Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices.

Author: CoelhoJoana E, CostenlaAna Rita, CunhaRodrigo A, LopesLuísa V, ParadaAntónio, RibeiroJ A, SebastiãoAna M, de MendonçaAlexandre

Paper Details 
Original Abstract of the Article :
The effects of carbamazepine on synaptic transmission in rat hippocampal slices were compared with those of two novel analogues (BIA2-093 and BIA2-024) with equivalent anticonvulsant efficacy but with fewer side effects. Carbamazepine (10-1000 microM) inhibited in a concentration-dependent manner th...See full text at original site
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引用元:
https://doi.org/10.1034/j.1600-0773.2002.900407.x

データ提供:米国国立医学図書館(NLM)

Investigating the Mechanisms of Carbamazepine and Analogues in Synaptic Transmission

The field of [Neuropharmacology] is constantly exploring the mechanisms of action of [anticonvulsant drugs] to optimize their therapeutic efficacy and minimize side effects. This research compares the effects of [carbamazepine] and two novel analogues on [synaptic transmission] in [rat hippocampal slices]. The study employs an [in vitro] approach to investigate the impact of these drugs on [field excitatory postsynaptic potential (fPSP)] responses, examining their potential targets within the neuronal circuitry.

Carbamazepine and its Analogues: Mechanistic Insights

This study provides valuable insights into the mechanisms of action of [carbamazepine] and its analogues. The findings indicate that [carbamazepine] and its analogues primarily inhibit [synaptic transmission] by [inhibiting conduction], although [carbamazepine] also exhibits a greater potency in inhibiting [NMDA receptor-mediated responses]. This suggests that these drugs may exert their anticonvulsant effects through a combination of mechanisms, targeting both [presynaptic and postsynaptic] components of neuronal communication.

Optimizing Anticonvulsant Therapy: A Focus on Mechanisms

This research highlights the importance of understanding the mechanisms of action of [anticonvulsant drugs] to optimize their therapeutic efficacy and minimize side effects. The study's findings suggest that [carbamazepine] and its analogues may exert their effects through a combination of mechanisms, targeting both [presynaptic and postsynaptic] components of neuronal communication. This information is crucial for developing more effective and targeted therapies for [seizure disorders].

Dr.Camel's Conclusion

Like a camel traversing a vast desert, researchers are constantly seeking new paths to understand the intricate mechanisms of anticonvulsant drugs. This study provides a map of the neural pathways that these drugs impact, helping to guide the development of more targeted and effective therapies for individuals struggling with seizure disorders.

Date :
  1. Date Completed 2002-12-17
  2. Date Revised 2019-09-06
Further Info :

Pubmed ID

12076316

DOI: Digital Object Identifier

10.1034/j.1600-0773.2002.900407.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

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