgery (Trabeculectomy, Viscocanalostomy, Drainage devices, Lens Extraction), Neuroprotective therapies

Keywords
Benefit Keywords
Pressure control
1
Controlled intraocular pressure
2
Glaucoma treatment
3
Glaucoma treatment
4
Improved optic disc health
Reduced intraocular pressure
5
Improved intraocular pressure control
Improved visual field protection
7
Glaucoma treatment
8
Reduced intraocular pressure
10
Glaucoma treatment
11
IOP control
Visual field stability
12
Glaucoma treatment
13
Reduced intraocular pressure
14
Reduced intraocular pressure
15
Improved glaucoma outcomes
16
Lower intraocular pressure
Trend for better visual function
17
Reduced intraocular pressure
18
Reduced intraocular pressure
19
Improved visual field
Stable intraocular pressure
20
Glaucoma treatment
21
Effective treatment
Reduced pressure
22
Improved open-angle glaucoma treatment
23
Improved understanding of advanced glaucoma
24
Improved glaucoma outcomes
25
Effective treatment
Reduced complications
26
Glaucoma treatment
27
Effective treatment
28
Improved glaucoma treatment
29
Effective treatment
30
Reduced glaucoma damage
31
Lower IOP
32
Improved efficacy
Improved side effects
33
Glaucoma treatment
34
Delayed glaucoma onset
35
Glaucoma progression delay
36
Improved quality of life
OAG treatment
37
Significant IOP decrease
38
Lowered IOP
39
Treatment of glaucoma
40
Alternate aqueous pathways
Treats unresponsive glaucoma
41
Glaucoma treatment
42
Improved vision
Reduced intraocular pressure
Reduced risk of blindness
43
Delayed visual field deterioration
Reduced risk of glaucoma
44
Glaucoma treatment
45
Protect neurons
47
Glaucoma treatment
48
Effective for newly diagnosed OAG
Reduced IOP
49
Reduced shallow anterior chamber
Safe technique
50
Improved angle-closure glaucoma treatment
51
Glaucoma treatment
52
Fluctuation reduction
IOP control
53
Glaucoma treatment
Lowered intraocular pressure
54
Glaucoma treatment
55
POAG treatment
56
Glaucoma treatment
57
Glaucoma treatment
58
Improved secondary glaucoma treatment
60
PACG treatment
61
Reduced IOP
Reduced complications
62
Treatment of angle-closure glaucoma
63
Improved visual acuity
Lower IOP
64
Treatment of POAG
65
Glaucoma treatment
66
Glaucoma treatment
67
SLT no worse than ALT
SLT no worse than medical therapy
68
Glaucoma treatment
69
Glaucoma treatment
70
Antimetabolites
Trabeculectomy
71
Better tolerated
72
Reduced use of anti-glaucoma medications
73
Similar success rates
74
Reduced IOP
75
Anti-vascular endothelial growth factor
76
Glaucoma treatment
77
Lower IOP
Safe procedure
78
Cataract and glaucoma treatment
79
Open-angle glaucoma treatment
80
Glaucoma treatment
81
Cost reduction
Glaucoma treatment
IOP lowering
Quality of life improvement
Treatment tolerance
82
Glaucoma treatment
83
Glaucoma treatment
84
Effective treatment
Lowered medication
Reduced IOP
Safe procedure
86
Improved visual function
87
Glaucoma treatment
88
Glaucoma treatment
89
Improved HRQL
90
Reduced intraocular pressure
92
NVG treatment
Therapeutic strategies
93
Cyclodestructive procedures
Glaucoma treatment
Laser cyclophotocoagulation
94
Glaucoma treatment
IOP reduction
95
Improved QoL
Improved visual field
96
Aqueous shunt
Glaucoma treatment
97
IOP lowering
Safer IOP lowering
98
Cost-effective
Improved HRQoL
100
Glaucoma treatment
MIGS
101
Reduced intraocular pressure
102
Reduced IOP
Reduced medications
103
POAG treatment
104
IOP control
Reduced surgery
105
Glaucoma treatment
106
IOP reduction
SLT efficacy
107
OAG treatment
108
Less surgery
Medication free
Reduced IOP
109
Improved glaucoma treatment
110
Reduced intraocular pressure
111
Brimonidine for glaucoma
112
Trabeculectomy efficacy
Viscotrabeculotomy efficacy
113
Improved surgical competence
114
Ab interno trabecular bypass surgery for glaucoma
115
PACG treatment
116
Glaucoma treatment
117
Glaucoma treatment
118
Glaucoma treatment
119
SLT for open-angle glaucoma
120
Glaucoma treatment
121
Glaucoma treatment
122
Controls eye pressure
Slows glaucoma progression
123
SLT for OHT and OAG
124
SLT for OAG and OHT
125
Glaucoma treatment
126
Risk Keywords
Vision changes
1
Pressure rises
2
Cataract
7
Glaucoma
Iridoplasty failure
Visual field loss
12
Higher complication rate
20
Visual loss
22
Increased intra-ocular pressure
Scar tissue blocking channel
34
Increased lens opacity
36
Ocular redness
39
Bleb formation
Surgical complications
41
Side effects
43
Less effective than trabeculectomy
49
Hypotony
Irido-corneal touch
50
Angle-closure glaucoma
51
None reported
54
Glaucoma complications
55
Loss of visual acuity
64
Local ocular irritation
Serious complications
66
Iris incarceration
69
Glaucoma
Scar tissue
71
Conjunctival hyperemia
72
Safety issues
74
Low scientific evidence
75
Retinal disease
76
Post-laser inflammation
78
Hypotony
85
Ocular surface side effects
Periocular side effects
92
Suboptimal adherence
95
Lack of high-quality evidence
98
Uncertain effectiveness
101
IOP spike
102
None reported
105
Intraocular bleeding
Vision loss
109
Hyphema
IOP spike
113
Low adherence
121
Literature analysis of 126 papers
Positive Content
119
Neutral Content
6
Negative Content
1
Article Type
78
27
37
32
126
1.

Visual effects of pilocarpine in glaucoma comparative study of administration by eyedrops or by ocular therapeutic systems.

Author: BrownH S, MeltzerG, MerrillR C, FisherM, FerréC, PlaceV A

Pressure control
Vision changes

A study of 18 glaucoma patients compared the effects of pilocarpine eye drops and pilocarpine ocular therapeutic systems. While both treatments effectively lowered intraocular pressure, the ocular therapeutic systems maintained pressure at a more consistent level. Eye drops caused more significant and variable changes in vision and pupil size compared to the therapeutic systems. These visual changes were temporary, with effects peaking 30 minutes after eye drop instillation and gradually returning to normal within 2-3 hours.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Primary argon laser trabeculoplasty vs. pilocarpine. Short-term effects.

Author: BergeåB, SvedberghB

Controlled intraocular pressure
Pressure rises

A prospective study of 82 patients with simplex or capsular glaucoma found that primary laser treatment resulted in a significantly higher number of patients with controlled intraocular pressure compared to pilocarpine. Argon laser trabeculoplasty was effective in lowering intraocular pressure, with the first treatment yielding the greatest reduction. A pressure-lowering medication on the day of treatment is recommended due to potential pressure spikes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

The Glaucoma Laser Trial: 4. Contralateral effects of timolol on the intraocular pressure of eyes treated with ALT. GLT Research Group.

Author:

Glaucoma treatment

This study examined the effect of timolol, a medication used to lower eye pressure, on the untreated eye in patients with glaucoma. Previous studies showed that applying timolol to one eye could reduce pressure in the other eye. This study, which investigated laser treatment for glaucoma, found a smaller reduction in pressure in the untreated eye. The study suggests that factors like lower initial eye pressure, longer treatment with timolol, and improved drainage in the treated eye may have contributed to the smaller effect in the untreated eye.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

The Glaucoma Laser Trial (GLT). 2. Results of argon laser trabeculoplasty versus topical medicines. The Glaucoma Laser Trial Research Group.

Author:

Glaucoma treatment

This study compared the effectiveness of laser treatment (ALT) to eye drops (timolol) in 271 patients with newly diagnosed glaucoma. After two years, patients who received laser treatment had lower average eye pressure and were less likely to need multiple eye drops to control pressure. However, both treatments resulted in similar outcomes for vision and visual field. The study suggests that laser treatment may be a valuable alternative to eye drops for managing glaucoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

5.

Laser trabeculoplasty versus medication treatment as primary therapy for glaucoma.

Author: TuulonenA, KoponenJ, AlankoH I, AiraksinenP J

Improved optic disc health
Reduced intraocular pressure

A study of 39 patients with open-angle glaucoma compared laser trabeculoplasty with medication therapy over 1 year. There was no significant difference in success rates, pressure reduction, or optic nerve or visual field changes between the two groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

[Argon laser trabeculoretraction in chronic open-angle glaucoma with normal pressure. A prospective study on the tonometric and perimetric effect].

Author: DemaillyP, LehrerM, KretzG

A study of 35 patients with low-tension glaucoma found that argon laser trabeculoplasty (ALT) did not affect intraocular pressure or visual field changes compared to medical management alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

7.

Early trabeculectomy versus conventional management in primary open angle glaucoma.

Author: JayJ L, MurrayS B

Improved intraocular pressure control
Improved visual field protection
Cataract

A study comparing early trabeculectomy with medical management for primary open angle glaucoma found that early surgery provided more stable control with fewer treatment changes and better visual field protection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

[Surgical peripheral iridectomy and argon laser iridotomy in primary closed-angle glaucoma. Comparative statistical study].

Author: Savelsbergh-FilletteM P, DemaillyP

Glaucoma treatment

This study compared the effectiveness of surgical iridotomy (a procedure to create an opening in the iris) and laser iridotomy in treating 60 eyes with angle-closure glaucoma. Patients were randomly assigned to receive either surgical iridotomy or laser iridotomy. The study found that both treatments were equally effective in reducing eye pressure, maintaining good vision, and preventing complications. The study concludes that both surgical and laser iridotomy are effective treatments for angle-closure glaucoma and offer similar long-term outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

9.

Treatment versus no treatment in chronic open angle glaucoma.

Author: HolminC, ThorburnW, KrakauC E

This study investigated the effectiveness of medication in slowing vision loss in 15 patients with open-angle glaucoma. Patients were randomly assigned to receive either treatment or no treatment. The study found no significant difference in the rate of vision loss between the groups, even though the treated group had a 4 mmHg decrease in eye pressure. The study concludes that while reducing eye pressure is important, it is difficult to conduct a randomized trial for glaucoma treatment due to the difficulty in controlling patient adherence and the potential for ethical concerns.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Control of chronic simple glaucoma with primary medical, surgical and laser treatment.

Author: MigdalC, HitchingsR

Reduced intraocular pressure

A study of 168 patients with chronic simple glaucoma found that surgery was most effective in lowering intraocular pressure, followed by laser trabeculoplasty and medical therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

[Effectiveness and tolerance of an active combination of timolol and pilocarpine--a pilot project].

Author: SchnarrK D, MertéH J

Glaucoma treatment

This study investigated whether combining timolol with pilocarpine in eye drops could further lower eye pressure in patients with glaucoma who were already taking timolol. The study found that combining timolol with pilocarpine significantly lowered eye pressure, with the greatest effect seen after 6 hours (for the 2% pilocarpine combination) and 12 hours (for the 4% pilocarpine combination). The study concludes that these combined treatments may be beneficial for patients with glaucoma who need additional pressure reduction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

12.

Argon laser trabeculoplasty in narrow angle glaucoma.

Author: WishartP K, NagasubramanianS, HitchingsR A

IOP control
Visual field stability
Glaucoma
Iridoplasty failure
Visual field loss

This study investigated the effectiveness of different treatments for narrow-angle glaucoma, a condition where the eye's drainage system is blocked. Patients were randomly assigned to receive either laser iridotomy (LI) or surgical iridotomy (PI), followed by laser trabeculoplasty (ALT), or ALT alone. The study found that ALT after PI or LI was not effective in controlling eye pressure or preventing vision loss. In fact, more than half of the patients who had ALT after PI or LI had further narrowing of the drainage angle. The study concludes that laser trabeculoplasty is not a suitable treatment for narrow-angle glaucoma, especially with existing vision loss, and that relief of the blockage alone may be more effective for early cases without vision loss.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Effects of laser trabeculoplasty on intraocular pressure in the medically untreated eye.

Author: DouglasG R, WijsmanK

Glaucoma treatment

A study of 38 patients with glaucoma found that laser trabeculoplasty with 50 or 100 burns resulted in significant pressure reduction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Laser trabeculoplasty as supplementary treatment for primary open angle glaucoma.

Author: SherwoodM B, LattimerJ, HitchingsR A

Reduced intraocular pressure

A study of elderly patients with open angle glaucoma found that laser trabeculoplasty was effective in reducing intraocular pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Argon laser trabeculoplasty or trabeculectomy a prospective randomised block study.

Author: WatsonP G, AllenE D, GrahamC M, PorterG P, PickeringM S

Reduced intraocular pressure

A study comparing argon laser trabeculoplasty and trabeculectomy for chronic open angle glaucoma found that trabeculectomy was more effective in permanently reducing intraocular pressure to normal limits.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Primary therapy for chronic simple glaucoma the role of argon laser trabeculoplasty.

Author: MigdalC, HitchingsR

Improved glaucoma outcomes

A study comparing laser, medical, and surgical treatment for chronic simple glaucoma found that surgical trabeculectomy is the preferred treatment for patients with advanced disease, while laser trabeculoplasty is a good option for other patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Earlier trabeculectomy.

Author: JayJ L

Lower intraocular pressure
Trend for better visual function

A study comparing early trabeculectomy with medical management for primary open angle glaucoma found that early surgery provided more stable control with fewer treatment changes and better visual field protection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

One- and two-session laser trabeculoplasty. A randomized, prospective study.

Author: HeijlA

Reduced intraocular pressure

In a study of 77 people with glaucoma, laser treatment to the full circumference of the eye in one session was compared to treatment in two sessions, one month apart. Both methods reduced eye pressure equally well. However, three patients who received treatment in one session experienced a temporary, high spike in pressure after treatment. While this difference was not statistically significant, it aligns with other studies suggesting that a two-session approach may be safer than treating the entire eye at once.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Laser trabeculoplasty. A prospective study of treatment variables.

Author: LustgartenJ, PodosS M, RitchR, FischerR, StetzD, ZborowskiL, BoasR

Reduced intraocular pressure

A study of 45 patients with glaucoma and uncontrolled eye pressure compared three different laser trabeculoplasty techniques. The study found that while all three groups showed a reduction in eye pressure after four weeks, the group receiving 100 spots over 360 degrees (group 1) had significantly more eyes with a greater than 12mmHg reduction in pressure compared to the other groups. Group 2, with 50 spots over 180 degrees, tended to have the fewest eyes requiring medication reduction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

20.

A comparison between peripheral iridectomy with thermal sclerostomy and trabeculectomy: a controlled study.

Author: SpaethG L, PoryzeesE

Improved visual field
Stable intraocular pressure
Higher complication rate

In a study of 15 people with glaucoma who underwent two different surgeries in each eye, peripheral iridectomy with thermal sclerostomy had a higher rate of immediate complications than trabeculectomy. However, after one year and five years, both procedures achieved similar control of eye pressure and vision. The average final eye pressure was lower in the group that received peripheral iridectomy with thermal sclerostomy (16 mmHg) compared to the trabeculectomy group (22 mmHg). However, twice as many people in the trabeculectomy group required additional medication to maintain eye pressure. The mechanism of pressure control was primarily through filtering in the iridectomy with thermal sclerostomy group, while it was less common in the trabeculectomy group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

The Glaucoma Laser Trial (GLT): 6. Treatment group differences in visual field changes. Glaucoma Laser Trial Research Group.

Author:

Glaucoma treatment

Eyes treated with argon laser trabeculoplasty first had slightly better visual field status than those treated with topical medication first during a 3.5-year follow-up period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

22.

Noncontact transscleral Nd:YAG cyclophotocoagulation: a long-term follow-up of 500 patients.

Author: ShieldsM B, ShieldsS E

Effective treatment
Reduced pressure
Visual loss

Transscleral cyclophotocoagulation was effective in reducing eye pressure in 94% of patients with high-risk glaucoma, with one or more treatment sessions. However, visual loss occurred in 39% of patients, particularly those with neovascular glaucoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Long-term functional outcome after early surgery compared with laser and medicine in open-angle glaucoma.

Author: MigdalC, GregoryW, HitchingsR

Improved open-angle glaucoma treatment

This study compared the effectiveness of laser trabeculoplasty, medical therapy, and trabeculectomy in treating open-angle glaucoma in patients who had not previously received treatment. The study focused on the ability of each treatment to control intraocular pressure and minimize visual field loss.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

The Advanced Glaucoma Intervention Study (AGIS): 1. Study design and methods and baseline characteristics of study patients.

Author: EdererF, GaasterlandD E, SullivanE K,

Improved understanding of advanced glaucoma

The Advanced Glaucoma Intervention Study (AGIS) is a long-term study of 789 eyes from 591 patients with advanced glaucoma. The study is designed to investigate the long-term course and outcomes of the disease and compare two different surgical treatment sequences. One sequence starts with laser treatment, followed by traditional filtering surgery if needed, then a second filtering surgery if the first fails. The other sequence starts with filtering surgery, followed by laser treatment if needed, and then a second filtering surgery. The main outcomes of the study include visual function, eye pressure, complications, and the need for additional medications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

25.

Primary argon laser trabeculoplasty vs pilocarpine. II: Long-term effects on intraocular pressure and facility of outflow. Study design and additional therapy.

Author: BergeåB, BodinL, SvedberghB

Improved glaucoma outcomes

A study of 82 patients with glaucoma compared laser trabeculoplasty to pilocarpine medication. Over a two-year follow-up, laser treatment resulted in a higher success rate with less need for additional therapy. The laser group had lower average and peak intraocular pressure and significantly less variation in daytime pressure. Laser treatment was particularly effective for capsular glaucoma, achieving significantly lower average pressure than medication. In simple glaucoma, both treatments had similar effects. Higher initial intraocular pressure was associated with lower success rates. The study suggests that laser trabeculoplasty may be a more effective treatment for glaucoma compared to pilocarpine medication.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Trabeculotomy ab externo: an alternative treatment in adult patients with primary open-angle glaucoma.

Author: ChiharaE, NishidaA, KodoM, YoshimuraN, MatsumuraM, YamamotoM, TsukadaT

Effective treatment
Reduced complications

Modified trabeculotomy ab externo (TAB) and trabeculectomy with adjunctive mitomycin C (TMC) had similar success rates in controlling intraocular pressure in patients with primary open-angle glaucoma. However, TAB had significantly fewer postoperative complications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

27.

The Glaucoma Laser Trial (GLT) and glaucoma laser trial follow-up study: 7. Results. Glaucoma Laser Trial Research Group.

Author:

Glaucoma treatment

Initial treatment with argon laser trabeculoplasty was at least as efficacious as initial treatment with topical medication.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

28.

Direct costs of glaucoma management following initiation of medical therapy. A simulation model based on an observational study of glaucoma treatment in Germany.

Author: KobeltG, JönssonL, GerdthamU, KrieglsteinG K

Effective treatment

This study examines the cost-effectiveness of different treatment strategies for glaucoma in Germany. The study focuses on patients newly diagnosed with primary open-angle glaucoma (POAG) or ocular hypertension (OH). Because the link between eye pressure (IOP) and blindness is not fully understood, the study measures the effectiveness of treatments based on their ability to control IOP over time. The study aims to assess the impact of new eye drops on the overall cost of glaucoma treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

The Collaborative Initial Glaucoma Treatment Study: study design, methods, and baseline characteristics of enrolled patients.

Author: MuschD C, LichterP R, GuireK E, StandardiC L

Improved glaucoma treatment

The Collaborative Initial Glaucoma Treatment Study (CIGTS) is a research study that compared two treatments for newly diagnosed open-angle glaucoma: initial medication versus immediate surgery. This study aimed to determine which approach resulted in better outcomes for patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

30.

Post-operative 5-fluorouracil for glaucoma surgery.

Author: WormaldR, WilkinsM R, BunceC

Effective treatment

Trabeculectomy is a surgery for glaucoma that creates a channel in the eye to reduce pressure. However, scar tissue can block this channel, causing the surgery to fail. To prevent this, antimetabolites like 5-Fluorouracil and Mitomycin C are used to slow down wound healing. These medications are applied during or after surgery to help keep the channel open.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Long-term effects of timolol therapy in ocular hypertension: a double-masked, randomised trial.

Author: HeijlA, BengtssonB

Reduced glaucoma damage

While high intraocular pressure (IOP) is a major risk factor for glaucoma, it is unclear whether lowering IOP can actually prevent glaucoma damage in people with ocular hypertension. This study aimed to investigate this question over a long period of time.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

Primary viscocanalostomy versus trabeculectomy in white patients with open-angle glaucoma: A randomized clinical trial.

Author: Jonescu-CuypersC, JacobiP, KonenW, KrieglsteinG

Lower IOP

Trabeculectomy was more effective than viscocanalostomy in lowering intraocular pressure (IOP) in glaucomatous eyes. A randomized controlled trial involving 20 patients with open-angle glaucoma found that trabeculectomy achieved success in 50% of cases compared to 0% for viscocanalostomy after a mean follow-up of 6 months.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Clinical and economic impact of new trends in glaucoma treatment.

Author: MarchettiA, MagarR, AnP, NicholM

Improved efficacy
Improved side effects

This study compared the effectiveness and cost implications of two glaucoma treatments: brimonidine and betaxolol. While traditional glaucoma treatments have side effects, newer medications like these offer improved benefits and fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Post-operative 5-Fluorouracil for glaucoma surgery.

Author: WormaldR, WilkinsM R, BunceC

Glaucoma treatment
Increased intra-ocular pressure
Scar tissue blocking channel

Trabeculectomy is a surgery used to treat various types of glaucoma by lowering intraocular pressure. It creates a channel in the eye's outer layer to allow fluid to drain. However, scar tissue can block this channel, causing pressure to rise and making the surgery unsuccessful. Antimetabolites like 5-Fluorouracil are used to slow down wound healing and prevent scarring that could block the drainage channel.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma.

Author: GordonMae O, BeiserJulia A, BrandtJames D, HeuerDale K, HigginbothamEve J, JohnsonChris A, KeltnerJohn L, MillerJ Philip, ParrishRichard K, WilsonM Roy, KassMichael A

Delayed glaucoma onset

Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS. Central corneal thickness was found to be a powerful predictor for the development of POAG.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

36.

Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial.

Author: HeijlAnders, LeskeM Cristina, BengtssonBo, HymanLeslie, BengtssonBoel, HusseinMohamed,

Glaucoma progression delay
Increased lens opacity

The Early Manifest Glaucoma Trial showed that early intervention with IOP reduction significantly delayed glaucoma progression compared to no treatment. This benefit was observed in patients with both elevated and normal IOP, and across different age groups, visual field loss levels, and glaucoma types. However, treatment was associated with an increased incidence of nuclear lens opacity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

37.

Collaborative Initial Glaucoma Treatment Study: a summary of results to date.

Author: FeinerLeonard, Piltz-SeymourJody R,

Improved quality of life
OAG treatment

This review summarizes the findings of a study comparing medical treatment and surgery (trabeculectomy) for open-angle glaucoma (OAG). The study examined the effectiveness of each treatment on vision, eye pressure, and quality of life.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

38.

Replacing maximum-tolerated medications with latanoprost versus adding latanoprost to maximum-tolerated medications: a two-center randomized prospective trial.

Author: GandolfiStefano A, RossettiLuca, CiminoLuca, MoraPaolo, TardiniMariagrazia, OrzalesiNicola

Significant IOP decrease

In glaucomatous eyes with poorly controlled intraocular pressure upon combination therapy, both the substitution of the pre-existing treatment with latanoprost and the addition of latanoprost to the pre-existing therapy provided a significant IOP decrease. However, adding latanoprost to the pre-existing therapy was more likely to achieve a target intraocular pressure less than or equal to 18 mm Hg.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

39.

Ocular hypotensive efficacy of bimatoprost 0.03% and travoprost 0.004% in patients with glaucoma or ocular hypertension.

Author: CantorLouis B, WuDunnDarrell, CortesArnold, HoopJoni, KnottsStephenie

Lowered IOP
Ocular redness

This study compared the efficacy of bimatoprost and travoprost in lowering intraocular pressure (IOP) in patients with glaucoma or ocular hypertension. Both medications significantly reduced IOP after 6 months of treatment, but bimatoprost provided larger mean IOP reductions and more patients achieved low target pressures. Both medications were well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

Factors for progression and glaucoma treatment: the Early Manifest Glaucoma Trial.

Author: LeskeM Cristina, HeijlAnders, HymanLeslie, BengtssonBo, KomaroffEugene

Treatment of glaucoma

The review summarizes factors that contribute to progression in early glaucoma, including the effect of treatment, based on the Early Manifest Glaucoma Trial (EMGT) data.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

41.

Glaucoma drainage devices: a systematic literature review and current controversies.

Author: HongChian-Huey, ArosemenaAnalisa, ZurakowskiDavid, AyyalaRamesh S

Alternate aqueous pathways
Treats unresponsive glaucoma
Bleb formation
Surgical complications

This review examines the use of glaucoma drainage devices, which are increasingly being used to treat glaucoma that doesn't respond to medications or trabeculectomy, and provides a systematic overview of the literature, including controversies surrounding different device designs, surgical success rates, and potential complications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

[Results of the Collaborative Initial Glaucoma Treatment Study (CIGTS)].

Author: WahlJ

Glaucoma treatment

This study compared two treatments for newly diagnosed open-angle glaucoma: medications and surgery (trabeculectomy). Both treatments lowered eye pressure, but surgery was more effective. While the two groups reported similar quality of life, patients treated with medications had slightly more eye symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

43.

Gold standard medical therapy for glaucoma: defining the criteria identifying measures for an evidence-based analysis.

Author: ObstbaumStephen A, CioffiGeorge A, KrieglsteinGuenther K, FennertyM Brian, AlmAlbert, AraieMakoto, CarassaRoberto G, GreveErik L, HitchingsRoger A, KaufmanPaul L, KitazawaYoshiaki, PongpunPrin Rojana, SusannaRemo, WaxMartin B, ZimmermanThom J

Improved vision
Reduced intraocular pressure
Reduced risk of blindness
Side effects

A gold standard treatment for primary open-angle glaucoma (POAG) should consistently reduce intraocular pressure (IOP) over 24 hours, be safe and well tolerated, promote patient compliance, and be effective in diverse patient populations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Treatment of ocular hypertension and open angle glaucoma: meta-analysis of randomised controlled trials.

Author: MaierPhilip C, FunkJens, SchwarzerGuido, AntesGerd, Falck-YtterYngve T

Delayed visual field deterioration
Reduced risk of glaucoma

Meta-analysis of trials showed that lowering intraocular pressure in patients with ocular hypertension or manifest glaucoma is beneficial in reducing the risk of visual field loss in the long term.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

45.

Baseline IOP predicts selective laser trabeculoplasty success at 1 year post-treatment: results from a randomised clinical trial.

Author: HodgeW G, DamjiK F, RockW, BuhrmannR, BovellA M, PanY

Glaucoma treatment

The study aimed to determine factors that predict successful selective laser trabeculoplasty (SLT) at 1 year post-treatment, highlighting its potential to replace argon laser trabeculoplasty (ALT) as the standard procedure for treating medically uncontrolled open angle glaucoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

46.

A Markov modelled pharmacoeconomic analysis of bimatoprost 0.03% in the treatment of glaucoma as an alternative to filtration surgery in Italy.

Author: ChristensenTorsten Lundgaard, PoulsenPeter Bo, HolmstromStefan, WaltJohn G, VetrugnoMichele

This pharmacoeconomic analysis compares the 4-year costs of bimatoprost 0.03% eye drops to filtration surgery (FS) as treatments for glaucoma patients on maximum tolerable medical therapy (MTMT).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

47.

Special considerations in low-tension glaucoma.

Author: KrupinTheodore

Protect neurons

This review examines low-pressure (low-tension) glaucoma in relation to neuroprotection and discusses baseline results from the Low-Pressure Glaucoma Treatment Study (LoGTS).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

48.

[Modified viscocanalostomy for the surgical treatment with primary open angle glaucoma].

Author: YuanZhi-lan, YangQin, ChenQin, ZhangWei-zhong, SunHong

Glaucoma treatment

Viscocanalostomy (VCO) showed long-term advantages over trabeculectomy in patients with primary open angle glaucoma (POAG). VCO resulted in better IOP control, a higher complete success rate, and fewer early transient postoperative complications.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

49.

Laser trabeculoplasty for open angle glaucoma.

Author: Rolim de MouraC, ParanhosA, WormaldR

Effective for newly diagnosed OAG
Reduced IOP
Less effective than trabeculectomy

Laser trabeculoplasty is a treatment for open angle glaucoma (OAG) that has not yet been fully established. This review analyzed 19 trials involving 2137 participants. In people with newly diagnosed OAG, laser trabeculoplasty was more effective than older medications used in the 1990s in controlling intraocular pressure (IOP) at two years. However, trabeculoplasty was less effective than trabeculectomy in controlling IOP at six months and two years. There is no evidence to determine the effectiveness of laser trabeculoplasty compared to contemporary medications (prostaglandin analogues, topical anhydrase inhibitors, and alpha2-agonists) or to contemporary surgical techniques. Further research is needed to determine the effectiveness of laser trabeculoplasty in specific racial groups, diagnostic groups, and stages of OAG.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Effectiveness of combination of permanent and releasable scleral flap sutures in trabeculectomy: a randomized clinical trial.

Author: KumariR, BadhuB P, DasH

Reduced shallow anterior chamber
Safe technique
Hypotony
Irido-corneal touch

A study comparing trabeculectomy with either traditional sutures or a combination of permanent and releasable sutures found that the combination of sutures significantly reduced the risk of a shallow anterior chamber after surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

51.

Laser peripheral iridoplasty for angle-closure.

Author: NgWai Siene, AngGhee Soon, Azuara-BlancoAugusto

Improved angle-closure glaucoma treatment
Angle-closure glaucoma

Angle-closure glaucoma is a major cause of irreversible blindness worldwide. Treatment aims to open the drainage angle in the eye and lower eye pressure using medications and/or surgery. Laser iridotomy is often used to widen the drainage angle by creating a small opening in the iris. If laser iridotomy is unsuccessful, laser iridoplasty may be used to shrink and pull the iris away from the drainage area. Laser iridoplasty can be used for acute angle closure as well as for ongoing problems.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Changes in visual function after intraocular pressure reduction using antiglaucoma medications.

Author: PrataT S, PiassiM V, MeloL A S

Glaucoma treatment

Visual quality perception, visual field mean deviation index, and contrast sensitivity at higher frequencies improve after starting glaucoma therapy. No correlation was found between IOP reduction and changes in visual function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

Intraocular pressure control and fluctuation: the effect of treatment with selective laser trabeculoplasty.

Author: NagarM, LuhishiE, ShahN

Fluctuation reduction
IOP control

Both selective laser trabeculoplasty (SLT) and latanoprost had a significant impact on intraocular pressure (IOP) control and fluctuation. SLT has the benefit of being a one-time intervention not requiring ongoing patient compliance.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

54.

Selective laser trabeculoplasty versus argon laser trabeculoplasty in patients with uncontrolled open-angle glaucoma.

Author: RussoVincenzo, BaroneAntonio, CosmaAnnesa, StellaAndrea, Delle NociNicola

Glaucoma treatment
Lowered intraocular pressure
None reported

SLT is effective as treatment for patients with OAG and appears to be equivalent to ALT in IOP lowering at 12 months only in patients without a prior treatment. In case of retreatment SLT appears to be better than ALT in IOP lowering.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

55.

Efficacy and tolerability of nonpenetrating filtering surgery in the treatment of open-angle glaucoma: a meta-analysis.

Author: ChengJin-Wei, XiGui-Lin, WeiRui-Li, CaiJi-Ping, LiYou

Glaucoma treatment
Glaucoma complications

Viscocanalostomy and deep sclerectomy were less effective than trabeculectomy in the treatment of open-angle glaucoma, but were associated with fewer complications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

56.

Mixed treatment comparison and meta-regression of the efficacy and safety of prostaglandin analogues and comparators for primary open-angle glaucoma and ocular hypertension.

Author: OrmeM, CollinsS, DakinH, KellyS, LoftusJ

POAG treatment

This analysis addresses methodological challenges in synthesizing data from glaucoma clinical trials due to variations in study methodology and intraocular pressure (IOP) measurement. Primary open-angle glaucoma (POAG) is a chronic condition characterized by optic neuropathy and vision loss, and IOP management is a key aspect of treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

57.

Neuroprotection for treatment of glaucoma in adults.

Author: SenaDayse F, RamchandKanchan, LindsleyKristina

Glaucoma treatment

Glaucoma is a group of eye conditions that damage the optic nerve, leading to vision loss. It is a major cause of blindness worldwide. Open-angle glaucoma (OAG), the most common type, is a chronic condition that may or may not involve high eye pressure. Neuroprotection for glaucoma aims to prevent damage to the optic nerve or cell death. Treatments can target factors outside the cells, such as lowering eye pressure, or factors within the cells, such as blocking signals that cause cell death.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

58.

Intraocular pressure reduction with a fixed treatment protocol in the Early Manifest Glaucoma Trial.

Author: HeijlAnders, LeskeM Cristina, HymanLeslie, YangZhongming, BengtssonBoel,

Glaucoma treatment

This study investigates the relationship between intraocular pressure (IOP) reduction achieved with a fixed treatment protocol and the initial IOP level in patients with glaucoma. It also examines the consistency of IOP reduction over time and explores the existence of a threshold IOP below which treatment may be less effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

59.

The effect of trabeculectomy on intraocular pressure of the untreated fellow eye in the collaborative initial glaucoma treatment study.

Author: RadcliffeNathan M, MuschDavid C, NiziolLeslie M, LiebmannJeffrey M, RitchRobert,

Trabeculectomy in one eye did not substantially affect the intraocular pressure (IOP) of the untreated fellow eye in patients with open-angle glaucoma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

60.

[Long-term results of secondary glaucoma surgical treatment].

Author: AlekseevV N, LevkoM A, HamedSalah Mohammed

Improved secondary glaucoma treatment

This study compared the efficacy of deep sclerectomy with angle dilatation to conventional sinusotrabeculectomy in treating secondary glaucoma. Deep sclerectomy with angle dilatation showed superior results in terms of stable IOP reduction, natural long-term hydrodynamics, and prolonged visual function preservation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

61.

The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): study protocol for a randomized controlled trial.

Author: Azuara-BlancoAugusto, BurrJennifer M, CochranClaire, RamsayCraig, ValeLuke, FosterPaul, FriedmanDavid, QuayyumZahidul, LaiJimmy, NolanWinnie, AungTin, ChewPaul, McPhersonGladys, McDonaldAlison, NorrieJohn,

PACG treatment

Glaucoma, a leading cause of blindness, is particularly severe in its angle-closure form. The current standard treatment combines laser surgery and eye drops to lower pressure. This study, EAGLE, investigates whether early removal of the eye's lens, which plays a role in angle-closure glaucoma, could improve outcomes, reduce the need for medications and surgery, and improve quality of life compared to the standard approach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

62.

Systematic overview of the efficacy of nonpenetrating glaucoma surgery in the treatment of open angle glaucoma.

Author: ChengJin-Wei, ChengShi-Wei, CaiJi-Ping, LiYou, WeiRui-Li

Reduced IOP
Reduced complications

Deep sclerectomy and viscocanalostomy are less effective than trabeculectomy in lowering intraocular pressure (IOP). However, both nonpenetrating glaucoma surgeries (NPGS) are associated with fewer complications than trabeculectomy.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

63.

Laser peripheral iridoplasty for angle-closure.

Author: NgWai Siene, AngGhee Soon, Azuara-BlancoAugusto

Treatment of angle-closure glaucoma

Angle-closure glaucoma is a major cause of irreversible blindness worldwide. Treatment aims to open the drainage angle in the eye and lower eye pressure using medications and/or surgery. Laser iridotomy is often used to widen the drainage angle by creating a small opening in the iris. If laser iridotomy is unsuccessful, laser iridoplasty may be used to shrink and pull the iris away from the drainage area. Laser iridoplasty can be used for acute angle closure as well as for ongoing problems.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

64.

A study of initial therapy for glaucoma in southern India: India Glaucoma Outcomes and Treatment (INGOT) Study.

Author: CongdonNathan G, KrishnadasR, FriedmanDavid S, GogginsWilliam, RamakrishnanR, KaderM A, GilbertDonna, TielschJames, QuigleyHarry A

Improved visual acuity
Lower IOP
Loss of visual acuity

Trabeculectomy lowered intraocular pressure (IOP) significantly more than medical treatment, but with a slightly greater loss of visual acuity. Combined phaco/IOL and trabeculectomy improved visual acuity with substantial IOP lowering.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

65.

Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy.

Author: VetrugnoMichele, UvaMaurizio G, RussoVincenzo, IesterMichele, CiancagliniMarco, BrusiniPaolo, CentofantiMarco, RossettiLuca M

Treatment of POAG

Lowering eye pressure (IOP) is the only current treatment for primary open angle glaucoma (POAG). However, some patients don't respond well to eye drops, and even with multiple medications, their eye pressure doesn't reach the target level. Forskolin, a natural compound, has shown promise in reducing IOP when applied to the eye.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

66.

Comparative effectiveness of treatments for open-angle glaucoma: a systematic review for the U.S. Preventive Services Task Force.

Author: BolandMichael V, ErvinAnn-Margret, FriedmanDavid S, JampelHenry D, HawkinsBarbara S, VollenweiderDaniela, ChelladuraiYohalakshmi, WardDarcy, Suarez-CuervoCatalina, RobinsonKaren A

Glaucoma treatment
Local ocular irritation
Serious complications

Medical and surgical treatments for open-angle glaucoma decrease intraocular pressure and reduce the risk of optic nerve damage in the short to medium term. However, the effects of these treatments on visual impairment are unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

67.

Neuroprotection for treatment of glaucoma in adults.

Author: SenaDayse F, LindsleyKristina

Glaucoma treatment

Glaucoma is a group of eye conditions that damage the optic nerve, leading to vision loss. Open angle glaucoma (OAG) is the most common type and may or may not involve high pressure inside the eye. Neuroprotection for glaucoma refers to treatments that aim to prevent damage to the optic nerve and cell death.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

Selective laser trabeculoplasty (SLT) vs other treatment modalities for glaucoma: systematic review.

Author: McAlindenC

SLT no worse than ALT
SLT no worse than medical therapy

SLT showed no significant difference in IOP-lowering effect compared to ALT, medical therapy, and 360° SLT. However, 180° SLT was found to be more efficacious than 90° SLT. ELT showed greater IOP reduction than 180° SLT in the long term.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

[Post-surgical treatment after non-penetrating glaucoma surgery: the goniopuncture].

Author: GesserC, KlemmM

Glaucoma treatment
Iris incarceration

This study recommends a procedure called goniopuncture as the first choice for treating high eye pressure after certain types of glaucoma surgery that don't involve opening the eye directly. Goniopuncture uses a laser to make small holes in the eye's drainage system, helping to lower pressure. This approach may be preferable to starting or restarting eye drops.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

70.

Impact of patient access to Internet health records on glaucoma medication: randomized controlled trial.

Author: KashiwagiKenji, TsukaharaShigeo

Glaucoma treatment

Glaucoma is a major cause of blindness. Lowering pressure inside the eye is the only proven way to prevent damage to the optic nerve. Most people with glaucoma need to use eye drops for the rest of their lives. It is very important for patients to consistently use their eye drops as prescribed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

71.

5-Fluorouracil for glaucoma surgery.

Author: GreenElspeth, WilkinsMark, BunceCatey, WormaldRichard

Antimetabolites
Trabeculectomy
Glaucoma
Scar tissue

This review examines the use of antimetabolites like 5-Fluorouracil (5-FU) to prevent scarring after trabeculectomy, a surgery for glaucoma. 5-FU helps lower intraocular pressure, but scarring can block the surgically created channel, causing the surgery to fail. The review updates previous research on this topic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

72.

Meta-analysis of randomized controlled trials comparing latanoprost with other glaucoma medications in chronic angle-closure glaucoma.

Author: LiJingjing, LinXiaoti, YuMinbin

Better tolerated
Conjunctival hyperemia

Travoprost and bimatoprost were superior to latanoprost in controlling intraocular pressure (IOP) in patients with chronic angle-closure glaucoma (CACG). However, latanoprost was better tolerated.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

73.

[Meta-analysis of randomized controlled trials comparing selective laser trabeculoplasty with prostaglandin analogue in the primary treatment of open-angle glaucoma or ocular hypertention].

Author: PengWei, ZhongXiao, YuMinbin

Reduced use of anti-glaucoma medications

Selective laser trabeculoplasty (SLT) was no more effective than prostaglandin analogue (PGA) in treating open angle glaucoma (OAG) or ocular hypertension (OHT). Although PGA resulted in a greater reduction in intraocular pressure (IOP), SLT reduced the use of anti-glaucoma medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Chinese

74.

Five-year treatment outcomes in the Ahmed Baerveldt comparison study.

Author: BudenzDonald L, BartonKeith, GeddeSteven J, FeuerWilliam J, SchiffmanJoyce, CostaVital P, GodfreyDavid G, BuysYvonne M,

Similar success rates
Safety issues

Both the Ahmed FP7 Glaucoma Valve and the Baerveldt 101-350 Glaucoma Implant showed similar rates of surgical success at 5 years. However, the Baerveldt implant produced greater IOP reduction and a lower rate of glaucoma reoperation, but it was associated with twice as many failures due to safety issues.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

75.

Guidelines for treatment of chronic primary angle-closure glaucoma.

Author: Muñoz-NegreteF J, González-Martín-MoroJ, Casas-LleraP, Urcelay-SeguraJ L, RebolledaG, UssaF, Güerri MonclúsN, Méndez HernándezC, Moreno-MontañésJ, Villegas PérezM P, PabloL E, García-FeijoóJ

Reduced IOP
Low scientific evidence

This article provides updated treatment recommendations for primary angle closure glaucoma in adults. The article discusses medical, laser, and surgical treatment options and reviews the level of scientific evidence for each.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

76.

Repeated intravitreous ranibizumab injections for diabetic macular edema and the risk of sustained elevation of intraocular pressure or the need for ocular hypotensive treatment.

Author: BresslerSusan B, AlmukhtarTalat, BhoradeAnjali, BresslerNeil M, GlassmanAdam R, HuangSuber S, JampolLee M, KimJudy E, MeliaMichele,

Anti-vascular endothelial growth factor
Retinal disease

This research examines the potential risks of intravitreous anti-vascular endothelial growth factor (VEGF) injections for retinal disease. While VEGF inhibitors are widely used, the study explores concerns about sustained elevation of intraocular pressure (IOP) and potential glaucoma risk.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

77.

iStent as a Solo Procedure for Glaucoma Patients: A Systematic Review and Meta-Analysis.

Author: Malvankar-MehtaMonali S, ChenYufeng Nancy, IordanousYiannis, WangWan Wendy, CostellaJohn, HutnikCindy M L

Glaucoma treatment

Glaucoma is a leading cause of blindness. While eye drops are usually the first treatment, they have significant drawbacks. New minimally invasive surgical procedures that target fluid drainage in the eye are prompting a shift in how glaucoma is treated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

78.

Influence on intraocular pressure of anti-inflammatory treatments after selective laser trabeculoplasty.

Author: ChampagneS, AnctilJ-L, GoyetteA, LajoieC, Des MarchaisB

Lower IOP
Safe procedure
Post-laser inflammation

This study examines the effect of post-treatment anti-inflammatory medication on intraocular pressure and side effects following selective laser trabeculoplasty (SLT) for open-angle glaucoma. The study investigates the potential benefits and risks of using anti-inflammatory treatments after SLT.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

79.

Combined surgery versus cataract surgery alone for eyes with cataract and glaucoma.

Author: ZhangMingjuan Lisa, HirunyachotePhenpan, JampelHenry

Cataract and glaucoma treatment

Cataracts and glaucoma are common eye conditions, especially in older adults. While treating both conditions at the same time may seem convenient, it can increase the risk of complications. Cataract surgery might actually help lower pressure in the eye, which could improve glaucoma control. This study aims to compare the effectiveness of doing both surgeries at once versus treating cataracts first. This will help doctors and patients make the best decision for their individual needs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

80.

Meta-analysis of selective laser trabeculoplasty versus topical medication in the treatment of open-angle glaucoma.

Author: LiXingyi, WangWei, ZhangXiulan

Open-angle glaucoma treatment

A meta-analysis of five prospective studies found that selective laser trabeculoplasty (SLT) and topical medication demonstrate similar success rates and effectiveness in lowering intraocular pressure in patients with open-angle glaucoma.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

81.

Comparing the effectiveness of selective laser trabeculoplasty with topical medication as initial treatment (the Glaucoma Initial Treatment Study): study protocol for a randomised controlled trial.

Author: LamoureuxEcosse L, McintoshRachel, ConstantinouMarios, FenwickEva K, XieJing, CassonRobert, FinkelsteinEric, GoldbergIvan, HealeyPaul, ThomasRavi, AngGhee Soon, PesudovsKonrad, CrowstonJonathan

Glaucoma treatment

Glaucoma is a leading cause of blindness, affecting millions worldwide. While eye drops are the usual first treatment, they have drawbacks like cost, side effects, and difficulty sticking to the treatment. Laser treatment has been shown to be as effective as eye drops in lowering pressure in the eye, but more research is needed to compare these options from the patient and economic perspectives.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

82.

Statistical analysis plan for the Laser-1st versus Drops-1st for Glaucoma and Ocular Hypertension Trial (LiGHT): a multi-centre randomised controlled trial.

Author: VickerstaffVictoria, AmblerGareth, BunceCatey, XingWen, GazzardGus,

Cost reduction
Glaucoma treatment
IOP lowering
Quality of life improvement
Treatment tolerance

This multicenter randomized controlled trial (LiGHT) compares two treatment pathways for newly diagnosed open-angle glaucoma (OAG) and ocular hypertension (OHT): selective laser trabeculoplasty (SLT) as the primary treatment ('Laser-1st') versus IOP-lowering drops ('Medicine-1st').

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

83.

Fornix-based versus limbal-based conjunctival trabeculectomy flaps for glaucoma.

Author: Al-HaddadChristiane, AbdulaalMarwan, Al-MoujahedAhmad, ErvinAnn-Margret

Glaucoma treatment

Glaucoma is a leading cause of preventable blindness. While eye drops and laser treatment are typically used first, surgery is an option if these treatments aren't effective. This review examines the different ways to perform a type of glaucoma surgery called trabeculectomy, focusing on the location of the incision (fornix-based vs. limbal-based) and comparing the outcomes of these approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

84.

Device-modified trabeculectomy for glaucoma.

Author: WangXue, KhanRabeea, ColemanAnne

Glaucoma treatment

Glaucoma is a leading cause of irreversible blindness. Lowering pressure inside the eye is the main way to prevent vision loss. While medications and laser surgery are commonly used, some patients need incisional surgery (trabeculectomy). New devices are being used with trabeculectomy to improve fluid drainage and lower eye pressure. The effectiveness and safety of these devices are still being studied.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

Refusal of Trabeculectomy for the Fellow Eye in Collaborative Initial Glaucoma Treatment Study (CIGTS) Participants.

Author: GuptaDivakar, MuschDavid C, NiziolLeslie M, ChenPhilip P

Hypotony

Refusal of fellow eye surgery was not uncommonly encountered in the CIGTS. Those who refused fellow eye surgery had lower fellow eye IOP and were more likely to have had hypotony after study eye trabeculectomy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

86.

[Trabeculotomy Combined with Cataract Surgery in Glaucoma: Outcome in a Rural Setting].

Author: KrönungS, WenzelM, WalterP, MazinaniB, RoesslerG, PlangeN

Effective treatment
Lowered medication
Reduced IOP
Safe procedure

This study examines the outcome of trabeculotomy combined with cataract surgery in patients with glaucoma. The study suggests that this combined approach can be a safe and effective treatment option for both conditions, even without intensified postoperative care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

87.

[Centrally acting cholinomimetics in the complex therapy of progressive glaucomatous optic neuropathy].

Author: ErichevV P, MazurovaYu V

Improved visual function

This study examines the therapeutic efficacy of Gliatilin as part of a complex treatment for progressive glaucomatous optic neuropathy. The study investigates the potential benefits of Gliatilin in stabilizing the disease process and preserving vision.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

88.

Neuroprotection for treatment of glaucoma in adults.

Author: SenaDayse F, LindsleyKristina

Glaucoma treatment

Glaucoma is a group of eye conditions that damage the optic nerve, leading to vision loss. Open-angle glaucoma (OAG) is the most common type and can occur with or without high eye pressure. Neuroprotection for glaucoma refers to treatments that aim to prevent damage to the optic nerve.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

Topical medication instillation techniques for glaucoma.

Author: XuLi, WangXuemei, WuMeijing

Glaucoma treatment

Glaucoma is a leading cause of blindness, and eye drops are the primary treatment to lower pressure in the eye. This study examines techniques for applying eye drops, such as closing the eyelid or blocking the tear duct, to increase how much medication goes into the eye and reduce how much enters the bloodstream.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

90.

Laser in Glaucoma and Ocular Hypertension (LiGHT) trial. A multicentre, randomised controlled trial: design and methodology.

Author: GazzardGus, KonstantakopoulouEvgenia, Garway-HeathDavid, BartonKeith, WormaldRichard, MorrisStephen, HunterRachael, RubinGary, BuszewiczMarta, AmblerGareth, BunceCatey,

Improved HRQL

The LiGHT Trial is a randomized controlled trial evaluating the effectiveness of initial treatment with selective laser trabeculoplasty (SLT) compared to topical medication for primary open-angle glaucoma (POAG) or ocular hypertension (OHT). The primary outcome is health-related quality of life (HRQL) and secondary outcomes include cost-effectiveness, clinical effectiveness, and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

91.

The Laser in Glaucoma and Ocular Hypertension (LiGHT) trial. A multicentre randomised controlled trial: baseline patient characteristics.

Author: KonstantakopoulouEvgenia, GazzardGus, VickerstaffVictoria, JiangYuzhen, NathwaniNeil, HunterRachael, AmblerGareth, BunceCatey,

This prospective, unmasked, multicentre, pragmatic, randomized controlled trial compared initial treatment with selective laser trabeculoplasty (SLT) to initial treatment with topical medication for primary open angle glaucoma (POAG) or ocular hypertension (OHT). The study recruited 718 previously untreated patients and will monitor them for three years.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

92.

<i>In Vivo</i> Analysis of Prostaglandins-induced Ocular Surface and Periocular Adnexa Modifications in Patients with Glaucoma.

Author: DI StasoSilvio, AgnifiliLuca, CecannecchiaSara, DI GregorioAngela, CiancagliniMarco

Reduced intraocular pressure
Ocular surface side effects
Periocular side effects

This review summarizes current knowledge about the periocular and ocular surface (OS) side effects of prostaglandin analogues (PGAs), a first-line medical treatment for glaucoma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

93.

Effectiveness of multiple therapeutic strategies in neovascular glaucoma patients: A PRISMA-compliant network meta-analysis.

Author: DongZixian, GongJianyang, LiaoRongfeng, XuShaojun

NVG treatment
Therapeutic strategies

Neovascular glaucoma (NVG) is a serious type of glaucoma with uncontrolled eye pressure that can cause severe pain and vision loss. While various treatments are available, they don't always work well. This study uses a network analysis to compare different treatment approaches for NVG.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

94.

Cyclodestructive procedures for non-refractory glaucoma.

Author: MichelessiManuele, BicketAmanda K, LindsleyKristina

Cyclodestructive procedures
Glaucoma treatment
Laser cyclophotocoagulation

Glaucoma is a major cause of blindness worldwide. Treatment focuses on preventing or slowing vision loss. High eye pressure is the main risk factor for glaucoma. One approach to lowering eye pressure is to destroy the part of the eye that produces fluid, using a procedure called laser cyclophotocoagulation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

95.

The Effect of an Educational Intervention on Adherence to Intraocular Pressure-Lowering Medications in a Large Cohort of Older Adults with Glaucoma.

Author: FiscellaRichard, CaplanEleanor, KamblePravin, BunniranSuvapun, UribeClaudia, ChandwaniHitesh

Glaucoma treatment
IOP reduction
Suboptimal adherence

Glaucoma is a condition that can cause vision loss if not properly treated. While effective treatments exist to lower eye pressure and slow the progression of glaucoma, many people don't consistently follow their treatment plans.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Validation StudyResearch to assess the validity and reliability of new measurement methods or diagnostic tests.

Language : English

96.

The Glaucoma Intensive Treatment Study (GITS), a randomized clinical trial: design, methodology and baseline data.

Author: BengtssonBoel, HeijlAnders, JohannessonGauti, Andersson-GeimerSabina, AspbergJohan, LindénChristina

Improved QoL
Improved visual field

The Glaucoma Intensive Treatment Study (GITS) compares the effectiveness of immediate intensive treatment versus a stepped regimen for glaucoma, evaluating visual field, quality of life, intraocular pressure reduction, side effects, adverse events, and treatment adherence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

97.

Aqueous shunt versus trabeculectomy for treatment of glaucoma.

Author: Ordenes-CavieresGonzalo, PimentelEduardo, SchmidtJimena

Aqueous shunt
Glaucoma treatment

Aqueous shunts are a newer type of surgery for glaucoma, an eye condition that can cause blindness. While traditional surgery (trabeculoectomy) is the standard treatment, aqueous shunts are often used when the traditional surgery doesn't work or is too risky for a specific type of glaucoma. However, their effectiveness compared to trabeculoectomy is still debated.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Spanish

98.

Surgical treatment of neovascular glaucoma: a systematic review and meta-analysis.

Author: ShchomakZakhar, Cordeiro SousaDavid, LealInês, Abegão PintoLuís

IOP lowering
Safer IOP lowering
Lack of high-quality evidence

Glaucoma drainage devices (GDDs) and cyclophotocoagulation showed similar IOP-lowering efficacy in neovascular glaucoma (NVG) patients, but GDDs had lower failure rates and loss of light perception. Ahmed glaucoma valve (AGV) and trabeculectomy also provided similar IOP-lowering results, with trabeculectomy having lower failure rates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

99.

Endoscopic cyclophotocoagulation (ECP) for open angle glaucoma and primary angle closure.

Author: TóthMárta, ShahAnupa, HuKuang, BunceCatey, GazzardGus

Endoscopic cyclophotocoagulation (ECP) is a minimally invasive surgical technique for glaucoma. However, there is no high-quality evidence for its efficacy and safety in people with open angle glaucoma (OAG) and primary angle closure. More research is needed to assess its medium and long-term effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

100.

Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial.

Author: GazzardGus, KonstantakopoulouEvgenia, Garway-HeathDavid, GargAnurag, VickerstaffVictoria, HunterRachael, AmblerGareth, BunceCatey, WormaldRichard, NathwaniNeil, BartonKeith, RubinGary, BuszewiczMarta,

Cost-effective
Improved HRQoL

Selective laser trabeculoplasty, compared to eye drops, is a cost-effective and safe first-line treatment for open angle glaucoma and ocular hypertension. It achieves similar quality of life and reduces the need for eye drops.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

101.

Ab interno trabecular bypass surgery with iStent for open-angle glaucoma.

Author: LeJimmy T, BicketAmanda K, WangLin, LiTianjing

Glaucoma treatment
MIGS
Uncertain effectiveness

Glaucoma is a leading cause of blindness that gradually causes loss of side vision and, in later stages, central vision. High eye pressure is the main risk factor for glaucoma. Minimally invasive glaucoma surgery (MIGS) is a new type of surgery for glaucoma. While these procedures are being used, it is not clear how effective they are at eliminating the need for eye drops and how they affect other outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

102.

Primary Selective Laser Trabeculoplasty for Open-Angle Glaucoma and Ocular Hypertension: Clinical Outcomes, Predictors of Success, and Safety from the Laser in Glaucoma and Ocular Hypertension Trial.

Author: GargAnurag, VickerstaffVictoria, NathwaniNeil, Garway-HeathDavid, KonstantakopoulouEvgenia, AmblerGareth, BunceCatey, WormaldRichard, BartonKeith, GazzardGus,

Reduced intraocular pressure
IOP spike

Primary selective laser trabeculoplasty (SLT) achieved comparable early absolute IOP-lowering in ocular hypertension (OHT) versus open-angle glaucoma (OAG) eyes. Drop-free disease-control was achieved in approximately 75% eyes at 36 months after 1 or 2 SLTs, the majority of these after single SLT.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

103.

A Prospective Randomized Trial Comparing Hydrus and iStent Microinvasive Glaucoma Surgery Implants for Standalone Treatment of Open-Angle Glaucoma: The COMPARE Study.

Author: AhmedIqbal Ike K, FeaAntonio, AuLeon, AngRobert E, HarasymowyczPaul, JampelHenry D, SamuelsonThomas W, ChangDavid F, RheeDouglas J,

Reduced IOP
Reduced medications

Standalone MIGS in OAG with the Hydrus resulted in a higher surgical success rate and fewer medications compared with the 2-iStent procedure. The 2 MIGS devices have similar safety profiles.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

104.

[Efficacy and safety of neuroprotection in patients with primary open-angle glaucoma].

Author: MalishevskayaT N, YusupovA R, ShatskikhS V, AntipinaN A, KlindyukT S, BogdanovaD S

POAG treatment

While high eye pressure is a major contributor to glaucoma, the disease can sometimes progress even when eye pressure is normal. This study emphasizes the need for new treatments that target other factors involved in glaucoma's progression, not just eye pressure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

105.

Selective laser trabeculoplasty versus drops for newly diagnosed ocular hypertension and glaucoma: the LiGHT RCT.

Author: GazzardGus, KonstantakopoulouEvgenia, Garway-HeathDavid, GargAnurag, VickerstaffVictoria, HunterRachael, AmblerGareth, BunceCatey, WormaldRichard, NathwaniNeil, BartonKeith, RubinGary, MorrisStephen, BuszewiczMarta

IOP control
Reduced surgery
None reported

A 36-month randomized controlled trial comparing selective laser trabeculoplasty (SLT) to topical IOP-lowering medication as first-line treatment for open-angle glaucoma (OAG) and ocular hypertension (OHT) found that SLT provided stable, drop-free IOP control in 74.2% of patients for at least 3 years, with reduced surgery, lower cost, and comparable health-related quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

106.

Primary baerveldt versus trabeculectomy study after 5 years of follow-up.

Author: IslamajEsma, WubbelsRené J, de WaardPeter W T

Glaucoma treatment

This study compares two surgical procedures for glaucoma, the Baerveldt glaucoma implant (BGI) and trabeculectomy (TE), in people who haven't had previous eye surgery. While BGI was initially used for glaucoma that didn't respond to other treatments, it is increasingly being used as the first treatment option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

107.

Efficacy of Repeat Selective Laser Trabeculoplasty in Medication-Naive Open-Angle Glaucoma and Ocular Hypertension during the LiGHT Trial.

Author: GargAnurag, VickerstaffVictoria, NathwaniNeil, Garway-HeathDavid, KonstantakopoulouEvgenia, AmblerGareth, BunceCatey, WormaldRichard, BartonKeith, GazzardGus,

IOP reduction
SLT efficacy

Repeat selective laser trabeculoplasty (SLT) maintained intraocular pressure (IOP) at or below target IOP in medication-naive open-angle glaucoma (OAG) and ocular hypertensive (OHT) eyes requiring retreatment, demonstrating an equivalent duration of effect to initial laser.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

108.

Selective laser trabeculoplasty versus medication for open-angle glaucoma: systematic review and meta-analysis of randomised clinical trials.

Author: ChiSheng Chu, KangYi-No, HwangDe-Kuang, LiuCatherine Jui-Ling

OAG treatment

The main treatment for open-angle glaucoma (OAG) is to lower eye pressure, typically with eye drops. A safe and effective alternative is laser treatment called selective laser trabeculoplasty (SLT). However, it's unclear whether SLT should be the first treatment for OAG instead of eye drops.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

109.

Ab interno trabecular bypass surgery with Schlemm´s canal microstent (Hydrus) for open angle glaucoma.

Author: OtarolaFrancisco, VirgiliGianni, ShahAnupa, HuKuang, BunceCatey, GazzardGus

Less surgery
Medication free
Reduced IOP
Intraocular bleeding
Vision loss

Adding the Hydrus microstent to cataract surgery in people with cataracts and mild to moderate open angle glaucoma likely increases the proportion of participants who do not require IOP lowering medication and may further reduce IOP at short- and medium-term follow-up.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

110.

Minimally Invasive Glaucoma Surgery: Where Is the Evidence?

Author: GillmannKevin, MansouriKaweh

Improved glaucoma treatment

This review provided an overview of minimally invasive glaucoma surgeries (MIGS), considering the growing number of treatment options for glaucoma and the need for evidence-based guidance on treatment choice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

111.

Laser Trabeculoplasty for Open-Angle Glaucoma: A Systematic Review and Network Meta-Analysis.

Author: ZhouRouxi, SunYi, ChenHaiying, ShaSha, HeMiao, WangWei

Reduced intraocular pressure

All types of laser trabeculoplasty (LT) are equally effective in reducing intraocular pressure compared to medication-based therapy. 180-degree selective LT was slightly more effective than argon LT in reducing the number of medications needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

112.

Evidence on the neuroprotective properties of brimonidine in glaucoma.

Author: ScuteriDamiana, BagettaGiacinto, NucciCarlo, AielloFrancesco, CesareoMassimo, ToninPaolo, CorasanitiMaria Tiziana

Brimonidine for glaucoma

This study discussed the neuroprotective mechanisms of α2 agonists, like brimonidine, in the treatment of glaucoma, considering their effectiveness in reducing visual field loss.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

113.

Viscotrabeculotomy versus trabeculectomy in the surgical treatment of open angle glaucoma: a single center, randomised controlled trial.

Author: ElwehidyAhmed S, MokbelTharwat H, BayoumiNader H L, BadawiAmani E, HagrasSherein M

Trabeculectomy efficacy
Viscotrabeculotomy efficacy
Hyphema
IOP spike

Viscotrabeculotomy showed better IOP reduction compared to trabeculectomy in OAG patients, while both procedures demonstrated efficacy and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

114.

Simulation-based surgical education for glaucoma versus conventional training alone: the GLAucoma Simulated Surgery (GLASS) trial. A multicentre, multicountry, randomised controlled, investigator-masked educational intervention efficacy trial in Kenya, South Africa, Tanzania, Uganda and Zimbabwe.

Author: DeanWilliam H, BuchanJohn, GichuhiStephen, PhilippinHeiko, ArungaSimon, MukomeAgrippa, AdmassuFisseha, LewisKarinya, MakupaWilliam, OtitiJuliet, KimMin J, MacleodDavid, CookColin, BurtonMatthew J

Improved surgical competence

This study assessed the impact of simulation-based surgical education for glaucoma in 51 trainee ophthalmologists in sub-Saharan Africa. The study found that an intensive simulation-based surgical training course significantly increased surgical competence at 3 months and 1 year, compared to the control group who received no simulation training.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

115.

Ab interno trabecular bypass surgery with Trabectome for open-angle glaucoma.

Author: HuKuang, ShahAnupa, VirgiliGianni, BunceCatey, GazzardGus

Ab interno trabecular bypass surgery for glaucoma

This review critically evaluated the evidence for the efficacy and safety of ab interno trabecular bypass surgery with Trabectome for treating open-angle glaucoma, considering the widespread uptake of this minimally invasive surgical technique.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

116.

Lens extraction for chronic angle-closure glaucoma.

Author: OngAriel Yuhan, NgSueko M, VedulaS Swaroop, FriedmanDavid S

PACG treatment

Primary angle-closure glaucoma (PACG) is a condition where pressure inside the eye increases due to blockage of fluid flow. Removing the lens of the eye may help reduce pressure by relieving the blockage. This study will compare removing the lens to other common treatments to see which works best for PACG.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

117.

Ab interno supraciliary microstent surgery for open-angle glaucoma.

Author: SandhuAmanjeet, JayaramHari, HuKuang, BunceCatey, GazzardGus

Glaucoma treatment

Glaucoma is a leading cause of blindness worldwide, and it's often caused by high pressure inside the eye. While medications and laser treatments can help, surgery is sometimes needed. Newer minimally invasive surgical procedures have been developed to reduce pressure with fewer risks. One such procedure involves inserting a small stent in a specific area of the eye (supraciliary microstent surgery) for open-angle glaucoma (OAG).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

118.

Minimally Invasive Glaucoma Surgical Techniques for Open-Angle Glaucoma: An Overview of Cochrane Systematic Reviews and Network Meta-analysis.

Author: BicketAmanda K, LeJimmy T, Azuara-BlancoAugusto, GazzardGus, WormaldRichard, BunceCatey, HuKuang, JayaramHari, KingAnthony, OtárolaFrancisco, NikitaEleni, ShahAnupa, SteadRichard, TóthMárta, LiTianjing

Glaucoma treatment

Glaucoma, a disease that affects eye pressure and can lead to vision loss, is a global concern. While surgery is a common treatment, newer minimally invasive glaucoma surgeries (MIGS) aim to reduce complications. This study seeks to understand the relative effectiveness and safety of these newer surgeries for glaucoma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

119.

Fornix-based versus limbal-based conjunctival trabeculectomy flaps for glaucoma.

Author: TheventhiranAlex B, KimGene, YaoWenJeng

Glaucoma treatment

Glaucoma is a leading cause of blindness, and surgery is often needed when medication and laser treatment don't work. This study focuses on a specific type of glaucoma surgery called trabeculectomy, looking at how two different approaches, fornix-based and limbal-based flaps, affect the outcomes and complications of the surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

120.

Effects of anti-inflammatory treatment on efficacy of selective laser trabeculoplasty: a systematic review and meta-analysis.

Author: ChenYu-Sheng, HungHai-Ting, GuoSiao-Pei, ChangHua-Ching

SLT for open-angle glaucoma

SLT (selective laser trabeculoplasty) can lower eye pressure in open-angle glaucoma. Some studies have looked at whether using anti-inflammatory medications to reduce discomfort after SLT affects how well the treatment works, but the answer is still unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

121.

Selective laser trabeculoplasty versus 0·5% timolol eye drops for the treatment of glaucoma in Tanzania: a randomised controlled trial.

Author: PhilippinHeiko, MatayanEinoti, KnollKarin M, MachaEdith, MbishiSia, MakupaAndrew, MatsinheCristóvão, da GamaVasco, MonjaneMario, NchedaAwum Joyce, MulobuanaFrancisco Alcides, MunaElisante, FopoussiNelly, GazzardGus, MarquesAna Patricia, ShahPeter, MacleodDavid, MakupaWilliam U, BurtonMatthew J

Glaucoma treatment
Low adherence

Glaucoma is a leading cause of blindness, especially in Africa. While eye drops are a common treatment, many people don't use them consistently. This study will compare a laser treatment (SLT) to eye drops to see which is better at controlling pressure inside the eye for people with open-angle glaucoma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

122.

Rho kinase inhibitor for primary open-angle glaucoma and ocular hypertension.

Author: Clement FreibergJosefine, von SpreckelsenAlexander, KolkoMiriam, Azuara-BlancoAugusto, VirgiliGianni

Glaucoma treatment

Glaucoma is a leading cause of blindness, affecting millions worldwide. Current treatments focus on lowering eye pressure to prevent further damage. Rho kinase inhibitors (ROKi) are a new type of medication for glaucoma that work differently than older treatments. While ROKi are becoming more widely available, more research is needed to assess their effectiveness and potential side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

123.

Laser trabeculoplasty for open-angle glaucoma and ocular hypertension.

Author: Rolim-de-MouraChristiane R, ParanhosAugusto, LoutfiMohamed, BurtonDavid, WormaldRichard, EvansJennifer R

Controls eye pressure
Slows glaucoma progression

Laser trabeculoplasty may be more effective than topical medication in slowing down the progression of open-angle glaucoma (OAG) and may be similar to modern eye drops in controlling eye pressure at a lower cost. It is not associated with serious unwanted effects, particularly for newer types of trabeculoplasty, such as selective laser trabeculoplasty.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

124.

Selective laser trabeculoplasty is safe and effective in patients previously treated with prostaglandin analogs: An evidence-based review.

Author: Ruiz-LozanoRaul E, Alamillo-VelazquezJimena, Ortiz-MoralesGustavo, Garza-GarzaLucas A, Quiroga-GarzaManuel E, Alvarez-GuzmanCarlos, Rodriguez-GarciaAlejandro

SLT for OHT and OAG

Prostaglandin analogs (PGAs) are commonly used to treat high eye pressure (OHT) and open-angle glaucoma (OAG), but they can cause side effects and are expensive. SLT (selective laser trabeculoplasty) is another option that is generally safe, has fewer side effects, and is less costly. Since PGAs and SLT work in similar ways, this study aimed to determine if prior use of PGAs affects the effectiveness of SLT.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

125.

Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial: Six-Year Results of Primary Selective Laser Trabeculoplasty versus Eye Drops for the Treatment of Glaucoma and Ocular Hypertension.

Author: GazzardGus, KonstantakopoulouEvgenia, Garway-HeathDavid, AdelekeMariam, VickerstaffVictoria, AmblerGareth, HunterRachael, BunceCatey, NathwaniNeil, BartonKeith,

SLT for OAG and OHT

This study reported the health-related quality of life (HRQoL) and clinical effectiveness of initial treatment with selective laser trabeculoplasty (SLT) compared to eye drops for open-angle glaucoma (OAG) and ocular hypertension (OHT).

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

126.

Device-modified trabeculectomy for glaucoma.

Author: ParkJunghyun, RittiphairojThanitsara, WangXue, EJian-Yu, BicketAmanda K

Glaucoma treatment

Glaucoma, a leading cause of blindness, damages the optic nerve and can lead to vision loss. Lowering eye pressure (IOP) is the main treatment. Trabeculectomy is a surgery that drains fluid from the eye to reduce IOP, but new devices are being developed to make the surgery safer and more effective. This study aims to compare the effectiveness and safety of these different devices used in trabeculectomy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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