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2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections.

Author: AndreiGraciela, BodaghiBahram, BousseauAnne, BronDominique, DaelemansDirk, LagneauxLaurence, MichelsonSusan, NaesensLieve, NemecekConception, NeytsJohan, OttoMichael J, RoyChristine, ScholsDominique, SnoeckRobert, de ClercqErik

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

CMV423, a novel antiviral agent, demonstrated potent in vitro activity against human cytomegalovirus (HCMV), including strains resistant to existing drugs.
Paper Details　
Original Abstract of the Article :
Human cytomegalovirus (HCMV) remains one of the major pathogens in immunocompromised patients (AIDS and transplants) and the main cause for congenital infections leading from slight cognitive defects up to severe mental retardation. The drugs that are currently available for the treatment of HCMV in...See full text at original site
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引用元：
https://doi.org/10.1016/s0166-3542(02)00074-8

データ提供：米国国立医学図書館（NLM）

A New Weapon Against Human Cytomegalovirus

Human cytomegalovirus (HCMV), a persistent threat, particularly for those with weakened immune systems, is like a desert bandit lurking in the shadows. This study introduces a promising new weapon against HCMV, a molecule called CMV423, which is like discovering a hidden oasis with potent anti-bandit properties. The researchers tested CMV423's effectiveness against various strains of HCMV, finding that it exhibited potent activity against both common and drug-resistant strains. This discovery is encouraging, as it could offer a new line of defense against this persistent foe.

CMV423: A Potential Game-Changer in the Fight Against HCMV

This study reveals the potential of CMV423 as a potent weapon against HCMV. Its high activity against both drug-sensitive and drug-resistant strains is a significant development, potentially opening up new avenues for treatment. The researchers also observed that CMV423 could work synergistically with existing anti-HCMV drugs, which is like having multiple warriors cooperating to defeat a common enemy.

Hope for Those Affected by HCMV

The development of CMV423 offers a glimmer of hope for those affected by HCMV. This discovery, like finding a hidden oasis in a vast desert, could offer a new and effective way to fight this persistent foe. The researchers' findings emphasize the importance of ongoing research and development in the battle against HCMV.

Dr.Camel's Conclusion

This study introduces a promising new tool in the fight against HCMV, a persistent bandit lurking in the shadows of our immune system. CMV423, like a hidden oasis, offers a potent defense against this formidable foe, potentially leading to new treatments for those affected by this debilitating virus. This is a step forward in the ongoing battle against HCMV, reminding us that even in the vast desert of viral infections, there is always hope for new discoveries and solutions.

Date :
  1. Date Completed 2003-04-02
  2. Date Revised 2019-09-22
Further Info :

Pubmed ID

12206879

DOI: Digital Object Identifier

10.1016/s0166-3542(02)00074-8

SNS
PICO Info
in preparation
Languages

English

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