Effects of fexofenadine and pseudoephedrine: A Synthesis of Findings from 6 Studies

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Original Abstract of the Article

Major findings

Several studies have shown that the combination of fexofenadine and pseudoephedrine is effective in improving symptoms of seasonal allergic rhinitis. 6 , 5 . Fexofenadine is a potent suppressor of histamine-induced wheal and flare response, with a rapid onset of action compared to other antihistamines. 2 . Fexofenadine has been shown to be relatively safe and free of disruptive effects on cognitive and psychomotor function, as compared to other antihistamines such as promethazine. 1 .

Benefits and risks

Benefits summary

Fexofenadine and pseudoephedrine combination can be effective in improving symptoms of seasonal allergic rhinitis and improving quality of life. Fexofenadine has been shown to be more effective and quicker in suppressing histamine-induced reactions compared to other antihistamines, and with fewer side effects.

Risks summary

Pseudoephedrine may cause insomnia. 6 . While fexofenadine is generally considered safe, it can rarely cause side effects such as digestive problems and headaches. 3

Comparison across studies

Commonalities

Several studies have shown that the combination of fexofenadine and pseudoephedrine is effective in improving symptoms of seasonal allergic rhinitis. 6 , 5 . Fexofenadine is consistently reported to be more effective and quicker in suppressing histamine-induced reactions compared to other antihistamines. 2 .

Differences

Studies have produced differing results regarding the effect of the fexofenadine and pseudoephedrine combination on sleep. 6 . Different studies have also reported different results regarding the effects of fexofenadine on cognitive and psychomotor function. 1

Consistency and contradictions

Multiple studies indicate the effectiveness of fexofenadine and pseudoephedrine combination in improving symptoms of seasonal allergic rhinitis. However, further research is needed to better understand the impact on sleep and cognitive function.

Application to daily life

Fexofenadine and pseudoephedrine combination can help to improve symptoms of seasonal allergic rhinitis. However, as pseudoephedrine can cause insomnia, avoid taking it close to bedtime. 6 . This medication can interact with other medications, so it is important to consult a doctor or pharmacist before taking it.

Limitations of current research

More research is needed to understand the long-term safety and effectiveness of the fexofenadine and pseudoephedrine combination. The impact on different age groups and ethnic populations also requires further study.

Future research directions

Further studies are needed to investigate the long-term safety and effectiveness of the fexofenadine and pseudoephedrine combination, its impact on different age groups and ethnic populations, and its effects on sleep and cognitive function.

Conclusion

Fexofenadine and pseudoephedrine combination can be effective in improving symptoms of seasonal allergic rhinitis. However, as this medication can affect sleep and cognitive function, it is essential to consult a doctor or pharmacist before taking it. If you are struggling with seasonal allergic rhinitis, consult a doctor for a proper diagnosis and treatment plan.

Literature analysis of 6 papers
Positive Content
6
Neutral Content
0
Negative Content
0
Article Type
4
1
1
0
6
1.

A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function.

Author: HindmarchI, ShamsiZ, StanleyN, FairweatherD B

No cognitive impairment

Fexofenadine at doses up to 180 mg appears free from disruptive effects on aspects of psychomotor and cognitive function. Loratadine did not cause any significant impairment of cognitive function. Promethazine caused significant impairment of cognitive function and increased sleep-like activity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Suppression of the histamine-induced wheal and flare response by fexofenadine HCl 60 mg twice daily, loratadine 10 mg once daily and placebo in healthy Japanese volunteers.

Author: BoyleJulia, RidoutFran, MeadowsRobert, JohnsenSigurd, HindmarchIan

Faster onset of action
Histamine suppression
Longer duration of effect

This study found that fexofenadine is a potent suppressor of the histamine-induced wheal and flare response in healthy Japanese volunteers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials.

Author: HuangCheng-Zhi, JiangZhi-Hui, WangJian, LuoYue, PengHua

Allergic disease treatment

This systematic review evaluated the antihistamine effects and safety of fexofenadine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Onset of action, efficacy, and safety of fexofenadine 60 mg/pseudoephedrine 120 mg versus placebo in the Atlanta allergen exposure unit.

Author: BerkowitzRobert B, WoodworthGeorge G, LutzCheryl, WeilerKay, WeilerJohn, MossMadelyn, MeevesSuzanne

Effective
Rapid onset of action
Safe

This single-dose, double-blind, placebo-controlled study determined the onset of action of fexofenadine-pseudoephedrine (Allegra-D, Aventis, Bridgewater, NJ) for treating moderate-to-severe seasonal allergies in an allergen exposure unit. Of 571 screened subjects, 298 were randomized. Onset of relief for fexofenadine-pseudoephedrine (n = 148) was 45 minutes postdose. Fexofenadine-pseudoephedrine was safe and effective in treating a broad range of allergy symptoms, with a rapid onset of action at 45 minutes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Comparison of the combinations of fexofenadine-pseudoephedrine and loratadine-montelukast in the treatment of seasonal allergic rhinitis.

Author: MoinuddinRizwan, deTineoMarcy, MaleckarBarbara, NaclerioRobert M, BaroodyFuad M

Reduced allergic rhinitis symptoms
Potential insomnia

Fexofenadine-pseudoephedrine and loratadine-montelukast had comparable efficacy in treating seasonal allergic rhinitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

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