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A multicenter, randomized, double-blind, placebo-controlled trial of adjuvant methotrexate treatment for giant cell arteritis.

Author: , BacaShawn, BorkDebora, CalabreseLeonard H, ChoiHyon K, CidMaria C, CohenPascal, DicklerHoward, EasleyKirk A, FerlandDiane, FesslerBarri J, FlynnJohn A, FortinPaul, GrossWolfgang, GuillevinLoic, HellmannDavid B, Hernández-RodríguezJ, HoffmanDiane B, HoffmanGary S, HunderGene G, KalunianKenneth, KlashmanDavid, KosmorskyGregory, LockerGeri A, Lopez-SotoAlfons, LudivicoCharles, LuqmaniRaashid A, MandellBrian F, McRorieEuan, MerkelPeter A, NukiGeorge, PraysonRichard, PuechalXavier, ScheetzRaymond J, SchnedEric, SchousboeJohn, SegalAllen M, SherrerYvonne, SnellerMichael C, SoubrierMartin, StoneJohn H, SwansonHoward, TuggleCarol, WalshBridgit, WilkeWilliam S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Methotrexate did not reduce the risk of treatment failure or the cumulative dose and toxicity of corticosteroids in patients with GCA.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate treatment with methotrexate (MTX) in patients with newly diagnosed giant cell arteritis (GCA) to determine if MTX reduces GCA relapses and cumulative corticosteroid (CS) requirements and diminishes disease- and treatment-related morbidity. METHODS: This was a multicenter, ran...See full text at original site
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引用元：
https://doi.org/10.1002/art.10262

データ提供：米国国立医学図書館（NLM）

A New Approach: Evaluating Methotrexate for Giant Cell Arteritis

Giant cell arteritis (GCA), an inflammatory condition affecting the arteries, can lead to severe complications if left untreated. This study investigated the potential benefits of adding methotrexate (MTX) to the standard treatment for GCA, which typically involves high doses of corticosteroids. The researchers conducted a randomized, double-blind, placebo-controlled trial to compare the effectiveness of MTX versus placebo in patients with newly diagnosed GCA.

Seeking a Safer Path: Evaluating Methotrexate for GCA

The study found that adding MTX to corticosteroid therapy did not significantly reduce the risk of GCA relapses or decrease the cumulative corticosteroid dose required to manage the condition. The study also found no significant differences in serious morbidity or treatment toxicity between the MTX and placebo groups. These results suggest that MTX may not be an effective adjunctive therapy for GCA.

Navigating the Complexities of GCA Treatment

Giant cell arteritis can be a challenging condition to manage, and finding the right treatment approach is crucial for preventing complications and improving quality of life. If you are diagnosed with GCA, it's important to work closely with your doctor to develop a personalized treatment plan that addresses your individual needs and risks.

Dr.Camel's Conclusion

This research provides valuable insights into the potential role of methotrexate in treating giant cell arteritis. While the study did not find evidence to support the use of MTX as an adjunctive therapy, it emphasizes the importance of rigorous research in evaluating new treatment options for complex medical conditions. As we continue to explore the vast desert of medical knowledge, we strive to find the most effective and safe treatments for those who need them.

Date :
  1. Date Completed 2002-07-31
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

12115238

DOI: Digital Object Identifier

10.1002/art.10262

SNS
PICO Info
in preparation
Languages

English

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