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Onset of action, efficacy, and safety of fexofenadine 60 mg/pseudoephedrine 120 mg versus placebo in the Atlanta allergen exposure unit.

Author: BerkowitzRobert B, LutzCheryl, MeevesSuzanne, MossMadelyn, WeilerJohn, WeilerKay, WoodworthGeorge G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This single-dose, double-blind, placebo-controlled study determined the onset of action of fexofenadine-pseudoephedrine (Allegra-D, Aventis, Bridgewater, NJ) for treating moderate-to-severe seasonal allergies in an allergen exposure unit. Of 571 screened subjects, 298 were randomized. Onset of relief for fexofenadine-pseudoephedrine (n = 148) was 45 minutes postdose. Fexofenadine-pseudoephedrine was safe and effective in treating a broad range of allergy symptoms, with a rapid onset of action at 45 minutes.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Second-generation antihistamine-decongestant combinations are often used to treat seasonal allergies. However, onset of action and efficacy data for these agents in a controlled setting are limited. OBJECTIVE: Determine onset of action of fexofenadine-pseudoephedrine (Allegra-D, Aventis...See full text at original site
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引用元：
https://doi.org/10.1016/S1081-1206(10)61909-6

データ提供：米国国立医学図書館（NLM）

Fexofenadine-Pseudoephedrine: A Quick Relief for Allergies

The desert of allergy season can be a harsh and uncomfortable environment, filled with sneezing, itchy eyes, and runny noses. This study investigated the effectiveness and speed of relief offered by fexofenadine-pseudoephedrine, a common treatment for seasonal allergies. The researchers, like scientists testing new desert survival strategies, conducted a controlled trial to assess the onset of action and efficacy of this medication. Their findings suggest that fexofenadine-pseudoephedrine provides a rapid and effective oasis from the discomfort of allergies.

Rapid Relief: A Quick Oasis in the Desert

The study revealed that fexofenadine-pseudoephedrine, like a refreshing spring in the desert, provided relief from allergy symptoms within 45 minutes of taking the medication. This rapid onset of action is significant, as it can quickly alleviate discomfort and allow individuals to navigate the challenging desert of allergy season with greater ease. The researchers also found that the medication was well-tolerated, indicating that it can be a reliable and effective tool for combating allergy symptoms.

Navigating the Desert of Allergy Season

The desert of allergy season can be a challenging landscape to navigate. This study offers valuable insights into a potential remedy that provides rapid relief from discomfort. It's important to consult with a healthcare professional to determine the best treatment approach based on individual needs and the specific characteristics of your allergy symptoms.

Dr. Camel's Conclusion

This research on fexofenadine-pseudoephedrine for allergies is like discovering a hidden oasis in the desert. It offers a rapid and effective solution for alleviating allergy symptoms, providing a quick reprieve from the discomfort and allowing individuals to navigate the desert of allergy season with greater ease. This study is a valuable guidepost in the quest for relief from allergy symptoms, offering a beacon of hope in the midst of the desert.

Date :
  1. Date Completed 2002-08-13
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

12141718

DOI: Digital Object Identifier

10.1016/S1081-1206(10)61909-6

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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