Side Effects of eslicarbazepine: A Synthesis of Findings from 32 Studies

  1. Home
  2. Side Effects of eslicarbazepine
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of eslicarbazepine: A Synthesis of Findings from 32 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of eslicarbazepine: A Synthesis of Findings from 32 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Eslicarbazepine acetate (ESL) is an anti-seizure medication taken once a day. Research shows that ESL is effective in treating partial-onset seizures (POS), a type of epilepsy. ESL was found to be generally safe and well-tolerated in patients. 14 12 17 19 24 20 27 30 29

Reason for Side Effects

ESL works by reducing the activity of nerve cells. This effect helps control seizures, but it can also lead to side effects. 14 18

Common Side Effects

Dizziness

Dizziness is one of the most common side effects of ESL. It can happen when ESL affects the part of the brain that controls balance. 14 18 19 27 30

Headache

Headache is another common side effect. It can occur when ESL affects blood vessels in the brain. 14 18 19 27

Nausea

Nausea is a possible side effect of ESL. It can happen when ESL affects the stomach. 14 27

Hyponatremia

ESL can cause hyponatremia, a condition where there is a low level of sodium in the blood. This can occur when ESL affects the kidneys. 14 19 25 27 31

Skin Reactions

ESL can cause skin reactions such as rashes, itching, and eczema. These reactions can happen when ESL affects the immune system. 10

Other Side Effects

Other reported side effects of ESL include fatigue, drowsiness, vision problems, and weight gain. 16 26 2 1

Managing Side Effects

Dizziness

If you experience dizziness, avoid driving, climbing stairs, or performing any dangerous tasks. Stay hydrated by drinking plenty of fluids. 14

Headache

For severe headaches, consult your doctor. They can determine the cause and prescribe appropriate treatment. 14

Nausea

To manage nausea, eat small, frequent meals. Avoid fatty or spicy foods and opt for easily digestible options. 14

Hyponatremia

If you experience symptoms of hyponatremia, seek medical attention immediately. Severe hyponatremia can lead to confusion, coma, and even death. 14

Skin Reactions

If you develop a skin reaction, stop taking ESL and consult your doctor. 10

Comparing Research

Commonalities

Multiple studies consistently demonstrate the effectiveness of ESL in treating partial-onset seizures. Research also indicates that ESL is generally considered a safe medication. 14 17 19 24 20 27 30 29

Differences

Some studies have found a weak correlation between ESL exposure and seizure-free rates, while others did not find this correlation. 14

Real-Life Application

While ESL is an effective treatment for partial-onset seizures, it's crucial to be aware of the potential side effects. Talk to your doctor before taking ESL to discuss the risks. Exercise caution when taking ESL, such as avoiding driving or performing dangerous tasks. 14

Limitations of Current Research

Research on ESL is still ongoing. More data is needed to fully understand the long-term effects of ESL, particularly concerning potential side effects. 14

Future Research Directions

Further research is needed to investigate the long-term side effects of ESL, its interactions with other medications, and optimal dosages and administration methods. 14

Conclusion

ESL is an effective treatment for partial-onset seizures but remember that potential side effects exist. Consult your doctor before taking ESL to discuss these risks. Exercise caution when taking ESL, such as avoiding driving or dangerous tasks. Further research is needed to better understand ESL's long-term effects, interactions with other medications, and optimal dosages and administration methods. 14

Keywords
Benefit Keywords
Depression treatment
2
ESL safety
3
Improved seizure control
Well-tolerated
5
Epilepsy treatment
6
epilepsy treatment
8
Seizure control
Tolerability
9
AED management
10
Epilepsy treatment
11
Improved quality of life
Reduced depression
Reduced seizure frequency
12
Effective treatment of FOS
13
Seizure control
14
Seizure control
15
Seizure control
17
Monotherapy option
POS treatment
19
Seizure control
21
Favorable tolerability profile
22
Improved alertness
Improved quality of life
Improved side effects
23
Improved epilepsy treatment
24
Seizure control
25
AED treatment
26
Partial-onset seizure treatment
27
Epilepsy treatment
28
Quality of life improvement
Seizure reduction
29
Reduced seizure frequency
30
Bipolar disorder treatment
Schizoaffective disorder treatment
31
Anticonvulsant efficacy
32
Risk Keywords
Antidepressant side effects
1
Side effects
Treatment outcome
2
Ataxia
Autistic features
Dystonia
Intractable epileptic seizures
Progressive cognitive decline
Psychomotor delay
4
Tiredness
Vertigo
5
Side effects
6
Dizziness
Hyponatremia
Somnolence
7
blood cell count changes
hyponatremia
lipid metabolism effects
liver function test changes
8
Drug allergy
Severe rash
10
Side effects
11
Allergic reaction
Depression
Dizziness
Falls
Hyponatremia
Hypothyroidism
12
Dizziness
Headache
Hyponatremia
Nausea
14
Adverse drug reactions
16
Dizziness
Fatigue
Headache
Hyponatremia
Nausea
Rash
Seizure
Somnolence
17
Diplopia
Dizziness
Headache
18
Dizziness
Instability
Somnolence
19
Psychiatric side effects
20
Side effects
21
Hyponatremia
25
Fatigue
26
Dizziness
Headache
Hyponatremia
Nausea
Oral contraceptive interactions
Somnolence
Vomiting
27
Side effects
29
Diplopia
Dizziness
Headache
30
Electrolyte abnormalities
Hyponatremic coma
31
Side effects
32
Literature analysis of 32 papers
Positive Content
28
Neutral Content
1
Negative Content
3
Article Type
9
1
0
9
31
1.

Common selective serotonin reuptake inhibitor side effects in older adults associated with genetic polymorphisms in the serotonin transporter and receptors: data from a randomized controlled trial.

Author: GarfieldLauren D, DixonDavid, NowotnyPetra, LotrichFrancis E, PollockBruce G, KristjanssonSean D, DoréPeter M, LenzeEric J

Antidepressant side effects

This study investigated the relationship between antidepressant side effects and genetic variations in the serotonin system in older adults experiencing anxiety. The research aimed to understand the impact of genetic variations on the effectiveness and tolerability of escitalopram, a selective serotonin reuptake inhibitor, in this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

2.

Antidepressant side effects and their impact on treatment outcome in people with major depressive disorder: an iSPOT-D report.

Author: BraundTaylor A, TillmanGabriel, PalmerDonna M, GordonEvian, RushA John, HarrisAnthony W F

Depression treatment
Side effects
Treatment outcome

This study looks at the frequency, intensity, and burden of side effects associated with antidepressant medications in people with major depressive disorder (MDD). The study found that the burden of side effects was associated with poorer treatment outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

In vitro effects of eslicarbazepine (S-licarbazepine) as a potential precision therapy on SCN8A variants causing neuropsychiatric disorders.

Author: BayraktarErva, LiuYuanyuan, SonnenbergLukas, HedrichUlrike B S, SaraYildirim, EltokhiAhmed, LyuHang, LercheHolger, WuttkeThomas V, LauxmannStephan

Ataxia
Autistic features
Dystonia
Intractable epileptic seizures
Progressive cognitive decline
Psychomotor delay

SCN8A gene variants can cause severe epilepsy and other neurological issues. Standard anticonvulsant treatment often has limited impact on these symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Efficacy and safety of antiseizure medication in post-stroke epilepsy.

Author: WinterYaroslav, UphausTimo, SandnerKatharina, KlimpeSven, Stuckrad-BarreSebastian von, GroppaSergiu

Improved seizure control
Well-tolerated
Tiredness
Vertigo

This study compared the effectiveness and safety of different antiseizure medications (ASM) in post-stroke epilepsy (PSE). ASMs acting via slow inactivation of sodium channels, like lacosamide and eslicarbazepine, were associated with better seizure control and were well-tolerated. Increased infarction size, cortical involvement, and neurological deficits were associated with increased seizure frequency.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

6.

Epilepsy in adults with neurodevelopmental disability - what every neurologist should know.

Author: WatkinsLance V, LinehanChristine, BrandtChristian, Snoeijen-SchouwenaarsFrancesca, McGowanPaula, ShankarRohit

Epilepsy treatment
Side effects

This seminar provides an overview of the special needs of persons with epilepsy and neurodevelopmental disorders (NDDs). The seminar explores the complexity of seizures in association with NDDs, focusing on intellectual disability, autism spectrum disorder, and attention deficit hyperactivity disorder. The seminar considers epidemiology, co-morbidities, risk factors, mortality, and the diagnostic and treatment challenges for these conditions.

CongressA conference or meeting where experts in a specific field gather. It provides opportunities for presentations, discussions, and networking, and serves as a place to share expertise and learn about the latest trends in the industry.

Language : English

7.

Safety of Eslicarbazepine Acetate in Elderly Versus Non-Elderly Patients with Focal Seizures: From Pooled Data of Clinical Studies to 8 Years of Post-Marketing Experience.

Author: MagalhãesLuís M, CostaRaquel, VieiraMariana, MoreiraJoana, GamaHelena, Soares-da-SilvaPatrício

Dizziness
Hyponatremia
Somnolence

A pooled analysis of seven phase II and III clinical trials of eslicarbazepine acetate (ESL) in adults with focal seizures revealed no specific safety concerns for elderly patients compared to non-elderly patients. The most commonly reported adverse events in both groups were dizziness, somnolence, and hyponatremia. Elderly patients experienced a higher incidence of serious adverse events, likely due to comorbidities and comedications. After 8 years of post-marketing surveillance, the safety profile of ESL remains consistent with the clinical trial findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Safety, tolerability and effectiveness of transition to eslicarbazepine acetate from carbamazepine or oxcarbazepine in clinical practice.

Author: RocamoraRodrigo, PeltolaJukka, AssenzaGiovanni, McMurrayRob, VillanuevaVicente

Seizure control
Tolerability

Eslicarbazepine acetate (ESL) was efficacious and generally well tolerated in patients transitioning from carbamazepine or oxcarbazepine due to inadequate seizure control or intolerable adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Risks and management of antiepileptic drug induced skin reactions in the adult out-patient setting.

Author: FowlerThomas, BansalAmolak S, LozsádiDora

AED management
Drug allergy
Severe rash

This study provides a management pathway for patients suffering from suspected drug-induced rash caused by antiepileptic drugs (AEDs). It includes pretreatment screening guidelines, clinical assessment, and information on alternative medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

[New antiepileptic drugs].

Author: VidaurreJorge, HerbstJames

Epilepsy treatment
Side effects

This study explores the effectiveness and safety profile of third-generation antiepileptic drugs for treating epilepsy. It highlights the benefits of newer drugs like brivaracetam, clobazam, lacosamide, and eslicarbazepine in managing different types of seizures and discusses the potential future role of drugs like cannabidiol, fenfluramine, allopregnenolona, and ganaxolone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Spanish

12.

Long-term safety and efficacy following conversion to eslicarbazepine acetate monotherapy in adults with focal seizures.

Author: ChungSteve, SinhaSaurabh R, ShahAashit, SternJohn M, ChengHailong, JungJungAh, GrinnellTodd, BlumDavid

Improved quality of life
Reduced depression
Reduced seizure frequency
Allergic reaction
Depression
Dizziness
Falls
Hyponatremia
Hypothyroidism

Long-term treatment with eslicarbazepine acetate (ESL) was effective and well tolerated for focal seizures (FS) as both a monotherapy and in combination with other antiepileptic drugs (AEDs). Median treatment retention time was >5 years. Quality of life and tolerability appeared to be better, and incidence of depression lower, in patients taking ESL as a monotherapy.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Exposure-safety and efficacy response relationships and population pharmacokinetics of eslicarbazepine acetate.

Author: GidalB E, JacobsonM P, Ben-MenachemE, CarreñoM, BlumD, Soares-da-SilvaP, FalcãoA, RochaF, MoreiraJ, GrinnellT, LudwigE, Fiedler-KellyJ, PassarellJ, SunkaraneniS

Effective treatment of FOS

This study developed pharmacokinetic (PK) and pharmacodynamic (PD) models for eslicarbazepine acetate (ESL), a once-daily antiepileptic drug (AED) for focal-onset seizures (FOS). These models aid in dose selection, identify significant AED drug interactions, and quantify relationships between exposure and safety and efficacy outcomes.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Population Pharmacokinetics and Exposure-Response Analyses of Eslicarbazepine Acetate Efficacy and Safety in Monotherapy of Partial-Onset Seizures.

Author: SunkaraneniSoujanya, LudwigElizabeth A, PassarellJulie A, BlumDavid, GrinnellTodd, Fiedler-KellyJill

Seizure control
Dizziness
Headache
Hyponatremia
Nausea

Eslicarbazepine acetate (ESL) is an antiepileptic drug used for partial-onset seizures. This study analyzed the pharmacokinetics (PK) and exposure-response of ESL in patients receiving monotherapy. The results suggest that ESL PK is similar to that observed in adjunctive therapy and that dose adjustment based on body weight is not necessary.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Efficacy and safety of eslicarbazepine acetate monotherapy in patients converting from carbamazepine.

Author: PazderaLadislav, SperlingMichael R, HarveyJay H, SamMaria C, StromLaura A, BlumDavid, GrinnellTodd, ChengHailong

Seizure control

This study investigated the impact of prior use of carbamazepine and other similar antiepileptic drugs on seizure outcomes and tolerability when switching to eslicarbazepine acetate. Data from two controlled clinical trials revealed that prior use of these medications did not significantly affect seizure outcomes or tolerability.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Safety Profile of the Newest Antiepileptic Drugs: A Curated Literature Review.

Author: PalleriaCaterina, CozzaGiuseppe, KhengarRajeshree, LibriVincenzo, De SarroGiovambattista

Adverse drug reactions

While there are new antiepileptic drugs (AEDs) available, many people with epilepsy still struggle with their condition and its treatment. While some new AEDs have been approved recently, we still don’t know much about how safe they are to use long-term.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Safety Profile of Eslicarbazepine Acetate as Add-On Therapy in Adults with Refractory Focal-Onset Seizures: From Clinical Studies to 6 Years of Post-Marketing Experience.

Author: GamaHelena, VieiraMariana, CostaRaquel, GraçaJoana, MagalhãesLuís M, Soares-da-SilvaPatrício

Seizure control
Dizziness
Fatigue
Headache
Hyponatremia
Nausea
Rash
Seizure
Somnolence

Eslicarbazepine acetate maintains a similar safety profile after 6 years of post-marketing surveillance as observed in pivotal clinical studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Eslicarbazepine Acetate: A New Improvement on a Classic Drug Family for the Treatment of Partial-Onset Seizures.

Author: GalianaGraciana L, GauthierAngela C, MattsonRichard H

Diplopia
Dizziness
Headache

Eslicarbazepine acetate is a new anti-epileptic drug that has shown promising results in treating patients with partial-onset seizures. The drug is generally well-tolerated and has fewer drug-drug interactions compared to older AEDs. Eslicarbazepine acetate is a valuable option for treating patients with partial-onset epilepsy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Efficacy and safety of eslicarbazepine acetate monotherapy for partial-onset seizures: Experience from a multicenter, observational study.

Author: ToledanoRafael, JovelCamilo Espinosa, Jiménez-HueteAdolfo, BayarriPau Giner, CamposDulce, GomarizElena López, GiráldezBeatriz González, García-MoralesIrene, FalipMercé, AgredanoPaula Martínez, PalaoSusana, PriorMaría José Aguilar Amat, PascualMaría Rosa Querol, NavacerradaFrancisco José, GonzálezFrancisco Javier López, OjedaJoaquín, SáezAránzazu Alfaro, BermejoPedro Emilio, Gil-NagelAntonio

Monotherapy option
POS treatment
Dizziness
Instability
Somnolence

This prospective, non-interventional study investigated the efficacy and tolerability of eslicarbazepine acetate (ESL) as monotherapy for partial-onset seizures (POS) in Spain. ESL was effective in reducing seizure frequency and well tolerated, with the majority of adverse events being mild and transient.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

21.

New developments in the management of partial-onset epilepsy: role of brivaracetam.

Author: CoppolaGiangennaro, IapadreGiulia, OpertoFrancesca Felicia, VerrottiAlberto

Seizure control
Side effects

Brivaracetam, a new anticonvulsant drug, is highly effective in a broad range of experimental models of focal and generalized seizures. It was approved in the European Union in January 2016 and in the US in February 2016 as an adjunctive therapy for the treatment of POS in patients older than 16 years of age. Brivaracetam is generally well tolerated with only mild-to-moderate side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

[Anticonvulsant add-on therapy with Eslicarbazepine acetate : Results of the EPOS-study in adults in Germany].

Author: LoschF-P, HoltkampM, McMurrayR, LendemansD, KockelmannE

Favorable tolerability profile

This study discusses the use of eslicarbazepine acetate (ESL) as an add-on therapy for patients with partial-onset seizures (POS). The study highlights the favorable tolerability profile of ESL and its potential for improving seizure control.

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : German

23.

Overnight switching from oxcarbazepine to eslicarbazepine acetate: an observational study.

Author: SchmidE, KuchukhidzeG, KirschnerM, LeitingerM, HöflerJ, RohracherA, KalssG, WendlingA-S, SteinhoffB J, TrinkaE

Improved alertness
Improved quality of life
Improved side effects

An overnight switch from immediate-release oxcarbazepine to eslicarbazepine acetate improved tolerability, quality of life, and alertness in patients with drug-resistant focal epilepsy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

24.

Third generation antiepileptic drug monotherapies in adults with epilepsy.

Author: MulaMarco

Improved epilepsy treatment

This paper reviews available data on monotherapy with third-generation antiepileptic drugs and discusses the ongoing debate about monotherapy licensing for epilepsy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

25.

Hyponatremia following esclicarbazepine therapy.

Author: GuptaDurgesh K, BhoiSanjeev K, KalitaJayantee, MisraUsha K

Seizure control
Hyponatremia

Eslicarbazepine acetate (ESL) treatment in new onset elderly poststroke seizure patients was associated with a high incidence of hyponatremia. Monitoring of serum sodium is recommended, especially in elderly patients, as hyponatremia symptoms can be subtle and delayed.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

26.

A review on antiepileptic drugs-dependent fatigue: pathophysiological mechanisms and incidence.

Author: SiniscalchiAntonio, GallelliLuca, RussoEmilio, De SarroGiovambattista

AED treatment
Fatigue

Antiepileptic drugs (AEDs) can cause fatigue through various mechanisms, including central nervous system depression and peripheral changes. The risk of fatigue varies depending on the drug and patient characteristics. AEDs acting on the GABAergic system have the highest incidence of fatigue, followed by Gabapentin and Levetiracetam, while those primarily inhibiting sodium channels have the lowest.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

27.

A review of eslicarbazepine acetate for the adjunctive treatment of partial-onset epilepsy.

Author: SinghRajinder P, AsconapéJorge J

Partial-onset seizure treatment
Dizziness
Headache
Hyponatremia
Nausea
Oral contraceptive interactions
Somnolence
Vomiting

Eslicarbazepine acetate is a novel antiepileptic drug effective in treating partial-onset seizures.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

28.

[Abrupt switch from extended-release oxcarbazepine to eslicarbazepine acetate].

Author: SteinhoffB J, TrinkaE, WendlingA S

Epilepsy treatment

This study investigated how to switch patients from oxcarbazepine (OXC) to eslicarbazepine acetate (ESL) and if this switch causes any clinical changes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

29.

Long-term efficacy and safety of eslicarbazepine acetate: results of a 1-year open-label extension study in partial-onset seizures in adults with epilepsy.

Author: HalászPeter, CramerJoyce A, HodobaDanilo, CzłonkowskaAnna, GuekhtAlla, MaiaJoana, ElgerChristian, AlmeidaLuis, Soares-da-SilvaPatricio,

Quality of life improvement
Seizure reduction
Side effects

Eslicarbazepine acetate (ESL) is an effective and safe treatment for partial-onset seizures in adults with epilepsy. In a one-year open-label study, ESL reduced seizure frequency by 39% in the first four weeks and by 48-56% thereafter. The responder rate (≥50% seizure reduction) was 41% during weeks 1-4 and ranged between 48-53% thereafter. The proportion of seizure-free patients ranged between 8.7% and 12.5%. Quality of life and depressive symptoms also improved significantly. Treatment-emergent adverse events (TEAEs) were reported by 51% of patients, most of which were mild to moderate. Eleven patients (3.5%) discontinued due to TEAEs.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: a randomized, double-blind, placebo-controlled, parallel-group phase III study.

Author: ElgerChristian, HalászPeter, MaiaJoana, AlmeidaLuis, Soares-da-SilvaPatrício,

Reduced seizure frequency
Diplopia
Dizziness
Headache

ESL, 800 and 1,200 mg once-daily, was well tolerated and more effective than placebo in patients who were refractory to treatment with one or two concomitant AEDs.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Oxcarbazepine in the treatment of bipolar and schizoaffective disorders.

Author: PopovaEkaterine, LeightonCaroline, BernabarreAntoni, BernardoMiquel, VietaEduard

Bipolar disorder treatment
Schizoaffective disorder treatment
Electrolyte abnormalities
Hyponatremic coma

Oxcarbazepine, an antiepileptic drug, may be effective for treating manic symptoms in patients with bipolar and schizoaffective disorders. However, more research is needed to confirm its efficacy and safety in these conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

32.

Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices.

Author: CunhaRodrigo A, CoelhoJoana E, CostenlaAna Rita, LopesLuísa V, ParadaAntónio, de MendonçaAlexandre, SebastiãoAna M, RibeiroJ A

Anticonvulsant efficacy
Side effects

This study compared the effects of carbamazepine and two new analogues (BIA2-093 and BIA2-024) on synaptic transmission in rat hippocampal slices. All three drugs inhibited synaptic transmission, but carbamazepine was more potent at inhibiting NMDA receptor-mediated responses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.